Published Research

Found 95 results for Williams R.

• A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution AuthorsSpokaite S., Ohashi Y., Bourguet M., Dessus A. N., Williams R. L. Journal Elife 15:RP110040 (2026)
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  DOI10.7554/elife.110040 PMID42207670 PMCIDPMC13218723 DivisionProtein & Nucleic Acid Chemistry
• Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome AuthorsTibarewal P., Rathbone V., Conduit S. E., Classen G. A. E., Black F., Danesh M. A., Constantinou G., Asgarian Z., Tohyama K., Kriplani N., Garcia V. A., Foxall E., Belarbi D., Leverve M., Pearce W., Adil M., Varyova Z., Conde L., Alves A., Masson G. R., Williams R. L., Flanagan A. M., Herrero J., Mohamed I. A., Stroud K., Tischkowitz M., Lachlan K., Scudamore C. L., Scott M. G. H., Leslie N. R., Kessaris N., Vanhaesebroeck B. Journal Disease Models & Mechanisms 19(1):dmm052527 (2026)
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  DOI10.1242/dmm.052527 PMID41215730 PMCIDPMC12817337 DivisionProtein & Nucleic Acid Chemistry
• Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant AuthorsTomlinson P. R., Knox R. G., Perisic O., Su H., Brierley G. V., Williams R. L., Semple R. K. Journal Elife 13:RP94420 (2025)
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  DOIdoi.org/10.7554/elife.94420 PMID39835783 PMCIDPMC11750134 DivisionProtein & Nucleic Acid Chemistry
• Making PI3K superfamily enzymes run faster AuthorsGong G. Q., Anandapadamanaban M., Islam M. S., Hay I. M., Bourguet M., Špokaitė S., Dessus A. N., Ohashi Y., Perisic O., Williams R. L. Journal Advances in Biological Regulation :101060 (2024)
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  DOI10.1016/j.jbior.2024.101060 PMID39592347 PMCID  DivisionProtein & Nucleic Acid Chemistry
• ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding AuthorsGong G. Q., Masson G. R., Lee W. J., Dickson J. M. J., Kendall J. D., Rathinaswamy M. K., Buchanan C. M., Middleditch M., Owen B., Spicer J. A., Rewcastle G. W., Denny W. A., Burke J. E., Shepherd P. R., Williams R. L., Flanagan J. U. Journal The Biochemical Journal :BCJ20240479 (2024)
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  DOI10.1042/bcj20240479 PMID39485310 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function AuthorsSwamynathan M. M., Kuang S., Watrud K. E., Doherty M. R., Gineste C., Mathew G., Gong G. Q., Cox H., Cheng E., Reiss D., Kendall J., Ghosh D., Reczek C. R., Zhao X., Herzka T., Špokaitė S., Dessus A. N., Kim S. T., Klingbeil O., Liu J., Nowak D. G., Alsudani H., Wee T. L., Park Y., Minicozzi F., Rivera K., Almeida A. S., Chang K., Chakrabarty R. P., Wilkinson J. E., Gimotty P. A., Diermeier S. D., Egeblad M., Vakoc C. R., Locasale J. W., Chandel N. S., Janowitz T., Hicks J. B., Wigler M., Pappin D. J., Williams R. L., Cifani P., Tuveson D. A., Laporte J., Trotman L. C. Journal Science 386(6720):eadk9167 (2024)
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  DOIdoi.org/10.1126/science. Adk9167 PMID39446948 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis AuthorsPacyna C. N., Anandapadamanaban M., Loudon K. W., Hay I. M., Perisic O., Li R., Byrne M., Allen L., Roberts K., Hooks Y., Warren A. Y., Stewart G. D., Clatworthy M. R., Teichmann S. A., Behjati S., Campbell P. J., Williams R. L., Mitchell T. J. Journal Oncogene 43(44):3268-3276 (2024)
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  DOI10.1038/s41388-024-03137‑7 PMID39271965 PMCIDPMC11518995 DivisionProtein & Nucleic Acid Chemistry, University
• Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress AuthorsHowes A. C., Perisic O., Williams R. L. Journal Science Advances 9(39):eadi8291 (2023)
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  DOI10.1126/sciadv. Adi8291 PMID37756394 PMCIDPMC10530080 DivisionProtein & Nucleic Acid Chemistry
• A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. AuthorsGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B Journal Nature 618(7963):159-168 (2023)
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  DOI10.1038/s41586-023-05972‑2 PMID37225977 PMCIDPMC7614683 DivisionProtein & Nucleic Acid Chemistry
• Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs AuthorsRathinaswamy M. K., Jenkins M. L., Duewell B. R., Zhang X., Harris N. J., Evans J. T., Stariha J. T. B., Dalwadi U., Fleming K. D., Ranga-Prasad H., Yip C. K., Williams R. L., Hansen S. D., Burke J. E. Journal Cell Reports 42(3):112172 (2023)
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  DOI10.1016/j.celrep.2023.112172 PMID36842083 PMCIDPMC10068899 DivisionProtein & Nucleic Acid Chemistry
