Published Research

Found 71 results for Sale J.

• Polymerase ι promotes C>T substitutions in smoking models and in the platinum chemotherapy-induced SBS31 mutation signature AuthorsEngel B., Szikriszt B., Gyüre Z., Sale J. E., Szüts D., Németh E. Journal Proceedings of the National Academy of Sciences of the United States of America 123(32):e2526551123 (2026)
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  DOI10.1073/pnas.2526551123 PMID42561022 PMCIDPMC13462832 DivisionProtein & Nucleic Acid Chemistry
• High-fidelity human chromosome transfer and elimination AuthorsGianluca Petris, Simona Grazioli, Linda van Bijsterveldt, Pierre Murat, Kim C. Liu, Jakob Birnbaum, Julian E. Sale, Jason W. Chin Journal Science 390(6777):1038-1043 (2025)
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  DOI10.1126/science.adv9797 PMID41343641 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Protocol for double-crosslinking ChIP-seq to improve data quality and enhance detection of challenging chromatin targets AuthorsBao Y., Cacioppo R., Crisp A., Shlamovitz I., Sale J.E., Tufegdzic Vidakovic A., Vervoort S.J., Zeller A. Journal STAR Protocols 6(4):104171 (2025)
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  DOI10.1016/j.xpro.2025.104171 PMID41166303 PMCID  DivisionProtein & Nucleic Acid Chemistry
• ecDNA replication is disorganized and vulnerable to replication stress AuthorsJaworski J.J., Pfuderer P.L., Czyz P., Petris G., Boemo M.A., Sale J.E. Journal Nucleic Acids Research 53(14):gkaf711 (2025)
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  DOI10.1093/nar/gkaf711 PMID40744497 PMCIDPMC12311790 DivisionProtein & Nucleic Acid Chemistry
• Engineered receptor capture combined with mass spectrometry enables high-throughput detection and quantitation of SARS-CoV-2 spike protein AuthorsBate N., Lane D., Evans S.E., Salim F., Allcock N.S., Haigh R., Sale J.E., Jones D.J.L., Brindle N.P.J. Journal JACS Au 5(2):747-755 (2025)
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  DOI10.1021/jacsau.4c00980 PMID40017752 PMCIDPMC11862925 DivisionProtein & Nucleic Acid Chemistry
• DNA replication initiation drives focal mutagenesis and rearrangements in human cancers AuthorsMurat P., Guilbaud G., Sale J. E. Journal Nature Communications 15(1):10850 (2024)
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  DOIdoi.org/10.1038/s41467-024-55148-3 PMID39738026 PMCIDPMC11685606 DivisionProtein & Nucleic Acid Chemistry
• CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription AuthorsCacioppo R., Gillis A., Shlamovitz I., Zeller A., Castiblanco D., Crisp A., Haworth B., Arabiotorre A., Abyaneh P., Bao Y., Sale J. E., Berry S., Tufegdžić Vidaković A. Journal Molecular Cell 84(24):4808-4823. E13 (2024)
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  DOIdoi.org/10.1016/j.molcel.2024.11.024 PMID39667934 PMCID  DivisionProtein & Nucleic Acid Chemistry
• FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions AuthorsAlcón P, Kaczmarczyk AP, Ray KK, Liolios T, Guilbaud G, Sijacki T, Shen Y, McLaughlin SH, Sale JE, Knipscheer P, Rueda DS, Passmore LA. Journal Nature 10.1038/s41586-024-07770-w (2024)
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  DOI10.1038/s41586-024-07770‑w PMID39085614 PMCID  DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• CRISPR in Nucleic Acids Research: the sequel AuthorsSale J. E., Stoddard B. L. Journal Nucleic Acids Research 52(7):3489-3492 (2024)
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  DOI10.1093/nar/gkae159 PMID38532709 PMCIDPMC11040143 DivisionProtein & Nucleic Acid Chemistry
• Fifty years of Nucleic Acids Research AuthorsSale J. E., Stoddard B. L. Journal Nucleic Acids Research 52(1): 1–3. (2024)
