Molecular rendering of a dimeric telomerase complex, showing large blue and orange protein structures intertwined with double-helical DNA strands.

Science

Research in the LMB spans the breadth of biology, from the origin of life, to the structures of macromolecules, to the molecular organisation of the brain and immune system.

A 3D view of the human telomerase complex, revealing its distinctive X-shaped structure. Learn how this important molecule was visualised in this news article.

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  • Matteo AllegrettiMatteo AllegrettiStructural StudiesThe macromolecular basis of nuclear shape and remodelling
  • Ivana BukvinProtein and Nucleic Acid ChemistryDe novo protein folding
  • Radu AricescuRadu AricescuNeurobiologyThe structural biology of neuronal connectivity
  • Diana ArseniDiana ArseniNeurobiologyLysosomal TMEM106B in brain ageing and disease
  • David BarfordDavid BarfordStructural StudiesMechanism and regulation of chromosome segregation in mitosis
  • Buzz BaumBuzz BaumCell BiologyThe generation and evolution of biological form: from archaea to eukaryotes
  • Anne BertolottiAnne BertolottiNeurobiologyUnderstanding and manipulating cellular resilience in health and disease
  • Tanmay BharatTanmay BharatStructural StudiesRole of surface molecules in microbial multicellularity
  • Simon BullockSimon BullockCell BiologyMolecular cell biology of cytoskeletal transport
  • Albert CardonaAlbert CardonaNeurobiologyExperimental and comparative connectomics
  • Andrew CarterAndrew CarterStructural StudiesThe structure and mechanism of dyneins
  • Emmanuel DeriveryEmmanuel DeriveryCell BiologyMolecular basis of cell polarisation and asymmetry
  • Juliette FedryJuliette FedryCell BiologyCellular proteostasis networks in physiology and diseases
  • Michel GoedertMichel GoedertNeurobiologyMolecular mechanisms of neurodegeneration
  • Joe GreenerJoe GreenerStructural StudiesImproving force fields for biomolecular simulation
  • Ingo GregerIngo GregerNeurobiologyAMPA receptor biogenesis, structure and function
  • Michael HastingsMichael HastingsNeurobiologyNeurons and biological timing: molecular neurobiology of the circadian clock
  • Ramanujan HegdeRamanujan HegdeCell BiologyMembrane protein biosynthesis and quality control
  • Philipp HolligerPhilipp HolligerProtein and Nucleic Acid ChemistryEvolution of novel biopolymers
  • Leo JamesLeo JamesProtein and Nucleic Acid ChemistryHost-pathogen biology
  • Gregory JefferisGregory JefferisNeurobiologyGenes, circuits and behaviour in Drosophila
  • Joergen KornfeldJoergen KornfeldNeurobiologyConnectomics of learned behaviour
  • Patrycja KozikPatrycja KozikProtein and Nucleic Acid ChemistryDendritic cells and initiation of immune responses
  • Madeline LancasterMadeline LancasterCell BiologyHuman brain development and evolution
  • Roni Levin KonigsbergRoni Levin KonigsbergCell BiologyMolecular physiology of phagocytic cells in health and disease
