Published Research
Found 21 results for Yeeles J.
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Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome
AuthorsFletcher E.E., Jones M.L., Yeeles J.T.P.
Journal
The EMBO Journal
44(8):2298-2322 (2025)
Details
DOI10.1038/s44318-025-00386-4 PMID40021844 PMCIDPMC12000384 DivisionProtein & Nucleic Acid Chemistry - Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes AuthorsWesthorpe R., Roske J. J., Yeeles J. T. P. Journal Molecular Cell 84(18):3469-3481.e7 (2024)
- Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε AuthorsRoske JJ, Yeeles JTP. Journal Nature Structural and Molecular Biology Aug 7. doi: 10.1038/s41594-024-01370-y. (2024)
- CST-polymerase α-primase solves a second telomere end-replication problem AuthorsTakai H., Aria V., Borges P., Yeeles J. T. P., de Lange T. Journal Nature 627(8004):664-670 (2024)
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Replication-induced DNA secondary structures drive fork uncoupling and breakage
AuthorsWilliams S. L, Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles J. T., Keyser U. F, Waller Z. A., Di Antonio M., Coster G.
Journal
The EMBO Journal
42(22):e114334 (2023)
Details
DOI10.15252/embj.2023114334 PMID37781931 PMCIDPMC10646557 DivisionProtein & Nucleic Acid Chemistry -
Replication-induced DNA secondary structures drive fork uncoupling and breakage
AuthorsWilliams S. L., Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles JT ., Keyser U. F., Waller Z. A., Di Antonio M., Coster G.
Journal
The EMBO Journal
42(22):e114334 (2023)
Details
DOI10.15252/embj.2023114334 PMID37781931 PMCIDPMC10646557 DivisionProtein & Nucleic Acid Chemistry -
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans
AuthorsXia Y., Sonneville R., Jenkyn-Bedford M., Ji L, Alabert C., Hong Y., Yeeles J. T. P., Labib K. P. M.
Journal
Science
381(6664):eadi4932 (2023)
Details
DOI10.1126/science. Adi4932 PMID37590372 PMCIDPMC7615117 DivisionProtein & Nucleic Acid Chemistry -
How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication
AuthorsJones M. L, Aria V., Baris Y., Yeeles J. T. P.
Journal
Molecular Cell
83(16):2911-2924.e16 (2023)
Details
DOI10.1016/j.molcel.2023.06.035 PMID37506699 PMCIDPMC10501992 DivisionProtein & Nucleic Acid Chemistry -
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
AuthorsRatnayeke N., Baris Y., Chung M., Yeeles J.T.P., Meyer T.
Journal
Molecular Cell
83(1):26-42.e13 (2023)
Details
DOI10.1016/j.molcel.2022.12.004 PMID36608667 PMCIDPMC7614657 DivisionProtein & Nucleic Acid Chemistry -
Fast and efficient DNA replication with purified human proteins
AuthorsBaris Y., Taylor M.R.G., Aria V., Yeeles J.T.P.
Journal
Nature
606(7912):204-210 (2022)
Details
DOI10.1038/s41586-022-04759-1 PMID35585232 PMCIDPMC7613936 DivisionProtein & Nucleic Acid Chemistry -
A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes
AuthorsJenkyn-Bedford M., Jones M. L., Baris Y., Labib K. P. M., Cannone G., Yeeles J. T. P., Deegan T. D.
Journal
Nature
600(7890):743-747 (2021)
Details
DOI10.1038/s41586-021-04145‑3 PMID34700328 PMCIDPMC8695382 DivisionProtein & Nucleic Acid Chemistry -
Structure of a human replisome shows the organisation and interactions of a DNA replication machine
AuthorsJones M. L., Baris Y., Taylor M. R. G., Yeeles J. T. P.
Journal
EMBO Journal
40(23):e108819 (2021)
Details
DOI10.15252/embj.2021108819 PMID34694004 PMCIDPMC8634136 DivisionProtein & Nucleic Acid Chemistry - Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse AuthorsPellicanò G., Al Mamun M., Jurado-Santiago D., Villa-Hernández S., Yin X., Giannattasio M., Lanz M. C., Smolka M. B., Yeeles J., Shirahige K., García-Díaz M., Bermejo R. Journal Molecular Cell 81(13):2778-2792.e4. 1 July 2021 (2021)
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The eukaryotic replisome tolerates leading-strand base damage by replicase switching
AuthorsGuilliam T. A., Yeeles J. T.
Journal
EMBO Journal
40(5):e107037. 1 March 2021 (2021)
Details
DOI10.15252/embj.2020107037 PMID33555053 PMCIDPMC7917549 DivisionProtein & Nucleic Acid Chemistry -
An updated perspective on the polymerase division of labor during eukaryotic DNA replication
AuthorsGuilliam T. A., Yeeles J. T. P.
Journal
Critical Reviews in Biochemistry and Molecular Biology
55(5):469-481. 3 September 2020 (2020)
Details
DOI10.1080/10409238.2020.1811630 PMID32883112 PMCID DivisionProtein & Nucleic Acid Chemistry -
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork
AuthorsBaretić D., Jenkyn-Bedford M., Aria V., Cannone G., Skehel M., Yeeles J. T. P.
Journal
Molecular Cell
78(5):926-940.e13. 4 June 2020 (2020)
Details
DOI10.1016/j.molcel.2020.04.012 PMID32369734 PMCIDPMC7276988 DivisionProtein & Nucleic Acid Chemistry, Cell Biology -
Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart
AuthorsGuilliam T. A., Yeeles J. T. P.
Journal
Nature Structural & Molecular Biology
27(5):450-460. May 2020 (2020)
Details
DOI10.1038/s41594-020-0418‑4 PMID32341533 PMCIDPMC7116498 DivisionProtein & Nucleic Acid Chemistry -
Dynamics of Replication Fork Progression Following Helicase-Polymerase Uncoupling in Eukaryotes
AuthorsTaylor M. R. G., Yeeles J. T. P.
Journal
Journal of Molecular Biology
431(10):2040-2049. 3 May 2019 (2019)
Details
DOI10.1016/j.jmb.2019.03.011 PMID30894292 PMCIDPMC6525111 DivisionProtein & Nucleic Acid Chemistry -
Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes
AuthorsDeegan T. D., Baxter J., Ortiz Bazán M. Á., Yeeles J. T. P., Labib K. P. M.
Journal
Molecular Cell
74(2):231-244.e9. 18 April 2019 (2019)
Details
DOI10.1016/j.molcel.2019.01.040 PMID30850330 PMCIDPMC6477153 DivisionProtein & Nucleic Acid Chemistry -
Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins
AuthorsAria V., Yeeles J. T. P.
Journal
Molecular Cell
73(2): 199–211. 17 January 2019 (2019)
Details
DOI10.1016/j.molcel.2018.10.019 PMID30451148 PMCIDPMC6344338 DivisionProtein & Nucleic Acid Chemistry -
The Initial Response of a Eukaryotic Replisome to DNA Damage
AuthorsTaylor M. R. G., Yeeles J. T. P.
Journal
Molecular Cell
70(6):1067-1080.e12. 21 June 2018 (2018)
Details
DOI10.1016/j.molcel.2018.04.022 PMID29944888 PMCIDPMC6024075 DivisionProtein & Nucleic Acid Chemistry