Published Research
Found 52 results for Murzin.
- Distinct tau filament folds in human MAPT mutants P301L and P301T AuthorsSchweighauser M., Shi Y., Murzin A.G., Garringer H.J., Vidal R., Murrell J.R., Elena Erro M., Seelaar H., Ferrer I., van Swieten J.C., Ghetti B., Scheres S.H.W., Goedert M. Journal Nature Structural & Molecular Biology (2025)
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Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W
AuthorsQi C., Lövestam S., Murzin A.G., Peak-Chew S., Franco C., Bogdani M., Latimer C., Murrell J.R., Cullinane P.W., Jaunmuktane Z., Bird T.D., Ghetti B., Scheres S.H.W., Goedert M.
Journal
Nature Structural & Molecular Biology
32(7):1297-1304 (2025)
Details
DOI10.1038/s41594-025-01498-5 PMID40044789 PMCIDPMC12263442 DivisionStructural Studies, Neurobiology - TMEM106B amyloid filaments in the Biondi bodies of ependymal cells AuthorsGhetti B., Schweighauser M., Jacobsen M. H., Gray D., Bacioglu M., Murzin A. G., Glazier B. S., Katsinelos T., Vidal R., Newell K. L., Gao S., Garringer H. J., Spillantini M. G., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 148(1):60 (2024)
- Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C AuthorsArseni D., Nonaka T., Jacobsen M. H., Murzin A. G., Cracco L., Peak-Chew S. Y., Garringer H. J., Kawakami I., Suzuki H., Onaya M., Saito Y., Murayama S., Geula C., Vidal R., Newell K. L., Mesulam M., Ghetti B., Hasegawa M., Ryskeldi-Falcon B. Journal Nature 634(8034):662-668 (2024)
- TAF15 amyloid filaments in frontotemporal lobar degeneration AuthorsTetter S., Arseni D., Murzin A. G., Buhidma Y., Peak-Chew S. Y., Garringer H. J. Newell K. L., Vidal R., Apostolova L. G., Lashley T., Ghetti B., Ryskeldi-Falcon B. Journal Nature, 625(7994):345-351 (2024)
- Disease-specific tau filaments assemble via polymorphic intermediates AuthorsLövestam S,. Li D., Wagstaff J. L., Kotecha A., Kimanius D., McLaughlin S. H., Murzin A. G., Freund S. M. V, Goedert M., Scheres S. H. W. Journal Nature 625(7993):119-125 (2024)
- Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau AuthorsSchweighauser M., Murzin A. G., Macdonald J., Lavenir I., Crowther R. A., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica Communications 11(1):160 (2023)
- TDP-43 forms amyloid filaments with a distinct fold in type A FTLD‑TDP AuthorsArseni D., Chen R., Murzin A. G., Peak-Chew S. Y., Garringer H. J., Newell K. L., Kametani F., Robinson A. C., Vidal R., Ghetti B., Hasegawa M., Ryskeldi-Falcon B. Journal Nature 620(7975):898-903 (2023)
- New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy AuthorsYang Y., Garringer H. J., Shi Y., Lövestam S., Peak-Chew S., Zhang X., Kotecha A., Bacioglu M., Koto A., Takao M., Spillantini M. G., Ghetti B., Vidal R., Murzin A. G., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 145(5):561-572 (2023)
- Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains AuthorsYang Y., Zhang W., Murzin A. G., Schweighauser M., Huang M., Lövestam S., Peak-Chew S. Y., Saito T., Saido T. C., Macdonald J., Lavenir I., Ghetti B., Graff C., Kumar A., Nordberg A., Goedert M., Scheres S. H. W. Journal Acta Neuropathologica 145(3):325-333 (2023)
- Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains AuthorsYang Y., Zhang W., Murzin A. G., Schweighauser M., Huang M., Lövestam S., Peak-Chew S. Y, Saito T., Saido T. C., Macdonald J., Lavenir I., Ghetti B., Graff C., Kumar A., Nordberg A., Goedert M., Scheres S. H. W. Journal Acta Neuropathologica 145(3):325-333 (2023)
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Structures of α-synuclein filaments from human brains with Lewy pathology
AuthorsYang Y., Shi Y., Schweighauser M., Zhang X., Kotecha A., Murzin A.G., Garringer H.J., Cullinane P.W., Saito Y., Foroud T., Warner T.T., Hasegawa K., Vidal R., Murayama S., Revesz T., Ghetti B., Hasegawa M., Lashley T., Scheres S.H.W., Goedert M.
