Published Research

Found 53 results for Randow.

• ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers AuthorsNaydenova K., Mund T., Yip M. C. J., Harper C. M., Leigh K. E., Hankinson J., Boyle K. B., Heatley A., Otten E. G., Lulla V., Modis Y., Randow F. Journal Molecular Cell 86(19):4018-4031.e4 (2026)
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  DOI10.1016/j.molcel.2026.09.002 PMID42822417 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Quality control of glycogen through direct ubiquitylation by RNF213 AuthorsYip M. C. J., Naydenova K., Otten E. G., Heatley A., Moe A., Anton L., de Los Reyes-Ramírez L., Jolin H. E., Langevin F., Wiacek M., Franco C., Bertolotti A., Kukulski W., McKenzie A. N. J., Randow F. Journal Nature (2026)
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  DOI10.1038/s41586-026-11139-6 PMID42744304 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213 AuthorsNaydenova K., Boyle K.B., Pathe C., Pothukuchi P., Crespillo-Casado A., Scharte F., Hammoudi P.M., Otten E.G., Alto N.M., Randow F. Journal Nature Structural & Molecular Biology 32(9):1741-1751 (2025)
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  DOIdoi.org/10.1038/s41594-025-01530-8 PMID40205224 PMCIDPMC12440826 DivisionProtein & Nucleic Acid Chemistry
• Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation Authorsde la Peña A., Retamal C., Pérez-Molina F., Díaz-Valdivia N., Veloso-Bahamondes F., Tapia D., Cancino J., Randow F., González A., Oyanadel C., Soza A. Journal European Journal of Cell Biology 104(2):151488 (2025)
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  DOIdoi.org/10.1016/j.ejcb.2025.151488 PMID40209344 PMCIDPMC12162348 DivisionProtein & Nucleic Acid Chemistry
• Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213 AuthorsCrespillo-Casado A., Pothukuchi P., Naydenova K., Yip M. C. J., Young J. M., Boulanger J., Dharamdasani V., Harper C., Hammoudi P. M., Otten E. G., Boyle K., Gogoi M., Malik H. S., Randow F. Journal EMBO Reports 25(11):4979-5005 (2024)
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  DOI10.1038/s44319-024-00280‑w PMID39375464 PMCIDPMC11549300 DivisionProtein & Nucleic Acid Chemistry
• Ubiquitylation: Sword and shield in the bacterial arsenal AuthorsPruneda J. N., Randow F. Journal Molecular Cell 84(18):3378-3380 (2024)
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  DOI10.1016/j.molcel.2024.08.034 PMID39303679 PMCID  DivisionProtein & Nucleic Acid Chemistry
• TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure AuthorsBoyle K. B., Ellison C. J., Elliott P. R., Schuschnig M., Grimes K., Dionne M. S., Sasakawa C., Munro S., Martens S., Randow F. Journal The EMBO Journal 42(17):e113012 (2023)
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  DOI10.15252/embj.2022113012 PMID37409490 PMCIDPMC10476172 DivisionProtein & Nucleic Acid Chemistry
• Comparative study of GBP recruitment on two cytosol-dwelling pathogens, Francisella novicida and Shigella flexneri highlights differences in GBP repertoire and in GBP1 motif requirements AuthorsValeva S. V., Degabriel M., Michal F., Gay G., Rohde J. R., Randow F., Lagrange B., Henry T. Journal Pathogens and Disease 81:ftad005 (2023)
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  DOI10.1093/femspd/ftad005 PMID37012222 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection AuthorsWu X, et al (including Randow F.) Journal EMBO Reports 22(7):e51678. 5 July 2021 (2021)
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  DOI10.15252/embr.202051678 PMID33987949 PMCIDPMC8256295 DivisionProtein & Nucleic Acid Chemistry
• Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome AuthorsLulla V., Wandel M. P., Bandyra K. J., Ulferts R., Wu M., Dendooven T., Yang X., Doyle N., Oerum S., Beale R., O'Rourke S. M., Randow F., Maier H. J., Scott W., Ding Y., Firth A. E., Bloznelyte K., Luisi B. F. Journal Journal of Virology 95(14):e0066321. July 2021 (2021)