  • Jan LöweJan LöweStructural StudiesProkaryotic cytoskeletons and other molecular machines
  • Kate McDoleKate McDoleCell BiologyMorphogenesis of the early mammalian embryo
  • Andrew McKenzieAndrew McKenzieProtein and Nucleic Acid ChemistryInvestigation of immune and haematopoietic disorders
  • Harvey McMahonHarvey McMahonNeurobiologyMembrane curvature as an organising principle for eukaryotic cell biology
  • Sean MunroSean MunroCell BiologyFunctional organisation of the Golgi apparatus
  • Garib MurshudovGarib MurshudovStructural StudiesComputational structural biology
  • Kelly NguyenKelly NguyenStructural StudiesMolecular mechanism of telomere maintenance
  • John O'NeillJohn O’NeillCell BiologyCellular rhythms, signalling and metabolic regulation
  • Lori PassmoreLori PassmoreStructural StudiesMolecular machines that regulate gene expression
  • Lalita RamakrishnanLalita RamakrishnanMolecular Immunity Unit, Cell BiologyMechanisms of tuberculosis pathogenesis
  • Felix RandowFelix RandowProtein and Nucleic Acid ChemistryCell-autonomous and innate immunity
  • Jing RenJing RenNeurobiologyDevelopmental assembly of the serotonin system
  • Wes RobertsonWes RobertsonProtein and Nucleic Acid ChemistrySynthetic genomics for microbiome reprogramming
  • Noe RodriguezNoe RodriguezProtein and Nucleic Acid ChemistryInvestigation of immunity and neuro-immune modulation in infection and cancer
  • Christopher RussoChristopher RussoStructural StudiesImaging the atomic structure of biological molecules by electron cryomicroscopy
  • Benjamin Ryskeldi-FalconBenjamin Ryskeldi‑FalconNeurobiologyPathological protein assembly in neurodegenerative diseases
  • Julian SaleJulian SaleProtein and Nucleic Acid ChemistryVertebrate mutagenesis
  • William SchaferWilliam SchaferNeurobiologyCellular and molecular mechanisms of behaviour
  • Sjors ScheresSjors ScheresStructural StudiesStructural biology of neurodegeneration
  • Marta ShahbaziMarta ShahbaziCell BiologyCell fate decisions in the early mammalian embryo
  • John SutherlandJohn SutherlandProtein and Nucleic Acid ChemistryChemical origins of molecular biology
  • Chris TateChris TateStructural StudiesStructure and function of G protein-coupled receptors
  • Marco TripodiMarco TripodiNeurobiologyNeural circuits for goal-oriented actions
  • Sven TruckenbrodtSven TruckenbrodtNeurobiologyMolecular brain mapping
  • Ana Tufegdžić VidakovićAna Tufegdžić VidakovićProtein and Nucleic Acid ChemistryMolecular basis of gene transcription
  • Roger WilliamsRoger WilliamsProtein and Nucleic Acid ChemistryStructural studies of phosphoinositide signalling and intracellular sorting
  • Joseph YeelesJoseph YeelesProtein and Nucleic Acid ChemistryMechanisms of chromosome replication
  • Suyang ZhangSuyang ZhangStructural StudiesMechanism of transcription-coupled alternative splicing
  • Marta ZlaticMarta ZlaticNeurobiologyCircuit mechanisms of learning and action‑selection