• Development of selective inhibitors of phosphatidylinositol 3-kinase C2α AuthorsLo W.T., Belabed H, Kücükdisli M., Metag J., Roske Y., Prokofeva P., Ohashi Y., Horatscheck A., Cirillo D., Krauss M., Schmied C., Neuenschwander M., von Kries J.P., Médard G., Kuster B., Perisic O., Williams R.L., Daumke O., Payrastre B., Severin S., Nazaré M., Haucke V. Journal Nature Chemical Biology 19(1):18-27 (2022)
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  DOI10.1038/s41589-022-01118-z PMID36109648 PMCIDPMC7613998 DivisionProtein & Nucleic Acid Chemistry
• PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation AuthorsGulluni F., et al (including Williams R. L.) Journal Science 374(6573):eabk0410 (2021)
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  DOI10.1126/science. Abk0410 PMID34882480 PMCIDPMC7612254 DivisionProtein & Nucleic Acid Chemistry
• Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace AuthorsHeimhalt M., Berndt A., Wagstaff J., Anandapadamanaban M., Perisic O., Maslen S., McLaughlin S., Yu C. W., Masson G. R., Boland A., Ni X., Yamashita K., Murshudov G. N., Skehel M., Freund S. M., Williams R. L. Journal Elife 10:e68799 (2021)
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  DOI10.7554/elife.68799 PMID34519269 PMCIDPMC8439657 DivisionCell Biology, Protein & Nucleic Acid Chemistry, Structural Studies
• Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy AuthorsMercer T. J., Ohashi Y., Boeing S., Jefferies H. B. J., De Tito S., Flynn H., Tremel S., Zhang W., Wirth M., Frith D., Snijders A. P., Williams R. L., Tooze S. A. Journal EMBO Journal 40(14):e105985. 15 July 2021 (2021)
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  DOI10.15252/embj.2020105985 PMID34121209 PMCIDPMC8280838 DivisionProtein & Nucleic Acid Chemistry
• Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes AuthorsTremel S., Ohashi Y., Morado D. R., Bertram J., Perisic O., Brandt L. T. L., von Wrisberg M. K., Chen Z. A., Maslen S. L., Kovtun O., Skehel M., Rappsilber J., Lang K., Munro S., Briggs J. A. G., Williams R. L. Journal Nature Communications 12(1):1564. 10 March 2021 (2021)
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  DOI10.1038/s41467-021-21695-2 PMID33692360 PMCIDPMC7946940 DivisionCell Biology, Structural Studies, Protein & Nucleic Acid Chemistry
• The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanismm AuthorsBuckles T. C., Ohashi Y., Tremel S., McLaughlin S. H., Pardon E., Steyaert J., Gordon M., Williams R. L., Falke J. J. Journal Biophysical Journal 119(11):2205-2218. 1 December 2020 (2020)
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  DOI10.1016/j. Bpj.2020.10.028 PMID33137306 PMCIDPMC7732812 DivisionProtein & Nucleic Acid Chemistry
• Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils AuthorsRynkiewicz N. K., Anderson K. E., Suire S., Collins D. M., Karanasios E., Vadas O., Williams R., Oxley D., Clark J., Stephens L. R., Hawkins P. T. Journal Science Signaling 13(656). 3 November 2020 (2020)
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  DOI10.1126/scisignal. Aaz4003 PMID33144519 PMCIDPMC7610408 DivisionProtein & Nucleic Acid Chemistry
• Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes AuthorsOhashi Y., Tremel S., Masson G. R., McGinney L., Boulanger J., Rostislavleva K., Johnson C. M., Niewczas I., Clark J., Williams R. L. Journal Elife 9: e58281. 30 June 2020 (2020)
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  DOI10.7554/elife.58281 PMID32602837 PMCIDPMC7326497 DivisionProtein & Nucleic Acid Chemistry
• Structural Mechanisms of PTEN Regulation AuthorsMasson G. R., Williams R. L. Journal Cold Spring Harbor Perspectives in Medicine 10(3):a036152. 2 March 2020 (2020)
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  DOI10.1101/cshperspect. A036152 PMID31636093 PMCIDPMC7050585 DivisionProtein & Nucleic Acid Chemistry
• Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time AuthorsAnandapadamanaban M., Williams R. L. Journal Structure 27(12):1739-1741. 3 December 2019 (2019)
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  DOI10.1016/j.str.2019.11.009 PMID31801096 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells AuthorsHarding H. P., Ordonez A., Allen F., Parts L., Inglis A. J., Williams R. L., Ron D. Journal Elife 8:e50149. 21 November 2019 (2019)
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  DOI10.7554/elife.50149 PMID31749445 PMCIDPMC6919976 DivisionProtein & Nucleic Acid Chemistry
