My group collaborates with Emmanuel Derivery’s group and James Manton with a shared interest in cell polarity and high-resolution imaging. The focus of my group at the Cambridge Institute for Medical Research is the remarkable changes in intracellular polarity that occur as cytotoxic T lymphocytes (CTLs) recognise and destroy cancer cells. As CTLs are much smaller and more dynamic than many of the cell lines used in cell biological studies, they present additional challenges for live cell imaging. Combining our expertise in CTLs with the Derivery group’s expertise in imaging and micropatterning, we aim to uncover the mechanisms of cell polarity that control the rapid and dynamic polarisation of organelles as CTLs form an immunological synapse and destroy the cancer targets.