Published Research

Found 55 results for Passmore.

• Phosphorylation-dependent tuning of mRNA deadenylation rates AuthorsJames A. W. Stowell, Conny W. H. Yu, Zhuo A. Chen, Lily K. DeBell, Giselle Lee, Tomos Morgan, Ludwig Sinn, Sylvie Agnello, Francis J. O'Reilly, Juri Rappsilber, Stefan M. V. Freund, Lori A. Passmore Journal Nature Structural & Molecular Biology (2025)
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  DOI10.1002/2211-5463.70124 PMID41184513 PMCIDPMC12767764 DivisionStructural Studies
• A kinetic ruler controls mRNA poly(A) tail length AuthorsGabs E., Aalto-Setälä E., Välisaari A., Malinen A.M., Jensen T.H., McLaughlin S.H., Passmore L.A., Turtola M. Journal Genes & Development (2025)
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  DOI10.1101/gad.352912.125 PMID40846642 PMCID  DivisionStructural Studies
• FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions AuthorsAlcón P, Kaczmarczyk AP, Ray KK, Liolios T, Guilbaud G, Sijacki T, Shen Y, McLaughlin SH, Sale JE, Knipscheer P, Rueda DS, Passmore LA. Journal Nature 10.1038/s41586-024-07770-w (2024)
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  DOI10.1038/s41586-024-07770‑w PMID39085614 PMCID  DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• A CPF-like phosphatase module links transcription termination to chromatin silencing AuthorsMateo-Bonmatí E, Montez M, Maple R, Fiedler M, Fang X, Saalbach G, Passmore LA, Dean C. Journal Molecular Cell Mol Cell. 2024 Jun 20;84(12):2272-2286.e7. doi: 10.1016/j.molcel.2024.05.016. Epub 2024 Jun 7. (2024)
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  DOI10.1016/j.molcel.2024.05.016 PMID38851185 PMCIDPMC7616277 DivisionStructural Studies
• Mechanisms of transcription and RNA processing AuthorsPassmore LA, Zhang S. Journal Nature Structural & Molecular Biology 31(5):730-731 (2024)
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  DOI10.1038/s41594-024-01312‑8 PMID38744993 PMCID  DivisionStructural Studies
• AlphaFold: Research accelerator and hypothesis generator AuthorsCampbell E. A., Walden H., Walter J. C., Shukla A. K ., Beck M., Passmore L. A ., Xu H. E. Journal Molecular Cell 84(3):404-408. (2024)
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  DOI10.1016/j.molcel.2023.12.035 PMID38306999 PMCID  DivisionStructural Studies
• A direct interaction between CPF and RNA Pol II links RNA 3' end processing to transcription AuthorsCarminati M, Rodríguez-Molina JB, Manav MC, Bellini D, Passmore LA. Journal Molecular Cell 83(24):4461-4478.e13 (2023)
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  DOI10.1016/j.molcel.2023.11.004 PMID38029752 PMCIDPMC10783616 DivisionStructural Studies
• Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4‑NOT AuthorsAbsmeier E., Chandrasekaran V., O'Reilly F. J., Stowell J. A. W., Rappsilber J., Passmore L. A.. Journal Nature Structural & Molecular Biology 30(9):1314-1322 (2023)
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  DOI30(9):1314‑1322 PMID37653243 PMCIDPMC7615087 DivisionStructural Studies
• Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation AuthorsHöpfler M., Absmeier E., Peak-Chew S. Y., Vartholomaiou E., Passmore L. A.,. Gasic I., Hegde R. S. Journal Molecular Cell 83(13):2290-2302.e13 (2023)
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  DOI10.1016/j.molcel.2023.05.020 PMID37295431 PMCIDPMC10403363 DivisionCell Biology
• In conversation with Lori Passmore AuthorsDhillon P., Skourti E., Passmore L. A. Journal The FEBS Journal (2023)
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  DOI10.1111/febs.16782 PMID37138518 PMCID  DivisionStructural Studies
• 3'-End Processing of eukaryotic mRNA: Machinery, regulation, and impact on gene expression AuthorsBoreikaitė V., Passmore L. A. Journal Annual Review of Biochemistry 92:199-225 (2023)
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  DOI10.1146/annurev-biochem-052521‑012445 PMID37001138 PMCIDPMC7614891 DivisionStructural Studies
• Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII AuthorsRodríguez-Molina J. B., West S., Passmore L. A. Journal Molecular Cell 83(3):404-415 (2023)
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  DOI10.1016/j.molcel.2022.12.021 PMID36634677 PMCIDPMC7614299 DivisionStructural Studies
• The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination AuthorsSijacki T., Alcón P., Chen Z.A., McLaughlin S.H., Shakeel S., Rappsilber J., Passmore L.A. Journal Nature Structural & Molecular Biology 29(9):881-890 (2022)
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  DOI10.1038/s41594-022-00820-9 PMID36050501 PMCIDPMC7613635 DivisionProtein & Nucleic Acid Chemistry, Structural Studied
• Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF AuthorsRodríguez-Molina J.B., O'Reilly F.J., Fagarasan H., Sheekey E., Maslen S., Skehel J.M., Rappsilber J., Passmore L.A. Journal Molecular Cell 82(13):2490-2504.e12 (2022)
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  DOI10.1016/j.molcel.2022.04.021 PMID35584695 PMCIDPMC9380774 DivisionStructural Studies, Cell Biology
• Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression AuthorsPassmore L. A., Coller J. Journal Nature reviews. Molecular Cell Biology 23(2):93-106 (2022)
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  DOI10.1038/s41580-021-00417-y PMID34594027 PMCID  DivisionStructural Studies
• RBBP6 activates the pre-mRNA 3' end processing machinery in humans AuthorsBoreikaite V., Elliott T. S., Chin J. W., Passmore L. A. Journal Genes & Development 36(3-4):210-224 (2022)
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  DOI10.1101/gad.349223.121 PMID35177536 PMCIDPMC8887125 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing AuthorsKumar A., Yu C. W. H., Rodríguez-Molina J. B., Li X. H., Freund S. M. V., Passmore L. A. Journal Genes & Development 35(21-22):1510-1526 (2021)
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  DOI10.1101/gad.348671.121 PMID34593603 PMCIDPMC8559680 DivisionStructural Studies, Cell Biology
• Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae AuthorsTurtola M., Manav M. C., Kumar A., Tudek A., Mroczek S., Krawczyk P. S., Dziembowski A., Schmid M., Passmore L. A., Casañal A., Jensen T. H. Journal Genes & Development 35(17-18):1290-1303 (2021)
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  DOI10.1101/gad.348634.121 PMID34385261 PMCIDPMC8415320 DivisionStructural Studies
• The long and short of it AuthorsPassmore L. A., Tang T. T. Journal Elife 10:e66493. 2 July 2021 (2021)
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  DOI10.7554/elife.70757 PMID34213415 PMCIDPMC8253592 DivisionStructural Studies
• Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM AuthorsFarrell D. P., Ivan Anishchenko I., Shakeel S., Lauko A., Passmore L. A., Bakera D., DiMaioa F. Journal Iucrj 7(Pt 5):881-892 (2020)
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  DOI10.1107/s2052252520009306 PMID32939280 PMCIDPMC7467173 DivisionStructural Studies
• Recognition of Poly(A) RNA through Its Intrinsic Helical Structure AuthorsTang T. T. L., Passmore L. A. Journal Cold Spring Harbor Symposia on Quantitative Biology 84:21-30. 15 April 2020 (2020)
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  DOI10.1101/sqb.2019.84.039818 PMID32295929 PMCIDPMC7116106 DivisionStructural Studies
• FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair AuthorsAlcón P., Shakeel S., Chen Z. A., Rappsilber J., Patel K. J., Passmore L. A. Journal Nature Structural & Molecular Biology 27(3):240-248. March 2020 (2020)
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  DOI10.1038/s41594-020-0380‑1 PMID32066963 PMCIDPMC7067600 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma AuthorsRoss N. T., Lohmann F., Carbonneau S., Fazal A., Weihofen W. A., Gleim S., Salcius M., Sigoillot F., Henault M., Carl S. H., Rodríguez-Molina J. B., Miller H. R., Brittain S. M., Murphy J., Zambrowski M., Boynton G., Wang Y., Chen A., Molind G. J., Wilbertz J. H., Artus-Revel C. G., Jia M., Akinjiyan F. A.,Turner J., Knehr J., Carbone W., Schuierer S., Reece-Hoyes J. S., Xie K., Saran C., Williams E. T., Roma G., Spencer M., Jenkins J., George E. L., Thomas J. R., Michaud G., Schirle M.,Tallarico J., Passmore L. A., Chao J. A., Beckwith R. E. J. Journal Nature Chemical Biology 16 (1), 50-59. January 2020 (2020)
