Published Research

Found 108 results for McMahon.

• Base editing reveals an essential role for NANOG in human embryogenesis AuthorsBower O. J., Orsi A. E. R., McMahon R., Staneva D., Blagrove J., Singh K., Simon C. S., McCarthy A., Garcia P., Shaikly V., Taranissi M., Wilding M., Serhal P., Odia R. A., Vasilic M., Choudhary M., Papathanasiou A., Elder K., Snell P., Christie L., Arbab M., Liu D. R., Herbert M., Harasimov K., Niakan K. K. Journal Nature (2026)
  Details

  DOI10.1038/s41586-026-10792-1 PMID42350792 PMCID  DivisionStructural Studies
• A single particle analysis method for detecting membrane remodelling and curvature sensing AuthorsColussi A., Almeida-Souza L., McMahon H. T. Journal Journal of Cell Science :jcs.263533 (2024)
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  DOI10.1242/jcs.263533 PMID39324332 PMCIDPMC11574359 DivisionNeurobiology
• Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1 AuthorsHakanpää L., Abouelezz A., Lenaerts A. S., Culfa S., Algie M., Bärlund J., Katajisto P., McMahon H., Almeida-Souza L. Journal The Journal of Cell Biology 222(8):e202303107 (2023)
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  DOI10.1083/jcb.202303107 PMID37233325 PMCIDPMC10225744 DivisionNeurobiology
• Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1 AuthorsHakanpää L., Abouelezz A., Lenaerts A. S., Culfa S, Algie M., Bärlund J., Katajisto P., McMahon H., Almeida-Souza L. Journal The Journal of Cell Biology 222(8):e202303107 (2023)
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  DOI0.1083/jcb.202303107 PMID37233325 PMCIDPMC10225744 DivisionNeurobiology
• Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis AuthorsPaul D., Stern O., Vallis., Dhillon J., Buchanan A., McMahon H Journal Nature Communications 14(1):947 (2023)
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  DOI10.1038/s41467-023-36496‑y PMID36854675 PMCIDPMC9974993 DivisionNeurobiology
• Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation AuthorsTillu V. A., Rae J., Gao Y., Ariotti N., Floetenmeyer M., Kovtun O., McMahon K. A., Chaudhary N., Parton R. G., Collins B. M. Journal Nature Communications 12(1):931. 10 February 2021 (2021)
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  DOI10.1038/s41467-021-21035-4 PMID33568658 PMCIDPMC7875971 DivisionStructural Studies
• Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion AuthorsHu M., Cebola I., Carrat G., Jiang S., Nawaz S., Khamis A., Canouil M., Froguel P., Schulte A., Solimena M., Ibberson M., Marchetti P., Cardenas-Diaz F. L., Gadue P. J., Hastoy B., Alemeida-Souza L., McMahon H., Rutter G. A. Journal Cell Reports 34(5):108703. 2 February 2021 (2021)
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  DOI10.1016/j. Celrep.2021.108703 PMID33535042 PMCIDPMC7856552 DivisionNeurobiology
• Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion AuthorsPapa G., Mallery D. L., Albecka A., Welch L. G., Cattin-Ortolá J., Luptak J., Paul D., McMahon H. T., Goodfellow I. G., Carter A., Munro S., James L. C. Journal Plos Pathogens 17(1):e1009246. 25 January 2021 (2021)
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  DOI10.1371/journal.ppat.1009246 PMID33493182 PMCIDPMC7861537 DivisionProtein & Nucleic Acid Chemistry, Neurobiology, Cell Biology, Structural Studies
• GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508 AuthorsLucken-Ardjomande Häsler S., Vallis Y., Pasche M., McMahon H. T. Journal Journal of Cell Biology 219(5):e201811014. 4 May 2020 (2020)
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  DOI10.1083/jcb.201811014 PMID32344433 PMCIDPMC7199855 DivisionNeurobiology
• The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease AuthorsWhite A. J., Wijeyekoon R. S., Scott K. M., Gunawardana N. P., Hayat S.,Solim I. H., McMahon H. T., Barker R. A., Williams-Gray C. H. Journal Frontiers in Neurology 9:946. 20 November 2018 (2018)
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  DOI10.3389/fneur.2018.00946 PMID30524354 PMCIDPMC6256248 DivisionNeurobiology
• FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis AuthorsChan Wah Hak L., Khan S., Di Meglio I., Law A. L., Häsler S. L., Quintaneiro L. M., Ferreira A. P. A., Krause M., McMahon H. T., Boucrot E. Journal Nature Cell Biology 20(9):1023-1031 (2018)
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  DOI10.1038/s41556-018-0146‑8 PMID30061681 PMCIDPMC6122583 DivisionNeurobiology
• A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits AuthorsAlmeida-Souza L., Frank R. A. W., García-Nafría J., Colussi A., Gunawardana N., Johnson C. M., Yu M., Howard G., Andrews B., Vallis Y., McMahon H. T. Journal Cell 174(2):325-337.e14. 12 July 2018 (2018)
