Published Research

Found 121 results for Scheres.

• The Pick fold in tau filaments from human MAPT mutants AuthorsQi C., Lövestam S., Shi J., Murzin A. G., Peak-Chew S., Warner T. T., Seelaar H., Cullinane P. W., Jaunmuktane Z., van Swieten J. C., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 152(1):6 (2026)
  Details

  DOI10.1007/s00401-026-03049-8 PMID42420562 PMCIDPMC13346262 DivisionStructural Studies/Neurobiology
• The amyloid packing difference: A pairwise comparison metric for amyloid structures AuthorsScheres S. H. W. Journal Structure :S0969-2126(26)00145-0 (2026)
  Details

  DOI10.1016/j.str.2026.04.014 PMID42173092 PMCID  DivisionStructural Studies
• Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments AuthorsLövestam S., Wagstaff J. L., Katsinelos T., Shi J., Freund S. M. V., Goedert M., Scheres S. H. W. Journal Elife 14:RP104778 (2026)
  Details

  DOI10.7554/elife.104778 PMID42159330 PMCIDPMC13189620 DivisionStructural Studies
• Seeding biosensor cell line that reproduces the Alzheimer tau fold AuthorsTaxiarchis Katsinelos, Sofia Lövestam, Chao Qi, Bejamin Ryskeldi-Falcon, Jennifer A. Macdonald, Gabriel Stephenson, Bernardino Ghetti, Ann McKee, Sjors H. W. Scheres, Michel Goedert. Journal The Journal of Biological Chemistry 301(12):110952 (2025)
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  DOI10.1016/j.jbc.2025.110952 PMID41260337 PMCIDPMC12765094 DivisionStructural Studies, Neurobiology
• Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency AuthorsKasen A., Lövestam S., Breton L., Meyerdirk L., McPhail J.A., Piche K., Louwrier A., Capan C.D., Lee H., Scheres S.H.W., Henderson M.X. Journal Nature Communications 16(1):9240 (2025)
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  DOI10.1038/s41467-025-64312-2 PMID41107248 PMCIDPMC12534512 DivisionStructural Studies
• Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau AuthorsSantambrogio A., Lövestam S., Metrick 2nd M.A, Löhr T., Xu P., Gallagher N.C.T., Ghetti B., Caughey B., Scheres S.H.W, Vendruscolo M. Journal FEBS Letters 599(19):2768-2778 (2025)
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  DOI10.1002/1873-3468.70141 PMID41026859 PMCID  DivisionStructural Studies
• Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments AuthorsLövestam S, Wagstaff JL, Katsinelos T, Shi J, Freund SM, Goedert M, Scheres SH Journal eLife (2025)
  Details

  DOI10.7554/eLife.104778 PMID  PMCID  DivisionStructural Studies, Neurobiology
• Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps AuthorsLövestam S., Scheres S.H.W. Journal Structure :S0969-2126(25)00262-X (2025)
  Details

  DOI10.1016/j.str.2025.07.014 PMID40803316 PMCID  DivisionStructural Studies
• GSK3β phosphorylated tau filaments are probably not like those from AD brains AuthorsScheres S.H.W. Journal Proceedings of the National Academy of Sciences of the United States of America 122(28):e2503730122 (2025)
  Details

  DOI10.1073/pnas.2503730122 PMID40623187 PMCIDPMC12280889 DivisionStructural Studies
• Distinct tau filament folds in human MAPT mutants P301L and P301T AuthorsSchweighauser M., Shi Y., Murzin A.G., Garringer H.J., Vidal R., Murrell J.R., Elena Erro M., Seelaar H., Ferrer I., van Swieten J.C., Ghetti B., Scheres S.H.W., Goedert M. Journal Nature Structural & Molecular Biology 32(8):1470-1478 (2025)
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  DOI10.1038/s41594-025-01575-9 PMID40442318 PMCIDPMC12350173 DivisionStructural Studies, Neurobiology
• Identical seeding characteristics and cryo-EM filament structures in FTLD-Synuclein and typical multiple system atrophy AuthorsCullinane P.W., Yang Y., Chelban V., Yen Goh Y., Ebanks K., Curless T., Wrigley S., de Pablo-Fernández E., Holton J., Peak-Chew S., Franco C., Woerman A.L., Houlden H., Warner T.T., Scheres S.H.W., Goedert M., Jaunmuktane Z. Journal Neuropathology and Applied Neurobiology 51(2):e70013 (2025)
  Details

  DOI10.1111/nan.70013 PMID40135351 PMCIDPMC11937994 DivisionStructural Studies, Neurobiology
• Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W AuthorsQi C., Lövestam S., Murzin A.G., Peak-Chew S., Franco C., Bogdani M., Latimer C., Murrell J.R., Cullinane P.W., Jaunmuktane Z., Bird T.D., Ghetti B., Scheres S.H.W., Goedert M. Journal Nature Structural & Molecular Biology 32(7):1297-1304 (2025)
  Details

  DOI10.1038/s41594-025-01498-5 PMID40044789 PMCIDPMC12263442 DivisionStructural Studies, Neurobiology
• Driving tau pathogenicity seeding - How fibril structure and post-translational modifications alter seeding capacity AuthorsKasen A. , Breton L. , Meyerdirk L. , Lövestam S. , McPhail J. , Louwrier A. , Scheres S. , Henderson M. Journal Alzheimer’s and Dementia 20 Suppl 8:e094584. (2025)
  Details

  DOI10.1002/alz.094584 PMID  PMCID  DivisionStructural Studies
• TMEM106B amyloid filaments in the Biondi bodies of ependymal cells AuthorsGhetti B., Schweighauser M., Jacobsen M. H., Gray D., Bacioglu M., Murzin A. G., Glazier B. S., Katsinelos T., Vidal R., Newell K. L., Gao S., Garringer H. J., Spillantini M. G., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 148(1):60 (2024)
  Details