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  DOI10.1038/s41589-019-0424-1 PMID31819276 PMCIDPMC7116157 DivisionStructural Studies
• Mechanistic insights into mRNA 3'-end processing AuthorsKumar A., Clerici M., Muckenfuss L. M., Passmore L. A., Jinek M. Journal Current Opinion in Structural Biology 59:143-150. December 2019 (2019)
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  DOI10.1016/j.sbi.2019.08.001 PMID31499460 PMCIDPMC6900580 DivisionStructural Studies
• Structure of the Fanconi anaemia monoubiquitin ligase complex AuthorsShakeel S., Rajendra E., Alcón P., O'Reilly F., Chorev D. S., Maslen S., Degliesposti G., Russo C. J., He S., Hill C. H., Skehel J. M., , Rappsilber J., Robinson C. V., Passmore L. A. Journal Nature 575(7781):234-237. 7 November 2019 (2019)
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  DOI10.1038/s41586-019-1703‑4 PMID31666700 PMCIDPMC6858856 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Interpretation of medium resolution cryoEM maps of multi-protein complexes AuthorsCasañal A., Shakeel S., Passmore L. A. Journal Current Opinion in Structural Biology 58:166-174. October 2019 (2019)
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  DOI10.1016/j.sbi.2019.06.009 PMID31362190 PMCIDPMC6863432 DivisionStructural Studies, Cell Biology
• Importance of the conserved carboxyl-terminal CNOT1 binding domain to tristetraprolin (TTP) activity in vivo AuthorsLai W. S., Stumpo D. J., Wells M. L., Gruzdev A., Hicks S. N., Nicholson C. O., Yang Z., Faccio R., Webster M. W., Passmore L. A., Blackshear P. J. Journal Molecular and Cellular Biology 39(13) e00029-19. 13 June 2019 (2019)
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  DOI10.1128/MCB.00029‑19 PMID31036567 PMCIDPMC6580703 DivisionStructural Studies
• The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases AuthorsTang T. T. L., Stowell J. A. W., Hill C. H., Passmore L A. Journal Nature Structural & Molecular Biology 26(6):433-442. 20 May 2019 (2019)
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  DOI10.1038/s41594-019-0227‑9 PMID31110294 PMCIDPMC6555765 DivisionStructural Studies
• Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex AuthorsHill C. H., Boreikaitė V., Kumar A., Casañal A., Kubík P., Degliesposti G., Maslen S., Mariani A., von Loeffelholz O., Girbig M., Skehel M, Passmore L. A. Journal Molecular Cell 73(6):1217-1231.e11. 21 March 2019 (2019)
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  DOI10.1016/j.molcel.2018.12.023 PMID30737185 PMCIDPMC6436931 DivisionStructural Studies
• RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4‑Not AuthorsWebster M. W., Stowell J. A., Passmore L. A. Journal ELife 8: e40670. 2 January 2019 (2019)
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  DOI10.7554/eLife.40670 PMID30601114 PMCIDPMC6340701 DivisionStructural Studies
• The APT complex is involved in non-coding RNA transcription and is distinct from CPF AuthorsLidschreiber M., Easter A. D., Battaglia S., Rodríguez-Molina J. B., Casañal A., Carminati M., Baejen C., Grzechnik P., Maier K. C., Cramer P., Passmore L. A. Journal Nucleic Acids Research 46(21):11528-11538. 30 November 2018 (2018)
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  DOI10.1093/nar/gky845 PMID30247719 PMCIDPMC6265451 DivisionStructural Studies
• mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases AuthorsWebster M. W., Chen Y. H., Stowell J. A. W., Alhusaini N., Sweet T., Graveley B. R., Coller J., Passmore L. A. Journal Molecular Cell 70(6):1089-1100.e8. 21 June 2018 (2018)
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  DOI10.1016/j.molcel.2018.05.033 PMID29932902 PMCIDPMC6024076 DivisionStructural Studies