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  DOI10.1016/j. Cell.2018.05.020 PMID29887380 PMCIDPMC6057269 DivisionNeurobiology; Protein & Nucleic Acid Chemistry
• Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering AuthorsKrols M., Detry S., Asselbergh B., Almeida-Souza L., Kremer A., Lippens S., De Rycke R., De Winter V., Müller F. J., Kurth I., McMahon H. T., Savvides S. N., Timmerman V., Janssens S. Journal Cell Reports 23(7):2026-2038. 15 May 2018 (2018)
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  DOI10.1016/j. Celrep.2018.04.071 PMID29768202 PMCIDPMC6020997 DivisionNeurobiology
• Galectin-8-mediated selective autophagy protects against seeded tau aggregation AuthorsFalcon B., Noad J., McMahon H., Randow F., Goedert M. Journal Journal of Biological Chemistry 293(7):2438-2451. 16 February 2018 (2018)
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  DOI10.1074/jbc. M117.809293 PMID29282296 PMCIDPMC5818177 DivisionProtein & Nucleic Acid Chemistry, Neurobiology
• Eps15R and clathrin regulate EphB2-mediated cell repulsion AuthorsEvergren E., Cobbe N., McMahon H. T. Journal Traffic 19(1):44-57. January 2018 (2018)
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  DOI10.1111/tra.12531 PMID28972287 PMCIDPMC5836524 DivisionNeurobiology
• Friction Mediates Scission of Tubular Membranes Scaffolded by BAR Proteins AuthorsSimunovic M., Manneville J. B., Renard H. F., Evergren E., Raghunathan K., Bhatia D., Kenworthy A. K., Voth G. A., Prost J., McMahon H. T., Johannes L., Bassereau P., Callan-Jones A. Journal Cell 170(1):172-184.e11. 29 June 2017 (2017)
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  DOI10.1016/j. Cell.2017.05.047 PMID28648660 PMCIDPMC5576516 DivisionNeurobiology
• Membrane fission by dynamin: what we know and what we need to know AuthorsAntonny B., Burd C., De Camilli P., Chen E., Daumke O., Faelber K., Ford M., Frolov V. A., Frost A., Hinshaw J. E., Kirchhausen T., Kozlov M. M. , Lenz M., Low H. H., McMahon H., Merrifield C., Pollard T. D., Robinson P. J., Roux A., Schmid S. Journal EMBO Journal 35(21):2270-2284. 2 November 2016 (2016)
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  DOI10.15252/embj.201694613 PMID27670760 PMCIDPMC5090216 DivisionNeurobiology
• How curvature-generating proteins build scaffolds on membrane nanotubes AuthorsSimunovic M., Evergren E., Golushko I., Prévost C., Renard H. F., Johannes L., McMahon H. T., Lorman V., Voth G. A., Bassereau P. Journal Proceedings of the National Academy of Sciences of the United States of America 113(40):11226-11231. 4 October 2016 (2016)
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  DOI10.1073/pnas.1606943113 PMID27655892 PMCIDPMC5056078 DivisionNeurobiology
• Membrane curvature at a glance. AuthorsMcMahon H. T., Boucrot E. Journal Journal of Cell Science 128(6):1065-1070. 15 March 2015 (2015)
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  DOI10.1242/jcs.114454 PMID25774051 PMCIDPMC4359918 DivisionNeurobiology
• Endophilin marks and controls a clathrin-independent endocytic pathway. AuthorsBoucrot E., Ferreira A. P., Almeida-Souza L., Debard S., Vallis Y., Howard G., Bertot L., Sauvonnet N., McMahon H. T. Journal Nature 517(7535):460-465. 22 January 2015 (2015)
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  DOI10.1038/nature14067 PMID25517094 PMCID  DivisionNeurobiology
• Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis. AuthorsRenard H. F., Simunovic M., Lemière J., Boucrot E., Garcia-Castillo M. D., Arumugam S., Chambon V., Lamaze C., Wunder C., Kenworthy A. K., Schmidt A. A., McMahon H. T., Sykes C., Bassereau P., Johannes L. Journal Nature 517(7535):493-496. 22 January 2015 (2015)
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  DOI10.1038/nature14064 PMID25517096 PMCIDPMC4342003 DivisionNeurobiology
• GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions AuthorsLucken-Ardjomande Häsler S., Vallis Y., Jolin H. E., McKenzie A. N., McMahon H. T. Journal Journal of Cell Science 127(Pt 21):4602-4619. 1 November 2014 (2014)
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  DOI10.1242/jcs.147694 PMID25189622 PMCIDPMC4215711 DivisionNeurobiology, Protein & Nucleic Acid Chemistry
• Mechanisms shaping cell membranes AuthorsKozlov M. M., Campelo F., Liska N., Chernomordik L. V., Marrink S. J., McMahon H. T. Journal Current Opinion in Cell Biology 29:53-60. August 2014 (2014)
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  DOI10.1016/j. Ceb.2014.03.006 PMID24747171 PMCIDPMC4180517 DivisionNeurobiology
• Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis AuthorsTakeda T., Robinson I. M., Savoian M. M., Griffiths J. R., Whetton A. D., McMahon H. T., Glover D. M. Journal Open Biology 3(8):130081. (2013)
