Published Research
Found 91 results for Williams R.
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
AuthorsTomlinson P. R., Knox R. G., Perisic O., Su H., Brierley G. V., Williams R. L., Semple R. K.
Journal
Elife
13:RP94420 (2025)
Details
DOIdoi.org/10.7554/elife.94420 PMID39835783 PMCIDPMC11750134 DivisionProtein & Nucleic Acid Chemistry - Making PI3K superfamily enzymes run faster AuthorsGong G. Q., Anandapadamanaban M., Islam M. S., Hay I. M., Bourguet M., ล pokaitฤ S., Dessus A. N., Ohashi Y., Perisic O., Williams R. L. Journal Advances in Biological Regulation :101060 (2024)
- ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding AuthorsGong G. Q., Masson G. R., Lee W. J., Dickson J. M. J., Kendall J. D., Rathinaswamy M. K., Buchanan C. M., Middleditch M., Owen B., Spicer J. A., Rewcastle G. W., Denny W. A., Burke J. E., Shepherd P. R., Williams R. L., Flanagan J. U. Journal The Biochemical Journal :BCJ20240479 (2024)
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Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
AuthorsSwamynathan M. M., Kuang S., Watrud K. E., Doherty M. R., Gineste C., Mathew G., Gong G. Q., Cox H., Cheng E., Reiss D., Kendall J., Ghosh D., Reczek C. R., Zhao X., Herzka T., ล pokaitฤ S., Dessus A. N., Kim S. T., Klingbeil O., Liu J., Nowak D. G., Alsudani H., Wee T. L., Park Y., Minicozzi F., Rivera K., Almeida A. S., Chang K., Chakrabarty R. P., Wilkinson J. E., Gimotty P. A., Diermeier S. D., Egeblad M., Vakoc C. R., Locasale J. W., Chandel N. S., Janowitz T., Hicks J. B., Wigler M., Pappin D. J., Williams R. L., Cifani P., Tuveson D. A., Laporte J., Trotman L. C.
Journal
Science
386(6720):eadk9167 (2024)
Details
DOIdoi.org/10.1126/science. Adk9167 PMID39446948 PMCID DivisionProtein & Nucleic Acid Chemistry -
Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis
AuthorsPacyna C. N., Anandapadamanaban M., Loudon K. W., Hay I. M., Perisic O., Li R., Byrne M., Allen L., Roberts K., Hooks Y., Warren A. Y., Stewart G. D., Clatworthy M. R., Teichmann S. A., Behjati S., Campbell P. J., Williams R. L., Mitchell T. J.
Journal
Oncogene
43(44):3268-3276 (2024)
Details
DOI10.1038/s41388-024-03137‑7 PMID39271965 PMCIDPMC11518995 DivisionProtein & Nucleic Acid Chemistry, University -
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
AuthorsHowes A. C., Perisic O., Williams R. L.
Journal
Science Advances
9(39):eadi8291 (2023)
Details
DOI10.1126/sciadv. Adi8291 PMID37756394 PMCIDPMC10530080 DivisionProtein & Nucleic Acid Chemistry -
A small-molecule PI3Kฮฑ activator for cardioprotection and neuroregeneration.
AuthorsGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B
Journal
Nature
618(7963):159-168 (2023)
Details
DOI10.1038/s41586-023-05972‑2 PMID37225977 PMCIDPMC7614683 DivisionProtein & Nucleic Acid Chemistry -
A small-molecule PI3Kฮฑ activator for cardioprotection and neuroregeneration
AuthorsGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B.
Journal
Nature
18(7963):159-168 (2023)
Details
DOI10.1038/s41586-023-05972‑2 PMID37225977 PMCIDPMC7614683 DivisionProtein & Nucleic Acid Chemistry - Molecular basis for differential activation of p101 and p84 complexes of PI3Kฮณ by Ras and GPCRs AuthorsRathinaswamy M. K., Jenkins M. L., Duewell B. R., Zhang X., Harris N. J., Evans J. T., Stariha J. T. B., Dalwadi U., Fleming K. D., Ranga-Prasad H., Yip C. K., Williams R. L., Hansen S. D., Burke J. E. Journal Cell Reports 42(3):112172 (2023)
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Development of selective inhibitors of phosphatidylinositol 3-kinase C2ฮฑ
AuthorsLo W.T., Belabed H, Kรผcรผkdisli M., Metag J., Roske Y., Prokofeva P., Ohashi Y., Horatscheck A., Cirillo D., Krauss M., Schmied C., Neuenschwander M., von Kries J.P., Mรฉdard G., Kuster B., Perisic O., Williams R.L., Daumke O., Payrastre B., Severin S., Nazarรฉ M., Haucke V.