  DOI10.1007/s00401-024-02807-w PMID39503754 PMCIDPMC11541264 DivisionNeurobiology
• An image processing pipeline for electron cryo-tomography in RELION-5 AuthorsBurt A, Toader B, Warshamanage R, von Kügelgen A, Pyle E, Zivanov J, Kimanius D, Bharat TAM, Scheres SHW. Journal FEBS Open bio 14(11):1788-1804 (2024)
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  DOIdoi.org/10.1002/2211-5463.13873 PMID39147729 PMCIDPMC11532982 DivisionStructural Studies
• DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images AuthorsSchwab J, Kimanius D, Burt A, Dendooven T, Scheres SHW. Journal Nature Methods 21(10):1855-1862 (2024)
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  DOI10.1038/s41592-024-02377-5 PMID39123079 PMCIDPMC11466895 DivisionStructural Studies
• Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems AuthorsBacioglu M, Schweighauser M, Gray D, Lövestam S, Katsinelos T, Quaegebeur A, van Swieten J, Jaunmuktane Z, Davies SW, Scheres SHW, Goedert M, Ghetti B, Spillantini MG. Journal Acta Neuropathologica Communications Jun 17;12(1):99 (2024)
  Details

  DOI10.1186/s40478-024-01813‑z PMID38886865 PMCIDPMC11181561 DivisionStructural Studies , Neurobiology
• Data-driven regularization lowers the size barrier of cryo-EM structure determination AuthorsKimanius D, Jamali K, Wilkinson ME, Lövestam S, Velazhahan V, Nakane T, Scheres SHW. Journal Nature Methods 10.1038/s41592-024-02304-8 (2024)
  Details

  DOI10.1038/s41592-024-02304‑8 PMID38862790 PMCIDPMC11239489 DivisionStructural Studies
• Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G AuthorsQi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M. Journal Acta Neuropathologica 147(1):86 (2024)
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  DOI0.1007/s00401-024-02741‑x PMID38758288 PMCIDPMC7616110 DivisionStructural Studies, Neurobiology
• Community recommendations on cryoEM data archiving and validation AuthorsKleywegt GJ, Adams PD, Butcher SJ, Lawson CL, Rohou A, Rosenthal PB, Subramaniam S, Topf M, Abbott S, Baldwin PR, Berrisford JM, Bricogne G, Choudhary P, Croll TI, Danev R, Ganesan SJ, Grant T, Gutmanas A, Henderson R, Heymann JB, Huiskonen JT, Istrate A, Kato T, Lander GC, Lok SM, Ludtke SJ, Murshudov GN, Pye R, Pintilie GD, Richardson JS, Sachse C, Salih O, Scheres SHW, Schroeder GF, Sorzano COS, Stagg SM, Wang Z, Warshamanage R, Westbrook JD, Winn MD, Young JY, Burley SK, Hoch JC, Kurisu G, Morris K, Patwardhan A, Velankar S. Journal Iucrj 11(Pt 2):140-151 (2024)
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  DOI10.1107/s2052252524001246 PMID38358351 PMCIDPMC10916293 DivisionStructural Studies
• Automated model building and protein identification in cryo-EM maps AuthorsJamali K., Käll L., Zhang R., Brown A., Kimanius D., Scheres S. H. W. Journal Nature 628(8007):450-457 (2024)
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  DOI10.1038/s41586-024-07215‑4 PMID38408488 PMCIDPMC11006616 DivisionStructural Studies
• Disease-specific tau filaments assemble via polymorphic intermediates AuthorsLövestam S, Li D., Wagstaff J. L., Kotecha A., Kimanius D., McLaughlin S. H., Murzin A. G., Freund S. M. V, Goedert M., Scheres S. H. W. Journal Nature 625(7993):119-125 (2024)
  Details

  DOI10.1038/s41586-023-06788‑w PMID38030728 PMCIDPMC10764278 DivisionStructural Studies
• Tau and neurodegeneration AuthorsGoedert M., Crowther R. A., Scheres S. H. W., Spillantini M. G. Journal Cytoskeleton 81(1):95-102 (2024)
  Details

  DOI10.1002/cm.21812 PMID38073060 PMCIDPMC7615684 DivisionNeurobiology
• Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau AuthorsSchweighauser M., Murzin A. G., Macdonald J., Lavenir I., Crowther R. A., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica Communications 11(1):160 (2023)
  Details

  DOI10.1186/s40478-023-01658‑y PMID37798679 PMCIDPMC10552433 DivisionStructural Studies
• Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids AuthorsScheres S. H. W., Ryskeldi-Falcon B., Goedert M. Journal Nature 621(7980):701-710 (2023)
  Details

  DOI10.1038/s41586-023-06437‑2 PMID37758888 PMCID  DivisionNeurobiology
• Structures, distributions, and conformations of SARS-CoV-2 spike proteins on intact virions by Cryo-EM and Cryo‑ET AuthorsKe Z., Oton J., Qu K., Scheres S. H. W., Briggs J. A. G. Journal Microscopy and Microanalysis 29 (Supplement_1) 902–903 (2023)
  Details

  DOI10.1093/micmic/ozad067.448 PMID  PMCID  DivisionStructural Studies
• Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere AuthorsDendooven T., Zhang Z., Yang J., McLaughlin S. H., Schwab J., Scheres S. H. W., Yatskevich S., Barford D. Journal Science Advances 9(30):eadg7480 (2023)
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  DOIdoi.org/10.1126/sciadv. Adg7480 PMID37506202 PMCIDPMC10381965 DivisionStructural Studies
• Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration AuthorsTarutani A., Lövestam S., Zhang X., Kotecha A., Robinson A. C., Mann D. M. A., Saito Y., Murayama S., Tomita T., Goedert M., Scheres S. H. W., Hasegawa M. Journal FEBS Open bio 13(8):1394-1404 (2023)
  Details

  DOI10.1002/2211-5463.13657 PMID37337995 PMCIDPMC10392052 DivisionStructural Studies
• Mutation ∆K281 in MAPT causes Pick's disease AuthorsSchweighauser M., Garringer H. J., Klingstedt T., Nilsson K. P. R., Masuda-Suzukake M., Murrell J. R., Risacher S L., Vidal R., Scheres S. H. W., Goedert M., Ghetti B., Newell K. L. Journal Acta Neuropathologica 146(2):211-226 (2023)
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  DOIdoi.org/10.1007/s00401-023-02598‑6 PMID37351604 PMCIDPMC10329087 DivisionStructural Studies
• Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains AuthorsStern A. M., Yang Y., Jin S., Yamashita K., Meunier A. L., Liu W., Cai Y., Ericsson M., Liu L., Goedert M., Scheres S. H. W., Selkoe D. J. Journal Neuron 111(13):2012-2020.e4 (2023)
  Details

