Published Research
Found 51 results for Randow.
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Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213
AuthorsNaydenova K., Boyle K.B., Pathe C., Pothukuchi P., Crespillo-Casado A., Scharte F., Hammoudi P.M., Otten E.G., Alto N.M., Randow F.
Journal
Nature Structural & Molecular Biology
(2025)
Details
DOIdoi.org/10.1038/s41594-025-01530-8 PMID40205224 PMCID DivisionProtein & Nucleic Acid Chemistry -
Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation
Authorsde la Peña A., Retamal C., Pérez-Molina F., Díaz-Valdivia N., Veloso-Bahamondes F., Tapia D., Cancino J., Randow F., González A., Oyanadel C., Soza A.
Journal
European Journal of Cell Biology
104(2):151488 (2025)
Details
DOIdoi.org/10.1016/j.ejcb.2025.151488 PMID40209344 PMCIDPMC12162348 DivisionProtein & Nucleic Acid Chemistry -
Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213
AuthorsCrespillo-Casado A., Pothukuchi P., Naydenova K., Yip M. C. J., Young J. M., Boulanger J., Dharamdasani V., Harper C., Hammoudi P. M., Otten E. G., Boyle K., Gogoi M., Malik H. S., Randow F.
Journal
EMBO Reports
25(11):4979-5005 (2024)
Details
DOI10.1038/s44319-024-00280‑w PMID39375464 PMCIDPMC11549300 DivisionProtein & Nucleic Acid Chemistry - Ubiquitylation: Sword and shield in the bacterial arsenal AuthorsPruneda J. N., Randow F. Journal Molecular Cell 84(18):3378-3380 (2024)
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TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure
AuthorsBoyle K. B., Ellison C. J., Elliott P. R., Schuschnig M., Grimes K., Dionne M. S., Sasakawa C., Munro S., Martens S., Randow F.
Journal
The EMBO Journal
42(17):e113012 (2023)
Details
DOI10.15252/embj.2022113012 PMID37409490 PMCIDPMC10476172 DivisionProtein & Nucleic Acid Chemistry - Comparative study of GBP recruitment on two cytosol-dwelling pathogens, Francisella novicida and Shigella flexneri highlights differences in GBP repertoire and in GBP1 motif requirements AuthorsValeva S. V., Degabriel M., Michal F., Gay G., Rohde J. R., Randow F., Lagrange B., Henry T. Journal Pathogens and Disease 81:ftad005 (2023)
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Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection
AuthorsWu X, et al (including Randow F.)
Journal
EMBO Reports
22(7):e51678. 5 July 2021 (2021)
Details
DOI10.15252/embr.202051678 PMID33987949 PMCIDPMC8256295 DivisionProtein & Nucleic Acid Chemistry -
Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome
AuthorsLulla V., Wandel M. P., Bandyra K. J., Ulferts R., Wu M., Dendooven T., Yang X., Doyle N., Oerum S., Beale R., O'Rourke S. M., Randow F., Maier H. J., Scott W., Ding Y., Firth A. E., Bloznelyte K., Luisi B. F.
Journal
Journal of Virology
95(14):e0066321. July 2021 (2021)
Details
DOI10.1128/jvi.00663‑21 PMID33963053 PMCIDPMC8223950 DivisionProtein & Nucleic Acid Chemistry -
Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection
AuthorsOtten E. G., Werner E., Crespillo-Casado A., Boyle K. B., Dharamdasani V., Pathe C., Santhanam B., Randow F.
Journal
Nature
594(7861):111-116. 3 June 2021 (2021)
Details
DOI10.1038/s41586-021-03566-4 PMID34012115 PMCIDPMC7610904 DivisionProtein & Nucleic Acid Chemistry -
SIK2 orchestrates actin-dependent host response upon Salmonella infection
AuthorsHahn M., Covarrubias-Pinto A., Herhaus L., Satpathy S., Klann K., Boyle K. B., Münch C., Rajalingam K., Randow F., Choudhary C., Dikic I.
Journal
Proceedings of the National Academy of Sciences of the United States of America
118(19): e2024144118. 11 May 2021 (2021)
Details
DOI10.1073/pnas.2024144118 PMID33947818 PMCIDPMC8126862 DivisionProtein & Nucleic Acid Chemistry -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
AuthorsKlionsky D. J., et al (including Randow F., Masson G. R..)