Journal
Nature Chemical Biology
19(1):18-27 (2022)
Details
DOI10.1038/s41589-022-01118-z PMID36109648 PMCIDPMC7613998 DivisionProtein & Nucleic Acid Chemistry -
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
AuthorsGulluni F., et al (including Williams R. L.)
Journal
Science
374(6573):eabk0410 (2021)
Details
DOI10.1126/science. Abk0410 PMID34882480 PMCIDPMC7612254 DivisionProtein & Nucleic Acid Chemistry -
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
AuthorsHeimhalt M., Berndt A., Wagstaff J., Anandapadamanaban M., Perisic O., Maslen S., McLaughlin S., Yu C. W., Masson G. R., Boland A., Ni X., Yamashita K., Murshudov G. N., Skehel M., Freund S. M., Williams R. L.
Journal
Elife
10:e68799 (2021)
Details
DOI10.7554/elife.68799 PMID34519269 PMCIDPMC8439657 DivisionCell Biology, Protein & Nucleic Acid Chemistry, Structural Studies -
Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy
AuthorsMercer T. J., Ohashi Y., Boeing S., Jefferies H. B. J., De Tito S., Flynn H., Tremel S., Zhang W., Wirth M., Frith D., Snijders A. P., Williams R. L., Tooze S. A.
Journal
EMBO Journal
40(14):e105985. 15 July 2021 (2021)
Details
DOI10.15252/embj.2020105985 PMID34121209 PMCIDPMC8280838 DivisionProtein & Nucleic Acid Chemistry -
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
AuthorsTremel S., Ohashi Y., Morado D. R., Bertram J., Perisic O., Brandt L. T. L., von Wrisberg M. K., Chen Z. A., Maslen S. L., Kovtun O., Skehel M., Rappsilber J., Lang K., Munro S., Briggs J. A. G., Williams R. L.
Journal
Nature Communications
12(1):1564. 10 March 2021 (2021)
Details
DOI10.1038/s41467-021-21695-2 PMID33692360 PMCIDPMC7946940 DivisionCell Biology, Structural Studies, Protein & Nucleic Acid Chemistry -
The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanismm
AuthorsBuckles T. C., Ohashi Y., Tremel S., McLaughlin S. H., Pardon E., Steyaert J., Gordon M., Williams R. L., Falke J. J.
Journal
Biophysical Journal
119(11):2205-2218. 1 December 2020 (2020)
Details
DOI10.1016/j. Bpj.2020.10.028 PMID33137306 PMCIDPMC7732812 DivisionProtein & Nucleic Acid Chemistry -
Gฮฒฮณ is a direct regulator of endogenous p101/p110ฮณ and p84/p110ฮณ PI3Kฮณ complexes in mouse neutrophils
AuthorsRynkiewicz N. K., Anderson K. E., Suire S., Collins D. M., Karanasios E., Vadas O., Williams R., Oxley D., Clark J., Stephens L. R., Hawkins P. T.
Journal
Science Signaling
13(656). 3 November 2020 (2020)
Details
DOI10.1126/scisignal. Aaz4003 PMID33144519 PMCIDPMC7610408 DivisionProtein & Nucleic Acid Chemistry -
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes
AuthorsOhashi Y., Tremel S., Masson G. R., McGinney L., Boulanger J., Rostislavleva K., Johnson C. M., Niewczas I., Clark J., Williams R. L.
Journal
Elife
9: e58281. 30 June 2020 (2020)
Details
DOI10.7554/elife.58281 PMID32602837 PMCIDPMC7326497 DivisionProtein & Nucleic Acid Chemistry -
Structural Mechanisms of PTEN Regulation
AuthorsMasson G. R., Williams R. L.
Journal
Cold Spring Harbor Perspectives in Medicine
10(3):a036152. 2 March 2020 (2020)
Details
DOI10.1101/cshperspect. A036152 PMID31636093 PMCIDPMC7050585 DivisionProtein & Nucleic Acid Chemistry - Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time AuthorsAnandapadamanaban M., Williams R. L. Journal Structure 27(12):1739-1741. 3 December 2019 (2019)
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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells
AuthorsHarding H. P., Ordonez A., Allen F., Parts L., Inglis A. J., Williams R. L., Ron D.