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  DOI10.1098/rsob.130081 PMID23926047 PMCIDPMC3758542 DivisionNeurobiology
• Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission AuthorsMeinecke M., Boucrot E., Camdere G., Hon W. C., Mittal R., McMahon H. T. Journal Journal of Biological Chemistry 288(9):6651-6661. 1 March 2013 (2013)
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  DOI10.1074/jbc. M112.444869 PMID23297414 PMCIDPMC3585104 DivisionNeurobiology
• The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments AuthorsCortese K., Howes M. T., Lundmark R., Tagliatti E., Bagnato P., Petrelli A., Bono M., McMahon H. T., Parton R. G., Tacchetti C. Journal Molecular Biology of the Cell 24(2):129-144. 15 January 2013 (2013)
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  DOI10.1091/mbc. E12-04‑0282 PMID23154999 PMCIDPMC3541960 DivisionNeurobiology
• Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis AuthorsSánchez-Barrena M. J., Vallis Y., Clatworthy M. R., Doherty G. J., Veprintsev D. B., Evans P. R., McMahon H. T. Journal PloS one 7(12):e52401. 20 December 2012 (2012)
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  DOI10.1371/journal.pone.0052401 PMID23285027 PMCIDPMC3527510 DivisionNeurobiology, Structural Studies, Protein & Nucleic Acid Chemistry
• Membrane binding and self-association of the epsin N-terminal homology domain AuthorsLai C. L., Jao C. C., Lyman E., Gallop J. L., Peter B. J., McMahon H. T., Langen R., Voth G. A. Journal Journal of Molecular Biology 423(5):800-817. 9 November 2012 (2012)
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  DOI10.1016/j.jmb.2012.08.010 PMID22922484 PMCIDPMC3682188 DivisionNeurobiology
• PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts AuthorsChitu V., Nacu V., Charles J. F, Henne W. M., McMahon H. T., Nandi S., Ketchum H., Harris R., Nakamura M. C., Stanley E. R. Journal Blood 120(15):3126-3135. 11 October 2012 (2012)
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  DOI10.1182/blood-2012-04‑425595 PMID22923495 PMCID  DivisionNeurobiology
• EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization AuthorsMorén B., Shah C., Howes M. T., Schieber N. L., McMahon H. T., Parton R. G., Daumke O., Lundmark R. Journal Molecular Biology of the Cell 23(7):1316-1329. 1 April 2012 (2012)
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  DOI10.1091/mbc. E11-09‑0787 PMID22323287 PMCIDPMC3315815 DivisionNeurobiology
• Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains AuthorsBoucrot E., Pick A., Çamdere G., Liska N., Evergren E., McMahon H. T., Kozlov M. M. Journal Cell 149(1):124-136. 30 March 2012 (2012)
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  DOI10.1016/j. Cell.2012.01.047 PMID22464325 PMCIDPMC3465558 DivisionNeurobiology
• Intracellular curvature-generating proteins in cell-to-cell fusion AuthorsRichard J. P., Leikina E., Langen R., Henne W. M., Popova M., Balla T., McMahon H. T., Kozlov M. M., Chernomordik L. V. Journal Biochemical Journal 440(2):185-193. 1 December 2011 (2011)
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  DOI10.1042/BJ20111243 PMID21895608 PMCIDPMC3216009 DivisionNeurobiology
• The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading AuthorsDoherty G. J., Åhlund M. K., Howes M. T., Morén B., Parton R. G., McMahon H. T., Lundmark R. Journal Molecular Biology of the Cell 22(22):4380-4389. 15 November 2011 (2011)
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  DOI10.1091/mbc. E10-12‑0936 PMID21965292 PMCIDPMC3216663 DivisionNeurobiology
• Molecular mechanism and physiological functions of clathrin-mediated endocytosis AuthorsMcMahon H. T., Boucrot E. Journal Nature Reviews. Molecular Cell Biology 12(8):517-533. August 2011 (2011)
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  DOI10.1038/nrm3151 PMID21779028 PMCID  DivisionNeurobiology
• Endophilin drives the fast mode of vesicle retrieval in a ribbon synapse AuthorsLlobet A., Gallop J. L., Burden J. J., Camdere G., Chandra P., Vallis Y., Hopkins C. R., Lagnado L., McMahon H. T. Journal Journal of Neuroscience 31(23):8512-8519. 8 June 2011 (2011)
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  DOI10.1523/JNEUROSCI.6223-09.2011 PMID21653855 PMCIDPMC3926091 DivisionNeurobiology
• [Nucleation of clathrin-coated pits - « membrane sculptors » at work] AuthorsBoucrot E., McMahon H. T. Journal Medecine Sciences 27(2):122-125. February 2011 (2011)
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  DOI10.1051/medsci/2011272122 PMID21382316 PMCID  DivisionNeurobiology
