Molecular rendering of a dimeric telomerase complex, showing large blue and orange protein structures intertwined with double-helical DNA strands.

Science

Research in the LMB spans the breadth of biology, from the origin of life, to the structures of macromolecules, to the molecular organisation of the brain and immune system.

A 3D view of the human telomerase complex, revealing its distinctive X-shaped structure. Learn how this important molecule was visualised in this news article.

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  • Matteo AllegrettiMatteo AllegrettiStructural StudiesThe macromolecular basis of nuclear shape and remodelling
  • Radu AricescuRadu AricescuNeurobiologyThe structural biology of neuronal connectivity
  • Diana ArseniDiana ArseniNeurobiologyLysosomal TMEM106B in brain ageing and disease
  • David BarfordDavid BarfordStructural StudiesMechanism and regulation of chromosome segregation in mitosis
  • Buzz BaumBuzz BaumCell BiologyThe generation and evolution of biological form: from archaea to eukaryotes
  • Anne BertolottiAnne BertolottiNeurobiologyUnderstanding and manipulating cellular resilience in health and disease
  • Tanmay BharatTanmay BharatStructural StudiesRole of surface molecules in microbial multicellularity
  • Simon BullockSimon BullockCell BiologyMolecular cell biology of cytoskeletal transport
  • Albert CardonaAlbert CardonaNeurobiologyExperimental and comparative connectomics
  • Andrew CarterAndrew CarterStructural StudiesThe structure and mechanism of dyneins
  • Emmanuel DeriveryEmmanuel DeriveryCell BiologyMolecular basis of cell polarisation and asymmetry
  • Juliette FedryJuliette FedryCell BiologyCellular proteostasis networks in physiology and diseases
  • Michel GoedertMichel GoedertNeurobiologyMolecular mechanisms of neurodegeneration
  • Joe GreenerJoe GreenerStructural StudiesImproving force fields for biomolecular simulation
  • Ingo GregerIngo GregerNeurobiologyAMPA receptor biogenesis, structure and function
  • Michael HastingsMichael HastingsNeurobiologyNeurons and biological timing: molecular neurobiology of the circadian clock
  • Ramanujan HegdeRamanujan HegdeCell BiologyMembrane protein biosynthesis and quality control
  • Philipp HolligerPhilipp HolligerProtein and Nucleic Acid ChemistryEvolution of novel biopolymers
  • Leo JamesLeo JamesProtein and Nucleic Acid ChemistryHost-pathogen biology
  • Gregory JefferisGregory JefferisNeurobiologyGenes, circuits and behaviour in Drosophila
  • Joergen KornfeldJoergen KornfeldNeurobiologyConnectomics of learned behaviour
  • Patrycja KozikPatrycja KozikProtein and Nucleic Acid ChemistryDendritic cells and initiation of immune responses
  • Madeline LancasterMadeline LancasterCell BiologyHuman brain development and evolution
  • Roni Levin KonigsbergRoni Levin KonigsbergCell BiologyMolecular physiology of phagocytic cells in health and disease
  • Jan LöweJan LöweStructural StudiesProkaryotic cytoskeletons and other molecular machines
  • Kate McDoleKate McDoleCell BiologyMorphogenesis of the early mammalian embryo
  • Andrew McKenzieAndrew McKenzieProtein and Nucleic Acid ChemistryInvestigation of immune and haematopoietic disorders
  • Harvey McMahonHarvey McMahonNeurobiologyMembrane curvature as an organising principle for eukaryotic cell biology
  • Sean MunroSean MunroCell BiologyFunctional organisation of the Golgi apparatus
  • Garib MurshudovGarib MurshudovStructural StudiesComputational structural biology
  • Kelly NguyenKelly NguyenStructural StudiesMolecular mechanism of telomere maintenance
  • John O'NeillJohn O’NeillCell BiologyCellular rhythms, signalling and metabolic regulation
  • Lori PassmoreLori PassmoreStructural StudiesMolecular machines that regulate gene expression
  • Lalita RamakrishnanLalita RamakrishnanMolecular Immunity Unit, Cell BiologyMechanisms of tuberculosis pathogenesis
  • Felix RandowFelix RandowProtein and Nucleic Acid ChemistryCell-autonomous and innate immunity
  • Jing RenJing RenNeurobiologyDevelopmental assembly of the serotonin system
  • Wes RobertsonWes RobertsonProtein and Nucleic Acid ChemistrySynthetic genomics for microbiome reprogramming
  • Noe RodriguezNoe RodriguezProtein and Nucleic Acid ChemistryInvestigation of immunity and neuro-immune modulation in infection and cancer
  • Christopher RussoChristopher RussoStructural StudiesImaging the atomic structure of biological molecules by electron cryomicroscopy
  • Benjamin Ryskeldi-FalconBenjamin Ryskeldi‑FalconNeurobiologyPathological protein assembly in neurodegenerative diseases
  • Julian SaleJulian SaleProtein and Nucleic Acid ChemistryVertebrate mutagenesis
  • William SchaferWilliam SchaferNeurobiologyCellular and molecular mechanisms of behaviour
  • Sjors ScheresSjors ScheresStructural StudiesStructural biology of neurodegeneration
  • Marta ShahbaziMarta ShahbaziCell BiologyCell fate decisions in the early mammalian embryo
  • John SutherlandJohn SutherlandProtein and Nucleic Acid ChemistryChemical origins of molecular biology
  • Chris TateChris TateStructural StudiesStructure and function of G protein-coupled receptors
  • Marco TripodiMarco TripodiNeurobiologyNeural circuits for goal-oriented actions
  • Sven TruckenbrodtSven TruckenbrodtNeurobiologyMolecular brain mapping
  • Ana Tufegdžić VidakovićAna Tufegdžić VidakovićProtein and Nucleic Acid ChemistryMolecular basis of gene transcription
  • Roger WilliamsRoger WilliamsProtein and Nucleic Acid ChemistryStructural studies of phosphoinositide signalling and intracellular sorting
  • Joseph YeelesJoseph YeelesProtein and Nucleic Acid ChemistryMechanisms of chromosome replication
  • Suyang ZhangSuyang ZhangStructural StudiesMechanism of transcription-coupled alternative splicing
  • Marta ZlaticMarta ZlaticNeurobiologyCircuit mechanisms of learning and action‑selection

