Published Research

Found 23 results for Yeeles J.

• Response of the replisome to araA and araC suggests a mechanism for arabinosyl nucleoside tolerance AuthorsOrrin H., Yeeles J. T. P. Journal The EMBO Journal (2026)
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  DOI10.1038/s44318-026-00901-1 PMID42649316 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cryo-EM maps of human DNA polymerase ε should be reevaluated in light of its unexpected behavior in vitro AuthorsRoske J. J., Yeeles J. T. P. Journal Proceedings of the National Academy of Sciences of the United States of America 123(11):e2533320123 (2026)
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  DOI10.1073/pnas.2533320123 PMID41790928 PMCIDPMC12993937 DivisionProtein & Nucleic Acid Chemistry
• Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome AuthorsFletcher E.E., Jones M.L., Yeeles J.T.P. Journal The EMBO Journal 44(8):2298-2322 (2025)
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  DOI10.1038/s44318-025-00386-4 PMID40021844 PMCIDPMC12000384 DivisionProtein & Nucleic Acid Chemistry
• Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes AuthorsWesthorpe R., Roske J. J., Yeeles J. T. P. Journal Molecular Cell 84(18):3469-3481.e7 (2024)
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  DOI10.1016/j.molcel.2024.08.004 PMID39236719 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε AuthorsRoske JJ, Yeeles JTP. Journal Nature Structural and Molecular Biology Aug 7. doi: 10.1038/s41594-024-01370-y. (2024)
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  DOI10.1038/s41594-024-01370-y PMID39112807 PMCID  DivisionProtein & Nucleic Acid Chemistry
• CST-polymerase α-primase solves a second telomere end-replication problem AuthorsTakai H., Aria V., Borges P., Yeeles J. T. P., de Lange T. Journal Nature 627(8004):664-670 (2024)
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  DOI10.1038/s41586-024-07137-1 PMID38418884 PMCIDPMC11160940 DivisionProtein & Nucleic Acid Chemistry
• Replication-induced DNA secondary structures drive fork uncoupling and breakage AuthorsWilliams S. L, Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles J. T., Keyser U. F, Waller Z. A., Di Antonio M., Coster G. Journal The EMBO Journal 42(22):e114334 (2023)
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  DOI10.15252/embj.2023114334 PMID37781931 PMCIDPMC10646557 DivisionProtein & Nucleic Acid Chemistry
• Replication-induced DNA secondary structures drive fork uncoupling and breakage AuthorsWilliams S. L., Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles JT ., Keyser U. F., Waller Z. A., Di Antonio M., Coster G. Journal The EMBO Journal 42(22):e114334 (2023)
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  DOI10.15252/embj.2023114334 PMID37781931 PMCIDPMC10646557 DivisionProtein & Nucleic Acid Chemistry
• DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans AuthorsXia Y., Sonneville R., Jenkyn-Bedford M., Ji L, Alabert C., Hong Y., Yeeles J. T. P., Labib K. P. M. Journal Science 381(6664):eadi4932 (2023)
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  DOI10.1126/science. Adi4932 PMID37590372 PMCIDPMC7615117 DivisionProtein & Nucleic Acid Chemistry
• How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication AuthorsJones M. L, Aria V., Baris Y., Yeeles J. T. P. Journal Molecular Cell 83(16):2911-2924.e16 (2023)
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  DOI10.1016/j.molcel.2023.06.035 PMID37506699 PMCIDPMC10501992 DivisionProtein & Nucleic Acid Chemistry
• CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis AuthorsRatnayeke N., Baris Y., Chung M., Yeeles J.T.P., Meyer T. Journal Molecular Cell 83(1):26-42.e13 (2023)
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  DOI10.1016/j.molcel.2022.12.004 PMID36608667 PMCIDPMC7614657 DivisionProtein & Nucleic Acid Chemistry
• Fast and efficient DNA replication with purified human proteins AuthorsBaris Y., Taylor M.R.G., Aria V., Yeeles J.T.P. Journal Nature 606(7912):204-210 (2022)
