Molecular rendering of a dimeric telomerase complex, showing large blue and orange protein structures intertwined with double-helical DNA strands.

Science

Research in the LMB spans the breadth of biology, from the origin of life, to the structures of macromolecules, to the molecular organisation of the brain and immune system.

A 3D view of the human telomerase complex, revealing its distinctive X-shaped structure. Learn how this important molecule was visualised in this news article.

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  • Matteo AllegrettiMatteo AllegrettiStructural StudiesThe macromolecular basis of nuclear shape and remodelling
  • Radu AricescuRadu AricescuNeurobiologyThe structural biology of neuronal connectivity
  • Diana ArseniDiana ArseniNeurobiologyLysosomal TMEM106B in brain ageing and disease
  • David BarfordDavid BarfordStructural StudiesMechanism and regulation of chromosome segregation in mitosis
  • Buzz BaumBuzz BaumCell BiologyThe generation and evolution of biological form: from archaea to eukaryotes
  • Anne BertolottiAnne BertolottiNeurobiologyUnderstanding and manipulating cellular resilience in health and disease
  • Tanmay BharatTanmay BharatStructural StudiesRole of surface molecules in microbial multicellularity
  • Simon BullockSimon BullockCell BiologyMolecular cell biology of cytoskeletal transport
  • Albert CardonaAlbert CardonaNeurobiologyExperimental and comparative connectomics
  • Andrew CarterAndrew CarterStructural StudiesThe structure and mechanism of dyneins
  • Emmanuel DeriveryEmmanuel DeriveryCell BiologyMolecular basis of cell polarisation and asymmetry
  • Juliette FedryJuliette FedryCell BiologyCellular proteostasis networks in physiology and diseases
  • Michel GoedertMichel GoedertNeurobiologyMolecular mechanisms of neurodegeneration
  • Joe GreenerJoe GreenerStructural StudiesImproving force fields for biomolecular simulation
  • Ingo GregerIngo GregerNeurobiologyAMPA receptor biogenesis, structure and function
  • Michael HastingsMichael HastingsNeurobiologyNeurons and biological timing: molecular neurobiology of the circadian clock
  • Ramanujan HegdeRamanujan HegdeCell BiologyMembrane protein biosynthesis and quality control
  • Philipp HolligerPhilipp HolligerProtein and Nucleic Acid ChemistryEvolution of novel biopolymers
  • Leo JamesLeo JamesProtein and Nucleic Acid ChemistryHost-pathogen biology
  • Gregory JefferisGregory JefferisNeurobiologyGenes, circuits and behaviour in Drosophila
  • Joergen KornfeldJoergen KornfeldNeurobiologyConnectomics of learned behaviour
  • Patrycja KozikPatrycja KozikProtein and Nucleic Acid ChemistryDendritic cells and initiation of immune responses
  • Madeline LancasterMadeline LancasterCell BiologyHuman brain development and evolution
  • Roni Levin KonigsbergRoni Levin KonigsbergCell BiologyMolecular physiology of phagocytic cells in health and disease
  • Jan LöweJan LöweStructural StudiesProkaryotic cytoskeletons and other molecular machines
  • Kate McDoleKate McDoleCell BiologyMorphogenesis of the early mammalian embryo
  • Andrew McKenzieAndrew McKenzieProtein and Nucleic Acid ChemistryInvestigation of immune and haematopoietic disorders
  • Harvey McMahonHarvey McMahonNeurobiologyMembrane curvature as an organising principle for eukaryotic cell biology
  • Sean MunroSean MunroCell BiologyOrganisation of the Golgi apparatus
  • Garib MurshudovGarib MurshudovStructural StudiesComputational structural biology
  • Kelly NguyenKelly NguyenStructural StudiesMolecular mechanism of telomere maintenance
  • John O'NeillJohn O’NeillCell BiologyCellular rhythms, signalling and metabolic regulation
  • Lori PassmoreLori PassmoreStructural StudiesMolecular machines that regulate gene expression
  • Lalita RamakrishnanLalita RamakrishnanMolecular Immunity Unit, Cell BiologyMechanisms of tuberculosis pathogenesis
  • Felix RandowFelix RandowProtein and Nucleic Acid ChemistryCell-autonomous and innate immunity
  • Jing RenJing RenNeurobiologyDevelopmental assembly of the serotonin system
  • Wes RobertsonWes RobertsonProtein and Nucleic Acid ChemistrySynthetic genomics for microbiome reprogramming
  • Noe RodriguezNoe RodriguezProtein and Nucleic Acid ChemistryInvestigation of immunity and neuro-immune modulation in infection and cancer
  • Christopher RussoChristopher RussoStructural StudiesImaging the atomic structure of biological molecules by electron cryomicroscopy
  • Benjamin Ryskeldi-FalconBenjamin Ryskeldi‑FalconNeurobiologyPathological protein assembly in neurodegenerative diseases
  • Julian SaleJulian SaleProtein and Nucleic Acid ChemistryVertebrate mutagenesis
  • William SchaferWilliam SchaferNeurobiologyCellular and molecular mechanisms of behaviour
  • Sjors ScheresSjors ScheresStructural StudiesStructural biology of neurodegeneration
  • Marta ShahbaziMarta ShahbaziCell BiologyCell fate decisions in the early mammalian embryo
  • John SutherlandJohn SutherlandProtein and Nucleic Acid ChemistryChemical origins of molecular biology
  • Chris TateChris TateStructural StudiesStructure and function of G protein-coupled receptors
  • Marco TripodiMarco TripodiNeurobiologyNeural circuits for goal-oriented actions
  • Sven TruckenbrodtSven TruckenbrodtNeurobiologyMolecular brain mapping
  • Ana Tufegdžić VidakovićAna Tufegdžić VidakovićProtein and Nucleic Acid ChemistryMolecular basis of gene transcription
  • Roger WilliamsRoger WilliamsProtein and Nucleic Acid ChemistryStructural studies of phosphoinositide signalling and intracellular sorting
  • Joseph YeelesJoseph YeelesProtein and Nucleic Acid ChemistryMechanisms of chromosome replication
  • Suyang ZhangSuyang ZhangStructural StudiesMechanism of transcription-coupled alternative splicing
  • Marta ZlaticMarta ZlaticNeurobiologyCircuit mechanisms of learning and action‑selection