Journal
Autophagy
1-382. 8 February 2021 (2021)
Details
DOI10.1080/15548627.2020.1797280 PMID33634751 PMCID DivisionProtein & Nucleic Acid Chemistry - Publisher Correction: The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens AuthorsCanton J., Blees H., Henry C. M., Buck M. D., Schulz O., Rogers N. C., Childs E., Zelenay S., Rhys H., Domart M. C., Collinson L., Alloatti A., Ellison C. J., Amigorena S., Papayannopoulos V., Thomas D. C., Randow F., Reis E Sousa C. Journal Nature Immunology 22(3):391. 2 February 2021 (2021)
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The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
AuthorsCanton J., Blees H., Henry C. M., Buck M. D., Schulz O., Rogers N. C., Childs E., Zelenay S., Rhys H., Domart M. C., Collinson L., Alloatti A., Ellison C. J., Amigorena S., Papayannopoulos V., Thomas D. C., Randow F., Reis E Sousa C.
Journal
Nature Immunology
22(2):140-153. February 2021 (2021)
Details
DOI10.1038/s41590-020-00824‑x PMID33349708 PMCIDPMC7116638 DivisionProtein & Nucleic Acid Chemistry -
Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles
AuthorsEllison C. J., Kukulski W., Boyle K. B. , Munro S., Randow F.
Journal
Current Biology : CB
30(15):2974-2983.e6. 3 August 2020 (2020)
Details
DOI10.1016/j. Cub.2020.05.083 PMID32649908 PMCIDPMC7416114 DivisionProtein & Nucleic Acid Chemistry. Cell Biology -
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms
AuthorsWandel M. P., Kim B. H., Park E. S., Boyle K. B., Nayak K., Lagrange B., Herod A., Henry T., Zilbauer M., Rohde J., MacMicking J. D., Randow F.
Journal
Nature Immunology
21(8):880-891. August 2020 (2020)
Details
DOI10.1038/s41590-020-0697‑2 PMID32541830 PMCIDPMC7381384 DivisionProtein & Nucleic Acid Chemistry -
CALCOCO2/NDP52 initiates selective autophagy through recruitment of ULK and TBK1 kinase complexes
AuthorsBoyle K. B., Ravenhill B. J., Randow F.
Journal
Autophagy
15(9):1655-1656, July 2019 (2019)
Details
DOI10.1080/15548627.2019.1628548 PMID31258038 PMCIDPMC6693467 DivisionProtein & Nucleic Acid Chemistry -
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria
AuthorsRavenhill B. J., Boyle K. B., von Muhlinen N., Ellison C. J., Masson G. R., Otten E. G., Foeglein A., Williams R., Randow F.
Journal
Molecular Cell
74(2):320-329.e6. 18 April 2019 (2019)
Details
DOI10.1016/j.molcel.2019.01.041 PMID30853402 PMCIDPMC6477152 DivisionProtein & Nucleic Acid Chemistry -
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
AuthorsVargas J. N. S., Wang C., Bunker E., Hao L., Maric D., Schiavo G., Randow F., Youle R. J.
Journal
Molecular Cell
74(2):347-362.e6. 18 April 2019 (2019)
Details
DOI10.1016/j.molcel.2019.02.010 PMID30853401 PMCIDPMC6642318 DivisionProtein & Nucleic Acid Chemistry - Measuring Antibacterial Autophagy AuthorsBoyle K. B., Randow F. Journal Methods in Molecular Biology 1880:679-690. 5 January 2019 (2019)
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Galectin-8-mediated selective autophagy protects against seeded tau aggregation
AuthorsFalcon B., Noad J., McMahon H., Randow F., Goedert M.
Journal
Journal of Biological Chemistry
293(7):2438-2451. 16 February 2018 (2018)
Details
DOI10.1074/jbc. M117.809293 PMID29282296 PMCIDPMC5818177 DivisionProtein & Nucleic Acid Chemistry, Neurobiology -
GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8
AuthorsWandel M. P., Pathe C., Werner E. I., Ellison C. J., Boyle K. B., von der Malsburg A., Rohde J., Randow F.
Journal
Cell Host & Microbe
22(4):507-518.e5. 11 October 2017 (2017)
Details
DOI10.1016/j. Chom.2017.09.007 PMID29024643 PMCIDPMC5644667 DivisionProtein & Nucleic Acid Chemistry -
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB
AuthorsNoad J., von der Malsburg A., Pathe C., Michel M. A., Komander D., Randow F.