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  DOI10.1093/nar/gkad1156 PMID38178306 PMCIDPMC10783492 DivisionProtein & Nucleic Acid Chemistry
• PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass AuthorsMellor C., Nassar J., Šviković S., Sale J. E. Journal Nucleic Acids Research 52(1):243-258 (2024)
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  DOIdoi.org/10.1093/nar/gkad1054 PMID37971291 PMCIDPMC10783524 DivisionProtein & Nucleic Acid Chemistry
• Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly AuthorsZürcher J. F, Kleefeldt A. A, Funke L. F. H, Birnbaum J, Fredens J, Grazioli S, Liu K. C., Spinck M., Petris G., Murat P., Rehm F. B. H, Sale J. E, Chin J. W. Journal Nature 619(7970):555-562 (2023)
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  DOI10.1038/s41586-023-06268-1 PMID37380776 PMCIDPMC7614783 DivisionProtein & Nucleic Acid Chemistry
• DNA replication initiation shapes the mutational landscape and expression of the human genome AuthorsMurat P, Perez C, Crisp A, van Eijk P, Reed SH, Guilbaud G, Sale JE. Journal Science Advances Nov 11;8(45):eadd3686 (2022)
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  DOI10.1126/sciadv. Add3686 PMID36351018 PMCIDPMC9645720 DivisionProtein & Nucleic Acid Chemistry
• Focus and persistence: how Pol IV unblocks stalled DNA synthesis AuthorsSale J.E. Journal Nature Structural & Molecular Biology 29(9):846-847 (2022)
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  DOI10.1038/s41594-022-00825‑4 PMID36127467 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Creation and resolution of non-B-DNA structural impediments during replication AuthorsMellor C., Perez C., Sale J.E. Journal Critical Reviews in Biochemistry and Molecular Biology 57(4):412-442 (2022)
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  DOI10.1080/10409238.2022.2121803 PMID36170051 PMCIDPMC7613824 DivisionProtein & Nucleic Acid Chemistry
• Mechanisms of APOBEC3 mutagenesis in human cancer cells AuthorsPetljak M., Dananberg A., Chu K., Bergstrom E. N., Striepen J., von Morgen P., Chen Y., Shah H., Sale J.E., Alexandrov L.B., Stratton M.R., Maciejowski J. Journal Nature 607(7920):799-807 (2022)
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  DOI10.1038/s41586-022-04972‑y PMID35859169 PMCIDPMC9329121 DivisionProtein & Nucleic Acid Chemistry
• In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding AuthorsBate N., Savva C.G., Moody P.C.E., Brown E.A., Evans S.E., Ball J.K., Schwabe J.W.R., Sale J.E., Brindle N.P.J. Journal Plos Pathogens 18(7):e1010733 (2022)
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  DOI10.1371/journal.ppat.1010733 PMID35849637 PMCIDPMC9333441 DivisionProtein & Nucleic Acid Chemistry
• Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation AuthorsGuilbaud G., Murat P., Wilkes H.S., Lerner L.K., Sale J.E., Krude T. Journal Nucleic Acids Research 50(13):7436-7450 (2022)
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  DOI10.1093/nar/gkac555 PMID35801867 PMCIDPMC9303276 DivisionProtein & Nucleic Acid Chemistry
• Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice AuthorsGalindo-Campos M. A,, et al (including Guilbaud G., Sale J.) Journal Blood 139(2):228-239 (2022)
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  DOI10.1182/blood.2021012805 PMID34359075 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Editorial: Single-molecule studies of DNA-protein interactions collection 2021 AuthorsBianco P. R., Sale J. E., Reyes-Lamothe R. Journal Nucleic Acids Research 49(11):6005-6006. 21 June 2021 (2021)
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  DOI10.1093/nar/gkab497 PMID34153108 PMCIDPMC8216273 DivisionProtein & Nucleic Acid Chemistry
