Molecular rendering of a dimeric telomerase complex, showing large blue and orange protein structures intertwined with double-helical DNA strands.

Science

Research in the LMB spans the breadth of biology, from the origin of life, to the structures of macromolecules, to the molecular organisation of the brain and immune system.

A 3D view of the human telomerase complex, revealing its distinctive X-shaped structure. Learn how this important molecule was visualised in this news article.

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  • Matteo AllegrettiMatteo AllegrettiStructural StudiesThe macromolecular basis of nuclear shape and remodelling
  • Radu AricescuRadu AricescuNeurobiologyThe structural biology of neuronal connectivity
  • Diana ArseniDiana ArseniNeurobiologyLysosomal TMEM106B in brain ageing and disease
  • David BarfordDavid BarfordStructural StudiesMechanism and regulation of chromosome segregation in mitosis
  • Buzz BaumBuzz BaumCell BiologyThe generation and evolution of biological form: from archaea to eukaryotes
  • Anne BertolottiAnne BertolottiNeurobiologyUnderstanding and manipulating cellular resilience in health and disease
  • Tanmay BharatTanmay BharatStructural StudiesRole of surface molecules in microbial multicellularity
  • Simon BullockSimon BullockCell BiologyMolecular cell biology of cytoskeletal transport
  • Albert CardonaAlbert CardonaNeurobiologyExperimental and comparative connectomics
  • Andrew CarterAndrew CarterStructural StudiesThe structure and mechanism of dyneins
  • Emmanuel DeriveryEmmanuel DeriveryCell BiologyMolecular basis of cell polarisation and asymmetry
  • Juliette FedryJuliette FedryCell BiologyCellular proteostasis networks in physiology and diseases
  • Michel GoedertMichel GoedertNeurobiologyMolecular mechanisms of neurodegeneration
  • Joe GreenerJoe GreenerStructural StudiesImproving force fields for biomolecular simulation
  • Ingo GregerIngo GregerNeurobiologyAMPA receptor biogenesis, structure and function
  • Michael HastingsMichael HastingsNeurobiologyNeurons and biological timing: molecular neurobiology of the circadian clock
  • Ramanujan HegdeRamanujan HegdeCell BiologyMembrane protein biosynthesis and quality control
  • Philipp HolligerPhilipp HolligerProtein and Nucleic Acid ChemistryEvolution of novel biopolymers
  • Leo JamesLeo JamesProtein and Nucleic Acid ChemistryHost-pathogen biology
  • Gregory JefferisGregory JefferisNeurobiologyGenes, circuits and behaviour in Drosophila
  • Joergen KornfeldJoergen KornfeldNeurobiologyConnectomics of learned behaviour
  • Patrycja KozikPatrycja KozikProtein and Nucleic Acid ChemistryDendritic cells and initiation of immune responses
  • Madeline LancasterMadeline LancasterCell BiologyHuman brain development and evolution
  • Roni Levin KonigsbergRoni Levin KonigsbergCell BiologyMolecular physiology of phagocytic cells in health and disease
  • Jan LöweJan LöweStructural StudiesProkaryotic cytoskeletons and other molecular machines
  • Kate McDoleKate McDoleCell BiologyMorphogenesis of the early mammalian embryo
  • Andrew McKenzieAndrew McKenzieProtein and Nucleic Acid ChemistryInvestigation of immune and haematopoietic disorders
  • Harvey McMahonHarvey McMahonNeurobiologyMembrane curvature as an organising principle for eukaryotic cell biology
  • Sean MunroSean MunroCell BiologyFunctional organisation of the Golgi apparatus
  • Garib MurshudovGarib MurshudovStructural StudiesComputational structural biology
  • Kelly NguyenKelly NguyenStructural StudiesMolecular mechanism of telomere maintenance
  • John O'NeillJohn O’NeillCell BiologyCellular rhythms, signalling and metabolic regulation
  • Lori PassmoreLori PassmoreStructural StudiesMolecular machines that regulate gene expression
  • Lalita RamakrishnanLalita RamakrishnanMolecular Immunity Unit, Cell BiologyMechanisms of tuberculosis pathogenesis
  • Felix RandowFelix RandowProtein and Nucleic Acid ChemistryCell-autonomous and innate immunity
  • Jing RenJing RenNeurobiologyDevelopmental assembly of the serotonin system
  • Wes RobertsonWes RobertsonProtein and Nucleic Acid ChemistrySynthetic genomics for microbiome reprogramming
  • Noe RodriguezNoe RodriguezProtein and Nucleic Acid ChemistryInvestigation of immunity and neuro-immune modulation in infection and cancer
  • Christopher RussoChristopher RussoStructural StudiesImaging the atomic structure of biological molecules by electron cryomicroscopy
  • Benjamin Ryskeldi-FalconBenjamin Ryskeldi‑FalconNeurobiologyPathological protein assembly in neurodegenerative diseases
  • Julian SaleJulian SaleProtein and Nucleic Acid ChemistryVertebrate mutagenesis
  • William SchaferWilliam SchaferNeurobiologyCellular and molecular mechanisms of behaviour
  • Sjors ScheresSjors ScheresStructural StudiesStructural biology of neurodegeneration
  • Marta ShahbaziMarta ShahbaziCell BiologyCell fate decisions in the early mammalian embryo
  • John SutherlandJohn SutherlandProtein and Nucleic Acid ChemistryChemical origins of molecular biology
  • Chris TateChris TateStructural StudiesStructure and function of G protein-coupled receptors
  • Marco TripodiMarco TripodiNeurobiologyNeural circuits for goal-oriented actions
  • Sven TruckenbrodtSven TruckenbrodtNeurobiologyMolecular brain mapping
  • Ana Tufegdžić VidakovićAna Tufegdžić VidakovićProtein and Nucleic Acid ChemistryMolecular basis of gene transcription
  • Roger WilliamsRoger WilliamsProtein and Nucleic Acid ChemistryStructural studies of phosphoinositide signalling and intracellular sorting
  • Joseph YeelesJoseph YeelesProtein and Nucleic Acid ChemistryMechanisms of chromosome replication
  • Suyang ZhangSuyang ZhangStructural StudiesMechanism of transcription-coupled alternative splicing
  • Marta ZlaticMarta ZlaticNeurobiologyCircuit mechanisms of learning and action‑selection

