Published Research
Found 81 results for Schafer W.
- DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings AuthorsFerguson L., Ouellet S., Vandewyer E., Wang C., Wunna Z., Lim T. K. Y., Schafer W. R., Beets I. Journal Molecular Cell 86(15):3102-3117.e5 (2026)
- An entropic measure of diverse specialization highlights multifunctional neurons in annotated connectomes AuthorsMoon S. S., Ripoll-Sánchez L., Vértes P., Schafer W. R., Ahnert S. E. Journal Network Neuroscience 10(1):204-220 (2026)
- Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species AuthorsAntoine Toker I., Ripoll-Sánchez L., Geiger L.T., Sussfeld A., Saini K.S., Beets I., Vértes P.E., Schafer W.R., Ben-David E., Hobert O. Journal Current Biology : CB 35(12):2927-2945.e7 (2025)
- The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans AuthorsRossi L., Amoako K., Busack I., Golinelli L., Courtney A., Besseling J., Schafer W., Beets I., Bringmann H. Journal Current Biology : CB 35(9):2183-2194.e10 (2025)
- C. elegans wired and wireless connectome: insights into principles of nervous system structure and function AuthorsVenkatesh K., Ripoll-Sánchez L., Beets I., Schafer W. R. Journal Journal of Biosciences 50, 16 (2025)
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior AuthorsWatteyne J., Chudinova A., Ripoll-Sánchez L., Schafer W. R., Beets I. Journal Genetics 228(3):iyae141 (2024)
- Constitutive sodium permeability in a C. elegans two-pore domain potassium channel AuthorsAndrini O., Ben Soussia I., Tardy P., Walker D. S., Peña-Varas C., Ramírez D., Gendrel M., Mercier M., El Mouridi S., Leclercq-Blondel A., González W., Schafer W. R., Jospin M., Boulin T. Journal Proceedings of the National Academy of Sciences of the United States of America 121(43):e2400650121 (2024)
- Behavioral plasticity AuthorsZhang Y, Iino Y, Schafer WR. Journal Genetics Aug 19:iyae105. (2024)
- Dynamic temperature control in microfluidics for in vivo imaging of cold-sensing in C. elegans AuthorsLee SA, Cho Y, Schafer WR, Lu H. Journal Biophysical Journal 123(8):947-956 (2024)
- Comparing engineered nuclear-localized reporter cassettes AuthorsSun H, Beets I, Schafer W, Hobert O. Journal micropublication biology 10.17912/micropub. Biology.001014 (2023)
- System-wide mapping of peptide-GPCR interactions in C. elegans AuthorsBeets I., Zels S., Vandewyer E., Demeulemeester J., Caers J., Baytemur E., Courtney A., Golinelli L., Hasakioğulları İ., Schafer W. R., Vértes P. E., Mirabeau O., Schoofs L. Journal Cell Reports 31.08.2023 (2023)
- A proton-inhibited DEG/ENaC ion channel maintains neuronal ionstasis and promotes neuronal survival under stress AuthorsPetratou D., Gjikolaj M., Kaulich E., Schafer W., Tavernarakis N. I Journal Iscience 26(7):107117 (2023)
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans AuthorsGómez-Escribano A. P., Mora-Martínez C., Roca M., Walker D. S., Panadero J., Sequedo M. D., Saini R., Knölker H. J., Blanca J., Burguera J., Lahoz A., Cañizares J., Millán J. M., Burton N. O., Schafer W. R., Vázquez-Manrique R. P. Journal EMBO Reports 24(6):e55556 (2023)
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans AuthorsGómez-Escribano A. P, Mora-Martínez C., Roca M., Walker D. S., Panadero J., Sequedo M. D., Saini R., Knölker H. J., Blanca J., Burguera J, Lahoz A., Cañizares J., Millán J. M., Burton N. O., Schafer W. R., Vázquez-Manrique R. P. Journal EMBO Reports, 24(6):e55556 (2023)
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans AuthorsGómez-Escribano A. P., Mora-Martínez C., Roca M., Walker D. S., Panadero J., Sequedo M. D., Saini R., Knölker H. J, Blanca J., Burguera J., Lahoz A., Cañizares J., Millán J. M., Burton N. O., Schafer W. R., Vázquez-Manrique R. P. Journal EMBO Reports 24(6):e55556 (2023)
- A Novel and Functionally Diverse Class of Acetylcholine-gated Ion Channels AuthorsHardege I., Morud J., Courtney A., Schafer W. R Journal The Journal of Neuroscience 43(7):1111-1124 (2023)
- The diverse functions of the DEG/ENaC family: linking genetic and physiological insights AuthorsKaulich E., Grundy L. J., Schafer W. R., Walker D. S. Journal The Journal of Physiology 601(9):1521-1542 (2023)
- Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels AuthorsKaulich E., McCubbin P. T. N., Schafer W. R., Walker D. S. Journal The Journal of Physiology 601(9):1625-1653 (2023)
- Neuropeptide signalling shapes feeding and reproductive behaviours in male Caenorhabditis elegans AuthorsGadenne M.J., Hardege I., Yemini E., Suleski D., Jaggers P., Beets I., Schafer W.R., Chew Y.L. Journal Life Science Alliance 5(10):e202201420 (2022)
- Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock AuthorsKaulich E., Carroll T., Ackley B., Tang Y.Q., Hardege I., Nehrke K., Schafer W.R., Walker D.S. Journal Elife 11:e75837 (2022)
- Deorphanization of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning AuthorsMorud J., Hardege I., Liu H., Wu T., Choi M. K., Basu S., Zhang Y., Schafer W. R. Journal Current Biology 31(19):4282-4292.e6 (2021)
- The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch AuthorsKaulich E., Walker D. S., Tang Y. Q., Schafer W. R. Journal Micropublication Biology 2021 (2021)
- Sleep analysis in adult C. elegans reveals state-dependent alteration of neural and behavioral responses AuthorsLawler D. E., Chew Y. L., Hawk J. D. , Aljobeh A., Schafer W. R., Albrecht D. R. Journal Journal of Neuroscience 41(9):1892-1907. 3 March 2021 (2021)
- Chemosensory Neurons Modulate the Response to Oomycete Recognition in Caenorhabditis elegans AuthorsFasseas M. K., Grover M., Drury F., Essmann C. L., Kaulich E., Schafer W. R., Barkoulas M. Journal Cell Reports 34(2):108604. 12 January 2021 (2021)
- Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans AuthorsÖzbey N. P., Imanikia S., Krueger C., Hardege I., Morud J., Sheng M., Schafer W. R., Casanueva M. O., Taylor R. C. Journal Developmental Cell 55(6):754-770.e6. 21 December 2020 (2020)
- Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels AuthorsTang Y. Q., Lee S. A., Rahman M., Vanapalli S. A., Lu H., Schafer W. R. Journal Neuron 107(1):112-125.e10. 8 July 2020 (2020)
- Invertebrate Models of Nociception: Learning From Flies and Worms AuthorsHesselson D., Walker D. S., Massingham J. N., Schafer W. R., Neely G. G., Chew Y. L. Journal The Oxford Handbook of the Neurobiology of Pain (2020)
- Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans AuthorsCho Y., Lee S. A., Chew Y. L., Broderick K., Schafer W. R., Lu H. Journal Small 16(10):e1905852. 12 March 2020 (2020)
- Distinct roles for innexin gap junctions and hemichannels in mechanosensation AuthorsWalker D. S., Schafer W. R. Journal Elife 9:e50597. 29 January 2020 (2020)
- Identification of a conserved, orphan G-protein coupled receptor required for efficient pathogen clearance in C. elegans AuthorsAnderson A., Chew Y. L., Schafer W., McMullan R. Journal Infection and Immunity 87(4). April 2019 (2019)
- EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling AuthorsLoucks C. M., Park K., Walker D. S., McEwan A. H., Timbers T. A., Ardiel E. L., Grundy L. J., Li C., Johnson J. L., Kennedy J., Blacque O. E., Schafer W., Rankin C. H., Leroux M. R. Journal ELife 8: e37271. 27 February 2019 (2019)
- Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in C. elegans AuthorsMartineau C. N., Baskaner B., Seinstra R. I., Schafer W R., Brown A. E. X., Nollen E. A. A., Laurent P. Journal bioRxiv (2019)
- The Worm Connectome: Back to the Future AuthorsSchafer W. R. Journal Trends in Neurosciences 41(11):763-765. 1 November 2018 (2018)
- Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3 AuthorsChew Y. L, Grundy L. J., Brown A. E. X., Beets I., Schafer W. R. Journal Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 373(1758). 19 October 2018 (2018)
- Caenorhabditis elegans and the network control framework‑FAQs AuthorsTowlson E. K., Vértes P. E., Yan G., Chew Y. L., Walker D. S., Schafer W. R., Barabási A. L. Journal Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 373(1758). 19 October 2018 (2018)
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An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans
AuthorsChew Y. L., Tanizawa Y., Cho Y., Zhao B., Yu A. J., Ardiel E. L., Rabinowitch I., Bai J., Rankin C. H., Lu H., Beets I., Schafer W. R.