  DOI10.1016/j.neuron.2023.04.007 PMID37167969 PMCIDPMC10330525 DivisionStructural Studies
• Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy AuthorsQi C., Hasegawa M., Takao M., Sakai M., Sasaki M., Mizutani M., Akagi A., Iwasaki Y., Miyahara H., Yoshida M., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica Communications 11(1):74 (2023)
  Details

  DOI10.1186/s40478-023-01565‑2 PMID37143123 PMCIDPMC10161654 DivisionStructural Studies
• New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy AuthorsYang Y., Garringer H. J., Shi Y., Lövestam S., Peak-Chew S., Zhang X., Kotecha A., Bacioglu M., Koto A., Takao M., Spillantini M. G., Ghetti B., Vidal R., Murzin A. G., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 145(5):561-572 (2023)
  Details

  DOI0.1007/s00401-023-02550‑8 PMID36847833 PMCIDPMC10119069 DivisionStructural Studies
• Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains AuthorsYang Y., Zhang W., Murzin A. G., Schweighauser M., Huang M., Lövestam S., Peak-Chew S. Y., Saito T., Saido T. C., Macdonald J., Lavenir I., Ghetti B., Graff C., Kumar A., Nordberg A., Goedert M., Scheres S. H. W. Journal Acta Neuropathologica 145(3):325-333 (2023)
  Details

  DOI10.1007/s00401-022-02533-1 PMID36611124 PMCIDPMC9925504 DivisionStructural Studies
• A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0 AuthorsZivanov J, Otón J, Ke Z, von Kügelgen A, Pyle E, Qu K, Morado D, Castaño-Díez D, Zanetti G, Bharat TAM, Briggs JAG, Scheres SHW. Journal Elife Dec 5;11:e83724 (2022)
  Details

  DOI10.7554/eLife.83724 PMID36468689 PMCIDPMC9815803 DivisionStructural Studies
• Pushing the limits in single particle cryo-EM: general discussion AuthorsBakker SE, Bhella D, Brescia R, Bullough P, Clare DK, Daum B, Frank RAW, Gold VAM, Jackson Hirst I, Kühlbrandt W, Lu P, McLaren M, Menday R, Muench SP, Rauschenbach S, Russo CJ, Saibil H, Scheres SHW, Shah AR, Smith C, Torpey J, Zanetti G. Journal Faraday Discussions 10.1039/d2fd90063g (2022)
  Details

  DOI10.1039/d2fd90063g PMID36285779 PMCID  DivisionStructural Studies
• Sample preparation in single particle cryo-EM: general discussion AuthorsAl-Otaibi N, Aminian J A, Anane RF, Baatsen P, Bakker SE, Bergeron J, Bharadwaj A, Bhella D, Braun T, Brescia R, Bullough P, Clare DK, Daum B, Esser TK, Farinas Lucas IDM, Frank RAW, Gold VAM, Harrison PJ, Hirst IJ, Klebl DP, Kühlbrandt W, Morton C, Muench SP, Nakasone M, Russo CJ, Saibil HR, Scheres SHW, Sehrawat V, Shah AR, Smith C, Thompson RF, Thorn A, Zanetti G. Journal Daraday Discussions 10.1039/d2fd90059a (2022)
  Details

  DOI10.1039/d2fd90059a PMID36278863 PMCID  DivisionStructural Studies
• Structures of α-synuclein filaments from human brains with Lewy pathology AuthorsYang Y., Shi Y., Schweighauser M., Zhang X., Kotecha A., Murzin A.G., Garringer H.J., Cullinane P.W., Saito Y., Foroud T., Warner T.T., Hasegawa K., Vidal R., Murayama S., Revesz T., Ghetti B., Hasegawa M., Lashley T., Scheres S.H.W., Goedert M. Journal Nature 610(7933):791-795 (2022)
  Details

  DOI10.1038/s41586-022-05319‑3 PMID36108674 PMCIDPMC7613749 DivisionStructural Studies, Neurobiology
• Age-dependent formation of TMEM106B amyloid filaments in human brains AuthorsSchweighauser M., Arseni D., Bacioglu M., Huang M., Lövestam S., Shi Y., Yang Y., Zhang W., Kotecha A., Garringer H. J., Vidal R., Hallinan G. I., Newell K. L., Tarutani A., Murayama S., Miyazaki M., Saito Y., Yoshida M., Hasegawa K., Lashley T., Revesz T., Kovacs G. G., van Swieten J., Takao M., Hasegawa M., Ghetti B., Spillantini M. G., Ryskeldi-Falcon B., Murzin A. G., Goedert M., Scheres S. H. W. Journal Nature 605(7909):310-314 (2022)
  Details

  DOI10.1038/s41586-022-04650-z PMID35344985 PMCIDPMC9095482 DivisionNeurobiology, Structural Studies
• High-throughput cryo-EM structure determination of amyloids AuthorsLövestam S, Scheres SHW. Journal Faraday Discussions Nov 8;240(0):243-260 (2022)
  Details

  DOI10.1039/d2fd00034b PMID35913272 PMCIDPMC9642048 DivisionStructural Studies
• Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy AuthorsLövestam S., Koh F. A., van Knippenberg B., Kotecha A., Murzin A. G., Goedert M., Scheres S. H. W. Journal Elife 11:e76494 (2022)
  Details

  DOI10.7554/elife.76494 PMID35244536 PMCIDPMC8983045 DivisionNeurobiology, Structural Studies
• Cryo-EM structures of amyloid-β 42 filaments from human brains AuthorsYang Y., Arseni D., Zhang W., Huang M., Lövestam S., Schweighauser M., Kotecha A., Murzin A. G., Peak-Chew S. Y., Macdonald J., Lavenir I., Garringer H. J., Gelpi E., Newell K. L., Kovacs G. G., Vidal R., Ghetti B., Ryskeldi-Falcon B., Scheres S. H. W., Goedert M. Journal Science 375(6577):167-172 (2022)
  Details

