Published Research
Found 63 results for O'Neill J.
- Intracellular potassium levels orchestrate circadian rhythmicity and cell division AuthorsGil Rodríguez S., Hansen L. L., Fraser O. J. P., Chew Y. P., Spangler R. K., Grünewald E., Beale A. D., Rabbitts B. M., Stangherlin A., O'Neill J. S., Partch C. L., Crosby P., van Ooijen G. Journal Nature Communications 17(1):6738 (2026)
- Clocks on steroids: how glucocorticoid receptors tell cells the time AuthorsEdmondson A., Menzies J., Ray D. W., O'Neill J. S. Journal The Journal of Endocrinology 269(1):e250340 (2026)
- A cellular basis for the mammalian nocturnal-diurnal switch AuthorsBeale A. D., Christmas M. J., Rzechorzek N. M., Mihut A., Zeng A., Ellis C., James N. R., Smyllie N. J., Pilorz V., Richardson R., Bertelsen M. F., Fazal S. V., Voysey Z., Moreau K., Pelletier J., Crosby P., Peak-Chew S. Y., Edgar R. S., Lancaster M. A., Hut R. A., O'Neill J. S. Journal Science 391(6788):eady2822 (2026)
- Design of intrinsically disordered region binding proteins AuthorsWu K., Jiang H., Hicks D.R., Liu C., Muratspahić E., Ramelot T.A., Liu Y., McNally K., Kenny S., Mihut A., Gaur A., Coventry B., Chen W., Bera A.K., Kang A., Gerben S., Lamb M.Y.L., Murray A., Li X., Kennedy M.A., Yang W., Song Z., Schober G., Brierley S.M., O'Neill J., Gelb M.H., Montelione G.T., Derivery E., Baker D. Journal Science 389(6757):eadr8063 (2025)
- Circadian control of protein synthesis AuthorsJames N. R., O'Neill J. S. Journal Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 47(3):e202300158 (2025)
- Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences AuthorsMajor-Styles C. T., Munns J., Zeng A., Vanden Oever M., O'Neill J., Edgar R. S. Journal Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 380(1918):20230344 (2025)
- PERspectives on circadian cell biology AuthorsMihut A., O'Neill J. S., Partch C. L., Crosby P. Journal Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 380(1918):20230483 (2025)
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Development of compounds for targeted degradation of mammalian cryptochrome proteins
AuthorsMunns J., Beale A. D., Michaelides I. N., Peak-Chew S. Y., Mihut A., Major-Styles C. T., Zeng A., Ian Storer E., Edgar R. S., Moreau K., O'Neill J. S.
Journal
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
380(1918):20230342 (2025)
Details
DOIdoi.org/10.1098/rstb.2023.0342 PMID39842482 PMCIDPMC11753880 DivisionCell Biology, Facilities (Mass Spectrometry) - The chronobiology of human heart failure: clinical implications and therapeutic opportunities AuthorsGentile F., Emdin M., Passino C., Montuoro S., Tognini P., Floras J. S., O'Neill J., Giannoni A. Journal Heart Failure Reviews 30(1):103-116 (2025)
- Circadian regulation of macromolecular complex turnover and proteome renewal AuthorsSeinkmane E, Edmondson A, Peak-Chew SY, Zeng A, Rzechorzek NM, James NR, West J, Munns J, Wong DC, Beale AD, O'Neill JS. Journal The EMBO Journal 43(13):2813-2833 (2024)
- Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking AuthorsChawla S, O'Neill J, Knight MI, He Y, Wang L, Maronde E, Rodríguez SG, van Ooijen G, Garbarino-Pico E, Wolf E, Dkhissi-Benyahya O, Nikhat A, Chakrabarti S, Youngstedt SD, Zi-Ching Mak N, Provencio I, Oster H, Goel N, Caba M, Oosthuizen M, Duffield GE, Chabot C, Davis SJ. Journal Journal of Circadian Rhythms 22:2 (2024)