Journal
Nature
610(7933):791-795 (2022)
Details
DOI10.1038/s41586-022-05319‑3 PMID36108674 PMCIDPMC7613749 DivisionStructural Studies, Neurobiology -
Age-dependent formation of TMEM106B amyloid filaments in human brains
AuthorsSchweighauser M., Arseni D., Bacioglu M., Huang M., Lövestam S., Shi Y., Yang Y., Zhang W., Kotecha A., Garringer H. J., Vidal R., Hallinan G. I., Newell K. L., Tarutani A., Murayama S., Miyazaki M., Saito Y., Yoshida M., Hasegawa K., Lashley T., Revesz T., Kovacs G. G., van Swieten J., Takao M., Hasegawa M., Ghetti B., Spillantini M. G., Ryskeldi-Falcon B., Murzin A. G., Goedert M., Scheres S. H. W.
Journal
Nature
605(7909):310-314 (2022)
Details
DOI10.1038/s41586-022-04650-z PMID35344985 PMCIDPMC9095482 DivisionNeurobiology, Structural Studies -
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
AuthorsLövestam S., Koh F. A., van Knippenberg B., Kotecha A., Murzin A. G., Goedert M., Scheres S. H. W.
Journal
Elife
11:e76494 (2022)
Details
DOI10.7554/elife.76494 PMID35244536 PMCIDPMC8983045 DivisionNeurobiology, Structural Studies -
Cryo-EM structures of amyloid-β 42 filaments from human brains
AuthorsYang Y., Arseni D., Zhang W., Huang M., Lövestam S., Schweighauser M., Kotecha A., Murzin A. G., Peak-Chew S. Y., Macdonald J., Lavenir I., Garringer H. J., Gelpi E., Newell K. L., Kovacs G. G., Vidal R., Ghetti B., Ryskeldi-Falcon B., Scheres S. H. W., Goedert M.
Journal
Science
375(6577):167-172 (2022)
Details
DOI10.1126/science. Abm7285 PMID35025654 PMCIDPMC7612234 DivisionStructural Studies, Neurobiology - Structure of pathological TDP-43 filaments from ALS with FTLD AuthorsArseni D., Hasegawa M., Murzin A. G., Kametani F., Arai M., Yoshida M., Ryskeldi-Falcon B. Journal Nature 601(7891):139-143 (2022)
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Structure-based classification of tauopathies
AuthorsShi Y., Zhang W., Yang Y., Murzin A. G., Falcon B., Kotecha A., van Beers M., Tarutani A., Kametani F., Garringer H. J., Vidal R., Hallinan G. I., Lashley T., Saito Y., Murayama S., Yoshida M., Tanaka H., Kakita A., Ikeuchi T., Robinson A. C., Mann D. M. A., Kovacs G. G., Revesz T., Ghetti B., Hasegawa M., Goedert M., Scheres S. H. W.
Journal
Nature
598(7880):359-363 (2021)
Details
DOI10.1038/s41586-021-03911-7 PMID34588692 PMCIDPMC7611841 DivisionNeurobiology, Structural Studies -
Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN‑1607
AuthorsShi Y., Murzin A. G., Falcon B., Epstein A., Machin J., Tempest P., Newell K. L., Vidal R., Garringer H. J., Sahara N., Higuchi M., Ghetti B., Jang M. K., Scheres S. H. W., Goedert M.