• Protein-driven membrane stresses in fusion and fission AuthorsKozlov M. M., McMahon H. T., Chernomordik L. V. Journal Trends in Biochemical Sciences 35(12):699-706. 1 December 2010 (2010)
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  DOI10.1016/j.tibs.2010.06.003 PMID20638285 PMCIDPMC3556487 DivisionNeurobiology
• Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis AuthorsYoun J. Y., Friesen H., Kishimoto T., Henne W. M., Kurat C. F., Ye W., Ceccarelli D. F., Sicheri F., Kohlwein S. D., McMahon H. T., Andrews B. J. Journal Molecular Biology of the Cell 21(17):3054-3069. 1 September 2010 (2010)
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  DOI10.1091/mbc. E10-03‑0181 PMID20610658 PMCIDPMC2929998 DivisionNeurobiology
• Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells AuthorsHowes M. T., Kirkham M., Riches J., Cortese K., Walser P. J., Simpson F., Hill M. M., Jones A., Lundmark R., Lindsay M. R., Hernandez-Deviez D. J., Hadzic G., McCluskey A., Bashir R., Liu L., Pilch P., McMahon H., Robinson P. J., Hancock J. F., Mayor S., Parton R. G. Journal Journal of Cell Biology 190(4):675-691. 23 August 2010 (2010)
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  DOI10.1083/jcb.201002119 PMID20713605 PMCIDPMC2928008 DivisionNeurobiology
• The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate AuthorsMittal R., Peak-Chew S. Y., Sade R. S, Vallis Y., McMahon H. T. Journal Journal of Biological Chemistry 285(26):19927-19934. 25 June 2010 (2010)
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  DOI10.1074/jbc. M110.126581 PMID20430892 PMCIDPMC2888404 DivisionNeurobiology
• Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation AuthorsJao C. C., Hegde B. G., Gallop J. L., Hegde P. B., McMahon H. T., Haworth I. S., Langen R. Journal Journal of Biological Chemistry 285(26):20164-20170. 25 June 2010 (2010)
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  DOI10.1074/jbc. M110.127811 PMID20418375 PMCIDPMC2888429 DivisionNeurobiology
• FCHo proteins are nucleators of clathrin-mediated endocytosis AuthorsHenne W. M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H. T. Journal Science 328(5983):1281-1284. 4 June 2010 (2010)
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  DOI10.1126/science.1188462 PMID20448150 PMCIDPMC2883440 DivisionNeurobiology
• The Scottish Structural Proteomics Facility: targets, methods and outputs AuthorsOke M., Carter L. G., Johnson K. A., Liu H., McMahon S. A., Yan X., Kerou M., Weikart N. D., Kadi N., Sheikh M. A., Schmelz S., Dorward M., Zawadzki M., Cozens C., Falconer H., Powers H., Overton I. M., van Niekerk C. A., Peng X., Patel P., Garrett R. A., Prangishvili D., Botting C. H., Coote P. J., Dryden D. T., Barton G. J., Schwarz-Linek U., Challis G. L., Taylor G. L., White M. F., Naismith J. H. Journal Journal of Structural and Functional Genomics 11(2):167-180. 1 June 2010 (2010)
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  DOI10.1007/s10969-010-9090-y PMID20419351 PMCIDPMC2883930 DivisionProtein & Nucleic Acid Chemistry
• Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release AuthorsGroffen A. J., Martens S., Díez Arazola R., Cornelisse L. N., Lozovaya N., de Jong A. P., Goriounova N. A., Habets R. L., Takai Y., Borst J. G., Brose N., McMahon H. T., Verhage M. Journal Science 327(5973):1614-1618. 26 March 2010 (2010)
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  DOI10.1126/science.1183765 PMID20150444 PMCIDPMC2846320 DivisionNeurobiology
• Membrane curvature in synaptic vesicle fusion and beyond AuthorsMcMahon H. T., Kozlov M. M., Martens S. Journal Cell 140(5):601-605. 5 March 2010 (2010)
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  DOI10.1016/j. Cell.2010.02.017 PMID20211126 PMCID  DivisionNeurobiology
• Mechanisms of endocytosis AuthorsDoherty G. J., McMahon H. T. Journal Annual Review of Biochemistry 78: 857-902. 7 July 2009 (2009)
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  DOI10.1146/annurev. Biochem.78.081307.110540 PMID19317650 PMCID  DivisionNeurobiology
• Arrestins as adaptors for ubiquitination in endocytosis and sorting AuthorsMittal R., McMahon H. T. Journal EMBO Reports 10(1): 41-3. January 2009 (2009)
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  DOI10.1038/embor.2008.240 PMID19057574 PMCIDPMC2613220 DivisionNeurobiology
• A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family AuthorsAlexander Eberth, Richard Lundmark, Lothar Gremer, Radovan Dvorsky, Katja T. Koessmeier, Harvey T. McMahon, Mohammad Reza Ahmadian Journal Biochemical Journal 417(1): 371-377 (2009) (2009)
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  DOI10.1042/BJ20081535 PMID18954304 PMCID  DivisionNeurobiology