Journal
Elife
8:e50149. 21 November 2019 (2019)
Details
DOI10.7554/elife.50149 PMID31749445 PMCIDPMC6919976 DivisionProtein & Nucleic Acid Chemistry -
Architecture of human Rag GTPase heterodimers and their complex with mTORC1
AuthorsAnandapadamanaban M., Masson G. R., Perisic O., Berndt A., Kaufman J., Johnson C. M., Santhanam B., Rogala K. B., Sabatini D. M., Williams R. L.
Journal
Science
366(6462):203-210. 11 October 2019 (2019)
Details
DOI10.1126/science. Aax3939 PMID31601764 PMCIDPMC6795536 DivisionProtein & Nucleic Acid Chemistry -
Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR
AuthorsBaretic D., Maia de Oliveira T., Niess M., Wan P., Pollard H., Johnson C. M., Truman C., McCall E., Fisher D., Williams R., Phillips C.
Journal
Progress in Biophysics and Molecular Biology
147:4-16. October 2019 (2019)
Details
DOI10.1016/j.pbiomolbio.2019.06.003 PMID31255703 PMCID DivisionProtein & Nucleic Acid Chemistry -
Human PI3Kฮณ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology
AuthorsTakeda A. J., Maher T. J., Zhang Y., Lanahan S. M., Bucklin M. L., Compton S. R., Tyler P. M., Comrie W. A., Matsuda M., Olivier K. N., Pittaluga S., McElwee J. J., Long Priel D. A., Kuhns D. B., Williams R. L., Mustillo P. J., Wymann M. P., Koneti Rao V., Lucas C. L.
Journal
Nature Communications
10(1):4364. 25 September 2019 (2019)
Details
DOI10.1038/s41467-019-12311-5 PMID31554793 PMCIDPMC6761123 DivisionProtein & Nucleic Acid Chemistry -
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria
AuthorsRavenhill B. J., Boyle K. B., von Muhlinen N., Ellison C. J., Masson G. R., Otten E. G., Foeglein A., Williams R., Randow F.
Journal
Molecular Cell
74(2):320-329.e6. 18 April 2019 (2019)
Details
DOI10.1016/j.molcel.2019.01.041 PMID30853402 PMCIDPMC6477152 DivisionProtein & Nucleic Acid Chemistry - A class of highly selective inhibitors bind to an active state of PI3Kฮณ AuthorsGangadhara G., Dahl G., Bohnacker T., Rae R., Gunnarsson J., Blaho S., รster L., Lindmark H., Karabelas K., Pemberton N., Tyrchan C., Mogemark M., Wymann M. P., Williams R. L., Perry M. W. D., Papavoine T., Petersen J. Journal Nature Chemical Biology 15(4):348-357. April 2019 (2019)
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Activation of GCN2 by the ribosomal P‑stalk
AuthorsInglis A. J., Masson G. R., Shao S., Perisic O., McLaughlin S. H., Hegde R. S., Williams R. L.
Journal
Proceedings of the National Academy of Sciences of the United States of America
116(11):4946-4954. 12 March 2019 (2019)
Details
DOI10.1073/pnas.1813352116 PMID30804176 PMCIDPMC6421407 DivisionCell Biology, Protein & Nucleic Acid Chemistry -
VPS34 complexes from a structural perspective
AuthorsOhashi Y., Tremel S., Williams R. L.
Journal
Journal of Lipid Research
60(2):229-241. February 2019 (2019)
Details
DOI10.1194/jlr. R089490 PMID30397185 PMCIDPMC6358306 DivisionProtein & Nucleic Acid Chemistry -
Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
AuthorsTsolakos N., Durrant T. N., Chessa T., Suire S. M., Oxley D., Kulkarni S., Downward J., Perisic O., Williams R. L., Stephens L., Hawkins P. T.
Journal
Proceedings of the National Academy of Sciences of the United States of America
115(48):12176-12181. 27 November 2018 (2018)
Details
DOI10.1073/pnas.1803446115 PMID30442661 PMCIDPMC6275495 DivisionProtein & Nucleic Acid Chemistry -
Disease variants of FGFR3 reveal molecular basis for the recognition and additional roles for Cdc37 in Hsp90 chaperone system
AuthorsBunney T. D., Inglis A. J., Sanfelice D., Farrell B., Kerr C. J., Thompson G. S., Masson G. R., Thiyagarajan N., Svergun D. I., Williams R. L., Breeze A. L., Katan M.