  DOI10.1126/science. Abm7285 PMID35025654 PMCIDPMC7612234 DivisionStructural Studies, Neurobiology
• New tools for automated cryo-EM single-particle analysis in RELION-4.0 AuthorsKimanius D., Dong L., Sharov G., Nakane T., Scheres S. H. W. Journal Biochemical Journal 478(24):4169-4185 (2021)
  Details

  DOI10.1042/bcj20210708 PMID34783343 PMCIDPMC8786306 DivisionStructural Studies
• Structure-based classification of tauopathies AuthorsShi Y., Zhang W., Yang Y., Murzin A. G., Falcon B., Kotecha A., van Beers M., Tarutani A., Kametani F., Garringer H. J., Vidal R., Hallinan G. I., Lashley T., Saito Y., Murayama S., Yoshida M., Tanaka H., Kakita A., Ikeuchi T., Robinson A. C., Mann D. M. A., Kovacs G. G., Revesz T., Ghetti B., Hasegawa M., Goedert M., Scheres S. H. W. Journal Nature 598(7880):359-363 (2021)
  Details

  DOI10.1038/s41586-021-03911-7 PMID34588692 PMCIDPMC7611841 DivisionNeurobiology, Structural Studies
• Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN‑1607 AuthorsShi Y., Murzin A. G., Falcon B., Epstein A., Machin J., Tempest P., Newell K. L., Vidal R., Garringer H. J., Sahara N., Higuchi M., Ghetti B., Jang M. K., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 141(6):983. June 2021 (2021)
  Details

  DOI10.1007/s00401-021-02303-5 PMID33830331 PMCIDPMC8496564 DivisionStructural Studies, Neurobiology
• Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy AuthorsLövestam S., Schweighauser M., Matsubara T., Murayama S., Tomita T., Ando T., Hasegawa K., Yoshida M., Tarutani A., Hasegawa M., Goedert M., Scheres S. H. W. Journal FEBS Open bio 11(4):999-1013. April 2021 (2021)
  Details

  DOI10.1002/2211-5463.13110 PMID33548114 PMCIDPMC8016116 DivisionNeurobiology, Structural Studies
• Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN‑1607 AuthorsShi Y., Murzin A. G., Falcon B., Epstein A., Machin J., Tempest P., Newell K. L., Vidal R., Garringer H. J., Sahara N., Higuchi M., Ghetti B., Jang M. K., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 141(5):697-708. 16 March 2021 (2021)
  Details

  DOI10.1007/s00401-021-02294-3 PMID33723967 PMCIDPMC8043864 DivisionStructural Studies, Neurobiology
• Multi-body Refinement of Cryo-EM Images in RELION AuthorsNakane T., Scheres S. H. W. Journal Methods in Molecular Biology 2215:145-160. January 2021 (2021)
  Details

  DOI10.1007/978-1-0716-0966-8_7 PMID33368003 PMCID  DivisionStructural Studies
• Tau Protein and Frontotemporal Dementias AuthorsGoedert M., Spillantini M. G., Falcon B., Zhang W., Newell K. L., Hasegawa M., Scheres S. H. W., Ghetti B. Journal Advances in Experimental Medicine and Biology 1281:177-199. January 2021 (2021)
  Details

  DOI10.1007/978-3-030-51140-1_12 PMID33433876 PMCID  DivisionNeurobiology, Structural Studies
• Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination AuthorsKimanius D., Zickert G., Nakane T., Adler J., Lunz S., Schönlieb C. B., Öktem O., Scheres S. H. W. Journal Iucrj 8(Pt 1):60-75. January 2021 (2021)
  Details

  DOI10.1107/s2052252520014384 PMID33520243 PMCIDPMC7793004 DivisionStructural Studies
• Structures and distributions of SARS-CoV-2 spike proteins on intact virions AuthorsKe Z., Oton J., Qu K., Cortese M., Zila V., McKeane L., Nakane T., Zivanov J., Neufeldt C. J., Cerikan B., Lu J. M., Peukes J., Xiong X., Kräusslich H. G., Scheres S. H. W., Bartenschlager R., Briggs J. A. G. Journal Nature 588(7838):498-502. 17 December 2020 (2020)
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  DOI10.1038/s41586-020-2665‑2 PMID32805734 PMCIDPMC7116492 DivisionStructural Studies
• Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution AuthorsKube M., Kohler F., Feigl E., Nagel-Yüksel B., Willner E. M., Funke J. J., Gerling T., Stömmer P., Honemann M. N., Martin T. G., Scheres S. H. W., Dietz H. Journal Nature Communications 11(1):6229. December 2020 (2020)
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  DOI10.1038/s41467-020-20020-7 PMID33277481 PMCIDPMC7718922 DivisionStructural Studies
• Single-particle cryo-EM at atomic resolution AuthorsNakane T., Kotecha A., Sente A., McMullan G., Masiulis S., Brown P. M. G. E., Grigoras I. T., Malinauskaite L., Malinauskas T., Miehling J., Uchański T., Yu L., Karia D., Pechnikova E. V., de Jong E., Keizer J., Bischoff M., McCormack J., Tiemeijer P., Hardwick S. W., Chirgadze D. Y., Murshudov G., Aricescu A. R., Scheres S. H. W. Journal Nature 587(7832):152-156. 5 November 2020 (2020)
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  DOI10.1038/s41586-020-2829‑0 PMID33087931 PMCIDPMC7611073 DivisionNeurobiology, Structural Studies
• Cryo-EM structures of tau filaments AuthorsScheres S. H., Zhang W., Falcon B., Goedert M. Journal Current Opinion in Structural Biology 64:17-25. October 2020 (2020)
  Details

  DOI10.1016/j.sbi.2020.05.011 PMID32603876 PMCID  DivisionStructural Studies, Neurobiology
• A thermostable, closed SARS-CoV-2 spike protein trimer AuthorsXiong X., Qu K., Ciazynska K. A., Hosmillo M., Carter A. P., Ebrahimi S., Ke Z., Scheres S. H. W., Bergamaschi L., Grice G. L., Zhang Y.; CITIID-NIHR COVID-19 BioResource Collaboration, Nathan J. A., Baker S., James L. C., Baxendale H. E., Goodfellow I., Doffinger R., Briggs J. A. G. Journal Nature Structural & Molecular Biology 27(10):934-941. October 2020 (2020)
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  DOI10.1038/s41594-020-0478‑5 PMID32737467 PMCIDPMC7116388 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Structures of α-synuclein filaments from multiple system atrophy AuthorsSchweighauser M., Shi Y., Tarutani A., Kametani F., Murzin A. G., Ghetti B., Matsubara T., Tomita T., Ando T., Hasegawa K., Murayama S., Yoshida M., Hasegawa M., Scheres S. H. W., Goedert M. Journal Nature 585(7825):464-469. 17 September 2020 (2020)
  Details