Latest Research Highlights

The cellular switch that explains why humans aren’t nocturnal
Comparison of ribozyme structures.Bridging the gap from chemistry to life: discovery of a tiny RNA that can copy itself
Cryo-EM structure of ADGRL4-CTF2B G protein complex with a tethered agonist, showing Gq and Gβγ subunits.Revealing the hidden switch behind aggressive cancers
Cryo-EM structure of a glutamate receptor (AMPA receptor) complex, showing its multi-subunit architecture with distinct domains in different colors.Distinct AMPA receptor sub-types reside within glial and neuronal cells of the cerebellum
SynHG logo where the H is a chromosomeTransplant of human chromosomes marks first step in genome synthesis project
EIF2B, a teal-colored protein, binds to and is inhibited by phosphorylated eIF2 (p-eIF2), shown in magenta with a 'P' indicating phosphorylation.How is the integrated stress response terminated?
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Exploring the molecular organisation of cells

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Understanding the brain in health and disease

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Molecular immunology, genome integrity, chemical and synthetic biology

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Mechanisms of life

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Published Research
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Latest Publications

Checking in on proteostasis. (13th Mar 2026)Sakata E, Hegde RS, Zhao YG, Ito T, Radford SE, Hatzgolou M, Jakob U, Park E, Lin Y, Deuerling E, Yang P, Choe YJNat Struct Mol Biol • doi: 10.1038/s41594-026-01772-0
Purification of the Active-State G Protein-Coupled Receptor ADGRL4 for Cryo-Electron Microscopy Using a Modular Tag System and a Tethered mini‑G. (5th Mar 2026)Favara DM, Tate CGBio Protoc • 16(5):e5617 • doi: 10.21769/BioProtoc.5617
aGPCR-HEK: A Stable High-Expression Inducible Mammalian Cell Expression System for Adhesion GPCR Structural Biology Applications. (5th Mar 2026)Favara DM, Tate CGBio Protoc • 16(5):e5621 • doi: 10.21769/BioProtoc.5621
Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly. (17th Mar 2026)Gupta M, Waltmann C, Renner N, Wang Y, James LC, Jacques DA, Böcking T, Voth GAProc Natl Acad Sci U S A • 123(11):e2524995123 • doi: 10.1073/pnas.2524995123
Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain. (5th Mar 2026)Slangewal K, Aimon S, Capelle MQ, Kämpf F, Naumann H, Slanchev K, Baier H, Bahl ANat Commun • 17(1) • doi: 10.1038/s41467-026-69633-4
Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice. (4th Mar 2026)Jiang W, Skoug C, Rodrigues I, Ciabatti E, Gribble FM, Reimann F, Brierley DI, Holt MK, Trapp SMol Metab • 102347 • doi: 10.1016/j.molmet.2026.102347
Publishing sleep and chronobiology research without barriers. (6th Dec 2025)O'Neill JNPJ Biol Timing Sleep • 2(1) • doi: 10.1038/s44323-025-00063-z
[Structural Study on the Molecular Interaction of the Pre-mRNA Splicing Factors].Muto YYakugaku Zasshi • 146(3):217-238 • doi: 10.1248/yakushi.25‑00159
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