Journal
Structure
26(3):446-458.e8. 6 March 2018 (2018)
Details
DOI10.1016/j.str.2018.01.016 PMID29478821 PMCIDPMC5846801 DivisionProtein & Nucleic Acid Chemistry - Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing AuthorsWilliams R. L., Anandapadamanaban M. Journal Biochemistry 56(49):6411-6412. 12 December 2017 (2017)
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Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kฮฑ and PIP3 Signaling
AuthorsBuckles T. C., Ziemba B. P., Masson G. R., Williams R. L., Falke J. J.
Journal
Biophysical Journal
113(11):2396-2405. 5 December 2017 (2017)
Details
DOI10.1016/j. Bpj.2017.09.018 PMID29211993 PMCIDPMC5738497 DivisionProtein & Nucleic Acid Chemistry -
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
AuthorsPirali T., Ciraolo E., Aprile S., Massarotti A., Berndt A., Griglio A., Serafini M., Mercalli V., Landoni C., Campa C. C., Margaria J. P., Silva R. L., Grosa G., Sorba G., Williams R., Hirsch E., Tron G. C.
Journal
ChemMedChem
12(18):1542-1554. 21 September 2017 (2017)
Details
DOI10.1002/cmdc.201700340 PMID28857471 PMCIDPMC5697638 DivisionProtein & Nucleic Acid Chemistry -
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
AuthorsBeaufils F., Cmiljanovic N., Cmiljanovic V., Bohnacker T., Melone A., Marone R., Jackson E., Zhang X., Sele A., Borsari C., Mestan J., Hebeisen P., Hillmann P., Giese B., Zvelebil M., Fabbro D., Williams R. L., Rageot D., Wymann M. P.
Journal
Journal of Medicinal Chemistry
60(17):7524-7538. 14 September 2017 (2017)
Details
DOI10.1021/acs.jmedchem.7b00930 PMID28829592 PMCIDPMC5656176 DivisionProtein & Nucleic Acid Chemistry -
Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron transfer dissociation hydrogen/deuterium exchange mass spectrometry
AuthorsMasson G. R., Maslen S. L., Williams R. L.
Journal
Biochemical Journal
474(11):1867-1877. 16 May 2017 (2017)
Details
DOI10.1042/BCJ20170127 PMID28381646 PMCIDPMC5544108 DivisionProtein & Nucleic Acid Chemistry, Cell Biology -
Structures of closed and open conformations of dimeric human ATM
AuthorsBaretiฤ D., Pollard H. K., Fisher D. I., Johnson C. M., Santhanam B., Truman C. M., Kouba T., Fersht A. R., Phillips C., Williams R. L.
Journal
Science Advances
3(5):e1700933. 10 May 2017 (2017)
Details
DOI10.1126/sciadv.1700933 PMID28508083 PMCIDPMC5425235 DivisionProtein & Nucleic Acid Chemistry -
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
AuthorsBohnacker T., Prota A. E., Beaufils F., Burke J. E., Melone A., Inglis A. J., Rageot D., Sele A. M., Cmiljanovic V., Cmiljanovic N., Bargsten K., Aher A., Akhmanova A., Dรญaz J. F., Fabbro D., Zvelebil M., Williams R. L., Steinmetz M. O., Wymann M. P.
Journal
Nature Communications
8:14683. 9 March 2017 (2017)
Details
DOI10.1038/ncomms14683 PMID28276440 PMCIDPMC5347140 DivisionProtein & Nucleic Acid Chemistry -
Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module
AuthorsZiemba B. P., Swisher G. H., Masson G., Burke J. E., Williams R. L., Falke J. J.
Journal
Biochemistry
55(46):6395-6405. 22 November 2016 (2016)
Details
DOI10.1021/acs. Biochem.6b00908 PMID27933776 PMCIDPMC5632315 DivisionProtein & Nucleic Acid Chemistry -
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex
AuthorsOhashi Y., Soler N., Ortegรณn M. G., Zhang L., Kirsten M. L., Perisic O., Masson G. R., Burke J. E., Jakobi A. J., Apostolakis A. A., Johnson C. M., Ohashi M., Ktistakis N. T., Sachse C., Williams R. L.
Journal
Autophagy
12(11):2129-2144. 14 September 2016 (2016)
Details
DOI10.1080/15548627.2016.1226736 PMID27630019 PMCIDPMC5103362 DivisionProtein & Nucleic Acid Chemistry -
Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans‑Golgi
AuthorsGalindo A., Soler N., McLaughlin S. H., Yu M., Williams R. L., Munro S.