• A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation AuthorsEldridge C. B., Allen F. J., Crisp A., Grandy R. A., Vallier L., Sale J. E. Journal Stem Cell Reports 15(4):827-835. 13 October 2020 (2020)
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  DOI10.1016/j.stemcr.2020.08.003 PMID32888504 PMCIDPMC7561492 DivisionProtein & Nucleic Acid Chemistry
• Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication AuthorsLerner L. K., Holzer S., Kilkenny M. L., Šviković S., Murat P., Schiavone D., Eldridge C. B., Bittleston A., Maman J. D., Branzei D., Stott K. Pellegrini L., Sale J. E. Journal EMBO Journal 39(18):e104185. 15 September 2020 (2020)
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  DOI10.15252/embj.2019104185 PMID32705708 PMCIDPMC7506991 DivisionProtein & Nucleic Acid Chemistry
• DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats AuthorsMurat P., Guilbaud G., Sale J. E. Journal Genome Biology 21(1):209. 21 August 2020 (2020)
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  DOI10.1186/s13059-020-02124‑x PMID32819438 PMCIDPMC7441554 DivisionProtein & Nucleic Acid Chemistry
• PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells AuthorsQuinet A., Tirman S., Jackson J., Šviković S., Lemaçon D., Carvajal-Maldonado D., González-Acosta D., Vessoni A. T., Cybulla E., Wood M., Tavis S., Batista L. F. Z., Méndez J., Sale J. E., Vindigni A. Journal Molecular Cell 77(3):461-474.e9. 6 February 2020 (2020)
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  DOI10.1016/j.molcel.2019.10.008 PMID31676232 PMCIDPMC7007862 DivisionProtein & Nucleic Acid Chemistry
• CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs AuthorsMohiuddin M., Rahman M. M., Sale J. E., Pearson C. E. Journal Nucleic Acids Research 47(6):2966-2980. 8 April 2019 (2019)
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  DOI10.1093/nar/gkz009 PMID30657944 PMCIDPMC6451104 DivisionProtein & Nucleic Acid Chemistry
• R-loop formation during S phase is restricted by PrimPol-mediated repriming AuthorsŠviković S., Crisp A., Tan-Wong S. M., Guilliam T. A, Doherty A. J., Proudfoot N. J., Guilbaud G., Sale J. E. Journal EMBO Journal 38(3). 1 February 2019 (2019)
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  DOI10.15252/embj.201899793 PMID30478192 PMCIDPMC6356060 DivisionProtein & Nucleic Acid Chemistry
• Replication of G Quadruplex DNA AuthorsLerner L. K., Sale J. E. Journal Genes 10(2). 29 January 2019 (2019)
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  DOI10.3390/genes10020095 PMID30700033 PMCIDPMC6409989 DivisionProtein & Nucleic Acid Chemistry
• A NuRD complex from Xenopus laevis eggs Is essential for DNA replication during early embryogenesis AuthorsChristov C. P., Dingwell K. S., Skehel M., Wilkes H. S., Sale J. E., Smith J. C., Krude T. Journal Cell Reports 22(9):2265-2278. 27 February 2018 (2018)
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  DOI10.1016/j. Celrep.2018.02.015 PMID29490265 PMCIDPMC5848848 DivisionProtein & Nucleic Acid Chemistry
• Local epigenetic reprogramming induced by G-quadruplex ligands AuthorsGuilbaud G., Murat P., Recolin B., Campbell B. C , Maiter A , Sale J. E., Balasubramanian S. Journal Nature Chemistry 9(11):1110-1117 (2017)
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  DOI10.1038/nchem.2828 PMID29064488 PMCIDPMC5669467 DivisionProtein & Nucleic Acid Chemistry
• The Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory AuthorsŠviković S., Sale J. E. Journal Journal of Molecular Biology 429(13):2011-2029 (2017)
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  DOI10.1016/j.jmb.2016.11.011 PMID27876548 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara‑C) AuthorsTsuda M., Terada K., Ooka M., Kobayashi K., Sasanuma H., Fujisawa R., Tsurimoto T., Yamamoto J., Iwai S., Kadoda K., Akagawa R., Huang S. N., Pommier Y., Sale J. E., Takeda S., Hirota K. Journal Oncotarget 8(20):33457-33474. 16 May 2017 (2017)