Journal
Neuron
99(6):1233-1246.e6. 19 September 2018 (2018)
Details
DOI10.1016/j.neuron.2018.08.003 PMID30146306 PMCIDPMC6162336 DivisionNeurobiology, Cell Biology - An open-source platform for analyzing and sharing worm-behavior data AuthorsJaver A., Currie M., Lee C. W., Hokanson J., Li K., Martineau C. N., Yemini E., Grundy L. J., Li C., Ch'ng Q., Schafer W. R., Nollen E. A. A., Kerr R., Brown A. E. X. Journal Nature Methods 15(9):645-646. September 2018 (2018)
- On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits AuthorsCho Y., Oakland D. N., Lee S. A., Schafer W. R., Lu H. Journal Lab on a Chip 18(4):601-609. 21 February 2018 (2018)
- Network control principles predict neuron function in the Caenorhabditis elegans connectome AuthorsYan G., Vértes P. E., Towlson E. K., Chew Y. L., Walker D. S., Schafer W. R., Barabási A. L. Journal Nature 550(7677):519-523. 26 October 2017 (2017)
- Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motorneurons AuthorsChew Y. L., Walker D. S., Towlson E. K., Vértes P. E., Yan G., Barabási A. L., Schafer W. R. Journal Scientific Data 4:170156.19 October 2017 (2017)
- A network for swimming AuthorsChew Y. L., Schafer W. R. Journal ELife 6: e28780. 5 July 2017 (2017)
- Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans AuthorsCho Y., Porto D. A., Hwang H., Grundy L. J., Schafer W. R., Lu H. Journal Lab on a Chip 17(15):2609-2618. 29 June 2017 (2017)
- CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells AuthorsGiese A. P. J., Tang Y. Q., Sinha G. P., Bowl M. R., Goldring A. C., Parker A., Freeman M. J., Brown S. D. M., Riazuddin S., Fettiplace R., Schafer W. R., Frolenkov G. I., Ahmed Z. M. Journal Nature Communications 8(1):43. 29 June 2017 (2017)
- The Bright Fluorescent Protein mNeonGreen Facilitates Protein Expression Analysis In Vivo AuthorsHostettler L., Grundy L., Käser-Pébernard S., Wicky C., Schafer W. R., Glauser D. A. Journal G3 7(2):607-615. February 2017 (2017)
- The Multilayer Connectome of Caenorhabditis elegans AuthorsBentley B., Branicky R., Barnes C. L. Chew Y. L., Yemini E., Bullmore E. T., Vértes P. E., Schafer W. R. Journal PLoS Computational Biology 12(12):e1005283. December 2016 (2016)
- Nematode nervous systems AuthorsSchafer W. Journal Current Biology 26(20):R955-R959. 24 October 2016 (2016)
- Dopamine helps worms deal with stress AuthorsChew Y. L., Schafer W. R. Journal EMBO Journal 35(17):1851-1852. 1 September 2016 (2016)
- PACRG, a protein linked to ciliary motility, mediates cellular signaling AuthorsLoucks C. M., Bialas N. J., Dekkers M. P., Walker D. S., Grundy L. J., Li C., Inglis P. N., Kida K., Schafer W. R., Blacque O. E., Jansen G., Leroux M. R. Journal Molecular Biology of the Cell 27(13):2133-2144. 1 July 2016 (2016)
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Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans
AuthorsEzcurra M., Walker D. S., Beets I., Swoboda P., Schafer W. R.