  DOI10.1038/s41586-020-2317-6 PMID32461689 PMCIDPMC7116528 DivisionStructural Studies, Neurobiology
• Novel tau filament fold in corticobasal degeneration AuthorsZhang W., Tarutani A., Newell K. L., Murzin A. G., Matsubara T., Falcon B., Vidal R., Garringer H. J., Shi Y., Ikeuchi T., Murayama S., Ghetti B., Hasegawa M., Goedert M., Scheres S. H. W. Journal Nature 580(7802):283-287. 9 April 2020 (2020)
  Details

  DOI10.1038/s41586-020-2043‑0 PMID32050258 PMCIDPMC7148158 DivisionNeurobiology, Structural Studies
• Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila AuthorsHervas R., Rau M. J., Park Y., Zhang W., Murzin A. G., Fitzpatrick J. A. J., Scheres S. H. W., Si K. Journal Science 367(6483):1230-1234. 13 March 2020 (2020)
  Details

  DOI10.1126/science. Aba3526 PMID32165583 PMCIDPMC7182444 DivisionStructural Studies
• Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1 AuthorsZivanov J., Nakane T., Scheres S. H. W. Journal Iucrj 7(Pt 2):253-267. March 2020 (2020)
  Details

  DOI10.1107/s2052252520000081 PMID32148853 PMCIDPMC7055373 DivisionStructural Studies
• Amyloid structure determination in RELION-3.1 AuthorsScheres S. H. W. Journal Acta crystallographica. Section D, Structural Biology 76(Pt 2):94-101. 1 February 2020 (2020)
  Details

  DOI10.1107/S2059798319016577 PMID32038040 PMCIDPMC7008511 DivisionStructural Studies
• Journal of Structural Biology – Paper of the Year 2019 AuthorsScheres S. H. W. Journal Journal of Structural Biology 209(1):107436. 1 January 2020 (2020)
  Details

  DOI10.1016/j.jsb.2019.107436 PMID  PMCID  DivisionStructural Studies
• Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule AuthorsLacey S. E., He S., Scheres S. H., Carter A. P. Journal ELife 8: e47145. 2 July 2019 (2019)
  Details

  DOI10.7554/eLife.47145 PMID31264960 PMCIDPMC6629372 DivisionStructural Studies
• Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules AuthorsFalcon B., Zivanov J., Zhang W., Murzin A. G., Garringer H. J., Vidal R., Crowther R. A., Newell K. L., Ghetti B., Goedert M., Scheres S. H. W. Journal Nature 568(7752):420-423. April 2019 (2019)
  Details

  DOI10.1038/s41586-019-1026-5 PMID30894745 PMCIDPMC6472968 DivisionNeurobiology, Structural Studies
• Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases AuthorsZhang W., Falcon B., Murzin A. G., Fan J., Crowther R. A., Goedert M., Scheres S. H. Journal ELife 8: e43584. 5 February 2019 (2019)
  Details

  DOI10.7554/eLife.43584 PMID30720432 PMCIDPMC6375701 DivisionNeurobiology, Structural Studies
• A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis AuthorsZivanov J., Nakane T., Scheres S. H. W. Journal Iucrj 6(Pt 1):5-17. January 2019 (2019)
  Details

  DOI10.1107/s205225251801463x PMID30713699 PMCIDPMC6327179 DivisionStructural Studies
• New tools for automated high-resolution cryo-EM structure determination in RELION-3 AuthorsZivanov J., Nakane T., Forsberg B. O., Kimanius D., Hagen W. J., Lindahl E., Scheres S. H. Journal ELife 7: e42166. 9 November 2018 (2018)
  Details

  DOI10.7554/eLife.42166 PMID30412051 PMCIDPMC6250425 DivisionStructural Studies
• Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold AuthorsFalcon B., Zhang W., Schweighauser M., Murzin A. G., Vidal R., Garringer H. J., Ghetti B., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 136(5):699-708. November 2018 (2018)
  Details

  DOI10.1007/s00401-018-1914-z PMID30276465 PMCIDPMC6208733 DivisionStructural Studies, Neurobiology
• Structures of filaments from Pick's disease reveal a novel tau protein fold AuthorsFalcon B., Zhang W., Murzin A. G., Murshudov G., Garringer H. J., Vidal R., Crowther R. A., Ghetti B., Scheres S. H. W., Goedert M. Journal Nature 561(7721):137-140. 6 September 2018 (2018)
  Details

  DOI10.1038/s41586-018-0454-y PMID30158706 PMCIDPMC6204212 DivisionStructural Studies, Neurobiology
• Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION AuthorsNakane T., Kimanius D., Lindahl E., Scheres S. H. Journal ELife 7: e36861. 1 June 2018 (2018)
  Details

  DOI10.7554/eLife.36861 PMID29856314 PMCIDPMC6005684 DivisionStructural Studies
• Atomic structure of type VI contractile sheath from Pseudomonas aeruginosa AuthorsSalih O., He S., Planamente S., Stach L., MacDonald J. T., Manoli E., Scheres S. H. W., Filloux A., Freemont P. S. Journal Structure 26(2):329-336.e3. 6 February 2018 (2018)
  Details

  DOI10.1016/j.str.2017.12.005 PMID29307484 PMCIDPMC5807055 DivisionStructural Studies
• Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases AuthorsGoedert M., Falcon B., Zhang W., Ghetti B., Scheres S. H. W. Journal Cold Spring Harbor Symposia on Quantitative Biology 83:163-171. January 2018 (2018)
  Details