Latest Research Highlights

The hidden rules of mRNA transport
Telomerase enzyme complex binds to and extends a chromosome's telomeric DNA strand, with multiple chromosomes visible.First telomerase structure identified in yeast
A primordial germ cell (magenta) exhibits a long, wavy actin-rich protrusion and internal green structures, indicative of cell motility.A long and dangerous journey: how primordial germ cells migrate in mouse embryos
Person adjusting a large clock with a day-night cycle, symbolizing the regulation of circadian rhythms and biological clocks.The cellular switch that explains why humans aren’t nocturnal
Comparison of ribozyme structures.Bridging the gap from chemistry to life: discovery of a tiny RNA that can copy itself
Cryo-EM structure of ADGRL4-CTF2B G protein complex with a tethered agonist, showing Gq and Gβγ subunits.Revealing the hidden switch behind aggressive cancers
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Exploring the molecular organisation of cells

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Molecular immunology, genome integrity, chemical and synthetic biology

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Published Research
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Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency. (22nd May 2026)Pérez-Sisqués L, Bhatt SU, Caruso A, Robb JL, Donovan APA, Bamford R, Torres-Cano A, Spring S, Hendy E, Gileadi TE, Panasiuk M, Trengove J, Jindal N, Ahmed MU, Sabbioni M, Taylor-Papadimitriou J, Cash D, Clifton N, Ellegood J, Andreae LC, Lerch JP, Scattoni ML, Giese KP, Fernandes C, Basson MASci Adv • 12(21):eadq6577 • doi: 10.1126/sciadv.adq6577
Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments. (20th May 2026)Lövestam S, Wagstaff JL, Katsinelos T, Shi J, Freund SMV, Goedert M, Scheres SHWElife • 14 • doi: 10.7554/eLife.104778
Architecture of clathrin-independent AP3:ARF1-coated carriers. (15th May 2026)Kaufman JGG, Tagiltsev G, Stalder DS, Taylor RJ, Sava I, Guo H, Ciazynska KA, Zaccai NR, Gray SR, Vallis Y, Höning S, Kelly BT, Gershlick DC, Briggs JAG, Owen DJSci Adv • 12(20):eaed1529 • doi: 10.1126/sciadv.aed1529
Applications and prospects of cryo-electron tomography in drug discovery and understanding disease. (14th May 2026)Clemente CM, Mobarec JC, Bharat TAMCurr Opin Struct Biol • 98:103283 • doi: 10.1016/j.sbi.2026.103283
Models for the architecture of the human inner kinetochore on centromeric α-satellite CENP-A nucleosome arrays. (12th May 2026)Yu C, Muir KW, Yang J, Zhang Z, McLaughlin SH, Barford DNat Commun • doi: 10.1038/s41467-026-72856-0
Interaction of Pf4 tactoids with bacteria and synthetic colloidal rods. (11th May 2026)Silva MO, Grobas I, Tarafder AK, Bharat TAM, Aarts DGALEur Biophys J • doi: 10.1007/s00249-026-01844-5
Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids.Øhlenschlæger MS, Criscuolo L, Jensen P, Lloyd-Davies Sánchez DJ, Sutcliffe M, Bhosale S, Bogetofte H, Tahir M, Jakobsen LA, Pihl M, Brewer J, Schwämmle V, Poulsen FR, Freude K, Lancaster MA, Robinson PJ, Larsen MRJ Neurochem • 170(5):e70458 • doi: 10.1111/jnc.70458
Measurement of atomic scattering factors by cryoelectron microscopy. (12th May 2026)Shtyrov A, Wilson H, Slowik D, Yamashita K, Li J, Wojdyr M, Chen S, McMullan G, Short JM, Russo CJ, Henderson R, Murshudov GNProc Natl Acad Sci U S A • 123(19):e2528758123 • doi: 10.1073/pnas.2528758123
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