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  DOI10.1128/jvi.00663‑21 PMID33963053 PMCIDPMC8223950 DivisionProtein & Nucleic Acid Chemistry
• Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection AuthorsOtten E. G., Werner E., Crespillo-Casado A., Boyle K. B., Dharamdasani V., Pathe C., Santhanam B., Randow F. Journal Nature 594(7861):111-116. 3 June 2021 (2021)
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  DOI10.1038/s41586-021-03566-4 PMID34012115 PMCIDPMC7610904 DivisionProtein & Nucleic Acid Chemistry
• SIK2 orchestrates actin-dependent host response upon Salmonella infection AuthorsHahn M., Covarrubias-Pinto A., Herhaus L., Satpathy S., Klann K., Boyle K. B., Münch C., Rajalingam K., Randow F., Choudhary C., Dikic I. Journal Proceedings of the National Academy of Sciences of the United States of America 118(19): e2024144118. 11 May 2021 (2021)
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  DOI10.1073/pnas.2024144118 PMID33947818 PMCIDPMC8126862 DivisionProtein & Nucleic Acid Chemistry
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) AuthorsKlionsky D. J., et al (including Randow F., Masson G. R..) Journal Autophagy 1-382. 8 February 2021 (2021)
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  DOI10.1080/15548627.2020.1797280 PMID33634751 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Publisher Correction: The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens AuthorsCanton J., Blees H., Henry C. M., Buck M. D., Schulz O., Rogers N. C., Childs E., Zelenay S., Rhys H., Domart M. C., Collinson L., Alloatti A., Ellison C. J., Amigorena S., Papayannopoulos V., Thomas D. C., Randow F., Reis E Sousa C. Journal Nature Immunology 22(3):391. 2 February 2021 (2021)
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  DOI10.1038/s41590-021-00885‑6 PMID33531713 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens AuthorsCanton J., Blees H., Henry C. M., Buck M. D., Schulz O., Rogers N. C., Childs E., Zelenay S., Rhys H., Domart M. C., Collinson L., Alloatti A., Ellison C. J., Amigorena S., Papayannopoulos V., Thomas D. C., Randow F., Reis E Sousa C. Journal Nature Immunology 22(2):140-153. February 2021 (2021)
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  DOI10.1038/s41590-020-00824‑x PMID33349708 PMCIDPMC7116638 DivisionProtein & Nucleic Acid Chemistry
• Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles AuthorsEllison C. J., Kukulski W., Boyle K. B. , Munro S., Randow F. Journal Current Biology : CB 30(15):2974-2983.e6. 3 August 2020 (2020)
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  DOI10.1016/j. Cub.2020.05.083 PMID32649908 PMCIDPMC7416114 DivisionProtein & Nucleic Acid Chemistry. Cell Biology
• Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms AuthorsWandel M. P., Kim B. H., Park E. S., Boyle K. B., Nayak K., Lagrange B., Herod A., Henry T., Zilbauer M., Rohde J., MacMicking J. D., Randow F. Journal Nature Immunology 21(8):880-891. August 2020 (2020)
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  DOI10.1038/s41590-020-0697‑2 PMID32541830 PMCIDPMC7381384 DivisionProtein & Nucleic Acid Chemistry
• CALCOCO2/NDP52 initiates selective autophagy through recruitment of ULK and TBK1 kinase complexes AuthorsBoyle K. B., Ravenhill B. J., Randow F. Journal Autophagy 15(9):1655-1656, July 2019 (2019)
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  DOI10.1080/15548627.2019.1628548 PMID31258038 PMCIDPMC6693467 DivisionProtein & Nucleic Acid Chemistry
• The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria AuthorsRavenhill B. J., Boyle K. B., von Muhlinen N., Ellison C. J., Masson G. R., Otten E. G., Foeglein A., Williams R., Randow F. Journal Molecular Cell 74(2):320-329.e6. 18 April 2019 (2019)
