Fellow

Wei-Chung Allen Lee

Sponsored by Albert Cardona

The mission of my research is to understand how neural computations and behaviour arise from neuronal circuits. Our focus is on understanding how neuronal circuits are wired and connected to enable action selection, execution, and refinement. Our approach is to develop and apply tools for ‘functional connectomics’: combining behaviour, activity imaging, comprehensive structural microscopy, machine learning, and modelling to reveal relationships between neuronal network structure and function.

My work at the LMB will seek to uncover organisational principles of neuronal circuits across species. A key technical aim of my work will be to make connectomics more accessible by developing affordable and scalable methods for data acquisition, processing, and analysis. This includes innovations in sample preparation, imaging, and automated reconstruction pipelines to lower cost and increase data generation and analysis throughput.

Selected Publications

Synaptic wiring motifs in posterior parietal cortex support decision‑making.Kuan AT, Bondanelli G, Driscoll LN, Han J, Kim M, Hildebrand DGC, Graham BJ, Wilson DE, Thomas LA, Panzeri S, Harvey CD, Lee WANature 627(8003): 367-373 (2024)
Structured cerebellar connectivity supports resilient pattern separation.Nguyen TM, Thomas LA, Rhoades JL, Ricchi I, Yuan XC, Sheridan A, Hildebrand DGC, Funke J, Regehr WG, Lee WANature 613(7944): 543-549 (2023)
Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy.Phelps JS, Hildebrand DGC, Graham BJ, Kuan AT, Thomas LA, Nguyen TM, Buhmann J, Azevedo AW, Sustar A, Agrawal S, Liu M, Shanny BL, Funke J, Tuthill JC, Lee WACell 184(3): 759-774.e18 (2021)
Dense neuronal reconstruction through X-ray holographic nano‑tomography.Kuan AT, Phelps JS, Thomas LA, Nguyen TM, Han J, Chen CL, Azevedo AW, Tuthill JC, Funke J, Cloetens P, Pacureanu A, Lee WANat Neurosci 23(12): 1637-1643 (2021)

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