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  DOI10.1038/s41586-022-04759-1 PMID35585232 PMCIDPMC7613936 DivisionProtein & Nucleic Acid Chemistry
• A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes AuthorsJenkyn-Bedford M., Jones M. L., Baris Y., Labib K. P. M., Cannone G., Yeeles J. T. P., Deegan T. D. Journal Nature 600(7890):743-747 (2021)
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  DOI10.1038/s41586-021-04145‑3 PMID34700328 PMCIDPMC8695382 DivisionProtein & Nucleic Acid Chemistry
• Structure of a human replisome shows the organisation and interactions of a DNA replication machine AuthorsJones M. L., Baris Y., Taylor M. R. G., Yeeles J. T. P. Journal EMBO Journal 40(23):e108819 (2021)
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  DOI10.15252/embj.2021108819 PMID34694004 PMCIDPMC8634136 DivisionProtein & Nucleic Acid Chemistry
• Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse AuthorsPellicanò G., Al Mamun M., Jurado-Santiago D., Villa-Hernández S., Yin X., Giannattasio M., Lanz M. C., Smolka M. B., Yeeles J., Shirahige K., García-Díaz M., Bermejo R. Journal Molecular Cell 81(13):2778-2792.e4. 1 July 2021 (2021)
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  DOI10.1016/j.molcel.2021.04.006 PMID33932350 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The eukaryotic replisome tolerates leading-strand base damage by replicase switching AuthorsGuilliam T. A., Yeeles J. T. Journal EMBO Journal 40(5):e107037. 1 March 2021 (2021)
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  DOI10.15252/embj.2020107037 PMID33555053 PMCIDPMC7917549 DivisionProtein & Nucleic Acid Chemistry
• An updated perspective on the polymerase division of labor during eukaryotic DNA replication AuthorsGuilliam T. A., Yeeles J. T. P. Journal Critical Reviews in Biochemistry and Molecular Biology 55(5):469-481. 3 September 2020 (2020)
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  DOI10.1080/10409238.2020.1811630 PMID32883112 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork AuthorsBaretić D., Jenkyn-Bedford M., Aria V., Cannone G., Skehel M., Yeeles J. T. P. Journal Molecular Cell 78(5):926-940.e13. 4 June 2020 (2020)
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  DOI10.1016/j.molcel.2020.04.012 PMID32369734 PMCIDPMC7276988 DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart AuthorsGuilliam T. A., Yeeles J. T. P. Journal Nature Structural & Molecular Biology 27(5):450-460. May 2020 (2020)
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  DOI10.1038/s41594-020-0418‑4 PMID32341533 PMCIDPMC7116498 DivisionProtein & Nucleic Acid Chemistry
• Dynamics of Replication Fork Progression Following Helicase-Polymerase Uncoupling in Eukaryotes AuthorsTaylor M. R. G., Yeeles J. T. P. Journal Journal of Molecular Biology 431(10):2040-2049. 3 May 2019 (2019)
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  DOI10.1016/j.jmb.2019.03.011 PMID30894292 PMCIDPMC6525111 DivisionProtein & Nucleic Acid Chemistry
• Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes AuthorsDeegan T. D., Baxter J., Ortiz Bazán M. Á., Yeeles J. T. P., Labib K. P. M. Journal Molecular Cell 74(2):231-244.e9. 18 April 2019 (2019)
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  DOI10.1016/j.molcel.2019.01.040 PMID30850330 PMCIDPMC6477153 DivisionProtein & Nucleic Acid Chemistry
• Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins AuthorsAria V., Yeeles J. T. P. Journal Molecular Cell 73(2): 199–211. 17 January 2019 (2019)
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  DOI10.1016/j.molcel.2018.10.019 PMID30451148 PMCIDPMC6344338 DivisionProtein & Nucleic Acid Chemistry
• The Initial Response of a Eukaryotic Replisome to DNA Damage AuthorsTaylor M. R. G., Yeeles J. T. P. Journal Molecular Cell 70(6):1067-1080.e12. 21 June 2018 (2018)
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  DOI10.1016/j.molcel.2018.04.022 PMID29944888 PMCIDPMC6024075 DivisionProtein & Nucleic Acid Chemistry