Journal
Acta Neuropathologica
141(6):983. June 2021 (2021)
Details
DOI10.1007/s00401-021-02303-5 PMID33830331 PMCIDPMC8496564 DivisionStructural Studies, Neurobiology -
Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN‑1607
AuthorsShi Y., Murzin A. G., Falcon B., Epstein A., Machin J., Tempest P., Newell K. L., Vidal R., Garringer H. J., Sahara N., Higuchi M., Ghetti B., Jang M. K., Scheres S. H. W., Goedert M.
Journal
Acta Neuropathologica
141(5):697-708. 16 March 2021 (2021)
Details
DOI10.1007/s00401-021-02294-3 PMID33723967 PMCIDPMC8043864 DivisionStructural Studies, Neurobiology - An Unusual Route for p-Aminobenzoate Biosynthesis in Chlamydia trachomatis Involves a Probable Self-Sacrificing Diiron Oxygenase AuthorsMacias-Orihuela Y., Cast T., Crawford I., Brandecker K. J., Thiaville J. J., Murzin A. G., de Crécy-Lagard V., White R. H., Allen K. D. Journal Journal of Bacteriology 202(20) e00319-20. October 2020 (2020)
- Implications of the Orb2 Amyloid Structure in Huntington's Disease AuthorsHervás R., Murzin A. G., Si K. Journal International Journal of Molecular Sciences 21(18). 21 September 2020 (2020)
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Structures of α-synuclein filaments from multiple system atrophy
AuthorsSchweighauser M., Shi Y., Tarutani A., Kametani F., Murzin A. G., Ghetti B., Matsubara T., Tomita T., Ando T., Hasegawa K., Murayama S., Yoshida M., Hasegawa M., Scheres S. H. W., Goedert M.
Journal
Nature
585(7825):464-469. 17 September 2020 (2020)
Details
DOI10.1038/s41586-020-2317-6 PMID32461689 PMCIDPMC7116528 DivisionStructural Studies, Neurobiology -
Novel tau filament fold in corticobasal degeneration
AuthorsZhang W., Tarutani A., Newell K. L., Murzin A. G., Matsubara T., Falcon B., Vidal R., Garringer H. J., Shi Y., Ikeuchi T., Murayama S., Ghetti B., Hasegawa M., Goedert M., Scheres S. H. W.
Journal
Nature
580(7802):283-287. 9 April 2020 (2020)
Details
DOI10.1038/s41586-020-2043‑0 PMID32050258 PMCIDPMC7148158 DivisionNeurobiology, Structural Studies - Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila AuthorsHervas R., Rau M. J., Park Y., Zhang W., Murzin A. G., Fitzpatrick J. A. J., Scheres S. H. W., Si K. Journal Science 367(6483):1230-1234. 13 March 2020 (2020)
- Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation AuthorsSillitoe I., Andreeva A., Blundell T. L., Buchan D. W. A., Finn R. D., Gough J., Jones D., Kelley L. A., Paysan-Lafosse T., Lam S. D., Murzin A. G., Pandurangan A. P, Salazar G. A., Skwark M. J., Sternberg M. J. E., Velankar S., Orengo C. Journal Nucleic Acids Research 48(D1):D314-D319. 8 January 2020 (2020)
- The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures AuthorsAndreeva A., Kulesha E., Gough J., Murzin A. G. Journal Nucleic Acids Research 48(D1):D376-D382. 8 January 2020 (2020)
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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
AuthorsFalcon B., Zivanov J., Zhang W., Murzin A. G., Garringer H. J., Vidal R., Crowther R. A., Newell K. L., Ghetti B., Goedert M., Scheres S. H. W.
Journal
Nature
568(7752):420-423. April 2019 (2019)
Details
DOI10.1038/s41586-019-1026-5 PMID30894745 PMCIDPMC6472968 DivisionNeurobiology, Structural Studies -
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases
AuthorsZhang W., Falcon B., Murzin A. G., Fan J., Crowther R. A., Goedert M., Scheres S. H.
Journal
ELife
8: e43584. 5 February 2019 (2019)
Details
DOI10.7554/eLife.43584 PMID30720432 PMCIDPMC6375701 DivisionNeurobiology, Structural Studies -
Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold
AuthorsFalcon B., Zhang W., Schweighauser M., Murzin A. G., Vidal R., Garringer H. J., Ghetti B., Scheres S. H. W., Goedert M.