• Architecture of human Rag GTPase heterodimers and their complex with mTORC1 AuthorsAnandapadamanaban M., Masson G. R., Perisic O., Berndt A., Kaufman J., Johnson C. M., Santhanam B., Rogala K. B., Sabatini D. M., Williams R. L. Journal Science 366(6462):203-210. 11 October 2019 (2019)
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  DOI10.1126/science. Aax3939 PMID31601764 PMCIDPMC6795536 DivisionProtein & Nucleic Acid Chemistry
• Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR AuthorsBaretic D., Maia de Oliveira T., Niess M., Wan P., Pollard H., Johnson C. M., Truman C., McCall E., Fisher D., Williams R., Phillips C. Journal Progress in Biophysics and Molecular Biology 147:4-16. October 2019 (2019)
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  DOI10.1016/j.pbiomolbio.2019.06.003 PMID31255703 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology AuthorsTakeda A. J., Maher T. J., Zhang Y., Lanahan S. M., Bucklin M. L., Compton S. R., Tyler P. M., Comrie W. A., Matsuda M., Olivier K. N., Pittaluga S., McElwee J. J., Long Priel D. A., Kuhns D. B., Williams R. L., Mustillo P. J., Wymann M. P., Koneti Rao V., Lucas C. L. Journal Nature Communications 10(1):4364. 25 September 2019 (2019)
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  DOI10.1038/s41467-019-12311-5 PMID31554793 PMCIDPMC6761123 DivisionProtein & Nucleic Acid Chemistry
• The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria AuthorsRavenhill B. J., Boyle K. B., von Muhlinen N., Ellison C. J., Masson G. R., Otten E. G., Foeglein A., Williams R., Randow F. Journal Molecular Cell 74(2):320-329.e6. 18 April 2019 (2019)
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  DOI10.1016/j.molcel.2019.01.041 PMID30853402 PMCIDPMC6477152 DivisionProtein & Nucleic Acid Chemistry
• A class of highly selective inhibitors bind to an active state of PI3Kγ AuthorsGangadhara G., Dahl G., Bohnacker T., Rae R., Gunnarsson J., Blaho S., Öster L., Lindmark H., Karabelas K., Pemberton N., Tyrchan C., Mogemark M., Wymann M. P., Williams R. L., Perry M. W. D., Papavoine T., Petersen J. Journal Nature Chemical Biology 15(4):348-357. April 2019 (2019)
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  DOI10.1038/s41589-018-0215‑0 PMID30718815 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Activation of GCN2 by the ribosomal P‑stalk AuthorsInglis A. J., Masson G. R., Shao S., Perisic O., McLaughlin S. H., Hegde R. S., Williams R. L. Journal Proceedings of the National Academy of Sciences of the United States of America 116(11):4946-4954. 12 March 2019 (2019)
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  DOI10.1073/pnas.1813352116 PMID30804176 PMCIDPMC6421407 DivisionCell Biology, Protein & Nucleic Acid Chemistry
• VPS34 complexes from a structural perspective AuthorsOhashi Y., Tremel S., Williams R. L. Journal Journal of Lipid Research 60(2):229-241. February 2019 (2019)
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  DOI10.1194/jlr. R089490 PMID30397185 PMCIDPMC6358306 DivisionProtein & Nucleic Acid Chemistry
• Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors AuthorsTsolakos N., Durrant T. N., Chessa T., Suire S. M., Oxley D., Kulkarni S., Downward J., Perisic O., Williams R. L., Stephens L., Hawkins P. T. Journal Proceedings of the National Academy of Sciences of the United States of America 115(48):12176-12181. 27 November 2018 (2018)
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  DOI10.1073/pnas.1803446115 PMID30442661 PMCIDPMC6275495 DivisionProtein & Nucleic Acid Chemistry
• Disease variants of FGFR3 reveal molecular basis for the recognition and additional roles for Cdc37 in Hsp90 chaperone system AuthorsBunney T. D., Inglis A. J., Sanfelice D., Farrell B., Kerr C. J., Thompson G. S., Masson G. R., Thiyagarajan N., Svergun D. I., Williams R. L., Breeze A. L., Katan M. Journal Structure 26(3):446-458.e8. 6 March 2018 (2018)
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  DOI10.1016/j.str.2018.01.016 PMID29478821 PMCIDPMC5846801 DivisionProtein & Nucleic Acid Chemistry
• Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing AuthorsWilliams R. L., Anandapadamanaban M. Journal Biochemistry 56(49):6411-6412. 12 December 2017 (2017)
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  DOI10.1021/acs. Biochem.7b01120 PMID29185712 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling AuthorsBuckles T. C., Ziemba B. P., Masson G. R., Williams R. L., Falke J. J. Journal Biophysical Journal 113(11):2396-2405. 5 December 2017 (2017)
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  DOI10.1016/j. Bpj.2017.09.018 PMID29211993 PMCIDPMC5738497 DivisionProtein & Nucleic Acid Chemistry
• Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs AuthorsPirali T., Ciraolo E., Aprile S., Massarotti A., Berndt A., Griglio A., Serafini M., Mercalli V., Landoni C., Campa C. C., Margaria J. P., Silva R. L., Grosa G., Sorba G., Williams R., Hirsch E., Tron G. C. Journal ChemMedChem 12(18):1542-1554. 21 September 2017 (2017)
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  DOI10.1002/cmdc.201700340 PMID28857471 PMCIDPMC5697638 DivisionProtein & Nucleic Acid Chemistry
• 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology AuthorsBeaufils F., Cmiljanovic N., Cmiljanovic V., Bohnacker T., Melone A., Marone R., Jackson E., Zhang X., Sele A., Borsari C., Mestan J., Hebeisen P., Hillmann P., Giese B., Zvelebil M., Fabbro D., Williams R. L., Rageot D., Wymann M. P. Journal Journal of Medicinal Chemistry 60(17):7524-7538. 14 September 2017 (2017)
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  DOI10.1021/acs.jmedchem.7b00930 PMID28829592 PMCIDPMC5656176 DivisionProtein & Nucleic Acid Chemistry
• Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron transfer dissociation hydrogen/deuterium exchange mass spectrometry AuthorsMasson G. R., Maslen S. L., Williams R. L. Journal Biochemical Journal 474(11):1867-1877. 16 May 2017 (2017)
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  DOI10.1042/BCJ20170127 PMID28381646 PMCIDPMC5544108 DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• Structures of closed and open conformations of dimeric human ATM AuthorsBaretić D., Pollard H. K., Fisher D. I., Johnson C. M., Santhanam B., Truman C. M., Kouba T., Fersht A. R., Phillips C., Williams R. L. Journal Science Advances 3(5):e1700933. 10 May 2017 (2017)
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  DOI10.1126/sciadv.1700933 PMID28508083 PMCIDPMC5425235 DivisionProtein & Nucleic Acid Chemistry
• Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention AuthorsBohnacker T., Prota A. E., Beaufils F., Burke J. E., Melone A., Inglis A. J., Rageot D., Sele A. M., Cmiljanovic V., Cmiljanovic N., Bargsten K., Aher A., Akhmanova A., Díaz J. F., Fabbro D., Zvelebil M., Williams R. L., Steinmetz M. O., Wymann M. P. Journal Nature Communications 8:14683. 9 March 2017 (2017)
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  DOI10.1038/ncomms14683 PMID28276440 PMCIDPMC5347140 DivisionProtein & Nucleic Acid Chemistry
• Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module AuthorsZiemba B. P., Swisher G. H., Masson G., Burke J. E., Williams R. L., Falke J. J. Journal Biochemistry 55(46):6395-6405. 22 November 2016 (2016)
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  DOI10.1021/acs. Biochem.6b00908 PMID27933776 PMCIDPMC5632315 DivisionProtein & Nucleic Acid Chemistry
• Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex AuthorsOhashi Y., Soler N., Ortegón M. G., Zhang L., Kirsten M. L., Perisic O., Masson G. R., Burke J. E., Jakobi A. J., Apostolakis A. A., Johnson C. M., Ohashi M., Ktistakis N. T., Sachse C., Williams R. L. Journal Autophagy 12(11):2129-2144. 14 September 2016 (2016)
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  DOI10.1080/15548627.2016.1226736 PMID27630019 PMCIDPMC5103362 DivisionProtein & Nucleic Acid Chemistry
• Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans‑Golgi AuthorsGalindo A., Soler N., McLaughlin S. H., Yu M., Williams R. L., Munro S. Journal Cell Reports 16(3):839-850. 19 July 2016 (2016)
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  DOI10.1016/j. Celrep.2016.06.022 PMID27373159 PMCIDPMC4956616 DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway AuthorsZiemba B. P., Burke J. E., Masson G., Williams R. L., Falke J. J. Journal Biophysical Journal 110(8):1811-1825. 26 April 2016 (2016)
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  DOI10.1016/j. Bpj.2016.03.001 PMID27119641 PMCIDPMC4850241 DivisionProtein & Nucleic Acid Chemistry
• Tor forms a dimer through an N-terminal helical solenoid with a complex topology AuthorsBaretić D., Berndt A., Ohashi Y., Johnson C. M., Williams R. L. Journal Nature Communications 7:11016. 13 April 2016 (2016)
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  DOI10.1038/ncomms11016 PMID27072897 PMCIDPMC4833857 DivisionProtein & Nucleic Acid Chemistry
• Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 AuthorsFowler M. L., McPhail J. A., Jenkins M. L., Masson G. R., Rutaganira F. U., Shokat K. M., Williams R. L., Burke J. E. Journal Protein Science : a Publication of the Protein Society 25(4):826-839. April 2016 (2016)
