LMB / Science / Research Leaders / Fellows / Malcolm Weir
Fellow

Malcolm Weir

Sponsored by Chris Tate

Malcolm Weir
Structural Studies

I am a biochemist and entrepreneur, working in the field of drug discovery and early development. I started my career in Glaxo (now GSK), where I established structure-based drug design and led a broad range of discovery technologies. I then moved as CEO to the structural chemo/bioinformatics company Inpharmatica. In 2007, along with Chris Tate, Richard Henderson and Fiona Marshall, I co-founded Heptares as CEO and after its sale remained as head of research and development until 2022. I am strongly interested in the molecular biosciences and their application to find new medicines.
 
I am a Visiting Professor of Biochemistry at Imperial College London and have honorary DSc degrees from ICL and the University of Hertfordshire. I am an Honorary Member of the British Biophysical Society, a Fellow of the Royal Society of Chemistry and was a co-recipient of the 2015 Royal Society of Chemistry Malcolm Campbell Award for Biological Chemistry. I am Executive Chairman of Kodiform Therapeutics, which was co-founded by Terry Rabbitts and Angela Russell, the former an LMB alumnus.

Selected Publications

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer’s disease.Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin ABCell 184(24): 5886-5901.e22 (2022)
Crystal structure of the GLP-1 receptor bound to a peptide agonist.Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, Cooke RM, Marshall FHNature 546(7657): 254-258 (2017)
Extra-helical binding site of a glucagon receptor antagonist.Jazayeri A, Doré AS, Lamb D, Krishnamurthy H, Southall SM, Baig AH, Bortolato A, Koglin M, Robertson NJ, Errey JC, Andrews SP, Teobald I, Brown AJ, Cooke RM, Weir M, Marshall FHNature 533(7602): 274-7 (2016)