Science
Research in the LMB spans the breadth of biology, from the origin of life, to the structures of macromolecules, to the molecular organisation of the brain and immune system.
A 3D view of the human telomerase complex, revealing its distinctive X-shaped structure. Learn how this important molecule was visualised in this news article.
Matteo AllegrettiStructural StudiesThe macromolecular basis of nuclear shape and remodelling
Ivana BukvinProtein and Nucleic Acid ChemistryDe novo protein folding
Radu AricescuNeurobiologyThe structural biology of neuronal connectivity
Diana ArseniNeurobiologyLysosomal TMEM106B in brain ageing and disease
David BarfordStructural StudiesMechanism and regulation of chromosome segregation in mitosis
Buzz BaumCell BiologyThe generation and evolution of biological form: from archaea to eukaryotes 
Anne BertolottiNeurobiologyUnderstanding and manipulating cellular resilience in health and disease
Tanmay BharatStructural StudiesRole of surface molecules in microbial multicellularity
Simon BullockCell BiologyMolecular cell biology of cytoskeletal transport
Albert CardonaNeurobiologyExperimental and comparative connectomics
Andrew CarterStructural StudiesThe structure and mechanism of dyneins
Emmanuel DeriveryCell BiologyMolecular basis of cell polarisation and asymmetry
Juliette FedryCell BiologyCellular proteostasis networks in physiology and diseases
Michel GoedertNeurobiologyMolecular mechanisms of neurodegeneration
Joe GreenerStructural StudiesImproving force fields for biomolecular simulation
Ingo GregerNeurobiologyAMPA receptor biogenesis, structure and function
Michael HastingsNeurobiologyNeurons and biological timing: molecular neurobiology of the circadian clock
Ramanujan HegdeCell BiologyMembrane protein biosynthesis and quality control
Philipp HolligerProtein and Nucleic Acid ChemistryEvolution of novel biopolymers
Leo JamesProtein and Nucleic Acid ChemistryHost-pathogen biology
Gregory JefferisNeurobiologyGenes, circuits and behaviour in Drosophila
Joergen KornfeldNeurobiologyConnectomics of learned behaviour
Patrycja KozikProtein and Nucleic Acid ChemistryDendritic cells and initiation of immune responses
Madeline LancasterCell BiologyHuman brain development and evolution
Roni Levin KonigsbergCell BiologyMolecular physiology of phagocytic cells in health and disease
Jan LöweStructural StudiesProkaryotic cytoskeletons and other molecular machines
Kate McDoleCell BiologyMorphogenesis of the early mammalian embryo
Andrew McKenzieProtein and Nucleic Acid ChemistryInvestigation of immune and haematopoietic disorders
Harvey McMahonNeurobiologyMembrane curvature as an organising principle for eukaryotic cell biology
Sean MunroCell BiologyFunctional organisation of the Golgi apparatus
Garib MurshudovStructural StudiesComputational structural biology
Kelly NguyenStructural StudiesMolecular mechanism of telomere maintenance
John O’NeillCell BiologyCellular rhythms, signalling and metabolic regulation
Lori PassmoreStructural StudiesMolecular machines that regulate gene expression 
Lalita RamakrishnanMolecular Immunity Unit, Cell BiologyMechanisms of tuberculosis pathogenesis
Felix RandowProtein and Nucleic Acid ChemistryCell-autonomous and innate immunity
Jing RenNeurobiologyDevelopmental assembly of the serotonin system
Wes RobertsonProtein and Nucleic Acid ChemistrySynthetic genomics for microbiome reprogramming
Noe RodriguezProtein and Nucleic Acid ChemistryInvestigation of immunity and neuro-immune modulation in infection and cancer 
Christopher RussoStructural StudiesImaging the atomic structure of biological molecules by electron cryomicroscopy
Benjamin Ryskeldi‑FalconNeurobiologyPathological protein assembly in neurodegenerative diseases
Julian SaleProtein and Nucleic Acid ChemistryVertebrate mutagenesis
William SchaferNeurobiologyCellular and molecular mechanisms of behaviour
Sjors ScheresStructural StudiesStructural biology of neurodegeneration
Marta ShahbaziCell BiologyCell fate decisions in the early mammalian embryo
John SutherlandProtein and Nucleic Acid ChemistryChemical origins of molecular biology
Chris TateStructural StudiesStructure and function of G protein-coupled receptors
Marco TripodiNeurobiologyNeural circuits for goal-oriented actions
Sven TruckenbrodtNeurobiologyMolecular brain mapping
Ana Tufegdžić VidakovićProtein and Nucleic Acid ChemistryMolecular basis of gene transcription
Roger WilliamsProtein and Nucleic Acid ChemistryStructural studies of phosphoinositide signalling and intracellular sorting
Joseph YeelesProtein and Nucleic Acid ChemistryMechanisms of chromosome replication
Suyang ZhangStructural StudiesMechanism of transcription-coupled alternative splicing
Marta ZlaticNeurobiologyCircuit mechanisms of learning and action‑selection
Latest Research Highlights
Scientific Divisions
Exploring the molecular organisation of cells
Understanding the brain in health and disease
Molecular immunology, genome integrity, chemical and synthetic biology
Mechanisms of life
Latest Publications
Crystal structure of a closed ternary complex of a HNA Reverse Transcriptase in complex with a HNA/DNA duplex.PLoS One • 21(7):e0351418 • doi: 10.1371/journal.pone.0351418
Determining the molecular and physiological actions of subtype-selective nanobodies of GABA receptors. (31st Jul 2026)Sci Adv • 12(31):eaeg3548 • doi: 10.1126/sciadv.aeg3548
Where next for structural bioinformatics?PLoS Biol • 24(7):e3003903 • doi: 10.1371/journal.pbio.3003903
Synergistic cytokine signaling drives angiofibrotic gene pathways in primary human retinal endothelial cells. (24th Jul 2026)Am J Pathol • doi: 10.1016/j.ajpath.2026.06.007
DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings. (23rd Jul 2026)Mol Cell • doi: 10.1016/j.molcel.2026.07.006
Eukaryotic-like microtubules and dynamic instability of Asgard archaeal tubulins. (24th Jul 2026)Sci Adv • 12(30):eaeh1082 • doi: 10.1126/sciadv.aeh1082
A global molecular code for birth order and neuronal identity in Drosophila. (22nd Jul 2026)Nature • doi: 10.1038/s41586-026-10797-w