- Propylene glycol inactivates respiratory viruses and prevents airborne transmission AuthorsStyles CT, Zhou J, Flight KE, Brown JC, Lewis C, Wang X, Vanden Oever M, Peacock TP, Wang Z, Millns R, O'Neill JS, Borodavka A, Grove J, Barclay WS, Tregoning JS, Edgar RS. Journal EMBO Molecular Medicine 15(12):e17932 (2023)
- Macromolecular condensation buffers intracellular water potential AuthorsWatson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E. Journal Nature 623(7988):842-852 (2023)
- Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells AuthorsBeale A. D, Hayter E. A, Crosby P., Valekunja U. K., Edgar R. S., Chesham J. E., Maywood E. S., Labeed F. H., Reddy A. B., Wright K. P. Jr, Lilley K. S., Bechtold D. A., Hastings M. H., O'Neill J. S. Journal The EMBO Journal 42(19):e114164 (2023)
- Healthy human brains have a daily heatwave AuthorsRzechorzek N. M., O'Neill J. S. Journal Temperature (Austin, Tex.) 10(2):155-158 (2023)
- A daily temperature rhythm in the human brain predicts survival after brain injury AuthorsRzechorzek N.M., Thrippleton M.J., Chappell F.M., Mair G., Ercole A., Cabeleira M., CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators, Rhodes J., Marshall I., O’Neill J.S. Journal Brain : a Journal of Neurology 145(6):2031-2048 (2022)
- CRYPTOCHROMES promote daily protein homeostasis AuthorsWong D. C. S., Seinkmane E., Zeng A., Stangherlin A., Rzechorzek N. M., Beale A. D., Day J., Reed M., Peak-Chew S. Y., Styles C. T., Edgar R. S., Putker M., O'Neill J. S. Journal EMBO Journal 41(1):e108883 (2022)
- Author Correction: Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis AuthorsO'Neill J. S., Hoyle N. P., Robertson J. B., Edgar R. S., Beale A. D., Peak-Chew S. Y., Day J., Costa A. S. H., Frezza C., Causton H. C. Journal Nature Communications 12(1):7269 (2021)
- Author Correction: Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia AuthorsHayter E. A., Wehrens S. M. T., Van Dongen H. P. A., Stangherlin A., Gaddameedhi S., Crooks E., Barron N. J., Venetucci L. A., O’Neill J. S., Brown T. M., Skene D. J., Trafford A. W., Bechtold D. A. Journal Nature Communications 12(1):7284 (2021)
- Understanding circadian regulation of mammalian cell function, protein homeostasis, and metabolism AuthorsStangherlin A., Seinkmane E., O'Neill J. S. Journal Current Opinion in Systems Biology 28:None (2021)
- Publisher Correction: Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology AuthorsStangherlin A., Watson J. L., Wong D. C. S., Barbiero S., Zeng A., Seinkmane E., Chew S. P., Beale A. D., Hayter E. A., Guna A., Inglis A. J., Putker M., Bartolami E., Matile S., Lequeux N., Pons T., Day J., van Ooijen G., Voorhees R. M., Bechtold D. A., Derivery E., Edgar R. S., Newham P., O'Neill J. S. Journal Nature Communications 12(1):6988 (2021)
- Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology AuthorsStangherlin A., Watson J. L., Wong D. C. S., Barbiero S., Zeng A., Seinkmane E., Chew S. P., Beale A. D., Hayter E. A., Guna A., Inglis A. J., Putker M., Bartolami E., Matile S., Lequeux N., Pons T., Day J., van Ooijen G., Voorhees R. M., Bechtold D. A., Derivery E., Edgar R. S., Newham P., O'Neill J. S. Journal Nature Communications 12(1):6035 (2021)
- Deep-coverage spatiotemporal proteome of the picoeukaryote Ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms AuthorsKay H., Grünewald E., Feord H. K., Gil S., Peak-Chew S. Y., Stangherlin A., O'Neill J. S., van Ooijen G. Journal Communications Biology 4(1):1147 (2021)
- Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice AuthorsRalph M. R., Shi S. Q., Johnson C. H., Houdek P., Shrestha T. C., Crosby P., O'Neill J. S., Sládek M., Stinchcombe A. R., Sumová A. Journal Plos Computational Biology 17(5):e1008987. 28 May 2021 (2021)
- Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia AuthorsHayter E. A., Wehrens S. M. T., Van Dongen H. P. A., Stangherlin A., Gaddameedhi S., Crooks E., Barron N. J., Venetucci L. A., O’Neill J. S., Brown T. M., Skene D. J., Trafford A. W., Bechtold D. A. Journal Nature Communications 12(1):2472. 30 April 2021 (2021)
- CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping AuthorsPutker M., Wong D. C. S., Seinkmane E., Rzechorzek N. M., Zeng A., Hoyle N. P., Chesham J. E., Edwards M. D., Feeney K. A., Fischer R., Peschel N., Chen K. F., Vanden Oever M., Edgar R. S., Selby C. P., Sancar A., O'Neill J. S. Journal EMBO Journal 40(7):e106745. 1 April 2021 (2021)
- Redox-coupled rhythm and brews AuthorsO'Neill J. S. Journal Nature Chemical Biology 17(4):373-374. April 2021 (2021)
- Diurnal brain temperature rhythms and mortality after brain injury: a prospective and retrospective cohort study AuthorsRzechorzek N. M., et al (including O’Neill J. S.) Journal medRxiv (2021)
- Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis in Circadian Biology AuthorsStangherlin A., Day J., O'Neill J. Journal Methods in Molecular Biology 2130:19-27. January 2021 (2021)
- Energetic substrate availability regulates synchronous activity in an excitatory neural network AuthorsTourigny D. S., Karim M. K. A., Echeveste R., Kotter M. R. N., O'Neill J. S. Journal PloS one 14(8):e0220937. 13 August 2019 (2019)
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Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time
AuthorsCrosby P., Hamnett R., Putker M., Hoyle N. P., Reed M., Karam C. J., Maywood E. S., Stangherlin A., Chesham J. E., Hayter E. A., Rosenbrier-Ribeiro L., Newham P., Clevers H., Bechtold D. A., O'Neill J. S.
Journal
Cell
177(4):896-909.e20. 25 April 2019 (2019)
Details
DOI10.1016/j. Cell.2019.02.017 PMID31030999 PMCIDPMC6506277 DivisionCell Biology, Neurobiology - Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells AuthorsBeale A. D., Kruchek E., Kitcatt S. J., Henslee E. A., Parry J. S. W., Braun G., Jabr R., von Schantz M., O'Neill J. S., Labeed F. H. Journal Journal of Biological Rhythms 34(2):144-153. April 2019 (2019)
- Signal Transduction: Magnesium Manifests as a Second Messenger AuthorsStangherlin A., O'Neill J. S. Journal Current Biology 28(24):R1403-R1405. 17 December 2018 (2018)
- Non-transcriptional processes in circadian rhythm generation AuthorsWong D. C., O'Neill J. S. Journal Current Opinion in Physiology 5:117-132, October 2018 (2018)
- Mammalian circadian period, but not phase and amplitude, is robust against redox and metabolic perturbations AuthorsPutker M., Crosby P., Feeney K. A., Hoyle N. P., da Costa A. S. H, Gaude E., Frezza C., O'Neill J. S. Journal Antioxidants & Redox Signaling 28(7):507-520. March 2018 (2018)
- NADH shuttling couples cytosolic reductive carboxylation of glutamine with glycolysis in cells with mitochondrial dysfunction AuthorsGaude E., Schmidt C., Gammage P. A., Dugourd A., Blacker T., Chew S. P., Saez-Rodriguez J., O'Neill J. S., Szabadkai G., Minczuk M., Frezza C. Journal Molecular Cell 69(4):581-593.e7. 15 February 2018 (2018)