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  DOI10.1016/j.molcel.2019.01.041 PMID30853402 PMCIDPMC6477152 DivisionProtein & Nucleic Acid Chemistry
• Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy AuthorsVargas J. N. S., Wang C., Bunker E., Hao L., Maric D., Schiavo G., Randow F., Youle R. J. Journal Molecular Cell 74(2):347-362.e6. 18 April 2019 (2019)
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  DOI10.1016/j.molcel.2019.02.010 PMID30853401 PMCIDPMC6642318 DivisionProtein & Nucleic Acid Chemistry
• Measuring Antibacterial Autophagy AuthorsBoyle K. B., Randow F. Journal Methods in Molecular Biology 1880:679-690. 5 January 2019 (2019)
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  DOI10.1007/978-1-4939-8873-0_45 PMID30610731 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Galectin-8-mediated selective autophagy protects against seeded tau aggregation AuthorsFalcon B., Noad J., McMahon H., Randow F., Goedert M. Journal Journal of Biological Chemistry 293(7):2438-2451. 16 February 2018 (2018)
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  DOI10.1074/jbc. M117.809293 PMID29282296 PMCIDPMC5818177 DivisionProtein & Nucleic Acid Chemistry, Neurobiology
• GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8 AuthorsWandel M. P., Pathe C., Werner E. I., Ellison C. J., Boyle K. B., von der Malsburg A., Rohde J., Randow F. Journal Cell Host & Microbe 22(4):507-518.e5. 11 October 2017 (2017)
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  DOI10.1016/j. Chom.2017.09.007 PMID29024643 PMCIDPMC5644667 DivisionProtein & Nucleic Acid Chemistry
• LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB AuthorsNoad J., von der Malsburg A., Pathe C., Michel M. A., Komander D., Randow F. Journal Nature Microbiology 2:17063. 8 May 2017 (2017)
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  DOI10.1038/nmicrobiol.2017.63 PMID28481331 PMCIDPMC5576533 DivisionProtein & Nucleic Acid Chemistry
• Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation AuthorsKomander D., Randow F. Journal Cell Host & Microbe 21(2):127-129. 8 February 2017 (2017)
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  DOI10.1016/j. Chom.2017.01.014 PMID28182945 PMCID  DivisionProtein & Nucleic Acid Chemistry
• TBK1 directs WIPI2 against Salmonella AuthorsBoyle K. B., Thurston T. L., Randow F. Journal Autophagy 12(12):2508-2509. 18 October 2016 (2016)
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  DOI10.1080/15548627.2016.1235126 PMID27753515 PMCIDPMC5172500 DivisionProtein & Nucleic Acid Chemistry
• Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy AuthorsThurston T. L., Boyle K. B., Allen M., Ravenhill B. J., Karpiyevich M., Bloor S., Kaul A., Noad J., Foeglein A., Matthews S. A., Komander D., Bycroft M., Randow F. Journal EMBO Journal 35(16):1779-92. 15 August 2016 (2016)
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  DOI10.15252/embj.201694491 PMID27370208 PMCIDPMC5010046 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Rubicon swaps autophagy for LAP AuthorsBoyle K. B., Randow F. Journal Nature Cell Biology 17(7):843-845. July 2015 (2015)
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  DOI10.1038/ncb3197 PMID26123110 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins AuthorsBoname J. M., Bloor S., Wandel M. P., Nathan J. A., Antrobus R., Dingwell K. S., Thurston T. L., Smith D. L., Smith J. C., Randow F., Lehner P. J. Journal Journal of Cell Biology 205(6):847-862. 23 June 2014 (2014)
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  DOI10.1083/jcb.201312009 PMID24958774 PMCIDPMC4068138 DivisionProtein & Nucleic Acid Chemistry
• Self and nonself: how autophagy targets mitochondria and bacteria AuthorsRandow F., Youle R. J. Journal Cell Host & Microbe 15(4):403-411. 9 April 2014 (2014)
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  DOI10.1016/j. Chom.2014.03.012 PMID24721569 PMCIDPMC4238923 DivisionProtein & Nucleic Acid Chemistry