Journal
Cell Reports
16(3):839-850. 19 July 2016 (2016)
Details
DOI10.1016/j. Celrep.2016.06.022 PMID27373159 PMCIDPMC4956616 DivisionProtein & Nucleic Acid Chemistry, Cell Biology -
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway
AuthorsZiemba B. P., Burke J. E., Masson G., Williams R. L., Falke J. J.
Journal
Biophysical Journal
110(8):1811-1825. 26 April 2016 (2016)
Details
DOI10.1016/j. Bpj.2016.03.001 PMID27119641 PMCIDPMC4850241 DivisionProtein & Nucleic Acid Chemistry -
Tor forms a dimer through an N-terminal helical solenoid with a complex topology
AuthorsBaretiฤ D., Berndt A., Ohashi Y., Johnson C. M., Williams R. L.
Journal
Nature Communications
7:11016. 13 April 2016 (2016)
Details
DOI10.1038/ncomms11016 PMID27072897 PMCIDPMC4833857 DivisionProtein & Nucleic Acid Chemistry - Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIฮฒ with Rab11 AuthorsFowler M. L., McPhail J. A., Jenkins M. L., Masson G. R., Rutaganira F. U., Shokat K. M., Williams R. L., Burke J. E. Journal Protein Science : a Publication of the Protein Society 25(4):826-839. April 2016 (2016)
- The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity AuthorsMasson G. R., Perisic O., Burke J. E., Williams R. L. Journal The Biochemical Journal 473(2):135-44. 15 January 2016 (2016)
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Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
AuthorsRostislavleva K., Soler N., Ohashi Y., Zhang L., Pardon E., Burke J. E., Masson G. R., Johnson C., Steyaert J., Ktistakis N. T., Williams R. L.
Journal
Science
350(6257):aac7365. 9 October 2015 (2015)
Details
DOI10.1126/science. Aac7365 PMID26450213 PMCIDPMC4601532 DivisionProtein & Nucleic Acid Chemistry - PTEN regulates cilia through Dishevelled AuthorsShnitsar I., Bashkurov M., Masson G. R., Ogunjimi A. A., Mosessian S., Cabeza E. A., Hirsch C. L., Trcka D., Gish G., Jiao J., Wu H., Winklbauer R., Williams R. L., Pelletier L., Wrana J. L., Barrios-Rodiles M. Journal Nature Communications 6:8388. 24 September 2015 (2015)
- Different inhibition of Gฮฒฮณ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gฮฒฮณ-dependent regulator of PI3Kฮณ enzymatic activity AuthorsShymanets A., Prajwal, Vadas O., Czupalla C., LoPiccolo J., Brenowitz M., Ghigo A., Hirsch E., Krause E., Wetzker R., Williams R. L., Harteneck C., Nรผrnberg B. Journal The Biochemical Journal 469(1):59-69. 19 June 2015 (2015)
- Synergy in activating class I PI3Ks. AuthorsBurke J. E., Williams R. L. Journal Trends in Biochemical Sciences 40(2):88-100, 1 February 2015 (2015)
- The structural basis for mTOR function AuthorsBaretiฤ D., Williams R. L. Journal Seminars in Cell & Developmental Biology 36:91-101. December 2014 (2014)
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Structures of PI4KIIIฮฒ complexes show simultaneous recruitment of Rab11 and its effectors
AuthorsBurke J. E., Inglis A. J., Perisic O., Masson G. R., McLaughlin S. H., Rutaganira F., Shokat K. M., Williams R. L.
Journal
Science
344(6187):1035-1038. 30 May 2014 (2014)
Details
DOI10.1126/science.1253397 PMID24876499 PMCIDPMC4046302 DivisionProtein & Nucleic Acid Chemistry -
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin ฮฑ.
AuthorsGanesh K., van Maldegem F., Telerman S. B., Simpson P., Johnson C. M., Williams R. L., Neuberger M. S., Rada C.
Journal
FEBS Letters
588(1):21-27. 3 January 2014 (2014)
Details
DOI10.1016/j.febslet.2013.11.013 PMID24269683 PMCIDPMC3885797 DivisionProtein & Nucleic Acid Chemistry -
Molecular determinants of PI3Kฮณ-mediated activation downstream of G-protein-coupled receptors (GPCRs)
AuthorsVadas O., Dbouk H. A., Shymanets A., Perisic O., Burke J. E., Abi Saab W. F., Khalil B. D., Harteneck C., Bresnick A. R., Nรผrnberg B., Backer J. M., Williams R. L.