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  DOI10.1002/pro.2879 PMID26756197 PMCIDPMC4832280 DivisionProtein & Nucleic Acid Chemistry
• The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity AuthorsMasson G. R., Perisic O., Burke J. E., Williams R. L. Journal The Biochemical Journal 473(2):135-44. 15 January 2016 (2016)
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  DOI10.1042/BJ20150931 PMID26527737 PMCIDPMC4700475 DivisionProtein & Nucleic Acid Chemistry
• Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes AuthorsRostislavleva K., Soler N., Ohashi Y., Zhang L., Pardon E., Burke J. E., Masson G. R., Johnson C., Steyaert J., Ktistakis N. T., Williams R. L. Journal Science 350(6257):aac7365. 9 October 2015 (2015)
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  DOI10.1126/science. Aac7365 PMID26450213 PMCIDPMC4601532 DivisionProtein & Nucleic Acid Chemistry
• PTEN regulates cilia through Dishevelled AuthorsShnitsar I., Bashkurov M., Masson G. R., Ogunjimi A. A., Mosessian S., Cabeza E. A., Hirsch C. L., Trcka D., Gish G., Jiao J., Wu H., Winklbauer R., Williams R. L., Pelletier L., Wrana J. L., Barrios-Rodiles M. Journal Nature Communications 6:8388. 24 September 2015 (2015)
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  DOI10.1038/ncomms9388 PMID26399523 PMCIDPMC4598566 DivisionProtein & Nucleic Acid Chemistry
• Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity AuthorsShymanets A., Prajwal, Vadas O., Czupalla C., LoPiccolo J., Brenowitz M., Ghigo A., Hirsch E., Krause E., Wetzker R., Williams R. L., Harteneck C., Nürnberg B. Journal The Biochemical Journal 469(1):59-69. 19 June 2015 (2015)
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  DOI10.1042/BJ20150099 PMID26173259 PMCIDPMC4655608 DivisionProtein & Nucleic Acid Chemistry
• Synergy in activating class I PI3Ks. AuthorsBurke J. E., Williams R. L. Journal Trends in Biochemical Sciences 40(2):88-100, 1 February 2015 (2015)
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  DOI10.1016/j.tibs.2014.12.003 PMID25573003 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The structural basis for mTOR function AuthorsBaretić D., Williams R. L. Journal Seminars in Cell & Developmental Biology 36:91-101. December 2014 (2014)
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  DOI10.1016/j.semcdb.2014.09.024 PMID25289568 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors AuthorsBurke J. E., Inglis A. J., Perisic O., Masson G. R., McLaughlin S. H., Rutaganira F., Shokat K. M., Williams R. L. Journal Science 344(6187):1035-1038. 30 May 2014 (2014)
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  DOI10.1126/science.1253397 PMID24876499 PMCIDPMC4046302 DivisionProtein & Nucleic Acid Chemistry
• Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α. AuthorsGanesh K., van Maldegem F., Telerman S. B., Simpson P., Johnson C. M., Williams R. L., Neuberger M. S., Rada C. Journal FEBS Letters 588(1):21-27. 3 January 2014 (2014)
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  DOI10.1016/j.febslet.2013.11.013 PMID24269683 PMCIDPMC3885797 DivisionProtein & Nucleic Acid Chemistry
• Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs) AuthorsVadas O., Dbouk H. A., Shymanets A., Perisic O., Burke J. E., Abi Saab W. F., Khalil B. D., Harteneck C., Bresnick A. R., Nürnberg B., Backer J. M., Williams R. L. Journal Proceedings of the National Academy of Sciences, USA 110(47):18862-18867. 19 November 2013 (2013)
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  DOI10.1073/pnas.1304801110 PMID24190998 PMCIDPMC3839701 DivisionProtein & Nucleic Acid Chemistry
• Connecting with an old partner in a new way AuthorsBurke J. E., Williams R. L. Journal Cancer Cell 23(5):559-561. 13 May 2013 (2013)
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  DOI10.1016/j. Ccr.2013.04.023 PMID23680139 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Allosteric activation of PI3Kα by oncogenic mutations AuthorsBurke J. E., Perisic O., Williams R. L. Journal Oncotarget 4(2):180-181. February 2013 (2013)
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  DOI  PMID23563630 PMCIDPMC3712563 DivisionProtein & Nucleic Acid Chemistry
• Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX‑MS) AuthorsBurke J. E., Williams R. L. Journal Advances in Biological Regulation 53(1):97-110. January 2013 (2013)
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  DOI10.1016/j.jbior.2012.09.005 PMID23194976 PMCIDPMC3613897 DivisionProtein & Nucleic Acid Chemistry