Journal
Journal of Neuroscience
36(11):3157-3169. 16 March 2016 (2016)
Details
DOI10.1523/JNEUROSCI.1128-15.2016 PMID26985027 PMCIDPMC4792932 DivisionNeurobiology; Cell Biology - Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans AuthorsRabinowitch I., Laurent P., Zhao B., Walker D., Beets I., Schoofs L., Bai J., Schafer W. R., Treinin M. Journal PLoS Biology 14(1):e1002348. 1 January 2016 (2016)
- Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion AuthorsSchwarz R. F., Branicky R., Grundy L. J., Schafer W. R., Brown A. E. Journal PLoS Computational Biology 11(8):e1004322. 21 August 2015 (2015)
- Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release AuthorsChoi S., Taylor K. P., Chatzigeorgiou M., Hu Z., Schafer W. R., Kaplan J. M. Journal PLoS Genetics 11(7):e100535. 8 July 2015 (2015)
- A consistent muscle activation strategy underlies crawling and swimming in Caenorhabditis elegans. AuthorsButler V. J., Branicky R., Yemini E., Liewald J. F., Gottschalk A., Kerr R. A., Chklovskii D. B., Schafer W. R. Journal Journal of the Royal Society, Interface / the Royal Society 12(102):20140963, 1 January 2015 (2015)
- Mechanosensory molecules and circuits in C. elegans. AuthorsSchafer W. R. Journal Pflugers Archiv : European Journal of Physiology 467(1):39-48, 1 January 2015 (2015)
- Rewiring neural circuits by the insertion of ectopic electrical synapses in transgenic C. elegans AuthorsRabinowitch I., Chatzigeorgiou M., Zhao B., Treinin M., Schafer W. R. Journal Nature Communications 5:4442. 16 July 2014 (2014)
- Stochastic blockmodeling of the modules and core of the Caenorhabditis elegans connectome AuthorsPavlovic D. M., Vértes P. E., Bullmore E. T., Schafer W. R., Nichols T. E. Journal PloS one 9(7):e97584. 2 July 2014 (2014)
- C. elegans nicotinic acetylcholine receptors are required for nociception AuthorsCohen E., Chatzigeorgiou M., Husson S. J., Steuer-Costa W., Gottschalk A., Schafer W. R., Treinin M. Journal Molecular and Cellular Neurosciences 59:85–96. March 2014 (2014)
- The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability AuthorsBranicky R., Miyazaki H., Strange K., Schafer W. R. Journal Journal of Neuroscience 34(3):764-775. 15 January 2014 (2014)
- A database of Caenorhabditis elegans behavioral phenotypes AuthorsYemini E., Jucikas T., Grundy L. J., Brown A. E., Schafer W. R. Journal Nature Methods 10(9):877-879. September 2013 (2013)
- Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization AuthorsSmith C. J., O'Brien T., Chatzigeorgiou M., Spencer W. C., Feingold-Link E., Husson S. J., Hori S., Mitani S., Gottschalk A., Schafer W. R., Miller D. M. 3rd Journal Neuron 79(2):266-280. 24 July 2013 (2013)
- Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans AuthorsChoi S., Chatzigeorgiou M., Taylor K. P., Schafer W. R., Kaplan J. M. Journal Neuron 78(5):869-880. 5 June 2013 (2013)
- A gap junction circuit enhances processing of coincident mechanosensory inputs AuthorsRabinowitch I., Chatzigeorgiou M., Schafer W. R. Journal Current Biology 23(11):963-967. 3 June 2013 (2013)
- Neuropeptide signaling: from the gut AuthorsZhao B., Schafer W. R. Journal Current Biology 23(11):R481-3. 3 June 2013 (2013)
- Phase transition in the economically modeled growth of a cellular nervous system AuthorsNicosia V., Vértes P. E., Schafer W. R., Latora V., Bullmore E. T. Journal Proceedings of the National Academy of Sciences, USA. 110(19):7880-7885. 7 May 2013 (2013)
- The rich club of the C. elegans neuronal connectome AuthorsTowlson E. K., Vértes P. E., Ahnert S. E., Schafer W. R., Bullmore E. T. Journal Journal of Neuroscience 33(15):6380-6387. 10 April 2013 (2013)
- tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans AuthorsChatzigeorgiou M., Bang S., Hwang S. W., Schafer W. R. Journal Nature 494(7435):95-99. 7 February 2013 (2013)
- A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion AuthorsBrown A. E., Yemini E. I., Grundy L. J., Jucikas T., Schafer W. R. Journal Proceedings of the National Academy of Sciences, USA 110(2):791-796. 8 January 2013 (2013)
- Proprioceptive coupling within motor neurons drives C. elegans forward locomotion AuthorsWen Q., Po M. D., Hulme E., Chen S., Liu X., Kwok S. W., Gershow M., Leifer A. M., Butler V., Fang-Yen C., Kawano T., Schafer W. R., Whitesides G., Wyart M., Chklovskii D. B., Zhen M., Samuel A. D. Journal Neuron 76(4):750-761. 11 November 2012 (2012)
- Tackling thermosensation with multidimensional phenotyping AuthorsSchafer W. R. Journal BMC Biology 10:91. 19 November 2012 (2012)
- A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans AuthorsAoki R., Yagami T., Sasakura H., Ogura K., Kajihara Y., Ibi M., Miyamae T., Nakamura F., Asakura T., Kanai Y., Misu Y., Iino Y., Ezcurra M., Schafer W. R., Mori I., Goshima Y. Journal Journal of Neuroscience 31(46):16603-16610. 16 November 2011 (2011)
- Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans AuthorsChatzigeorgiou M., Schafer W. R. Journal Neuron 70(2):299-309. 28 April 2011 (2011)
- Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling AuthorsEzcurra M., Tanizawa Y., Swoboda P., Schafer W. R. Journal EMBO Journal 30(6):1110-1122. 16 March 2011 (2011)
- Unrestrained worms bridled by the light AuthorsBrown A. E., Schafer W. R. Journal Nature Methods 8(2):129-130. February 2011 (2011)
- C. elegans multi-dendritic sensory neurons: morphology and function AuthorsAlbeg A., Smith C. J., Chatzigeorgiou M., Feitelson D. G., Hall D. H., Schafer W. R., Miller D. M. 3rd., Treinin M. Journal Molecular and Cellular Neurosciences 46(1):308-317. January 2011 (2011)
- Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec‑10 AuthorsChatzigeorgiou M., Grundy L., Kindt K. S., Lee W. H., Driscoll M., Schafer W. R. Journal Journal of Neurophysiology 104(6):3334-3344. 1 December 2010 (2010)
- C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel AuthorsKang L., Gao J., Schafer W. R., Xie Z., Xu X. Z. Journal Neuron 67(3):381-391. 12 August 2010 (2010)
- A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior AuthorsZhang M., Schafer W. R., Breitling R. Journal BMC Systems Biology 4:81. 7 June 2010 (2010)
- Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors AuthorsChatzigeorgiou M., Yoo S., Watson J. D., Lee W. H., Spencer W. C., Kindt K. S., Hwang S. W., Miller D. M. 3rd, Treinin M., Driscoll M., Schafer W. R. Journal Nature Neuroscience 13(7):861-868. July 2010 (2010)
- Automated imaging of neuronal activity in freely behaving Caenorhabditis elegans AuthorsBen Arous J., Tanizawa Y., Rabinowitch I., Chatenay D., Schafer W. R. Journal Journal of Neuroscience Methods 187(2):229-234. 30 March 2010 (2010)
- Worms with a single functional sensory cilium generate proper neuron-specific behavioral output AuthorsSenti G., Ezcurra M., Löbner J., Schafer W. R., Swoboda P. Journal Genetics 183(2):595-605, 1SI-3SI. October 2009 (2009)
- A self-regulating feed-forward circuit controlling C. elegans egg-laying behavior AuthorsZhang M., Chung S. H., Fang-Yen C., Craig C., Kerr R. A., Suzuki H., Samuel A. D., Mazur E., Schafer W. R. Journal Current Biology 18(19):1445-1455. 14 October 2008 (2008)