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  DOI10.18632/oncotarget.16508 PMID28380422 PMCIDPMC5464882 DivisionProtein & Nucleic Acid Chemistry
• Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium AuthorsTian X., Patel K., Ridpath J. R., Chen Y., Zhou Y. H, Neo D., Clement J., Takata M., Takeda S., Sale J., Wright F. A, Swenberg J. A, Nakamura J. Journal PloS one 11(12):e0167503. 1 December 2016 (2016)
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  DOI10.1371/journal.pone.0167503 PMID27907204 PMCIDPMC5132242 DivisionProtein & Nucleic Acid Chemistry
• In vivo evidence for translesion synthesis by the replicative DNA polymerase δ AuthorsHirota K., Tsuda M., Mohiuddin, Tsurimoto T., Cohen I. S., Livneh Z., Kobayashi K., Narita T., Nishihara K., Murai J., Iwai S., Guilbaud G., Sale J. E., Takeda S. Journal Nucleic Acids Research 44(15):7242-7250. 6 September 2016 (2016)
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  DOI10.1093/nar/gkw439 PMID27185888 PMCIDPMC5009730 DivisionProtein & Nucleic Acid Chemistry
• Starting over: Primpol reprimes after chain termination AuthorsSale J. E. Journal Cell Cycle 15(16):2099-2100. 6 July 2016 (2016)
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  DOI10.1080/15384101.2016.1204855 PMID27384604 PMCIDPMC4993428 DivisionProtein & Nucleic Acid Chemistry
• Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA AuthorsRomanello M., Schiavone D., Frey A., Sale J. E. Journal EMBO Journal 35(13):1452-1464. 1 July 2016 (2016)
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  DOI10.15252/embj.201693958 PMID27220848 PMCIDPMC4883027 DivisionProtein & Nucleic Acid Chemistry
• Editorial AuthorsSale J. E., Cox T. M. Journal Expert Reviews in Molecular Medicine 18:e10. 10 May 2016 (2016)
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  DOI10.1017/erm.2016.10 PMID27160347 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The topography of mutational processes in breast cancer genomes AuthorsMorganella S., Alexandrov L. B., Glodzik D., Zou X., Davies H., Staaf J., Sieuwerts A. M., Brinkman A. B., Martin S., Ramakrishna M., Butler A., Kim H. Y., Borg Å., Sotiriou C., Futreal P. A., Campbell P. J., Span P. N., Van Laere S., Lakhani S. R., Eyfjord J. E., Thompson A. M., Stunnenberg H. G., van de Vijver M. J., Martens J. W., Børresen-Dale A. L., Richardson A. L., Kong G., Thomas G., Sale J., Rada C., Stratton M. R., Birney E., Nik-Zainal S. Journal Nature Communications 7:11383. 2 May 2016 (2016)
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  DOI10.1038/ncomms11383 PMID27136393 PMCIDPMC5001788 DivisionProtein & Nucleic Acid Chemistry
• The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability AuthorsHo T. L., Guilbaud G., Blow J. J., Sale J. E., Watson C. J. Journal Cell Reports 15(4): 724-734. 26 April 2016 (2016)
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  DOI10.1016/j. Celrep.2016.03.078 PMID27149840 PMCIDPMC4850358 DivisionProtein & Nucleic Acid Chemistry
• The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line AuthorsMohiuddin , Kobayashi S., Keka I. S., Guilbaud G., Sale J., Narita T., Abdel-Aziz H. I., Wang X., Ogawa S., Sasanuma H., Chiu R., Oestergaard V. H., Lisby M., Takeda S. Journal DNA Repair 40:67-76. April 2016 (2016)
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  DOI10.1016/j. dnarep.2016.02.002 PMID26994443 PMCIDPMC5351851 DivisionProtein & Nucleic Acid Chemistry
• Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds AuthorsZimmer J., Tacconi E. M., Folio C., Badie S., Porru M., Klare K., Tumiati M., Markkanen E., Halder S., Ryan A., Jackson S. P., Ramadan K., Kuznetsov S. G., Biroccio A., Sale J. E., Tarsounas M. Journal Molecular Cell 61(3):449-460. 4 February 2016 (2016)
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  DOI10.1016/j.molcel.2015.12.004 PMID26748828 PMCIDPMC4747901 DivisionProtein & Nucleic Acid Chemistry
• Directed evolution of human scFvs in DT40 cells AuthorsLim A. W., Williams G. T., Rada C., Sale J. E. Journal Protein Engineering, Design & Selection : PEDS 29(2):39-48. February 2016 (2016)
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  DOI10.1093/protein/gzv058 PMID26519451 PMCIDPMC4840456 DivisionProtein & Nucleic Acid Chemistry
• PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells AuthorsSchiavone D., Jozwiakowski S. K., Romanello M., Guilbaud G., Guilliam T. A., Bailey L. J., Sale J. E., Doherty A. J. Journal Molecular Cell 61(1):161–169. 7 January 2016 (2016)
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  DOI10.1016/j.molcel.2015.10.038 PMID26626482 PMCIDPMC4712188 DivisionProtein & Nucleic Acid Chemistry
• Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression AuthorsPapadopoulou C., Guilbaud G., Schiavone D., Sale J. E. Journal Cell Reports 13(11):2491-2503. 22 December 2015 (2015)
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  DOI10.1016/j. Celrep.2015.11.039 PMID26686635 PMCIDPMC4695339 DivisionProtein & Nucleic Acid Chemistry
• Clock-like mutational processes in human somatic cells AuthorsAlexandrov L. B., Jones P. H., Wedge D. C., Sale J. E., Campbell P. J., Nik-Zainal S., Stratton M. R. Journal Nature Genetics 47(12):1402-1407. December 2015 (2015)
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  DOI10.1038/ng.3441 PMID26551669 PMCIDPMC4783858 DivisionProtein & Nucleic Acid Chemistry
• REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination AuthorsSale J. E. Journal EMBO Journal 34(12): 1609-1611. 12 June 2015 (2015)
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  DOI10.15252/embj.201591697 PMID25896508 PMCIDPMC4475396 DivisionProtein & Nucleic Acid Chemistry
• Contributions of the specialised DNA polymerases to replication of structured DNA. AuthorsWickramasinghe C. M., Arzouk H., Frey A., Maiter A., Sale J. E. Journal DNA Repair 29:83-90. 01 May 2015 (2015)
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  DOI10.1016/j. dnarep.2015.01.004 PMID25704659 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ AuthorsHirota K., Yoshikiyo K., Guilbaud G., Tsurimoto T., Murai J., Tsuda M., Phillips L. G., Narita T., Nishihara K., Kobayashi K., Yamada K., Nakamura J., Pommier Y., Lehmann A., Sale J. E., Takeda S. Journal Nucleic Acids Research 43(3):1671-1683. 18 February 2015 (2015)
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  DOI10.1093/nar/gkv023 PMID25628356 PMCIDPMC4330384 DivisionProtein & Nucleic Acid Chemistry
• Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells AuthorsSchiavone D., Guilbaud G., Murat P., Papadopoulou C., Sarkies P., Prioleau M. N., Balasubramanian S., Sale J. E. Journal EMBO Journal 33(21):2507-2520. 3 November 2014 (2014)
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  DOI10.15252/embj.201488398 PMID25190518 PMCIDPMC4282387 DivisionProtein & Nucleic Acid Chemistry
• Histone H3.3 is required to maintain replication fork progression after UV damage AuthorsFrey A., Listovsky T., Guilbaud G., Sarkies P., Sale J. E. Journal Current Biology 24(18):2195-2201. 22 September 2014 (2014)
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  DOI10.1016/j. Cub.2014.07.077 PMID25201682 PMCIDPMC4175177 DivisionProtein & Nucleic Acid Chemistry
• Retrospective. Michael Neuberger (1953‑2013) AuthorsSale J. E., Patel K. J., Batista F. D. Journal Science 342(6164):1335. 13 December 2013 (2013)
