Published Research

Found 66 results for Unwin.

• Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor AuthorsUnwin N. Journal Proceedings of the National Academy of Sciences of the United States of America 121(19):e2319913121 (2024)
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  DOI10.1073/pnas.2319913121 PMID38683987 PMCIDPMC11087746 DivisionNeurobiology
• MRC2020: improvements to Ximdisp and the MRC image-processing programs AuthorsShort J. M., Palmer C. M., Burnley T., Winn M. D., Zhang Q., Venkataram Prasad B. V., Chen S., Crowther R. A., Unwin P. N. T., Henderson R. Journal Iucrj 10(Pt 5):579-583 (2023)
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  DOI10(Pt 5):579‑583 PMID37493524 PMCIDPMC10478516 DivisionStructural Studies
• Structure of a cholinergic cell membrane AuthorsUnwin N. Journal Proceedings of the National Academy of Sciences of the United States of America Aug 23;119(34):e2207641119 (2022)
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  DOI10.1073/pnas.2207641119 PMID35969788 PMCIDPMC9407305 DivisionNeurobiology
• Protein-Lipid Interplay at the Neuromuscular Junction AuthorsUnwin N. Journal Microscopy e-pub: published online 13 July 2021 (2021)
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  DOI10.1093/jmicro/dfab023 PMID34226930 PMCID  DivisionNeurobiology
• Protein-lipid architecture of a cholinergic postsynaptic membrane AuthorsUnwin N. Journal Iucrj 7(Pt 5):852-859 (2020)
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  DOI10.1107/s2052252520009446 PMID32939277 PMCIDPMC7467168 DivisionNeurobiology
• Segregation of lipids near acetylcholine-receptor channels imaged by cryo‑EM AuthorsUnwin N. Journal Iucrj 4(Pt 4):393-399. July 2017 (2017)
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  DOI10.1107/s2052252517005243 PMID28875026 PMCIDPMC5571802 DivisionNeurobiology
• Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes AuthorsUnwin N. Journal Quarterly Reviews of Biophysics 46(4):283-322. November 2013 (2013)
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  DOI10.1017/S0033583513000061 PMID24050525 PMCIDPMC3820380 DivisionNeurobiology
• Structure and superorganization of acetylcholine receptor-rapsyn complexes AuthorsZuber B., Unwin N. Journal Proceedings of the National Academy of Sciences, USA. 110(26):10622-10627. 25 June 2013 (2013)
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  DOI10.1073/pnas.1301277110 PMID23754381 PMCID  DivisionNeurobiology
• Gating movement of acetylcholine receptor caught by plunge‑freezing AuthorsUnwin N., Fujiyoshi Y. Journal Journal of Molecular Biology 422(5):617-634. 5 October 2012 (2012)
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  DOI10.1016/j.jmb.2012.07.010 PMID22841691 PMCIDPMC3443390 DivisionNeurobiology
• A helical processing pipeline for EM structure determination of membrane proteins AuthorsFisher L. S., Ward A., Milligan R. A., Unwin N., Potter C. S., Carragher B. Journal Methods 55(4):350-362. December 2011 (2011)
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  DOIorg/10.1016/j.ymeth.2011.09.013 PMID21964395 PMCIDPMC3262078 DivisionNeurobiology
• Electron crystallography of proteins in membranes AuthorsYoshinori Fujiyoshi, Nigel Unwin Journal Current Opinion in Structural Biology 18 (5): 587-592 (2008)
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• Organization of spines on the dendrites of Purkinje cells AuthorsO'Brien J., Unwin N. Journal Proceedings of the National Academy of Sciences, USA 103(5):1575-1580. 19 January 2006 (2006)
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  DOI10.1073/pnas.0507884103 PMID16423897 PMCIDPMC1360541 DivisionNeurobiology
• Refined structure of the nicotinic acetylcholine receptor at 4 Angstrom resolution AuthorsUnwin N. Journal Journal of Molecular Biology 346: 967-989 (2005) (2005)
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• Structure and gating mechanism of the acetylcholine receptor pore AuthorsAtsuo Miyazawa, Yoshinori Fujiyoshi, Nigel Unwin Journal Nature 423: 949-955 (2003) (2003)
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• Nicotinic actylcholine receptors AuthorsDavid Colquhoun, Nigel Unwin, Chris Shelley, Chris Hatton, Lucia Sivilotti Journal Burger's Medicinal Chemistry, Vol II Drug Discovery and Drug Development (Ed. D. Abraham), J. Wiley, New York pp.357-405 (2003) (2003)