• Modeling membrane shaping by proteins: focus on EHD2 and N-BAR domains AuthorsCampelo F., Fabrikant G., McMahon H. T., Kozlov M. M. Journal FEBS Letters 584(9):1830-1839 (2009) (2009)
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  DOI10.1016/j.febslet.2009.10.023 PMID19836393 PMCID  DivisionNeurobiology
• Solitary and repetitive binding motifs for the AP2 complex alpha-appendage in amphiphysin and other accessory proteins AuthorsLene E. Olesen, Marijn G. J. Ford, Eva M. Schmid, Yvonne Vallis, M. Madan Babu, Peter H. Li, Ian G. Mills, Harvey T. McMahon, Gerrit J. K. Praefcke Journal Journal of Biological Chemistry 283 (8): 5099-5109 (2008)
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  DOI  PMID17986441 PMCID  Division 
• Mediation, modulation, and consequences of membrane-cytoskeleton interactions AuthorsGary J. Doherty, Harvey T. McMahon Journal Annual Review of Biophysics 37: 65-95 (2008)
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  DOI  PMID18573073 PMCID  Division 
• Arf family GTP loading is activated by, and generates, positive membrane curvature AuthorsRichard Lundmark, Gary J. Doherty, Yvonne Vallis, Brian J. Peter, Harvey T. McMahon Journal Biochemical Journal 414 (2): 189-94. (2008)
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  DOI  PMID18597672 PMCIDPMC2518064 Division 
• Mechanisms of membrane fusion: disparate players and common principles AuthorsSascha Martens, Harvey T. McMahon Journal Nature Reviews Molecular Cell Biology 9 (7): 543-56 (2008)
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  DOI  PMID18496517 PMCID  Division 
• The Hydrophonic Insertion Mechanism of Membrane Curvature Generation by Proteins AuthorsFelix Campelo, Harvey T. McMahon, Michael M. Kozlov Journal Biophysical Journal 95 (5): 2325-2339 (2008)
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  DOI  PMID18515373 PMCIDPMC2517036 Division 
• The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic Pathway AuthorsRichard Lundmark, Gary J. Doherty, Mark T. Howes, Katia Cortese, Yvonne Vallis, Robert G. Parton, Harvey T. McMahon Journal Current Biology 18 (22): 1802-1808 (2008)
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  DOI  PMID19036340 PMCIDPMC2726289 Division 
• Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion AuthorsKara L. Lynch, Roy R. L. Gerona, Dana M. Kielar, Sascha Martens, Harvey T. McMahon, Thomas F. J. Martin Journal Molecular Biology of the Cell 19(12): 5093-5103 (2008) (2008)
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  DOI  PMID18799625 PMCIDPMC2592635 Division 
• Membrane Localization is Critical for Activation of the PICK1 BAR Domain AuthorsKenneth L. Madsen, Jacob Eriksen, Laura Milan-Lobo, Daniel S. Han, Masha Y. Niv, Ina Ammendrup-Johnsen, Ulla Henriksen, Vikram K. Bhatia, Dimitrios Stamou, Harald H. Sitte, Harvey T. McMahon, Harel Weinstein, Ulrik Gether Journal Traffic 9 (8): 1327-1343 (2008)
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  DOI  PMID18466293 PMCID  Division 
• Structure and analysis of FCHo2 F-BAR domain : a dimerizing and membrane recrutiment module that effects membrane curvature AuthorsWilliam Mike Henne, Helen M. Kent, Marijn G. J. Ford, Balachandra G. Hegde, Oliver Daumke, P. Jonathan G. Butler, Rohit Mittal, Ralf Langen, Philip R. Evans, Harvey T. McMahon Journal Structure 15(7): 839-852 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• How synaptotagmin promotes membrane fusion AuthorsSascha Martens, Michael M. Kozlov, Harvey T. McMahon Journal Science 316(5828): 1205-1208 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• Integrating molecular and network biology to decode endocytosis AuthorsEva M. Schmid, Harvey T. McMahon Journal Nature 448(7156): 883-888 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling AuthorsOliver Daumke, Richard Lundmark, Yvonne Vallis, Sascha Martens, P. Jonathan G. Butler, Harvey T. McMahon Journal Nature 449(7164): 923-929 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• The conserved isoleucine-valine-phenylalanine motif couples activation state and endocytic functions of beta‑arrestins AuthorsAnne Burtey, Eva M. Schmid, Marijn G. J. Ford, Joshua Z. Rappoport, Mark G. H. Scott, Stefano Marullo, Sanford M. Simon, Harvey T. McMahon, Alexandre Benmerah Journal Traffic 8: 914-931 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• Role of the AP2 {beta}-appendage hub in recruiting partners for clathrin-coated vesicle assembly AuthorsEva Schmid, Marijn G. J. Ford, Anne Burtey, Gerrit J. K. Praefcke, Sew-Yeu Peak-Chew, Ian G. Mills, Alexandre Benmerah, Harvey T. McMahon Journal PLoS Biology 4(9):e262 (2006) (2006)
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  DOI10.1371/journal.pbio.0040262 PMID16903783 PMCIDPMC1540706 DivisionNeurobiology
• Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signalling AuthorsElizabeth S. Maywood, Akhilesh B. Reddy, Gabriel K. Y. Wong, John S. O'Neill, John A. O'Brien, Douglas G. McMahon, Anthony J. Harmar, Hitoshi Okamura, Michael H. Hastings Journal Current Biology 16(6):599-605. 21 March 2006 (2006 )
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  DOI10.1016/j. Cub.2006.02.023 PMID16546085 PMCID  DivisionNeurobiology
• Acetylation of MEK2 and I{kappa}B kinase(IKK) activation loop residues by YopJ inhibits signaling AuthorsRohit Mittal, Sew-Yeu Peak-Chew, Harvey T. McMahon Journal Proceedings of the National Academy of Sciences, USA 103 : 18574-18579 (2006) (2006)
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  DOI  PMID  PMCID  Division 
• Mechanism of endophilin N-BAR domain-mediated membrane curvature AuthorsJennifer L. Gallop, Christine C. Jao, Helen M. Kent, P. Jonathan G. Butler, Philip R. Evans, Ralf Langen, Harvey T. McMahon Journal EMBO Journal 25: 2898-2910 (2006) (2006)
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  DOI  PMID  PMCID  Division 
• Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission AuthorsGallop J. L., Butler P. J. G., McMahon H. T. Journal Nature 438(7068):675-678. 1 December 2005 (2005)
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  DOI10.1038/nature04136 PMID16319893 PMCID  DivisionNeurobiology
• Membrane curvature and mechanisms of dynamic cell membrane remodelling AuthorsMcMahon H. T., Gallop J. L. Journal Nature 438(7068):590-596. 30 November 2005 (2005)
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  DOI10.1038/nature04396 PMID16319878 PMCID  DivisionNeurobiology
• Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cells AuthorsJockusch W. J., Praefcke G. J. K., McMahon H. T., Lagnado L. Journal Neuron 46(6):869-878. 16 June 2005 (2005)
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  DOI10.1016/j.neuron.2005.05.004 PMID15953416 PMCID  DivisionNeurobiology
• BAR domains and membrane curvature: bringing your curves to the BAR AuthorsJennifer L. Gallop, Harvey T. McMahon Journal Biochem. Soc. Symp. 72: 223-231 (2005) (2005)
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• In vitro reconstitution of discrete stages of dynamin-dependent endocytosis AuthorsHiggins M. K., McMahon H. T. Journal Methods in Enzymology 404: 597-611 January 2005 (2005)
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  DOI10.1016/s0076-6879(05)04052-8 PMID16413303 PMCID  DivisionNeurobiology
• Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport AuthorsJez G. Carlton, Miriam V. Bujny, Brian J. Peter, Viola M. J. Oorschot, Anna Rutherford, Rebecca S. Arkell, Judith Klumperman, Harvey T. McMahon, Peter J. Cullen Journal Journal of Cell Science 118: 4527-4539 (2005) (2005)
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• Analysis of circadian mechanisms in the suprachiasmatic nucleus by transgenesis and biolistic transfection AuthorsMichael H. Hastings, Akhilesh B. Reddy, Douglas G. McMahon, Elisabeth S. Maywood Journal Methods in Enzymology 393: 579-592 (2005) (2005)
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• Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis AuthorsPraefcke G. J. K., Ford M. G. J., Schmid E. M., Olesen L. E., Gallop J. L., Peak-Chew S-Y., Vallis Y., Babu M. M., Mills I. G., McMahon H. T. Journal EMBO Journal 23(22):4371-4383. 10 November 2004 (2004)
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  DOI10.1038/sj.emboj.7600445 PMID15496985 PMCIDPMC526462 DivisionStructural Studies, Neurobiology
• Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells AuthorsTsuboi T., McMahon H. T., Rutter G. A. Journal Journal of Biological Chemistry 279(45):47115-47124. 5 November 2004 (2004)
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  DOI10.1074/jbc.m408179200 PMID15331588 PMCID  DivisionNeurobiology
• Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3‑phosphoinositides AuthorsCarlton J., Bujny M., Peter B. J., Oorschot V. M. J., Rutherford A., Mellor H., Klumperman J., McMahon H. T., Cullen P. J. Journal Current Biology 14(20):1791-1800. 26 October 2004 (2004)
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  DOI10.1016/j. Cub.2004.09.077 PMID15498486 PMCID  DivisionNeurobiology
• COP and clathrin-coated vesicle budding: different pathways, common approaches AuthorsMcMahon H. T., Mills I. G. Journal Current Opinion in Cell Biology 16(4):379-391. August 2004 (2004)
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  DOI10.1016/j. Ceb.2004.06.009 PMID15261670 PMCID  DivisionNeurobiology