Journal
Nature Microbiology
2:17063. 8 May 2017 (2017)
Details
DOI10.1038/nmicrobiol.2017.63 PMID28481331 PMCIDPMC5576533 DivisionProtein & Nucleic Acid Chemistry - Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation AuthorsKomander D., Randow F. Journal Cell Host & Microbe 21(2):127-129. 8 February 2017 (2017)
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TBK1 directs WIPI2 against Salmonella
AuthorsBoyle K. B., Thurston T. L., Randow F.
Journal
Autophagy
12(12):2508-2509. 18 October 2016 (2016)
Details
DOI10.1080/15548627.2016.1235126 PMID27753515 PMCIDPMC5172500 DivisionProtein & Nucleic Acid Chemistry -
Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy
AuthorsThurston T. L., Boyle K. B., Allen M., Ravenhill B. J., Karpiyevich M., Bloor S., Kaul A., Noad J., Foeglein A., Matthews S. A., Komander D., Bycroft M., Randow F.
Journal
EMBO Journal
35(16):1779-92. 15 August 2016 (2016)
Details
DOI10.15252/embj.201694491 PMID27370208 PMCIDPMC5010046 DivisionProtein & Nucleic Acid Chemistry, Structural Studies - Rubicon swaps autophagy for LAP AuthorsBoyle K. B., Randow F. Journal Nature Cell Biology 17(7):843-845. July 2015 (2015)
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Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins
AuthorsBoname J. M., Bloor S., Wandel M. P., Nathan J. A., Antrobus R., Dingwell K. S., Thurston T. L., Smith D. L., Smith J. C., Randow F., Lehner P. J.
Journal
Journal of Cell Biology
205(6):847-862. 23 June 2014 (2014)
Details
DOI10.1083/jcb.201312009 PMID24958774 PMCIDPMC4068138 DivisionProtein & Nucleic Acid Chemistry -
Self and nonself: how autophagy targets mitochondria and bacteria
AuthorsRandow F., Youle R. J.
Journal
Cell Host & Microbe
15(4):403-411. 9 April 2014 (2014)
Details
DOI10.1016/j. Chom.2014.03.012 PMID24721569 PMCIDPMC4238923 DivisionProtein & Nucleic Acid Chemistry -
A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability.
AuthorsBeale R., Wise H., Stuart A., Ravenhill B. J., Digard P., Randow F.
Journal
Cell Host & Microbe
15(2):239-247. 12 February 2014 (2014)
Details
DOI10.1016/j. Chom.2014.01.006 PMID24528869 PMCIDPMC3991421 DivisionProtein & Nucleic Acid Chemistry - The role of 'eat-me' signals and autophagy cargo receptors in innate immunity AuthorsBoyle K. B., Randow F. Journal Current Opinion in Microbiology 16(3):339-348. June 2013 (2013)
- Cellular self-defense: how cell-autonomous immunity protects against pathogens AuthorsRandow F., MacMicking J. D., James L. C. Journal Science 340(6133):701-706. 10 May 2013 (2013)
- An essential role for the ATG8 ortholog LC3C in antibacterial autophagy Authorsvon Muhlinen N., Akutsu M., Ravenhill B. J., Foeglein Á., Bloor S., Rutherford T. J., Freund S. M., Komander D., Randow F. Journal Autophagy 9(5):784-786. May 2013 (2013)
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Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy
AuthorsLi S., Wandel M. P., Li F., Liu Z., He C., Wu J., Shi Y., Randow F.
Journal
Science Signaling
6(261):ra9. 5 February 2013 (2013)
Details
DOI10.1126/scisignal.2003730 PMID23386746 PMCIDPMC3713453 DivisionProtein & Nucleic Acid Chemistry -
LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Authorsvon Muhlinen N., Akutsu M., Ravenhill B. J., Foeglein Á., Bloor S., Rutherford T. J., Freund S. M., Komander D., Randow F.
Journal
Molecular Cell
48(3):329-342. 9 November 2012 (2012)
Details
DOI10.1016/j.molcel.2012.08.024 PMID23022382 PMCIDPMC3510444 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
Autophagy in the regulation of pathogen replication and adaptive immunity
AuthorsRandow F., Münz C.
Journal
Trends in Immunology
33(10):475-487. October 2012 (2012)
Details
DOI10.1016/j.it.2012.06.003 PMID22796170 PMCIDPMC3461100 DivisionProtein & Nucleic Acid Chemistry -
Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells
AuthorsDuncan L. M., Timms R. T., Zavodszky E., Cano F., Dougan G., Randow F., Lehner P. J.