Journal
Acta Neuropathologica
136(5):699-708. November 2018 (2018)
Details
DOI10.1007/s00401-018-1914-z PMID30276465 PMCIDPMC6208733 DivisionStructural Studies, Neurobiology -
Structures of filaments from Pick's disease reveal a novel tau protein fold
AuthorsFalcon B., Zhang W., Murzin A. G., Murshudov G., Garringer H. J., Vidal R., Crowther R. A., Ghetti B., Scheres S. H. W., Goedert M.
Journal
Nature
561(7721):137-140. 6 September 2018 (2018)
Details
DOI10.1038/s41586-018-0454-y PMID30158706 PMCIDPMC6204212 DivisionStructural Studies, Neurobiology -
Cryo-EM structures of tau filaments from Alzheimer's disease
AuthorsFitzpatrick A. W. P., Falcon B., He S., Murzin A. G., Murshudov G., Garringer H. J., Crowther R. A., Ghetti B., Goedert M., Scheres S. H. W.
Journal
Nature
547(7662):185-190 (2017)
Details
DOI10.1038/nature23002 PMID28678775 PMCIDPMC5552202 DivisionNeurobiology, Structural Studies - Investigating Protein Structure and Evolution with SCOP2. AuthorsAndreeva A., Howorth D., Chothia C., Kulesha E., Murzin A. G. Journal Current Protocols in Bioinformatics 49:1.26.1-1.26.21. 1 March 2015 (2015)
- Genome3D: exploiting structure to help users understand their sequences. AuthorsLewis T. E., Sillitoe I., Andreeva A., Blundell T. L., Buchan D. W., Chothia C., Cozzetto D., Dana J. M., Filippis I., Gough J., Jones D. T., Kelley L. A., Kleywegt G. J., Minneci F., Mistry J., Murzin A. G., Ochoa-Montaño B., Oates M. E., Punta M., Rackham O. J., Stahlhacke J., Sternberg M. J., Velankar S., Orengo C. Journal Nucleic Acids Research 43(Database issue):D382-6. 28 January 2015 (2015)
- Structure of the virulence-associated protein VapD from the intracellular pathogen Rhodococcus equi AuthorsWhittingham J. L., Blagova E. V., Finn C. E., Luo H., Miranda-CasoLuengo R., Turkenburg J. P., Leech A. P., Walton P. H., Murzin A. G., Meijer W. G., Wilkinson A. J. Journal Acta Crystallographica. Section D, Biological Crystallography 70(Pt 8):2139-2151. 1 August 2014 (2014)
- Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis AuthorsDas D., Murzin A. G., Rawlings N. D., Finn R. D., Coggill P., Bateman A., Godzik A., Aravind L. Journal BMC Bioinformatics 15:75. 19 March 2014 (2014)
- SCOP2 prototype: a new approach to protein structure mining AuthorsAndreeva A., Howorth D., Chothia C., Kulesha E., Murzin A. G. Journal Nucleic Acids Research 42(Database issue):D310-4. January 2014 (2014)
- Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains AuthorsLewis T E., Sillitoe I., Andreeva A., Blundell T. L., Buchan D. W., Chothia C., Cuff A., Dana J. M., Filippis I., Gough J., Hunter S., Jones D. T., Kelley L. A., Kleywegt G. J., Minneci F., Mitchell A., Murzin A. G., Ochoa-Montaño B., Rackham O. J., Smith J., Sternberg M. J., Velankar S., Yeats C., Orengo C. Journal Nucleic Acids Research 41(Database issue):D499-507. January 2013 (2013)
- Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate Authorsde Crécy-Lagard V., Phillips G., Grochowski L. L., El Yacoubi B., Jenney F., Adams M. W., Murzin A. G., White R. H. Journal ACS Chemical Biology 7(11):1807-1816. 16 November 2012 (2012)
- Structural classification of proteins and structural genomics: new insights into protein folding and evolution AuthorsAndreeva A., Murzin A. G. Journal Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 66(10):1190-1197. 1 October 2010 (2010)
- Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255‑15 AuthorsHan G. W., Elsliger M. A., Yeates T. O., Xu Q., Murzin A. G., Krishna S. S., Jaroszewski L., Abdubek P., Astakhova T., Axelrod H. L., Carlton D., Chen C., Chiu H. J., Clayton T., Das D., Deller M. C., Duan L., Ernst D., Feuerhelm J., Grant J. C., Grzechnik A., Jin K. K., Johnson H. A., Klock H. E., Knuth M. W., Kozbial P., Kumar A., Lam W. W., Marciano D., McMullan D., Miller M. D., Morse A. T., Nigoghossian E., Okach L., Reyes R., Rife C. L., Sefcovic N., Tien H. J., Trame C. B., van den Bedem H., Weekes D., Hodgson K. O., Wooley J., Deacon A. M., Godzik A., Lesley S. A., Wilson I. A. Journal Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 66(10):1237-1244. 1 October 2010 (2010)
- Data growth and its impact on the SCOP database: new developments AuthorsAntonina Andreeva, Dave Howorth, John-Marc Chandonia, Steven E. Brenner, Tim J. P. Hubbard, Cyrus Chothia, Alexey G. Murzin Journal Nucleic Acids Research 36 (Database issue): D419-D425 (2008)
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SCOP database in 2004: refinements integrate structure and sequence family data
AuthorsAntonina Andreeva, Dave Howorth, Steven E. Brenner, Tim J. P. Hubbard, Cyrus Chothia, Alexey G. Murzin
Journal
Nucleic Acids Research
32 (Database Issue): D226-D229 (2004) (2004)
Details
DOI PMID PMCID Division -
Determination of protein function, evolution and interactions by structural genomics
AuthorsSarah A. Teichmann, Alexey G. Murzin, Cyrus Chothia
Journal
Current Opinion in Structural Biology
11: 354-363 (2001) (2001)
Details
DOI PMID PMCID Division - Protein folds in the all-beta and all-alpha classes AuthorsChothia C., Hubbard T., Brenner S., Barns H., Murzin A. Journal Annual Review of Biophysics and Biomolecular Structure 26: 597-627. June 1997 (1997)
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The 2.0-Angstrom resolution crystal strucutre of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3
AuthorsXue Y. Pei, Philipp Holliger, Alexey G. Murzin, Roger L. Williams
Journal
Proceedings of the National Academy of Sciences, USA
94: 9637-9642 (1997) (1997)
Details
DOI PMID PMCID Division - Gene duplications in H. influenzae AuthorsBrenner S. E., Hubbard T., Murzin A., Chothia C. Journal Nature 378(6553):140. 9 November 1995 (1995)
- SCOP: a structural classification of proteins database for the investigation of sequences and structures AuthorsMurzin A. G., Brenner S. E., Hubbard T., Chothia C. Journal Journal of Molecular Biology 247(4):536-540. 7 April 1995 (1995)
- Principles determining the structure of beta-sheet barrels in proteins. I. A theoretical analysis AuthorsMurzin A. G., Lesk A. M., Chothia C. Journal Journal of Molecular Biology 236(5):1369-1381. 11 March 1994 (1994)
- Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures AuthorsMurzin A. G., Lesk A. L., Chothia C. Journal Journal of Molecular Biology 236(5):1382-1400. 11 March 1994 (1994)
- New folds for all-beta proteins AuthorsChothia C., Murzin A. G. Journal Structure 1(4):217-222 (1993) (1993)
- Beta-trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1beta and 1alpha and fibroblast growth factors AuthorsMurzin A. G., Lesk A. L., Chothia C. Journal Journal of Molecular Biology 223(2):531-543 (1992) (1992)
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Protein architecture: new superfamilies
AuthorsMurzin A. G., Chothia C.
Journal
Current Opinion in Structural Biology
2(6): 895-903 (1992) (1992)
Details
DOI PMID PMCID Division