• G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness AuthorsDbouk H. A., Vadas O., Shymanets A., Burke J. E., Salamon R. S., Khalil B. D., Barrett M. O., Waldo G. L., Surve C., Hsueh C., Perisic O., Harteneck C., Shepherd P. R., Harden T. K., Smrcka A. V., Taussig R., Bresnick A. R., Nürnberg B., Williams R. L., Backer J. M. Journal Science Signaling 5(253):ra89. 4 December 2012 (2012)
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  DOI10.1126/scisignal.2003264 PMID23211529 PMCIDPMC3979326 DivisionProtein & Nucleic Acid Chemistry
• PI3Kβ downstream of GPCRs - crucial partners in oncogenesis AuthorsDbouk H. A., Vadas O., Williams R. L., Backer J. M. Journal Oncotarget 3(12):1485-1486. December 2012 (2012)
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  DOI  PMID23328076 PMCIDPMC3681480 DivisionProtein & Nucleic Acid Chemistry
• ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes AuthorsHadders M. A., Agromayor M., Obita T., Perisic O., Caballe A., Kloc M., Lamers M. H., Williams R. L., Martin-Serrano J. Journal Proceedings of the National Academy of Sciences, USA 109(43):17424-17429. 23 October 2012 (2012)
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  DOI10.1073/pnas.1206839109 PMID23045692 PMCIDPMC3491508 DivisionProtein & Nucleic Acid Chemistry
• Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA) AuthorsBurke J. E., Perisic O., Masson G. R., Vadas O., Williams R. L. Journal Proceedings of the National Academy of Sciences, USA 109(38):15259-15264. 18 September 2012 (2012)
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  DOI10.1073/pnas.1205508109 PMID22949682 PMCIDPMC3458343 DivisionProtein & Nucleic Acid Chemistry
• Regulation of lipid binding underlies the activation mechanism of class IA PI3‑kinases AuthorsHon W. C., Berndt A., Williams R. L. Journal Oncogene 31(32):3655-3666. 9 August 2012 (2012)
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  DOI10.1038/onc.2011.532 PMID22120714 PMCIDPMC3378484 DivisionNeurobiology; Protein & Nucleic Acid Chemistry
• Guidelines for the use and interpretation of assays for monitoring autophagy AuthorsKlionsky D. J. .... Randow F. .... Williams R. L. et al Journal Autophagy 8(4):445-544. 1 April 2012 (2012)
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  DOI10.4161/auto.19496 PMID22966490 PMCIDPMC3404883 DivisionProtein & Nucleic Acid Chemistry
• The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain AuthorsAgromayor M., Soler N., Caballe A., Kueck T., Freund S. M., Allen M. D., Bycroft M., Perisic O., Ye Y., McDonald B., Scheel H., Hofmann K., Neil S. J., Martin-Serrano J., Williams R. L. Journal Structure 20(3):414-428. 7 March 2012 (2012)
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  DOI10.1016/j.str.2011.12.013 PMID22405001 PMCIDPMC3314968 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Membrane trafficking: Arls squeeze the fat out AuthorsWilliams R. L. Journal Nature Chemical Biology 7(12):863-864. December 2011 (2011)
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  DOI10.1038/nchembio.713 PMID22086287 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural basis for activation and inhibition of class I phosphoinositide 3‑kinases AuthorsVadas O., Burke J. E., Zhang X., Berndt A., Williams R. L. Journal Science Signaling 4(195):re2. 18 October 2011 (2011)
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  DOI10.1126/scisignal.2002165 PMID22009150 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α AuthorsBurke J. E., Vadas O., Berndt A., Finegan T., Perisic O., Williams R. L. Journal Structure 19(8):1127-1137. 10 August 2010 (2011)
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  DOI10.1016/j.str.2011.06.003 PMID21827948 PMCIDPMC3155019 DivisionProtein & Nucleic Acid Chemistry
• Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism AuthorsZhang X., Vadas O., Perisic O., Anderson K. E., Clark J., Hawkins P. T., Stephens L. R., Williams R. L. Journal Molecular Cell 41(5):567-578. 4 March 2011 (2011)
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  DOI10.1016/j.molcel.2011.01.026 PMID21362552 PMCIDPMC3670040 DivisionProtein & Nucleic Acid Chemistry
• Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division AuthorsSamson R. Y., Obita T., Hodgson B., Shaw M. K., Chong P. L., Williams R. L., Bell S. D. Journal Molecular Cell 41(2):186-196. 21 January 2011 (2011)
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  DOI10.1016/j.molcel.2010.12.018 PMID21255729 PMCIDPMC3763469 DivisionProtein & Nucleic Acid Chemistry
• Kinases charging to the membrane AuthorsHadders M. A., Williams R. L. Journal Cell 143(6):865-867. 10 December 2010 (2010)