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  DOI10.1126/science.1248808 PMID24337288 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset AuthorsListovsky T., Sale J. E. Journal Journal of Cell Biology 203(1):87-100. 14 October 2013 (2013)
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  DOI10.1083/jcb.201302060 PMID24100295 PMCIDPMC3798251 DivisionProtein & Nucleic Acid Chemistry
• Translesion DNA synthesis and mutagenesis in eukaryotes AuthorsSale J. E. Journal Cold Spring Harbor Perspectives in Biology 5(3):a012708. March 2013 (2013)
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  DOI10.1101/cshperspect. A012708 PMID23457261 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Unwinding to recombine AuthorsGuilbaud G., Sale J. E. Journal Molecular Cell 47(4):493-494. 24 August 2012 (2012)
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  DOI10.1016/j.molcel.2012.08.006 PMID22920289 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Competition, collaboration and coordination--determining how cells bypass DNA damage AuthorsSale J. E. Journal Journal of Cell Science 125(Pt 7):1633-1643. 1 April 2012 (2012)
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  DOI10.1242/jcs.094748 PMID22499669 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cellular epigenetic stability and cancer AuthorsSarkies P., Sale J. E. Journal Trends in Genetics 28(3):118-127. March 2012 (2012)
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  DOI10.1016/j.tig.2011.11.005 PMID22226176 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Propagation of histone marks and epigenetic memory during normal and interrupted DNA replication AuthorsSarkies P., Sale J. E. Journal Cellular and Molecular Life Sciences 69(5):697-716. March 2012 (2012)
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  DOI10.1007/s00018-011-0824-1 PMID21964926 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Y-family DNA polymerases and their role in tolerance of cellular DNA damage AuthorsSale J. E., Lehmann A. R., Woodgate R. Journal Nature Reviews. Molecular Cell Biology 13(3):141-152. March 2012 (2012)
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  DOI10.1038/nrm3289 PMID22358330 PMCID  DivisionProtein & Nucleic Acid Chemistry
• FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA AuthorsSarkies P., Murat P., Phillips L. G., Patel K. J., Balasubramanian S., Sale J. E. Journal Nucleic Acids Research 40(4):1485-1498. February 2012 (2012)
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  DOI10.1093/nar/gkr868 PMID22021381 PMCIDPMC3287192 DivisionProtein & Nucleic Acid Chemistry
• Measurement of diversification in the immunoglobulin light chain gene of DT40 cells AuthorsSale J. E. Journal Methods in Molecular Biology 920:417-432. 2012 (2012)
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  DOI10.1007/978-1-61779-998-3_29 PMID22941620 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Monitoring I-SceI-induced double-strand break repair in DT40 cells AuthorsPlessis D. d, Sale J. E. Journal Methods in Molecular Biology 920:371-377. 2012 (2012)
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  DOI10.1007/978-1-61779-998-3_26 PMID22941617 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Epigenetic instability due to defective replication of structured DNA AuthorsSarkies P., Reams C., Simpson L. J., Sale J. E. Journal Molecular Cell 40(5):703-713. 10 December 2010 (2010)
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  DOI10.1016/j.molcel.2010.11.009 PMID21145480 PMCIDPMC3145961 DivisionProtein & Nucleic Acid Chemistry
• Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions AuthorsHirota K., Sonoda E., Kawamoto T., Motegi A., Masutani C., Hanaoka F., Szüts D., Iwai S., Sale J. E., Lehmann A., Takeda S. Journal PLoS Genetics 6(10);e1001151. 7 October 2010 (2010)
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  DOI10.1371/journal.pgen.1001151 PMID20949111 PMCIDPMC2951353 DivisionProtein & Nucleic Acid Chemistry
• The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA AuthorsPhillips L. G., Sale J. E. Journal DNA Repair 9(10):1064-1072. 5 October 2010 (2010)
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  DOI10.1016/j. dnarep.2010.07.006 PMID20691646 PMCIDPMC2956782 DivisionProtein & Nucleic Acid Chemistry
• Visualisation of PCNA monoubiquitination in vivo by single pass spectral imaging FRET microscopy AuthorsBatters C., Zhu H., Sale J. E. Journal PloS one 5(2):e9008. 2 February 2010 (2010)
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  DOI10.1371/journal.pone.0009008 PMID20126408 PMCIDPMC2814862 DivisionProtein & Nucleic Acid Chemistry
• Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines AuthorsCumbers S. J., Williams G. T., Davies S. L., Grenfell R. L., Takeda S., Batista F. D., Sale J. E., Neuberger M,. S. Journal Nature Biotechnology 20(11):1129-1134 (2002) (2002)
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  DOI10.1038/nbt752 PMID12379869 PMCID  DivisionProtein & Nucleic Acid Chemistry
• AID is essential for immunoglobulin V gene conversion in a cultured B cell line AuthorsHarris R. S., Sale J. E., Petersen-Mahrt S. K., Neuberger M. S. Journal Current Biology 12(5):435-438. 5 March 2002 (2002)
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  DOI10.1016/s0960-9822(02)00717‑0 PMID11882297 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation AuthorsSale J. E., Calandrini D. M., Takata M., Takeda S., Neuberger M. S. Journal Nature 412(6850):921-926. 30 August 2001 (2001)
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  DOI10.1038/35091100 PMID11528482 PMCID  DivisionProtein & Nucleic Acid Chemistry
• In vivo and in vitro studies of immunoglobulin gene somatic hypermutation AuthorsSale J. E., Bemark M., Williams G. T., Jolly C J., Ehrenstein M. R., Rada C., Milstein C., Neuberger M. S. Journal Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 356(1405):21-28. 29 January 2001 (2001)
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  DOI10.1098/rstb.2000.0744 PMID11205326 PMCIDPMC1087687 DivisionProtein & Nucleic Acid Chemistry
• Memory in the B-cell compartment: antibody affinity maturation AuthorsNeuberger M. S., Ehrenstein M. R., Rada C., Sale J., Batista F. D., Williams G., Milstein C. Journal Phil. Trans. R. Soc. Lond. B 355(1395):357-360 (2000) (2000)
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  DOI10.1098/rstb.2000.0573 PMID10794054 PMCIDPMC1692737 DivisionProtein & Nucleic Acid Chemistry
• Diversification and selection mechanisms for the production of protein repertoires. Lessons from the immune system AuthorsNeuberger M. S., Sale J. E., Cumbers S. J., Jolly C. J., M. P., Ehrenstein M. R., Lanoue A., Bruggemann M., Batista F. D., Davies S. L., Williams G. T. Journal Applied Biochemistry and Biotechnology 83(1-3):53-60 (2000) (2000)
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  DOI10.1385/abab:83:1-3:53 PMID10826948 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Antibody diversification and selection in the mature B-cell compartment AuthorsNeuberger M. S., Lanoue A., Ehrenstein M. R., Batista F. D., Sale J. E., Williams G. T. Journal Cold Spring Harbor Symposia on Quantitative Biology LXIV: 211-216 (1999) (1999)
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  DOI10.1101/sqb.1999.64.211 PMID11232288 PMCID  DivisionProtein & Nucleic Acid Chemistry