- Flexible Measurement of Bioluminescent Reporters Using an Automated Longitudinal Luciferase Imaging Gas- and Temperature-optimized Recorder (ALLIGATOR) AuthorsCrosby P., Hoyle N. P., O'Neill J. S. Journal Journal of Visualized Experiments : JoVE (130): 56623. 13 December 2017 (2017)
- Rhythmic potassium transport regulates the circadian clock in human red blood cells AuthorsHenslee E. A., Crosby P., Kitcatt S. J., Parry J. S. W., Bernardini A., Abdallat R. G., Braun G., Fatoyinbo H. O., Harrison E. J., Edgar R. S., Hoettges K. F., Reddy A. B., Jabr R. I., von Schantz M., O'Neill J. S., Labeed F. H. Journal Nature Communications 8(1):1978. 7 December 2017 (2017)
- Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing AuthorsHoyle N. P., Seinkmane E., Putker M., Feeney K. A., Krogager T. P., Chesham J. E., Bray L. K., Thomas J. M., Dunn K., Blaikley J., O'Neill J. S. Journal Science Translational Medicine 9(415). 8 November 2017 (2017)
- In-depth Characterization of Firefly Luciferase as a Reporter of Circadian Gene Expression in Mammalian Cells AuthorsFeeney K. A., Putker M., Brancaccio M., O'Neill J. S. Journal Journal of Biological Rhythms 31(6):540-550. December 2016 (2016)
- Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model AuthorsKhabirova E., Chen K. F., O'Neill J. S., Crowther D. C. Journal Scientific Reports 6:33759. 23 September 2016 (2016)
- The Pentose Phosphate Pathway Regulates the Circadian Clock AuthorsRey G., Valekunja U. K., Feeney K. A., Wulund L., Milev N. B., Stangherlin A., Ansel-Bollepalli L., Velagapudi V., O'Neill J. S., Reddy A. B. Journal Cell Metabolism 24(3):462-473. 13 September 2016 (2016)
- Cell autonomous regulation of herpes and influenza virus infection by the circadian clock AuthorsEdgar R. S., Stangherlin A., Nagy A. D., Nicoll M. P., Efstathiou S., O'Neill J. S., Reddy A. B. Journal Proceedings of the National Academy of Sciences of the United States of America 113(36):10085-10090. 6 September 2016 (2016)
- Intracellular magnesium and the rhythms of life Authorsvan Ooijen G., O'Neill J. S. Journal Cell Cycle 15(22):2997-2998. 27 July 2016 (2016)
- Daily magnesium fluxes regulate cellular timekeeping and energy balance AuthorsFeeney K. A., Hansen L. L., Putker M., Olivares-Yañez C., Day J., Eades L. J., Larrondo L. F., Hoyle N. P., O'Neill J. S., van Ooijen G. Journal Nature 532(7599):375-379. 21 April 2016 (2016)
- Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal AuthorsPutker M., O'Neill J. S. Journal Molecules and Cells 39(1):6-19. 25 January 2016 (2016)
- Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks AuthorsTataroglu O., Zhao X., Busza A., Ling J., O'Neill J. S., Emery P. Journal Cell 163(5):1214-1224. 19 November 2015 (2015)
- Effects of caffeine on the human circadian clock in vivo and in vitro AuthorsBurke T. M., Markwald R. R., McHill A. W., Chinoy E. D., Snider J. A., Bessman S. C., Jung C. M., O'Neill J. S., Wright K. P. Jr Journal Science Translational Medicine 7(305):305ra146. 16 September 2015 (2015)
- Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms AuthorsCauston H. C., Feeney K. A., Ziegler C. A., O'Neill J. S. Journal Current Biology 25(8):1056-1062. 20 April 2015 (2015)
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Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra
AuthorsO'Neill J. S, Lee K. D., Zhang L., Feeney K., Webster S. G., Blades M. J., Kyriacou C. P., Hastings M. H., Wilcockson D. C.