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  DOI10.1016/j. Cell.2010.11.044 PMID21145452 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor AuthorsMiller S., Oleksy A., Perisic O., Williams R. L. Journal Autophagy 6(6):805-807. 16 August 2010 (2010)
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  DOI10.4161/auto.6.6.12577 PMID20574157 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34 AuthorsMiller S., Tavshanjian B., Oleksy A., Perisic O., Houseman B. T., Shokat K. M., Williams R. L. Journal Science 327(5973):1638-1642. 26 March 2010 (2010)
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  DOI10.1126/science.1184429 PMID20339072 PMCIDPMC2860105 DivisionProtein & Nucleic Acid Chemistry
• The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors AuthorsBerndt A., Miller S., Williams O., Le D. D., Houseman B. T., Pacold J. I., Gorrec F., Hon W-C., Liu Y., Rommel C., Gaillard P., Ruckle T., Schwarz M. K., Shokat K. M., Shaw J. P., Williams R. L. Journal Nature Chemical Biology 6(2):117-124. 12 February 2010 (2010)
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  DOI10.1038/nchembio.293 PMID20081827 PMCIDPMC2880452 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Structural basis for selective recognition of ESCRT-III by the AAA-ATPase Vps4 AuthorsObita T., Saksena S., Ghazi-Tabatabai S., Gill D. J., Perisic O., Emr S. D., Williams R. L. Journal Nature 449(7163): 735-739. 11 October 2007 (2007)
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  DOI10.1038/nature06171 PMID17928861 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit AuthorsMiled N., Yan Y., Hon W-C., Perisic O., Zvelebil M., Inbar Y., Schneidman-Duhovny D., Wolfson H. J., Backer J. M., Williams R. L. Journal Science 317(5835): 239-242. 13 July 2007 (2007)
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  DOI10.1126/science.1135394 PMID17626883 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural insight into the ESCRT-I/-II link and its role in MVB trafficking AuthorsGill D. J., Teo H., Sun J., Perisic O., Veprintsev D., Emr S. D., Williams R. L. Journal EMBO Journal 26(2): 600-612. 24 January 2007 (2007)
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  DOI10.1038/sj.emboj.7601501 PMID17215868 PMCIDPMC1783442 DivisionProtein & Nucleic Acid Chemistry
• Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies AuthorsGill D. J., Teo H., Sun J., Perisic O., Veprintsev D. B., Vallis Y., Emr S. D., Williams R. L. Journal Biochemical Society Symposium 74: 47-57. January 2007 (2007)
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  DOI10.1042/BSS0740047 PMID17233579 PMCID  Division 
• A pharmacological map of P13-K family defines a role for p110alpha in insulin signaling AuthorsZachary A. Knight, Beatriz Gonzalez, Morri E. Feldman, Eli R. Zunder, David D. Goldenberg, Olusegun Williams, Robbie Loewith, David Stokoe, Andras Balla, Balazs Toth, Tamas Balla, William A. Weiss, Roger L. Williams, Kevan M. Shokat Journal Cell 125: 733-747 (2006) (2006)
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• PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62 AuthorsWilson M. I., Gill D. J., Perisic O., Quinn M. T., Williams R. L. Journal Molecular Cell 12(1):39-50. July 2003 (2003)
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  DOI10.1016/s1097-2765(03)00246-6 PMID12887891 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction AuthorsKarathanassis D., Stahelin R. V., Bravo J., Perisic O., Pacold C. M., Cho W., Williams R. L. Journal EMBO Journal 21(19):5057-5068. 1 October 2002 (2002)
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  DOI10.1093/emboj/cdf519 PMID12356722 PMCIDPMC129041 DivisionProtein & Nucleic Acid Chemistry
• Tyrosine residues in phospholipase Cgamma2 essential for the enzyme function in B-cell signaling AuthorsRodriguez R., Matsuda M., Perisic O., Bravo J., Paul A., Jones N. P., Light Y., Swann K., Williams R. L., Katan M. Journal Journal of Biological Chemistry 276(51):47982-47992. 21 December 2001 (2001)
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  DOI10.1074/jbc.m107577200 PMID11606584 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The crystal structure of the PX domain from p40phox bound to phosphatidylinositol 3‑phosphate AuthorsBravo J., Karathanassis D., Pacold C. M., Pacold M. E., Ellson C. D., Anderson K. E., Butler P. J. G., Lavenir I., Perisic O., Hawkins P. T.,Stephens L., Williams R. L. Journal Molecular Cell 8(4):829-839 (2001) (2001)
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  DOI10.1016/s1097-2765(01)00372-0 PMID11684018 PMCID  Division 