• A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding AuthorsStowell J. A. W., Wagstaff J. L., Hill C. H., Yu M., McLaughlin S. H., Freund S. M. V., Passmore L. A. Journal Journal of Biological Chemistry 293(24):9210-9222. 15 June 2018 (2018)
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  DOI10.1074/jbc. RA118.002291 PMID29695507 PMCIDPMC6005420 DivisionStructural Studies, Protein & Nucleic Acid Chemistry, Cell Biology
• Architecture of eukaryotic mRNA 3'-end processing machinery AuthorsCasañal A., Kumar A., Hill C. H., Easter A. D., Emsley P., Degliesposti G., Gordiyenko Y., Santhanam B., Wolf J., Wiederhold K., Dornan G. L., Skehel M., Robinson C. V., Passmore L. A. Journal Science 358(6366):1056-1059. 24 November 2017 (2017)
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  DOI10.1126/science. Aao6535 PMID29074584 PMCIDPMC5788269 DivisionStructural Studies
• Analysis of mRNA deadenylation by multi-protein complexes AuthorsWebster M. W., Stowell J. A. W., Tang T. T. L., Passmore L. A. Journal Methods 126:95-104. 15 August 2017 (2017)
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  DOI10.1016/j.ymeth.2017.06.009 PMID28624538 PMCIDPMC5595164 DivisionStructural Studies
• Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1 AuthorsStowell J. A., Webster M. W., Kögel A., Wolf J., Shelley K. L., Passmore L. A. Journal Cell Reports 17(8):1978-1989. 15 November 2016 (2016)
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  DOI10.1016/j. Celrep.2016.10.066 PMID27851962 PMCIDPMC5120349 DivisionStructural Studies
• Macromolecular Complexes in Transcription and Co-Transcriptional RNA Processing AuthorsPassmore L. A., Taatjes D. J. Journal Journal of Molecular Biology 428(12):2539-2541. 19 June 2016 (2016)
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  DOI10.1016/j.jmb.2016.05.001 PMID27155574 PMCID  DivisionStructural Studies
• Specimen Preparation for High-Resolution Cryo‑EM AuthorsPassmore L. A., Russo C. J. Journal Methods in Enzymology 579:51-86. 16 June 2016 (2016)
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  DOI10.1016/bs.mie.2016.04.011 PMID27572723 PMCIDPMC5140023 DivisionStructural Studies
• Progress towards an optimal specimen support for electron cryomicroscopy AuthorsRusso C. J., Passmore L. A. Journal Current Opinion in Structural Biology 37:81-89. 1 April 2016 (2016)
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  DOI10.1016/j.sbi.2015.12.007 PMID26774849 PMCIDPMC4863039 DivisionStructural Studies
• Ultrastable gold substrates: Properties of a support for high-resolution electron cryomicroscopy of biological specimens AuthorsRusso C. J., Passmore L. A. Journal Journal of Structural Biology 193(1):33-44. January 2016 (2016)
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  DOI10.1016/j.jsb.2015.11.006 PMID26592474 PMCIDPMC4711342 DivisionStructural Studies
• Structural insights into the bacterial carbon-phosphorus lyase machinery AuthorsSeweryn P., Van L. B., Kjeldgaard M., Russo C. J., Passmore L. A., Hove-Jensen B., Jochimsen B., Brodersen D. E. Journal Nature 525(7567):68-72. 3 September 2015 (2015)
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  DOI10.1038/nature14683 PMID26280334 PMCIDPMC4617613 DivisionStructural Studies
• Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging AuthorsBharat T. A., Russo C. J., Löwe J., Passmore L. A., Scheres S. H. Journal Structure 23(9):1743-1753. 1 September 2015 (2015)
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  DOI10.1016/j.str.2015.06.026 PMID26256537 PMCIDPMC4559595 DivisionStructural Studies
• Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage AuthorsGibbs-Seymour I., Oka Y., Rajendra E., Weinert B. T., Passmore L. A., Patel K. J., Olsen J. V., Choudhary C., Bekker-Jensen S., Mailand N. Journal Molecular Cell 57(1):150-164. 8 January 2015 (2015)
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  DOI10.1016/j.molcel.2014.12.001 PMID25557546 PMCIDPMC4416315 DivisionStructural Studies, Protein & Nucleic Acid Chemistry
• Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases AuthorsRajendra E., Garaycoechea J. I., Patel K. J., Passmore L. A. Journal Nucleic Acids Research 42(22):13736-13748. 16 December 2014 (2014)
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  DOI10.1093/nar/gku1230 PMID25428364 PMCIDPMC4267650 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Ultrastable gold substrates for electron cryomicroscopy AuthorsPassmore, L. A., Russo, C. J. Journal Science 346 (6215) 1377-1380 (2014)
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  DOI10.1126/science.1259530 PMID  PMCID  DivisionStructural Studies
• Robust evaluation of 3D electron cryomicroscopy data using tilt‑pairs AuthorsRusso C. J., Passmore L. A. Journal Journal of Structural Biology 187(2):112-118. August 2014 (2014)
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  DOI10.1016/j.jsb.2014.06.006 PMID25016098 PMCIDPMC4136738 DivisionStructural Studies
• Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation AuthorsWolf J., Valkov E., Allen M. D., Meineke B., Gordiyenko Y., McLaughlin S. H., Olsen T. M., Robinson C. V., Bycroft M., Stewart M., Passmore L. A. Journal EMBO Journal 33(14):1514-1526. 17 July 2014 (2014)
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  DOI10.15252/embj.201488373 PMID24872509 PMCIDPMC4158885 DivisionStructural Studies
• The genetic and biochemical basis of FANCD2 monoubiquitination AuthorsRajendra E., Oestergaard V. H., Langevin F., Wang M., Dornan G. L., Patel K. J., Passmore L. A. Journal Molecular Cell 54(5):858-869. 5 June 2014 (2014)
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  DOI10.1016/j.molcel.2014.05.001 PMID24905007 PMCIDPMC4051986 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas AuthorsRusso C. J., Passmore L. A. Journal Nature Methods 11(6):649-652. June 2014 (2014)
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  DOI10.1038/nmeth.2931 PMID24747813 PMCIDPMC4141966 DivisionStructural Studies
• RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7 AuthorsSchreieck A., Easter A. D., Etzold S., Wiederhold K., Lidschreiber M., Cramer P., Passmore L. A. Journal Nature Structural & Molecular Biology 21(2):175-179. February 2014 (2014)
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  DOI10.1038/nsmb.2753 PMID24413056 PMCIDPMC3917824 DivisionStructural Studies
• mRNA deadenylation by Pan2‑Pan3 AuthorsWolf J., Passmore L. A. Journal Biochemical Society Transactions 42(1):184-187. February 2014 (2014)
  Details

  DOI10.1042/BST20130211 PMID24450649 PMCIDPMC3992365 DivisionStructural Studies
• The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity AuthorsBøggild A., Sofos N., Andersen K. R., Feddersen A., Easter A. D., Passmore L. A., Brodersen D. E. Journal Structure 20(10):1641-1648. 10 October 2012 (2012)
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  DOI10.1016/j.str.2012.08.017 PMID22981948 PMCIDPMC3507626 DivisionStructural Studies
• Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy AuthorsHenderson R., Chen S., Chen J. Z., Grigorieff N., Passmore L. A., Ciccarelli L., Rubinstein J. L., Crowther R. A., Stewart P. L., Rosenthal P. B. Journal Journal of Molecular Biology 413(5):1028-1046. 11 November 2011 (2011)
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  DOI10.1016/j.jmb.2011.09.008 PMID21939668 PMCIDPMC3220764 DivisionStructural Studies
• Cytoplasmic deadenylation: regulation of mRNA fate AuthorsWiederhold K., Passmore L. A. Journal Biochemical Society Transactions 38(6):1531-1536. December 2010 (2010)
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  DOI10.1042/BST0381531 PMID21118121 PMCIDPMC3890232 DivisionStructural Studies
• The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome AuthorsLori A. Passmore, T. Martin Schmeing, David Maag, Drew J. Applefield, Michael G. Acker, Mikkel A. Algire, Jon R. Lorsch, V. Ramakrishnan Journal Molecular Cell 26(1): 41-50 (2007) (2007)
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  DOI  PMID  PMCID  Division