Journal
Current Biology
25(8):R326-7. 20 April 2015 (2015)
Details
DOI10.1016/j. Cub.2015.02.052 PMID25898100 PMCIDPMC4406942 DivisionNeurobiology, Cell Biology - Oxidation-reduction cycles of peroxiredoxin proteins and nontranscriptional aspects of timekeeping. AuthorsHoyle N. P., O'Neill J. S. Journal Biochemistry 54(2):184-193. 20 January 2015 (2015)
- Class IIa histone deacetylases are conserved regulators of circadian function AuthorsFogg P. C., O'Neill J. S., Dobrzycki T., Calvert S., Lord E. C., McIntosh R L., Elliott C. J., Sweeney S. T., Hastings M. H., Chawla S. Journal Journal of Biological Chemistry 289(49):34341-34348. 5 December 2014 (2014)
- Circadian redox and metabolic oscillations in mammalian systems AuthorsO'Neill J. S., Feeney K. A. Journal Antioxidants & Redox Signaling 20(18):2966-2981. 20 June 2014 (2014)
- Functional analysis of Casein Kinase 1 in a minimal circadian system Authorsvan Ooijen G., Hindle M., Martin S. F., Barrios-Llerena M., Sanchez F., Bouget F. Y., O'Neill J. S., Le Bihan T., Millar A. J. Journal PloS one 8(7):e70021. 25 July 2013 (2013)
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Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse
AuthorsMaywood E. S., Drynan L., Chesham J. E., Edwards M. D., Dardente H., Fustin J. M., Hazlerigg D. G., O'Neill J. S., Codner G. F., Smyllie N. J., Brancaccio M., Hastings M. H.
Journal
Proceedings of the National Academy of Sciences, USA.
110(23):9547-9552. 4 June 2013 (2013)
Details
DOI10.1073/pnas.1220894110 PMID23690615 PMCIDPMC3677432 DivisionNeurobiology, Cell Biology, Protein & Nucleic Acid Chemistry - Cellular mechanisms of circadian pacemaking: beyond transcriptional loops AuthorsO'Neill J. S., Maywood E. S., Hastings M. H. Journal Handbook of Experimental Pharmacology (217):67-103. 2013 (2013)
- Peroxiredoxins are conserved markers of circadian rhythms AuthorsEdgar R. S., Green E. W., Zhao Y., van Ooijen G., Olmedo M., Qin X., Xu Y., Pan M., Valekunja U. K., Feeney K. A., Maywood E. S., Hastings M. H., Baliga N. S., Merrow M., Millar A. J., Johnson C. H., Kyriacou C. P., O'Neill J. S., Reddy A. B. Journal Nature 485(7399):459-464. 16 May 2012 (2012)
- Circadian clocks: regulators of endocrine and metabolic rhythms AuthorsHastings M., O'Neill J. S., Maywood E. S. Journal Journal of Endocrinology 195(2):187-198. November 2007 (2007)
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The circadian clockwork of the suprachiasmatic nuclei - analysis of a cellular oscillator that drives endocrine rhythms (Minireview)
AuthorsElizabeth S. Maywood, John S. O'Neill, Johanna E. Chesham, Michael H. Hastings
Journal
Endocrinology
148(12): 5624-5634 (2007) (2007)
Details
DOI PMID PMCID Division -
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period
AuthorsSofia I. H. Godinho, Elizabeth S. Maywood, Linda Shaw, Valter Tucci, Alun R. Barnard, Luca Busino, Michele Pagano, Rachel Kendall, Mohamed M. Quwailid, M. Rosario Romero, John O'Neill, Johanna E. Chesham, Debra Brooker, Zuzanna Lalanne, Michael H. Hastings, Patrick M. Nolan
Journal
Science
316(5826): 897-900 (2007) (2007)
Details
DOI PMID PMCID Division -
Insight into the circadian clock within rat colonic epithelial cells.
AuthorsM. Sládek, M. Rybová, Z. Jindráková, Z. Zemanová, L. Polidarová, L. Mrnka, J. O'Neill, J. Pácha, A. Sumová
Journal
Gastroenterology
133(4): 1240-9 (2007) (2007)
Details
DOI PMID PMCID Division - Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signalling AuthorsElizabeth S. Maywood, Akhilesh B. Reddy, Gabriel K. Y. Wong, John S. O'Neill, John A. O'Brien, Douglas G. McMahon, Anthony J. Harmar, Hitoshi Okamura, Michael H. Hastings Journal Current Biology 16(6):599-605. 21 March 2006 (2006 )
- Circadian clocks: neural and peripheral pacemakers that impact upon the cell division cycle AuthorsReddy A. B., Wong G. K. Y., O'Neill J., Maywood E. S., Hastings M. H. Journal Mutation Research 574(1-2):76-91. 1 July 2005 (2005)