• Crystal structure and functional analysis of Ras binding to its effector phosophoinositide 3-kinase gamma AuthorsPacold M. E., Suire S., Perisic O., Lara-Gonzalez S., Davis C. T., Walker E. H., Hawkins P. T., Stephens L., Eccleston J. F., Williams R. L. Journal Cell 103(6):931-943. 8 December 2000 (2000)
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  DOI10.1016/s0092-8674(00)00196-3 PMID11136978 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine AuthorsWalker E. H., Pacold M. E., Perisic O., Stephens L.,Hawkins P. T., Wymann M. P., Williams R. L. Journal Molecular Cell 6(4):909-919. October 2000 (2000)
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  DOI10.1016/s1097-2765(05)00089-4 PMID11090628 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta AuthorsWarren A. J., Bravo J., Williams R. L., Rabbitts T. H. Journal EMBO Journal 19(12):3004-3015 (2000) (2000)
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  DOI10.1093/emboj/19.12.3004 PMID10856244 PMCIDPMC203359 DivisionProtein & Nucleic Acid Chemistry
• Mammalian phosphoinositide-specific phospholipase C AuthorsWilliams R. L. Journal Biochimica et Biophysica Acta 1441(2-3):255-267. 23 November 1999 (1999)
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  DOI10.1016/s1388-1981(99)00150-x PMID10570253 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural insights into phosphoinositide 3-kinase catalysis and signalling AuthorsWalker E. H., Perisic O., Ried C., Stephens L., Williams R. L. Journal Nature 402(6759):313-320. 18 November 1999 (1999)
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  DOI10.1038/46319 PMID10580505 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2 AuthorsPerisic O., Paterson H. F., Mosedale G., Lara-Gonzalez S., Williams R. L. Journal Journal of Biological Chemistry 274(21):14979-14987 (1999) (1999)
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  DOI10.1074/jbc.274.21.14979 PMID10329700 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 Angstrom: evidence for conformational lability AuthorsHolliger P., Riechmann L., Williams R. L. Journal Journal of Molecular Biology 288(4):649-657. 14 May 1999 (1999)
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  DOI10.1006/jmbi.1999.2720 PMID10329170 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D‑galactose AuthorsPoget S. F., Legge G. B., Proctor M. R., Butler P. J. G., Bycroft M., Williams R. L. Journal Journal of Molecular Biology 290(4):867-879 (1999 ) (1999)
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  DOI10.1006/jmbi.1999.2910 PMID10398588 PMCID  Division 
• Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C AuthorsHeinz D. W., Essen L-O., Williams R. L. Journal Journal of Molecular Biology 275(4):635-650 (1998) (1998)
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  DOI10.1006/jmbi.1997.1490 PMID9466937 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Catalytic domain of phosphoinositide-specific phospholipase C (PLC) AuthorsEllis M. V., James S. R., Perisic O., Downes C. P., Williams R. L., Katan M. Journal Journal of Biological Chemistry 273(19):11650-11659 (1998) (1998)
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  DOI10.1074/jbc.273.19.11650 PMID9565585 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2 AuthorsPerisic O., Fong S., Lynch D. E., Bycroft M., Williams R. L. Journal Journal of Biological Chemistry 273(3):1596-1604. 16 January 1998 (1998)
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  DOI10.1074/jbc.273.3.1596 PMID9430701 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation AuthorsWu Y., Perisic O., Williams R. L., Katan M., Roberts M. F. Journal Biochemistry 36(37):11223-11233 (1997) (1997)
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  DOI10.1021/bi971039s PMID9287165 PMCID  Division 
• Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions AuthorsKatan M., Williams R. L. Journal Seminars in Cell & Developmental Biology 8(3):287-296. June 1997 (1997)
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  DOI10.1006/scdb.1997.0150 PMID10024492 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Recombinant antibodies possessing novel effector functions AuthorsMichael S. Neuberger, Gareth T. Williams, Robert O. Fox Journal Nature 312: 604-608 (1984) (1984)
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• An efficient general method for the synthesis of gastrins AuthorsEvelyn Brown, Brian J. Williams, Robert C. Sheppard Journal Journal of the Chemical Society. Chemical Communications pp.1093-1095 (1980) (1980)
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