Journal
Proceedings of the National Academy of Sciences, USA
110(47):18862-18867. 19 November 2013 (2013)
Details
DOI10.1073/pnas.1304801110 PMID24190998 PMCIDPMC3839701 DivisionProtein & Nucleic Acid Chemistry - Connecting with an old partner in a new way AuthorsBurke J. E., Williams R. L. Journal Cancer Cell 23(5):559-561. 13 May 2013 (2013)
- Allosteric activation of PI3Kฮฑ by oncogenic mutations AuthorsBurke J. E., Perisic O., Williams R. L. Journal Oncotarget 4(2):180-181. February 2013 (2013)
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Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX‑MS)
AuthorsBurke J. E., Williams R. L.
Journal
Advances in Biological Regulation
53(1):97-110. January 2013 (2013)
Details
DOI10.1016/j.jbior.2012.09.005 PMID23194976 PMCIDPMC3613897 DivisionProtein & Nucleic Acid Chemistry -
G protein-coupled receptor-mediated activation of p110ฮฒ by Gฮฒฮณ is required for cellular transformation and invasiveness
AuthorsDbouk H. A., Vadas O., Shymanets A., Burke J. E., Salamon R. S., Khalil B. D., Barrett M. O., Waldo G. L., Surve C., Hsueh C., Perisic O., Harteneck C., Shepherd P. R., Harden T. K., Smrcka A. V., Taussig R., Bresnick A. R., Nรผrnberg B., Williams R. L., Backer J. M.
Journal
Science Signaling
5(253):ra89. 4 December 2012 (2012)
Details
DOI10.1126/scisignal.2003264 PMID23211529 PMCIDPMC3979326 DivisionProtein & Nucleic Acid Chemistry - PI3Kฮฒ downstream of GPCRs - crucial partners in oncogenesis AuthorsDbouk H. A., Vadas O., Williams R. L., Backer J. M. Journal Oncotarget 3(12):1485-1486. December 2012 (2012)
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ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes
AuthorsHadders M. A., Agromayor M., Obita T., Perisic O., Caballe A., Kloc M., Lamers M. H., Williams R. L., Martin-Serrano J.
Journal
Proceedings of the National Academy of Sciences, USA
109(43):17424-17429. 23 October 2012 (2012)
Details
DOI10.1073/pnas.1206839109 PMID23045692 PMCIDPMC3491508 DivisionProtein & Nucleic Acid Chemistry -
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110ฮฑ (PIK3CA)
AuthorsBurke J. E., Perisic O., Masson G. R., Vadas O., Williams R. L.
Journal
Proceedings of the National Academy of Sciences, USA
109(38):15259-15264. 18 September 2012 (2012)
Details
DOI10.1073/pnas.1205508109 PMID22949682 PMCIDPMC3458343 DivisionProtein & Nucleic Acid Chemistry -
Regulation of lipid binding underlies the activation mechanism of class IA PI3‑kinases
AuthorsHon W. C., Berndt A., Williams R. L.
Journal
Oncogene
31(32):3655-3666. 9 August 2012 (2012)
Details
DOI10.1038/onc.2011.532 PMID22120714 PMCIDPMC3378484 DivisionNeurobiology; Protein & Nucleic Acid Chemistry - Guidelines for the use and interpretation of assays for monitoring autophagy AuthorsKlionsky D. J. .... Randow F. .... Williams R. L. et al Journal Autophagy 8(4):445-544. 1 April 2012 (2012)
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The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain
AuthorsAgromayor M., Soler N., Caballe A., Kueck T., Freund S. M., Allen M. D., Bycroft M., Perisic O., Ye Y., McDonald B., Scheel H., Hofmann K., Neil S. J., Martin-Serrano J., Williams R. L.
Journal
Structure
20(3):414-428. 7 March 2012 (2012)
Details
DOI10.1016/j.str.2011.12.013 PMID22405001 PMCIDPMC3314968 DivisionProtein & Nucleic Acid Chemistry, Structural Studies - Membrane trafficking: Arls squeeze the fat out AuthorsWilliams R. L. Journal Nature Chemical Biology 7(12):863-864. December 2011 (2011)
- Structural basis for activation and inhibition of class I phosphoinositide 3‑kinases AuthorsVadas O., Burke J. E., Zhang X., Berndt A., Williams R. L. Journal Science Signaling 4(195):re2. 18 October 2011 (2011)
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Dynamics of the phosphoinositide 3-kinase p110ฮด interaction with p85ฮฑ and membranes reveals aspects of regulation distinct from p110ฮฑ
AuthorsBurke J. E., Vadas O., Berndt A., Finegan T., Perisic O., Williams R. L.