  DOI10.1101/sqb.2018.83.037580 PMID30886056 PMCID  DivisionNeurobiology, Structural Studies
• The structural basis of proton driven zinc transport by ZntB AuthorsGati C., Stetsenko A., Slotboom D. J., Scheres S. H. W., Guskov A. Journal Nature Communications 8(1):1313. 3 November 2017 (2017)
  Details

  DOI10.1038/s41467-017-01483‑7 PMID29101379 PMCIDPMC5670123 DivisionStructural Studies
• CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing AuthorsScheres S. H., Nagai K. Journal Current Opinion in Structural Biology 46:130-139. October 2017 (2017)
  Details

  DOI10.1016/j.sbi.2017.08.001 PMID28888105 PMCID  DivisionStructural Studies
• CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction AuthorsAlvarez F. J. D., He S., Perilla J. R., Jang S., Schulten K., Engelman A. N., Scheres S. H. W., Zhang P. Journal Science Advances 3(9):e1701264. 15 September 2017 (2017)
  Details

  DOI10.1126/sciadv.1701264 PMID28929138 PMCIDPMC5600524 DivisionStructural Studies
• Cryo-EM structures of tau filaments from Alzheimer's disease AuthorsFitzpatrick A. W. P., Falcon B., He S., Murzin A. G., Murshudov G., Garringer H. J., Crowther R. A., Ghetti B., Goedert M., Scheres S. H. W. Journal Nature 547(7662):185-190 (2017)
  Details

  DOI10.1038/nature23002 PMID28678775 PMCIDPMC5552202 DivisionNeurobiology, Structural Studies
• Helical reconstruction in RELION AuthorsHe S., Scheres S. H. Journal Journal of Structural Biology 198(3):163-176. June 2017 (2017)
  Details

  DOI10.1016/j.jsb.2017.02.003 PMID28193500 PMCIDPMC5479445 DivisionStructural Studies
• A pipeline approach to single-particle processing in RELION AuthorsFernandez-Leiro R., Scheres S. H. W. Journal Acta Crystallographica. Section D, Structural Biology 73(Pt 6):496-502. 1 June 2017 (2017)
  Details

  DOI10.1107/S2059798316019276 PMID28580911 PMCIDPMC5458491 DivisionStructural Studies
• Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump AuthorsFitzpatrick A. W. P., Llabrés S., Neuberger A., Blaza J. N., Bai X. C., Okada U., Murakami S., van Veen H. W., Zachariae U., Scheres S. H. W., Luisi B. F., Du D. Journal Nature Microbiology 2:17070. 15 May 2017 (2017)
  Details

  DOI10.1038/nmicrobiol.2017.70 PMID28504659 PMCIDPMC5447821 DivisionStructural Studies
• Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution AuthorsBoland A., Martin T. G., Zhang Z., Yang J., Bai X. C., Chang L., Scheres S. H., Barford D. Journal Nature Structural & Molecular Biology 24(4):414-418. April 2017 (2017)
  Details

  DOI10.1038/nsmb.3386 PMID28263324 PMCIDPMC5385133 DivisionStructural Studies
• Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis AuthorsWong W., Bai X. C., Sleebs B. E., Triglia T., Brown A., Thompson J. K., Jackson K. E., Hanssen E., Marapana D. S., Fernandez I. S., Ralph S. A., Cowman A. F., Scheres S. H., Baum J. Journal Nature Microbiology 2:17031. 13 March 2017 (2017)
  Details

  DOI10.1038/nmicrobiol.2017.31 PMID28288098 PMCIDPMC5439513 DivisionStructural Studies
• Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme AuthorsLi Y., Zhou M., Hu Q., Bai X. C., Huang W., Scheres S. H., Shi Y. Journal Proceedings of the National Academy of Sciences of the United States of America 114(7):1542-1547.14 February 2017 (2017)
  Details

  DOI10.1073/pnas.1620626114 PMID28143931 PMCIDPMC5320974 DivisionStructural Studies
• Self-correcting mismatches during high-fidelity DNA replication AuthorsFernandez-Leiro R. , Conrad J., Yang J. C., Freund S. M., Scheres S. H., Lamers M. H1. Journal Nature Structural & Molecular Biology 24(2):140-143. February 2017 (2017)
  Details

  DOI10.1038/nsmb.3348 PMID28067916 PMCIDPMC5300136 DivisionStructural Studies
• X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization AuthorsLöwe J., He S., Scheres S. H. Savva C. G. Journal Proceedings of the National Academy of Sciences of the United States of America 113(47):13396-13401. 22 November 2016 (2016)
  Details

  DOI10.1073/pnas.1612034113 PMID27821762 PMCIDPMC5127371 DivisionStructural Studies
• Design of a molecular support for cryo-EM structure determination AuthorsMartin T. G., Bharat T. A., Joerger A. C., Bai X. C., Praetorius F., Fersht A. R., Dietz H., Scheres S. H. Journal Proceedings of the National Academy of Sciences of the United States of America 113(47):E7456-E7463. 22 November 2016 (2016)
  Details

  DOI10.1073/pnas.1612720113 PMID27821763 PMCIDPMC5127339 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 AuthorsKimanius D., Forsberg B. O., Scheres S. H., Lindahl E. Journal ELife 5:e18722. 15 November 2016 (2016)
  Details

  DOI10.7554/eLife.18722 PMID27845625 PMCIDPMC5310839 DivisionStructural Studies
• Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION AuthorsBharat T. A., Scheres S. H. Journal Nature Protocols 11(11):2054-2065. November 2016 (2016)
  Details

  DOI10.1038/nprot.2016.124 PMID27685097 PMCIDPMC5215819 DivisionStructural Studies
• Unravelling biological macromolecules with cryo-electron microscopy AuthorsFernandez-Leiro R., Scheres S. H. Journal Nature 537(7620):339-346. 15 September 2016 (2016)
  Details

  DOI10.1038/nature19948 PMID27629640 PMCIDPMC5074357 DivisionStructural Studies
• Processing of Structurally Heterogeneous Cryo-EM Data in RELION AuthorsScheres S. H. Journal Methods in Enzymology 579:125-157. 31 May 2016 (2016)
  Details