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• Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy AuthorsNigel Unwin Journal FEBS Letters 555: 91-95 (2003) (2003)
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• Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the α subunits AuthorsUnwin N., Miyazawa A., LI J., Fujiyoshi Y. Journal Journal of Molecular Biology 319(5):1165-1176. 21 June 2002 (2002)
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  DOI10.1016/s0022-2836(02)00381‑9 PMID12079355 PMCID  DivisionNeurobiology
• Structure of the acetylcholine-gated channel AuthorsUnwin N. Journal Novartis Foundation Symposium 245: 5-21 (2002) (2002)
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  DOI  PMID12027014 PMCID  DivisionNeurobiology
• The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission AuthorsUnwin N. Journal Phil. Trans. R. Soc. Lond. B 355(1404):1813-1829 (2000) (2000)
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  DOI10.1098/rstb.2000.0737 PMID11205343 PMCIDPMC1692909 DivisionNeurobiology
• Electron microscopic evidence for the assembly of soluble pentameric extracellular domains of the nicotinic acetylcholine receptor AuthorsTierney M. L., Unwin N. Journal Journal of Molecular Biology 303(2):185-196. 20 October 2000 (2000)
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  DOI10.1006/jmbi.2000.4137 PMID11023785 PMCID  DivisionNeurobiology
• Nicotinic acetylcholine receptor at 4.6 angstrom resolution: transverse tunnels in the channel wall AuthorsA. Miyazawa, Y. Fujiyoshi, M. Stowell, N. Unwin Journal Journal of Molecular Biology 288: 765-786 (1999) (1999)
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• The nicotinic acetylcholine receptor of the Torpedo electric ray AuthorsNigel Unwin Journal Journal of Structural Biology 121: 181-190 (1998) (1998)
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• Macromolecular structure determination by electron microscopy: new advances and recent results AuthorsM. H. B. Stowell, A. Miyazawa, N. Unwin Journal Current Opinion in Structural Biology 8: 595-600 (1998) (1998)
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• Distortion correction of tubular crystals: improvements in the acetylcholine receptor structure AuthorsRameen Beroukhim, Nigel Unwin Journal Ultramicroscopy 70: 57-81 (1997) (1997)
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• Projection structure of the nicotinic acetylcholine receptor: distinct conformations of the alpha subunits AuthorsNigel Unwin Journal Journal of Molecular Biology 257: 586-596 (1996) (1996)
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• Three-dimensional location of the main immunogenic region of the acetylcholine receptor AuthorsBeroukhim R., Unwin N. Journal Neuron 15(2):323-331. August 1995 (1995 )
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  DOI10.1016/0896-6273(95)90037-3 PMID7544140 PMCID  DivisionNeurobiology
• Acetylcholine receptor channel imaged in the open state AuthorsNigel Unwin Journal Nature 373(6509):37-43. 5 January 1995 (1995)
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  DOI10.1038/373037a0 PMID7800037 PMCID  DivisionNeurobiology
• Analysis of transient structures by cryo-microscopy combined with rapid mixing of spray droplets AuthorsBerriman J., Unwin N. Journal Ultramicroscopy 56(4):241-252. December 1994 (1994 )
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  DOI10.1016/0304-3991(94)90012‑4 PMID7831735 PMCID  DivisionNeurobiology
• Nicotinic acetylcholine receptor at 9 Angstrom resolution AuthorsN. Unwin Journal Journal of Molecular Biology 229(4):1101-1124. 20 February 1993 (1993)
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  DOI10.1006/jmbi.1993.1107 PMID8445638 PMCID  DivisionStructural Studies
• Biochemistry of gap-junction channels AuthorsKathrin A. Stauffer, Nalin M. Kumar, Norton B. Gilula, Nigel Unwin Journal Progress in Cell Research 3: 57-59 (1993) (1993)
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• Neurotransmitter action: opening of ligand-gated ion channels AuthorsUnwin N. Journal Cell & Neuron Supplement 72 & 10 (Suppl): 31-41. January 1993 (1993)