Journal
Structure
19(8):1127-1137. 10 August 2010 (2011)
Details
DOI10.1016/j.str.2011.06.003 PMID21827948 PMCIDPMC3155019 DivisionProtein & Nucleic Acid Chemistry -
Structure of lipid kinase p110ฮฒ/p85ฮฒ elucidates an unusual SH2-domain-mediated inhibitory mechanism
AuthorsZhang X., Vadas O., Perisic O., Anderson K. E., Clark J., Hawkins P. T., Stephens L. R., Williams R. L.
Journal
Molecular Cell
41(5):567-578. 4 March 2011 (2011)
Details
DOI10.1016/j.molcel.2011.01.026 PMID21362552 PMCIDPMC3670040 DivisionProtein & Nucleic Acid Chemistry -
Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division
AuthorsSamson R. Y., Obita T., Hodgson B., Shaw M. K., Chong P. L., Williams R. L., Bell S. D.
Journal
Molecular Cell
41(2):186-196. 21 January 2011 (2011)
Details
DOI10.1016/j.molcel.2010.12.018 PMID21255729 PMCIDPMC3763469 DivisionProtein & Nucleic Acid Chemistry - Kinases charging to the membrane AuthorsHadders M. A., Williams R. L. Journal Cell 143(6):865-867. 10 December 2010 (2010)
- Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor AuthorsMiller S., Oleksy A., Perisic O., Williams R. L. Journal Autophagy 6(6):805-807. 16 August 2010 (2010)
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Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34
AuthorsMiller S., Tavshanjian B., Oleksy A., Perisic O., Houseman B. T., Shokat K. M., Williams R. L.
Journal
Science
327(5973):1638-1642. 26 March 2010 (2010)
Details
DOI10.1126/science.1184429 PMID20339072 PMCIDPMC2860105 DivisionProtein & Nucleic Acid Chemistry -
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
AuthorsBerndt A., Miller S., Williams O., Le D. D., Houseman B. T., Pacold J. I., Gorrec F., Hon W-C., Liu Y., Rommel C., Gaillard P., Ruckle T., Schwarz M. K., Shokat K. M., Shaw J. P., Williams R. L.
Journal
Nature Chemical Biology
6(2):117-124. 12 February 2010 (2010)
Details
DOI10.1038/nchembio.293 PMID20081827 PMCIDPMC2880452 DivisionProtein & Nucleic Acid Chemistry, Structural Studies - Structural basis for selective recognition of ESCRT-III by the AAA-ATPase Vps4 AuthorsObita T., Saksena S., Ghazi-Tabatabai S., Gill D. J., Perisic O., Emr S. D., Williams R. L. Journal Nature 449(7163): 735-739. 11 October 2007 (2007)
- Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit AuthorsMiled N., Yan Y., Hon W-C., Perisic O., Zvelebil M., Inbar Y., Schneidman-Duhovny D., Wolfson H. J., Backer J. M., Williams R. L. Journal Science 317(5835): 239-242. 13 July 2007 (2007)
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Structural insight into the ESCRT-I/-II link and its role in MVB trafficking
AuthorsGill D. J., Teo H., Sun J., Perisic O., Veprintsev D., Emr S. D., Williams R. L.
Journal
EMBO Journal
26(2): 600-612. 24 January 2007 (2007)
Details
DOI10.1038/sj.emboj.7601501 PMID17215868 PMCIDPMC1783442 DivisionProtein & Nucleic Acid Chemistry - Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies AuthorsGill D. J., Teo H., Sun J., Perisic O., Veprintsev D. B., Vallis Y., Emr S. D., Williams R. L. Journal Biochemical Society Symposium 74: 47-57. January 2007 (2007)
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PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62
AuthorsWilson M. I., Gill D. J., Perisic O., Quinn M. T., Williams R. L.
Journal
Molecular Cell
12(1):39-50. July 2003 (2003)
Details
DOI10.1016/s1097-2765(03)00246-6 PMID12887891 PMCID DivisionProtein & Nucleic Acid Chemistry -
Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction
AuthorsKarathanassis D., Stahelin R. V., Bravo J., Perisic O., Pacold C. M., Cho W., Williams R. L.