Latest Research Highlights

TRIM21 induces autophagy to defend against cell-invading pathogens
Focused Ion Beam (FIB) ablates a sample with gallium ions, generating secondary ions analyzed by Time-of-Flight (ToF) mass spectrometry.Imaging mass spectrometry adds the chemical dimension to cryo‑EM
The hidden rules of mRNA transport
Telomerase enzyme complex binds to and extends a chromosome's telomeric DNA strand, with multiple chromosomes visible.First telomerase structure identified in yeast
A primordial germ cell (magenta) exhibits a long, wavy actin-rich protrusion and internal green structures, indicative of cell motility.A long and dangerous journey: how primordial germ cells migrate in mouse embryos
Person adjusting a large clock with a day-night cycle, symbolizing the regulation of circadian rhythms and biological clocks.The cellular switch that explains why humans aren’t nocturnal
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Exploring the molecular organisation of cells

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Molecular immunology, genome integrity, chemical and synthetic biology

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Published Research
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Cancer-associated fibroblast subtypes differentially modulate natural killer cells in cancer. (11th Jun 2026)Rodrigues LN, Munir H, Arrazola IT, Gaida MM, Eckert C, Boulanger J, Ferreira ACF, McKenzie ANJ, Shields JDCell Rep • 45(6):117527 • doi: 10.1016/j.celrep.2026.117527
Mechanisms of ubiquitylation of the mitotic regulatory protein Cdc20. (16th Jun 2026)Sitry-Shevah D, Miniowitz-Shemtov S, Liburkin Dan T, Barford D, Hershko AProc Natl Acad Sci U S A • 123(24):e2612003123 • doi: 10.1073/pnas.2612003123
Distributed control circuits across a brain-and-cord connectome. (8th Jun 2026)Bates AS, Phelps JS, Kim M, Yang HH, Matsliah A, Ajabi Z, Perlman E, Delgado KM, Osman MAM, Salmon CK, Gager J, Silverman B, Renauld S, Salman F, Patel J, Collie MF, Fan J, Pacheco DA, Zhao Y, Zhang W, Capdevila LS, Roberts RJV, Munnelly EJ, Griggs N, Langley H, Moya-Llamas B, Zhang Z, Maloney RT, Yu SC, Sterling AR, Sorek M, Kruk K, Serafetinidis N, Dhawan S, Klemm F, Brooks P, Lesser E, Jones JM, Pierce-Lundgren SE, Lee SY, Luo Y, Cook AP, McKim TH, Giakoumas DS, Gorko B, Ellis-Joyce J, Zhang J, Kophs EC, Falt T, Negron-Morales AM, Burke A, Hebditch J, Willie KP, Willie R, Popovych S, Kemnitz N, Ih D, Lee K, Lu R, Halageri A, Bae JA, Jourdan B, Schwartzman G, Demarest DD, Behnke E, Bland D, Kristiansen A, Skelton J, Stocks T, Garner D, Hernandez A, Kumar S, Daly KC, Dorkenwald S, Collman F, Suver MP, Fenk LM, Pankratz MJ, Yao Z, Wang F, Huston SJ, Stürner T, Jefferis GSXE, Eichler K, Seeds AM, Hampel S, Agrawal S, Okubo TS, Zandawala M, Macrina T, Adjavon DY, Funke J, Tuthill JC, Azevedo A, Seung HS, de Bivort BL, Murthy M, Drugowitsch J, Wilson RI, Lee WANature • doi: 10.1038/s41586-026-10735-w
Cryo-EM: the revolution continues. (1st Jul 2026)Subramaniam S, Kühlbrandt W, Henderson RIUCrJ • doi: 10.1107/S2052252526003842
Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms.Tarafder AK, Graham M, Davis LK, Pratt S, Böhning J, Manivannan P, Wang Z, Clemente CM, Weimann A, Floto RA, Owens RJ, O'Toole GA, Pearce P, Bharat TAMPLoS Biol • 24(6):e3003834 • doi: 10.1371/journal.pbio.3003834
TRIM21 induces selective autophagy of viruses and bacteria. (4th Jun 2026)Rhinesmith T, Albecka A, Vaysburd M, Puri C, Luptak J, Boulanger J, Nguyen Le QM, Gratian MJ, O'Connell K, Few L, Donaldson-Wing M, Kozik P, Rubinsztein DC, James LCMol Cell • doi: 10.1016/j.molcel.2026.04.031
De Novo Design of Near-Infrared Fluorescence-Activating Proteins. (2nd Jun 2026)Liu Y, Arús BA, Mishra K, Wang T, Zhang K, Luciano MP, Bandi VG, Kumar A, Guo Z, Guan Y, Bick MJ, Xu M, Lingg J, Bae J, Kang A, Gerben SR, Bera AK, Vaughan JC, Manton JD, Derivery E, Schnermann MJ, Stiel AC, Bruns OT, Xu C, Baker DJ Am Chem Soc • doi: 10.1021/jacs.5c19594
Design principles of human membrane protein topology. (3rd Aug 2026)Wu H, Hegde RSJ Cell Biol • 225(8) • doi: 10.1083/jcb.202604059
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