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  DOI10.1016/S0092-8674(05)80026-1 PMID7679054 PMCID  DivisionNeurobiology
• Structure of gap junction channels AuthorsStauffer K. A., Unwin N. Journal Seminars in Cell Biology 3(1):17-20. February 1992 (1992)
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  DOI10.1016/s1043-4682(10)80004-2 PMID1377970 PMCID  DivisionNeurobiology
• Isolation and purification of gap junction channels AuthorsStauffer K. A., Kumar N. M., Gilula N. B., Unwin N. Journal Journal of Cell Biology 115(1):141-150. 1 October 1991 (1991)
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  DOI10.1083/jcb.115.1.141 PMID1655801 PMCIDPMC2289915 DivisionStructural Studies
• Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction AuthorsChikashi Toyoshima, Nigel Unwin Journal Journal of Cell Biology 111 : 2623-2635 (1990) (1990 )
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• The structure of ion channels in membranes of excitable cells AuthorsUnwin N. Journal Neuron 3(6):665-676. December 1989 (1989)
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  DOI10.1016/0896-6273(89)90235-3 PMID2484344 PMCID  DivisionStructural Studies
• Organization of connexons in isolated rat liver gap junctions AuthorsEdward Gogol, Nigel Unwin Journal Biophysical Journal 54: 105-112 (1988) (1988)
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• Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations AuthorsLinda C. Milks, Nalin M. Kumar, Richard Houghten, Nigel Unwin, Norton B. Gilula Journal EMBO Journal 7: 2967-2975 (1988) (1988)
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• Three-dimensional structure of gap junctions in fragmented plasma membranes from rat liver AuthorsSantosh S. Sikerwar, Nigel Unwin Journal Biophysical Journal 54: 113-119 (1988) (1988)
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• Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes AuthorsNigel Unwin, Chikashi Toyoshima, Elizabeth Kubalek Journal Journal of Cell Biology 107: 1123-1138 (1988) (1988)
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• Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes AuthorsChikashi Toyoshima, Nigel Unwin Journal Nature 336: 247-250 (1988) (1988)
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• Contrast transfer for frozen-hydrated specimens: determination from pairs of defocused images AuthorsChikashi Toyoshima, Nigel Unwin Journal Ultramicroscopy 25: 279-292 (1988) (1988)
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• The structure of proteins in biological membranes AuthorsNigel Unwin, Richard Henderson Journal Scientific American February 1984: 78-86, 91-94 (1984) (1984)
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• A cold stage for the Philips EM300 electron microscope AuthorsTaylor K. A., Milligan R. A., Raeburn C., Unwin, P. N. Journal Ultramicroscopy 13(3):185-189. 1984 (1984)
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  DOI10.1016/0304-3991(84)90197-9 PMID6485128 PMCID  DivisionStructural Studies
• Three-dimensional structure determination by electron microscopy of two-dimensional crystals AuthorsL. A. Amos, Richard Henderson, P. N. T. Unwin Journal Prog. Biophys. Molec. Biol. 39: 183-231 (1982) (1982)
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• Distribution of RNA and protein in crystalline eukaryotic ribosomes AuthorsW. Kuhlbrandt, P. N. T. Unwin Journal Journal of Molecular Biology 156: 431-448 (1982) (1982)
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• In vitro crystallization of ribosomes from chick embryos AuthorsR. A. Milligan, P. N. T. Unwin Journal Journal of Cell Biology 95: 648-653 (1982) (1982)
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• A large particle associated with the perimeter of the nuclear pore complex AuthorsP. N. T. Unwin, R. A. Milligan Journal Journal of Cell Biology 93: 63-75 (1982) (1982)
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• Structure of the junction between communicating cells AuthorsP. N. T. Unwin, G. Zampighi Journal Nature 283: 545-549 (1980) (1980)
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• Structural analysis of stained and unstained two-dimensional ribosome crystals AuthorsW. Kuhlbrandt, P. N. T. Unwin Journal Electron Microscopy at Molecular Dimension. Edited by Wolfgang Baumeister and Wolrad Vogell pp.108-116 (1980) (1980)