Journal
EMBO Journal
21(19):5057-5068. 1 October 2002 (2002)
Details
DOI10.1093/emboj/cdf519 PMID12356722 PMCIDPMC129041 DivisionProtein & Nucleic Acid Chemistry - Tyrosine residues in phospholipase Cgamma2 essential for the enzyme function in B-cell signaling AuthorsRodriguez R., Matsuda M., Perisic O., Bravo J., Paul A., Jones N. P., Light Y., Swann K., Williams R. L., Katan M. Journal Journal of Biological Chemistry 276(51):47982-47992. 21 December 2001 (2001)
- The crystal structure of the PX domain from p40phox bound to phosphatidylinositol 3‑phosphate AuthorsBravo J., Karathanassis D., Pacold C. M., Pacold M. E., Ellson C. D., Anderson K. E., Butler P. J. G., Lavenir I., Perisic O., Hawkins P. T.,Stephens L., Williams R. L. Journal Molecular Cell 8(4):829-839 (2001) (2001)
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Crystal structure and functional analysis of Ras binding to its effector phosophoinositide 3-kinase gamma
AuthorsPacold M. E., Suire S., Perisic O., Lara-Gonzalez S., Davis C. T., Walker E. H., Hawkins P. T., Stephens L., Eccleston J. F., Williams R. L.
Journal
Cell
103(6):931-943. 8 December 2000 (2000)
Details
DOI10.1016/s0092-8674(00)00196-3 PMID11136978 PMCID DivisionProtein & Nucleic Acid Chemistry -
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
AuthorsWalker E. H., Pacold M. E., Perisic O., Stephens L.,Hawkins P. T., Wymann M. P., Williams R. L.
Journal
Molecular Cell
6(4):909-919. October 2000 (2000)
Details
DOI10.1016/s1097-2765(05)00089-4 PMID11090628 PMCID DivisionProtein & Nucleic Acid Chemistry -
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta
AuthorsWarren A. J., Bravo J., Williams R. L., Rabbitts T. H.
Journal
EMBO Journal
19(12):3004-3015 (2000) (2000)
Details
DOI10.1093/emboj/19.12.3004 PMID10856244 PMCIDPMC203359 DivisionProtein & Nucleic Acid Chemistry -
Mammalian phosphoinositide-specific phospholipase C
AuthorsWilliams R. L.
Journal
Biochimica et Biophysica Acta
1441(2-3):255-267. 23 November 1999 (1999)
Details
DOI10.1016/s1388-1981(99)00150-x PMID10570253 PMCID DivisionProtein & Nucleic Acid Chemistry - Structural insights into phosphoinositide 3-kinase catalysis and signalling AuthorsWalker E. H., Perisic O., Ried C., Stephens L., Williams R. L. Journal Nature 402(6759):313-320. 18 November 1999 (1999)
- Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2 AuthorsPerisic O., Paterson H. F., Mosedale G., Lara-Gonzalez S., Williams R. L. Journal Journal of Biological Chemistry 274(21):14979-14987 (1999) (1999)
- Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 Angstrom: evidence for conformational lability AuthorsHolliger P., Riechmann L., Williams R. L. Journal Journal of Molecular Biology 288(4):649-657. 14 May 1999 (1999)
- The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D‑galactose AuthorsPoget S. F., Legge G. B., Proctor M. R., Butler P. J. G., Bycroft M., Williams R. L. Journal Journal of Molecular Biology 290(4):867-879 (1999 ) (1999)
- Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C AuthorsHeinz D. W., Essen L-O., Williams R. L. Journal Journal of Molecular Biology 275(4):635-650 (1998) (1998)
- Catalytic domain of phosphoinositide-specific phospholipase C (PLC) AuthorsEllis M. V., James S. R., Perisic O., Downes C. P., Williams R. L., Katan M. Journal Journal of Biological Chemistry 273(19):11650-11659 (1998) (1998)
- Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2 AuthorsPerisic O., Fong S., Lynch D. E., Bycroft M., Williams R. L. Journal Journal of Biological Chemistry 273(3):1596-1604. 16 January 1998 (1998)
- Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation AuthorsWu Y., Perisic O., Williams R. L., Katan M., Roberts M. F. Journal Biochemistry 36(37):11223-11233 (1997) (1997)
- Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions AuthorsKatan M., Williams R. L. Journal Seminars in Cell & Developmental Biology 8(3):287-296. June 1997 (1997)