  DOI10.1016/bs.mie.2016.04.012 PMID27572726 PMCID  DivisionStructural Studies
• Cryo-EM structure of the yeast U4/U6. U5 tri-snRNP at 3.7 A resolution AuthorsNguyen T. H., Galej W. P., Bai X. C., Oubridge C., Newman A. J., Scheres S. H., Nagai K. Journal Nature 530(7590):298-302. 18 February 2016 (2016)
  Details

  DOI10.1038/nature16940 PMID26829225 PMCIDPMC4762201 DivisionStructural Studies
• Sampling the conformational space of the catalytic subunit of human γ-secretase AuthorsBai X. C., Rajendra E., Yang G., Shi Y., Scheres S. H. Journal ELife 4: e11182. 1 December 2015 (2015)
  Details

  DOI10.7554/eLife.11182 PMID26623517 PMCIDPMC4718806 DivisionStructural Studies
• Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1 AuthorsZhou M., Li Y., Hu Q., Bai X. C., Huang W., Yan C., Scheres S. H., Shi Y. Journal Genes & Development 29(22):2349-2361. 15 November 2015 (2015)
  Details

  DOI10.1101/gad.272278.115 PMID26543158 PMCIDPMC4691890 DivisionStructural Studies
• cryo-EM structures of the E. coli replicative DNA polymerase reveal dynamic interactions with clamp, exonuclease and τ AuthorsFernández-Leiro R., Conrad J., Scheres S. H., Lamers M. H. Journal ELife 4:e11134. 24 October 2015 (2015)
  Details

  DOI10.7554/eLife.11134 PMID26499492 PMCIDPMC4703070 DivisionStructural Studies
• An atomic structure of human γ-secretase AuthorsBai X. C., Yan C., Yang G., Lu P., Ma D., Sun L., Zhou R., Scheres S. H., Shi Y. Journal Nature 525(7568):212-217. 10 September 2015 (2015)
  Details

  DOI10.1038/nature14892 PMID26280335 PMCIDPMC4568306 DivisionStructural Studies
• Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging AuthorsBharat T. A., Russo C. J., Löwe J., Passmore L. A., Scheres S. H. Journal Structure 23(9):1743-1753. 1 September 2015 (2015)
  Details

  DOI10.1016/j.str.2015.06.026 PMID26256537 PMCIDPMC4559595 DivisionStructural Studies
• The architecture of the spliceosomal U4/U6. U5 tri‑snRNP AuthorsNguyen T. H., Galej W. P., Bai X. C., Savva C. G., Newman A. J., Scheres S. H., Nagai K. Journal Nature 523(7558):47-52. 2 July 2015 (2015)
  Details

  DOI10.1038/nature14548 PMID26106855 PMCIDPMC4536768 DivisionStructural Studies
• Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity AuthorsNogales E., Scheres S. H. Journal Molecular Cell 58(4):677-689. 21 May 2015 (2015)
  Details

  DOI10.1016/j.molcel.2015.02.019 PMID26000851 PMCIDPMC4441764 DivisionStructural Studies
• Ribosome. The structure of the human mitochondrial ribosome AuthorsAmunts A., Brown A., Toots J., Scheres S. H., Ramakrishnan V. Journal Science 348(6230):95-98. 3 April 2015 (2015)
  Details

  DOI10.1126/science. Aaa1193 PMID25838379 PMCIDPMC4501431 DivisionStructural Studies
• Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila AuthorsPang Y., Bai X. C., Yan C., Hao Q., Chen Z., Wang J. W., Scheres S. H., Shi Y. Journal Genes & Development 29(3):277-287. 1 February 2015 (2015)
  Details

  DOI10.1101/gad.255877.114 PMID25644603 PMCIDPMC4318144 DivisionStructural Studies
• Semi-automated selection of cryo-EM particles in RELION-1.3. AuthorsScheres S. H. Journal Journal of Structural Biology 189(2):114-122. 1 February 2015 (2015)
  Details

  DOI10.1016/j.jsb.2014.11.010 PMID25486611 PMCIDPMC4318617 DivisionStructural Studies
• Collaborative Computational Project for Electron cryo‑Microscopy. AuthorsWood C., Burnley T., Patwardhan A., Scheres S., Topf M., Roseman A., Winn M. Journal Acta Crystallographica. Section D, Biological Crystallography 71(Pt 1):123-126, 1 January 2015 (2015)
  Details

  DOI10.1107/S1399004714018070 PMID25615866 PMCIDPMC4304692 DivisionStructural Studies
• How cryo-EM is revolutionizing structural biology. AuthorsBai X. C., McMullan G., Scheres S. H. Journal Trends in Biochemical Sciences 40(1):49-57, 1 January 2015 (2015)
  Details

  DOI10.1016/j.tibs.2014.10.005 PMID25544475 PMCID  DivisionStructural Studies
• Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. AuthorsYan Z., Bai X. C., Yan C., Wu J., Li Z., Xie T., Peng W., Yin C. C., Li X., Scheres S. H., Shi Y., Yan N. Journal Nature 517(7532):50-55, 1 January 2015 (2015)
  Details

  DOI10.1038/nature14063 PMID25517095 PMCIDPMC4338550 DivisionStructural Studies
• Structure of the large ribosomal subunit from human mitochondria AuthorsBrown A., Amunts A., Bai X. C., Sugimoto Y., Edwards P. C., Murshudov G., Scheres S. H., Ramakrishnan V. Journal Science 346(6210):718-722. 7 November 2014 (2014)
  Details

  DOI10.1126/science.1258026 PMID25278503 PMCIDPMC4246062 DivisionStructural Studies
• Three-dimensional structure of human γ-secretase AuthorsLu P., Bai X. C., Ma D., Xie T., Yan C., Sun L., Yang G., Zhao Y., Zhou R., Scheres S. H., Shi Y. Journal Nature 512(7513):166-170. 14 August 2014 (2014)
  Details

  DOI10.1038/nature13567 PMID25043039 PMCIDPMC4134323 DivisionStructural Studies
• Beam-induced motion correction for sub-megadalton cryo-EM particles AuthorsScheres S. H. Journal ELife 3:e03665. 13 August 2014 (2014)
  Details

  DOI10.7554/eLife.03665 PMID25122622 PMCIDPMC4130160 DivisionStructural Studies
• Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution AuthorsVoorhees R. M., Fernández I. S., Scheres S. H., Hegde R. S. Journal Cell 157(7):1632-1643. 19 June 2014 (2014)
  Details