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• Attachment of ribosome crystals to intracellular membranes AuthorsP. N. T. Unwin Journal Journal of Molecular Biology 132: 69-84 (1979) (1979)
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• Two forms of isolated gap junctions AuthorsG. Zampighi, P. N. T. Unwin Journal Journal of Molecular Biology 135: 451-464 (1979) (1979)
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• Structure of purple membrane from Halobacterium halobium AuthorsR. Henderson, P. N. T. Unwin Journal Biophysics of Structure and Mechanism 3: 121 (1977) (1977)
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• Packing of ribosomes in crystals from the lizard Lacerta sicula AuthorsP. N. T. Unwin, C. Taddei Journal Journal of Molecular Biology 114: 491-506 (1977) (1977)
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• Three-dimensional model of membrane-bound ribosomes obtained by electron microscopy AuthorsP. N. T. Unwin Journal Nature 269: 118-122 (1977) (1977)
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• The hand of the stacked-disk aggregate of tobacco mosaic virus protein AuthorsA. C. Bloomer, J. N. Champness, P. N. T. Unwin Journal Journal of Molecular Biology 105: 453-457 (1976) (1976)
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• Molecular structure determination by electron microscopy of unstained crystalline specimens AuthorsP. N. T. Unwin, R. Henderson Journal Journal of Molecular Biology 94: 425-440 (1975) (1975)
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• Beef liver catalase structure: interpretation of electron micrographs AuthorsP. N. T. Unwin Journal Journal of Molecular Biology 98: 235-242 (1975) (1975)
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• Three-dimensional model of purple membrane obtained by electron microscopy AuthorsR. Henderson, P. N. T. Unwin Journal Nature 257: 28-32 (1975) (1975)
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• A new electron microscope imaging method for enhancing detail in thin biological specimens AuthorsP. N. T. Unwin Journal Z. Naturforsch. 29a: 158-163 (1974) (1974)
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• Electron microscopy of the stacked disk aggregate of tobacco mosaic virus protein. I. Three-dimensional image reconstruction AuthorsP. N. T. Unwin, A. Klug Journal Journal of Molecular Biology 87: 641-656 (1974) (1974)
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• Electron microscopy of the stacked disk aggregate of tobacco mosaic virus protein. II. The influence of electron irradiation on the stain distribution AuthorsP. N. T. Unwin Journal Journal of Molecular Biology 87: 657-670 (1974) (1974)
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• Negative staining of biological specimens using mixture salts AuthorsP. N. T. Unwin Journal Proceedings of the Fifth European Congress on Electron Microscopy 232-233 (1972)
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• Electron microscopy of biological specimens by means of an electrostatic phase plate AuthorsP. N. T. Unwin Journal Proceedings of the Royal Society of London, A. 329 (1578) : 327-359 (1972)
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  DOI10.1098/rspa.1972.0116 PMID  PMCID  Division 
• Transmission electron microscopy of ice AuthorsUnwin P. N. T., Muguruma J. Journal Journal of Applied Physics 42(9):3640-1. August 1971 (1971)
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  DOI10.1063/1.1660782 PMID  PMCID  DivisionStructural Studies
• Phase contrast and interference microscopy with the electron microscope AuthorsP. N. T. Unwin Journal Philosophical Transactions of the Royal Society of London, B 261: 95-104 (1971)
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  DOI10.1098/rstb.1971.0039 PMID4399209 PMCID  Division 
• An electrostatic phase plate for the electron microscope AuthorsP. N. T. Unwin Journal Berichte der Bunsen-Gesellschaft fur physikalische Chemie (fruher Zeitschrift fur Elektrochemie) 74 (11) : 1137-1141 (1970)
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  DOI10.1002/bbpc.19700741110 PMID  PMCID  Division