Journal
PloS one
7(6):e39651. 22 June 2012 (2012)
Details
DOI10.1371/journal.pone.0039651 PMID22745803 PMCIDPMC3382162 DivisionProtein & Nucleic Acid Chemistry - Guidelines for the use and interpretation of assays for monitoring autophagy AuthorsKlionsky D. J. .... Randow F. .... Williams R. L. et al Journal Autophagy 8(4):445-544. 1 April 2012 (2012)
- Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6 AuthorsWeekes M. P., Antrobus R., Talbot S., Hör S., Simecek N., Smith D. L., Bloor S., Randow F., Lehner P. J. Journal Journal of Proteome Research 11(3):1475-1484. 2 March 2012 (2012)
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Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
AuthorsThurston T. L., Wandel M. P., von Muhlinen N., Foeglein A., Randow F.
Journal
Nature
482(7385):414-418. 16 February 2012 (2012)
Details
DOI10.1038/nature10744 PMID22246324 PMCIDPMC3343631 DivisionProtein & Nucleic Acid Chemistry -
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
AuthorsUnterholzner L., Sumner R. P., Baran M., Ren H., Mansur D. S., Bourke N. M., Randow F., Smith G. L., Bowie A. G.
Journal
PLoS Pathogens
7(9):e1002247. September 2011 (2011)
Details
DOI10.1371/journal.ppat.1002247 PMID21931555 PMCIDPMC3169548 DivisionProtein & Nucleic Acid Chemistry - How cells deploy ubiquitin and autophagy to defend their cytosol from bacterial invasion AuthorsRandow F. Journal Autophagy 7(3): 304-309. March 2011 (2011)
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Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus
AuthorsBloor S., Maelfait J., Krumbach R., Beyaert R., Randow F.
Journal
Proceedings of the National Academy of Sciences, USA
107(15):6970-6975. 13 April 2010 (2010)
Details
DOI10.1073/pnas.0908536107 PMID20351288 PMCIDPMC2872420 DivisionProtein & Nucleic Acid Chemistry - NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria Authorsvon Muhlinen N., Thurston T., Ryzhakov G., Bloor S., Randow F. Journal Autophagy 6(2):288-289. February 2010 (2010)
- The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria AuthorsThurston T. L. M., Ryzhakov G., Bloor S., von Muhlinen N., Randow F. Journal Nature Immunology 10(11):1215-1221. November 2009 (2009)
- Viral avoidance and exploitation of the ubiquitin system AuthorsFelix Randow, Paul J. Lehner Journal Nature Cell Biology 11(5):527-534. May 2009 (2009)
- Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation AuthorsSimin Rahighi, Fumiyo Ikeda, Masato Kawasaki, Masato Akutsu, Nobuhiro Suzuki, Ryuichi Kato, Tobias Kensche, Tamami Uejima, Stuart Bloor, David Komander, Felix Randow, Soichi Wakatsuki, Ivan Dikic Journal Cell 136(6):1098-1109 (2009) (2009)
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Signal processing by its coil zipper domain activates IKK gamma
AuthorsBloor S., Ryzhakov G., Wagner S., P. Butler P. J. G., Smith D. L., Krumbach R., Dikic I., Randow F.
Journal
Proceedings of the National Academy of Sciences of the United States of America
105(4):1279-1284 (2008)
Details
DOI10.1073/pnas.0706552105 PMID18216269 PMCIDPMC2234129 DivisionProtein & Nucleic Acid Chemistry - Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. AuthorsMilka Sarris, Kristian G. Andersen, Felix Randow, Luzia Mayr, Alexander G. Betz Journal Immunity 28(3): 402-13 (2008)
- Inhibition of IkappaB kinase by vaccinia virus virulence factor B14 AuthorsRon A.-J Chen, Grigory Ryzhakov, Samantha Cooray, Felix Randow, Geoffrey L. Smith Journal PLoS Pathogens 4 (2): e22 (2008)
- Somatic Cell Genetics for the Study of NF-kappaB Signalling in Innate Immunity AuthorsRebekka Krumbach, Stuart Bloor, Grigory Ryzhakov, Felix Randow Journal Science Signalling 1 (39): pt 7 (2008)
- SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK AuthorsGrigory Ryzhakov, Felix Randow Journal EMBO Journal 26(13): 3180-3190. 11 July 2007 (2007)