  DOI10.1016/j. Cell.2014.05.024 PMID24930395 PMCIDPMC4081569 DivisionCell Biology, Structural Studies
• Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine AuthorsWong W., Bai X. C., Brown A., Fernandez I. S., Hanssen E., Condron M., Tan Y. H., Baum J., Scheres S. H. Journal ELife 3:e03080. 9 June 2014 (2014)
  Details

  DOI10.7554/eLife.03080 PMID24913268 PMCIDPMC4086275 DivisionStructural Studies
• Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome AuthorsFernández I. S., Bai X. C., Murshudov G., Scheres S. H., Ramakrishnan V. Journal Cell 157(4):823-831. 8 May 2014 (2014)
  Details

  DOI10.1016/j. Cell.2014.04.015 PMID24792965 PMCIDPMC4017093 DivisionStructural Studies
• Structure of the yeast mitochondrial large ribosomal subunit AuthorsAmunts A., Brown A., Bai X. C., Llácer J. L., Hussain T., Emsley P., Long F., Murshudov G., Scheres S. H., Ramakrishnan V. Journal Science 343(6178):1485-1489. 28 March 2014 (2014)
  Details

  DOI10.1126/science.1249410 PMID24675956 PMCIDPMC4046073 DivisionStructural Studies
• Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V‑ATPase AuthorsMuench S. P., Scheres S. H., Huss M., Phillips C., Vitavska O., Wieczorek H., Trinick J., Harrison M. A. Journal Journal of Molecular Biology 426(2):286-300. 23 January 2014 (2014)
  Details

  DOI10.1016/j.jmb.2013.09.018 PMID24075871 PMCIDPMC3899036 DivisionStructural Studies
• High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy AuthorsChen S., McMullan G., Faruqi A. R., Murshudov G. N., Short J. M., Scheres S. H., Henderson R. Journal Ultramicroscopy 135C:24-35. December 2013 (2013)
  Details

  DOI10.1016/j.ultramic.2013.06.004 PMID23872039 PMCID  DivisionStructural Studies
• Molecular architecture of a eukaryotic translational initiation complex AuthorsFernández I. S., Bai X. C., Hussain T., Kelley A. C., Lorsch J. R., Ramakrishnan V., Scheres S. H. Journal Science 342(6160):1240585. 15 November 2013 (2013)
  Details

  DOI10.1126/science.1240585 PMID24200810 PMCIDPMC3836175 DivisionProtein & Nucleic Acid Chemistry
• Structure of active dimeric human telomerase AuthorsSauerwald A., Sandin S., Cristofari G., Scheres S. H., Lingner J., Rhodes D. Journal Nature Structural & Molecular Biology 20(4):454-460. April 2013 (2013)
  Details

  DOI10.1038/nsmb.2530 PMID23474713 PMCID  DivisionStructural Studies
• Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles AuthorsBai X. C., Fernandez I. S., McMullan G., Scheres S. H. Journal ELife 2:e00461. 19 February 2013 (2013)
  Details

  DOI10.7554/eLife.00461 PMID23427024 PMCIDPMC3576727 DivisionStructural Studies
• Cryo-EM structure of a 3D DNA-origami object AuthorsBai X. C., Martin T. G., Scheres S. H., Dietz H. Journal Proceedings of the National Academy of Sciences, USA 109(49):20012-20017. 4 December 2012 (2012)
  Details

  DOI10.1073/pnas.1215713109 PMID23169645 PMCIDPMC3523823 DivisionStructural Studies
• RELION: implementation of a Bayesian approach to cryo-EM structure determination AuthorsScheres S. H. Journal Journal of Structural Biology 180(3):519-530. December 2012 (2012)
  Details

  DOI10.1016/j.jsb.2012.09.006 PMID23000701 PMCIDPMC3690530 DivisionStructural Studies
• Data management challenges in three-dimensional EM AuthorsPatwardhan A., Carazo J. M., Carragher B., Henderson R., Heymann J. B., Hill E., Jensen G. J., Lagerstedt I., Lawson C. L., Ludtke S. J., Mastronarde D., Moore W. J., Roseman A., Rosenthal P., Sorzano C. O., Sanz-García E., Scheres S. H., Subramaniam S., Westbrook J., Winn M., Swedlow J. R., Kleywegt G. J. Journal Nature Structural & Molecular Biology 19(12):1203-1207. December 2012 (2012)
  Details

  DOI10.1038/nsmb.2426 PMID23211764 PMCID  DivisionStructural Studies
• Prevention of overfitting in cryo-EM structure determination AuthorsScheres S. H., Chen S. Journal Nature Methods 9(9):853-854. September 2012 (2012)
  Details

  DOI10.1038/nmeth.2115 PMID22842542 PMCIDPMC4912033 DivisionStructural Studies
• A Bayesian view on cryo-EM structure determination AuthorsScheres S. H. W. Journal Journal of Molecular Biology 415(2):406-418. 13 January 2012 (2012)
  Details

  DOI10.1016/j.jmb.2011.11.010 PMID22100448 PMCIDPMC3314964 DivisionStructural Studies
• Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA AuthorsMelero R., Rajagopalan S., Lázaro M., Joerger A. C., Brandt T., Veprintsev D. B., Lasso G., Gil D., Scheres S. H., Carazo J. M., Fersht A. R., Valle M. Journal Proceedings of the National Academy of Sciences, USA 108(2):557-562. 11 January 2011 (2011)
  Details

  DOI10.1073/pnas.1015520107 PMID21178074 PMCIDPMC3021029 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Classification of structural heterogeneity by maximum-likelihood methods AuthorsScheres S. H. W. Journal Methods in Enzymology 482:295-320. 29 November 2010 (2010)
  Details

  DOI10.1016/S0076-6879(10)82012-9 PMID20888966 PMCIDPMC3080752 DivisionStructural Studies
• Visualizing molecular machines in action: Single-particle analysis with structural variability AuthorsScheres S. H. Journal Advances in Protein Chemistry and Structural Biology 81:89-119. 27 November 2010 (published online) (2010)
  Details

  DOI10.1016/B978-0-12-381357-2.00004-9 PMID21115174 PMCID  DivisionStructural Studies