Latest Research Highlights

Cryo-EM structure of ADGRL4-CTF2B G protein complex with a tethered agonist, showing Gq and Gβγ subunits.Revealing the hidden switch behind aggressive cancers
Cryo-EM structure of a glutamate receptor (AMPA receptor) complex, showing its multi-subunit architecture with distinct domains in different colors.Distinct AMPA receptor sub-types reside within glial and neuronal cells of the cerebellum
SynHG logo where the H is a chromosomeTransplant of human chromosomes marks first step in genome synthesis project
EIF2B, a teal-colored protein, binds to and is inhibited by phosphorylated eIF2 (p-eIF2), shown in magenta with a 'P' indicating phosphorylation.How is the integrated stress response terminated?
Sprayer nozzle emitting a conical fine mist of liquid droplets, observed through high-speed photography.A new method to prepare cryo-EM samples avoids protein damage during freezing
Cryo-ET structure of the GOLPH3 complex, displaying various protein domains in color within a translucent molecular envelope.Protein sorting in the Golgi: Should I stay or should I go?
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Exploring the molecular organisation of cells

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Molecular immunology, genome integrity, chemical and synthetic biology

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Published Research
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Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profiles. (4th Feb 2026)Øhlenschlæger MS, Jensen P, Havelund JF, Schmidt SI, Mohamed FA, Sutcliffe M, Elmkvist SB, Criscuolo L, Wingett SW, Chiaradia I, Bayram E, Nicolaisen JAA, Jakobsen LA, Brewer J, Benros ME, Freude K, Færgeman NJ, Lancaster MA, Larsen MR, Bogetofte HCell Rep Methods • 101295 • doi: 10.1016/j.crmeth.2025.101295
An NSP2-MYB module orchestrates flavonoid biosynthesis and nodule symbiosis. (4th Feb 2026)Gao JP, Xia C, Chiu CH, Chen Q, Jiang S, Wu X, Liang W, Sun J, Jhu MY, Wen J, Wang E, Murray JD, Oldroyd GEDCurr Biol • doi: 10.1016/j.cub.2026.01.013
Organizers in a dish: Modeling human CNS morphogenesis. (4th Feb 2026)Miller G, Lloyd-Davies Sánchez DJ, González Martínez J, Justin AW, Lancaster MA, Guglielmi LDev Cell • doi: 10.1016/j.devcel.2026.01.003
The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid.Hong J, Deshpande A, Thakare Y, Simonovsky L, Douglas AW, Guinness CM, Rotem-Dai N, Kortyna ML, Klarhof JO, Shi J, James LC, Boecking T, Francis AC, Rousso I, Aiken CPLoS Pathog • 22(1):e1013910 • doi: 10.1371/journal.ppat.1013910
Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution. (1st Feb 2026)Liu Z, Bellini D, Gorrec F, Wagner A, El Omari K, Sutherland JDActa Crystallogr F Struct Biol Commun • 82(Pt 2):57-65 • doi: 10.1107/S2053230X26000658
How human-derived brain organoids are built differently from brain organoids derived from genetically-close relatives: a multi-scale hypothesis. (26th Jan 2026)Zhang T, Gupta S, Lancaster MA, Schwarz JMSoft Matter • doi: 10.1039/d5sm01116g
Molecular architecture and diversity of StopGo/2A translational recoding. (27th Jan 2026)Li X, Zuber PK, Loughran G, Bhatt PR, Alquraish F, Ramakrishnan V, Firth AE, Atkins JFProc Natl Acad Sci U S A • 123(4):e2528667123 • doi: 10.1073/pnas.2528667123
Transcription termination counteracts DNA damage after WEE1 inhibition. (22nd Jan 2026)Landsverk HB, Sandquist LE, Bay LTE, Hauge S, van Bijsterveldt L, Lindbergsengen L, Lund-Andersen C, Kanduri C, Lyng H, Fjeldbo CS, Hompland T, Humphrey TC, Syljuåsen RGNucleic Acids Res • 54(3) • doi: 10.1093/nar/gkaf1487
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