• The dynamin superfamily: universal membrane tubulation and fission molecules? AuthorsPraefcke G. J. K., McMahon H. T. Journal Nature Reviews Molecular Cell Biology 5(2):133-147. February 2004 (2004)
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  DOI10.1038/nrm1313 PMID15040446 PMCID  DivisionNeurobiology
• BAR domains as sensors of membrane curvature: the amphiphysin BAR structure AuthorsBrian J. Peter, Helen M. Kent, Ian G. Mills, Yvonne Vallis, P. Jonathan G. Butler, Philip R. Evans, Harvey T. McMahon Journal Science 303(5657):495-499 (2004) (2004)
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  DOI10.1126/science.1092586 PMID14645856 PMCID  DivisionNeurobiology
• Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes AuthorsAgnes Saint-Pol, Belen Yelamos, Mohamed Amessou, Ian G. Mills, Marc Dugast, Daniele Tenza, Peter Schu, Claude Antony, Harvey T. McMahon, Christophe Lamaze, Ludger Johannes Journal Developmental Cell 6: 525-538 (2004) (2004)
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• EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking AuthorsMills I. G., Praefcke G. J. K., Vallis Y., Peter B. J., Olesen L. E., Gallop J. L., Butler P. J. G., Evans P. R.,McMahon H. T. Journal Journal of Cell Biology 160(2):213-222. 21 January 2003 (2003)
  Details

  DOI10.1083/jcb.200208023 PMID12538641 PMCIDPMC2172650 DivisionNeurobiology, Structural Studies
• Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminology homology (ENTH) domains AuthorsRobert V. Stahelin, Fei Long, Brian J. Peter, Diana Murray, Pietro de Camilli, Harvey T. McMahon, Wonhwa Cho Journal Journal of Biological Chemistry 278: 28993-28999 (2003) (2003)
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• Curvature of clathrin-coated pits driven by epsin AuthorsFord M. G. J., Mills I. G., Peter B. J., Vallis Y., Praefcke G. J. K., Evans P. R., McMahon H. T. Journal Nature 419(6905):361-366. 26 September 2002 (2002)
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  DOI10.1038/nature01020 PMID12353027 PMCID  DivisionStructural Studies, Neurobiology
• Gamma-Adaptin appendage domain: structure and binding site for Eps15 and gamma‑synergin AuthorsKent H. M., McMahon H. T., Evans P. R., Benmerah A., Owen D. J. Journal Structure 10(8):1139-1148. August 2002 (2002)
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  DOI10.1016/s0969-2126(02)00801-8 PMID12176391 PMCID  DivisionNeurobiology, Structural Studies
• Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size AuthorsGraham M. E., O'Callaghan D. W., McMahon H. T., Burgoyne R. D. Journal Proceedings of the National Academy of Sciences, USA 99(10):7124-7129. 14 May 2002 (2002)
  Details

  DOI10.1073/pnas.102645099 PMID11997474 PMCIDPMC124539 DivisionNeurobiology
• Snap-shots of clathrin-mediated endocytosis AuthorsHiggins M. K., McMahon H. T. Journal Trends in Biochemical Sciences 27(5):257-263. 1 May 2002 (2002)
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  DOI10.1016/s0968-0004(02)02089-3 PMID12076538 PMCID  DivisionNeurobiology
• Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila AuthorsRazzaq A., Robinson I. M., McMahon H. T., Skepper J. N., Su Y., Zelhof A. C., Jackson A. P., Gay N. J., O'Kane C. J. Journal Genes & Development 15(22):2967-2979 (2001) (2001)
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  DOI10.1101/gad.207801 PMID11711432 PMCIDPMC312829 DivisionNeurobiology
• Simultaneous binding of Ptdlns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes AuthorsFord M. G. J., Pearse B. M. F., Higgins M. K., Vallis Y., Owen D. J., Gibson A., Hopkins C. R., Evans P. R., McMahon H. T. Journal Science 291(5506):1051-1055. 9 February 2001 (2001)
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  DOI10.1126/science.291.5506.1051 PMID11161218 PMCID  DivisionStructural Studies, Neurobiology
• Complexins regulate a late step in Ca2+-dependent neurotransmitter release AuthorsKerstin Reim, Michael Mansour, Frederique Varoqueaux, Harvey T. McMahon, Thomas C. Sudhof, Nils Brose, Christian Rosenmund Journal Cell 104: 71-81 (2001) (2001)
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• GTPase activity of dynamin and resulting conformation change are essential for endocytosis AuthorsBruno Marks, Michael H. B. Stowell, Yvonne Vallis, Ian G. Mills, Adele Gibson, Colin R. Hopkins, Harvey T. McMahon Journal Nature 410: 231-235 (2001) (2001)
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• Synaptic vesicle recycling: multiple pathways and functions in the nervous system AuthorsWigge P., McMahon H. T. Journal Endocytosis. Edited by Mark Marsh. (Frontiers in Molecular Biology) pp.204-217 (2001) (2001)