• A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability. AuthorsBeale R., Wise H., Stuart A., Ravenhill B. J., Digard P., Randow F. Journal Cell Host & Microbe 15(2):239-247. 12 February 2014 (2014)
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  DOI10.1016/j. Chom.2014.01.006 PMID24528869 PMCIDPMC3991421 DivisionProtein & Nucleic Acid Chemistry
• The role of 'eat-me' signals and autophagy cargo receptors in innate immunity AuthorsBoyle K. B., Randow F. Journal Current Opinion in Microbiology 16(3):339-348. June 2013 (2013)
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  DOI10.1016/j.mib.2013.03.010 PMID23623150 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cellular self-defense: how cell-autonomous immunity protects against pathogens AuthorsRandow F., MacMicking J. D., James L. C. Journal Science 340(6133):701-706. 10 May 2013 (2013)
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  DOI10.1126/science.1233028 PMID23661752 PMCID  DivisionProtein & Nucleic Acid Chemistry
• An essential role for the ATG8 ortholog LC3C in antibacterial autophagy Authorsvon Muhlinen N., Akutsu M., Ravenhill B. J., Foeglein Á., Bloor S., Rutherford T. J., Freund S. M., Komander D., Randow F. Journal Autophagy 9(5):784-786. May 2013 (2013)
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  DOI10.4161/auto.23698 PMID23434839 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy AuthorsLi S., Wandel M. P., Li F., Liu Z., He C., Wu J., Shi Y., Randow F. Journal Science Signaling 6(261):ra9. 5 February 2013 (2013)
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  DOI10.1126/scisignal.2003730 PMID23386746 PMCIDPMC3713453 DivisionProtein & Nucleic Acid Chemistry
• LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy Authorsvon Muhlinen N., Akutsu M., Ravenhill B. J., Foeglein Á., Bloor S., Rutherford T. J., Freund S. M., Komander D., Randow F. Journal Molecular Cell 48(3):329-342. 9 November 2012 (2012)
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  DOI10.1016/j.molcel.2012.08.024 PMID23022382 PMCIDPMC3510444 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Autophagy in the regulation of pathogen replication and adaptive immunity AuthorsRandow F., Münz C. Journal Trends in Immunology 33(10):475-487. October 2012 (2012)
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  DOI10.1016/j.it.2012.06.003 PMID22796170 PMCIDPMC3461100 DivisionProtein & Nucleic Acid Chemistry
• Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells AuthorsDuncan L. M., Timms R. T., Zavodszky E., Cano F., Dougan G., Randow F., Lehner P. J. Journal PloS one 7(6):e39651. 22 June 2012 (2012)
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  DOI10.1371/journal.pone.0039651 PMID22745803 PMCIDPMC3382162 DivisionProtein & Nucleic Acid Chemistry
• Guidelines for the use and interpretation of assays for monitoring autophagy AuthorsKlionsky D. J. .... Randow F. .... Williams R. L. et al Journal Autophagy 8(4):445-544. 1 April 2012 (2012)
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  DOI10.4161/auto.19496 PMID22966490 PMCIDPMC3404883 DivisionProtein & Nucleic Acid Chemistry
• Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6 AuthorsWeekes M. P., Antrobus R., Talbot S., Hör S., Simecek N., Smith D. L., Bloor S., Randow F., Lehner P. J. Journal Journal of Proteome Research 11(3):1475-1484. 2 March 2012 (2012)
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  DOI10.1021/pr201135e PMID22292497 PMCIDPMC3292266 DivisionProtein & Nucleic Acid Chemistry
• Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion AuthorsThurston T. L., Wandel M. P., von Muhlinen N., Foeglein A., Randow F. Journal Nature 482(7385):414-418. 16 February 2012 (2012)
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  DOI10.1038/nature10744 PMID22246324 PMCIDPMC3343631 DivisionProtein & Nucleic Acid Chemistry
• Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7 AuthorsUnterholzner L., Sumner R. P., Baran M., Ren H., Mansur D. S., Bourke N. M., Randow F., Smith G. L., Bowie A. G. Journal PLoS Pathogens 7(9):e1002247. September 2011 (2011)
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  DOI10.1371/journal.ppat.1002247 PMID21931555 PMCIDPMC3169548 DivisionProtein & Nucleic Acid Chemistry
• How cells deploy ubiquitin and autophagy to defend their cytosol from bacterial invasion AuthorsRandow F. Journal Autophagy 7(3): 304-309. March 2011 (2011)
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  DOI10.4161/auto.7.3.14539 PMID21193841 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus AuthorsBloor S., Maelfait J., Krumbach R., Beyaert R., Randow F. Journal Proceedings of the National Academy of Sciences, USA 107(15):6970-6975. 13 April 2010 (2010)
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  DOI10.1073/pnas.0908536107 PMID20351288 PMCIDPMC2872420 DivisionProtein & Nucleic Acid Chemistry
• NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria Authorsvon Muhlinen N., Thurston T., Ryzhakov G., Bloor S., Randow F. Journal Autophagy 6(2):288-289. February 2010 (2010)
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  DOI10.4161/auto.6.2.11118 PMID20104023 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria AuthorsThurston T. L. M., Ryzhakov G., Bloor S., von Muhlinen N., Randow F. Journal Nature Immunology 10(11):1215-1221. November 2009 (2009)
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  DOI10.1038/ni.1800 PMID19820708 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Viral avoidance and exploitation of the ubiquitin system AuthorsFelix Randow, Paul J. Lehner Journal Nature Cell Biology 11(5):527-534. May 2009 (2009)
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  DOI10.1038/ncb0509‑527 PMID19404332 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation AuthorsSimin Rahighi, Fumiyo Ikeda, Masato Kawasaki, Masato Akutsu, Nobuhiro Suzuki, Ryuichi Kato, Tobias Kensche, Tamami Uejima, Stuart Bloor, David Komander, Felix Randow, Soichi Wakatsuki, Ivan Dikic Journal Cell 136(6):1098-1109 (2009) (2009)
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  DOI10.1016/j. Cell.2009.03.007 PMID19303852 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Signal processing by its coil zipper domain activates IKK gamma AuthorsBloor S., Ryzhakov G., Wagner S., P. Butler P. J. G., Smith D. L., Krumbach R., Dikic I., Randow F. Journal Proceedings of the National Academy of Sciences of the United States of America 105(4):1279-1284 (2008)
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  DOI10.1073/pnas.0706552105 PMID18216269 PMCIDPMC2234129 DivisionProtein & Nucleic Acid Chemistry
• Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. AuthorsMilka Sarris, Kristian G. Andersen, Felix Randow, Luzia Mayr, Alexander G. Betz Journal Immunity 28(3): 402-13 (2008)
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  DOI  PMID18328743 PMCIDPMC2726439 Division 
• Inhibition of IkappaB kinase by vaccinia virus virulence factor B14 AuthorsRon A.-J Chen, Grigory Ryzhakov, Samantha Cooray, Felix Randow, Geoffrey L. Smith Journal PLoS Pathogens 4 (2): e22 (2008)
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  DOI  PMID18266467 PMCIDPMC2233672 Division 
• Somatic Cell Genetics for the Study of NF-kappaB Signalling in Innate Immunity AuthorsRebekka Krumbach, Stuart Bloor, Grigory Ryzhakov, Felix Randow Journal Science Signalling 1 (39): pt 7 (2008)
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  DOI  PMID18827221 PMCID  Division 
• SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK AuthorsGrigory Ryzhakov, Felix Randow Journal EMBO Journal 26(13): 3180-3190. 11 July 2007 (2007)
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  DOI10.1038/sj.emboj.7601743 PMID17568778 PMCIDPMC1914091 Division