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• The structure and function of the beta2-adaptin appendage domain AuthorsOwen D. J., Vallis Y., Pearse B. M. F., McMahon H. T., Evans P. R. Journal EMBO Journal 19(16):4216-4227. 15 August 2000 (2000)
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  DOI10.1093/emboj/19.16.4216 PMID10944104 PMCIDPMC302036 DivisionNeurobiology
• The structure and function of the beta2-adaptin appendage domain AuthorsOwen D. J., Vallis Y., Pearse B. M. F., McMahon H. T., Evans P. R. Journal EMBO Journal 19(16):4216-4227 (2000) (2000)
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  DOI10.1093/emboj/19.16.4216 PMID10944104 PMCIDPMC302036 DivisionNeurobiology
• The structural era of endocytosis AuthorsMarsh M., McMahon H. T. Journal Science 285(5425):215-220 (1999) (1999)
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  DOI10.1126/science.285.5425.215 PMID10398591 PMCID  DivisionNeurobiology
• A structural explanation for the binding of multiple ligands by the alpha - adaptin appendage domain AuthorsOwen D. J., Vallis Y., Noble M. E. M., Hunter J. B., Dafforn T. R., Evans P. R., McMahon H. T. Journal Cell 97(6):805-815 (1999) (1999)
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  DOI10.1016/S0092-8674(00)80791‑6 PMID10380931 PMCID  Division 
• Endocytosis: An assembly protein for clathrin cages AuthorsMcMahon H. T. Journal Current Biology 9(9):R332-5 (1999) (1999)
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  DOI10.1016/S0960-9822(99)80206‑1 PMID10330371 PMCID  DivisionNeurobiology
• Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring AuthorsStowell M. H. B., Marks B., Wigge P., McMahon H. T. Journal Nature Cell Biology 1(1):27-32 (1999) (1999)
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  DOI10.1038/8997 PMID10559860 PMCID  DivisionNeurobiology
• Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis AuthorsVallis Y., Wigge P., Marks B., Evans P. R., McMahon H. T. Journal Current Biology 9(5):257-260 (1999) (1999)
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  DOI10.1016/s0960-9822(99)80114-6 PMID10074456 PMCID  DivisionNeurobiology, Structural Studies
• Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis AuthorsVallis Y., Wigge P., Marks B., Evans P. R., McMahon H. T. Journal Current Biology 9(5):257-260 (1999) (1999)
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  DOI10.1016/s0960-9822(99)80114‑6 PMID10074456 PMCID  DivisionNeurobiology
• The amphiphysin family of proteins and their role in endocytosis at the synapse AuthorsPatrick Wigge, Harvey T. McMahon Journal Trends in Neuroscience 21: 339-344 (1998) (1998)
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• Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals AuthorsBruno Marks, Harvey T. McMahon Journal Current Biology 8: 740-749 (1998) (1998)
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• Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation AuthorsD. J. Owen, P. Wigge, Y. Vallis, J. D. A. Moore, P. R. Evans, H. T. McMahon Journal EMBO Journal 17: 5273-5285 (1998) (1998)
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• Clathrin interacts specifically with amphiphysin and is displaced by dynamin AuthorsHarvey T. McMahon, Patrick Wigge, Corrin Smith Journal FEBS Letters 413: 319-322 (1997) (1997)
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• Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain AuthorsPatrick Wigge, Yvonne Vallis, Harvey T. McMahon Journal Current Biology 7: 554-560 (1997) (1997)
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• Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis AuthorsPatrick Wigge, Katinka Kohler, Yvonne Vallis, Christopher A. Doyle, David Owen, Stephen P. Hunt, Harvey T. McMahon Journal Molecular Biology of the Cell 8: 2003-2015 (1997) (1997)
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• Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release AuthorsHarvey T. McMahon, Vadim Y. Bolshakov, Roger Janz, Robert E. Hammer, Steven A. Siegelbaum, Thomas C. Sudhof Journal Proceedings of the National Academy of Sciences, USA 93: 4760-4764 (1996) (1996)
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• Complexins: cytosolic proteins that regulate SNAP receptor function AuthorsHarvey T. McMahon, Markus Missler, Cai Li, Thomas C. Sudhof Journal Cell 83: 111-119 (1995) (1995)
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• Expression of c-Jun as a response to dorsal root and peripheral nerve section in damaged and adjacent intact primary sensory neurons in the rat AuthorsR. Jenkins, S. B. McMahon, A. B. Bond, S. P. Hunt Journal European Journal of Neuroscience 5: 751-759 (1993) (1993)
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