Published Research

Found 104 results for James L.

• Antibody-dependent xenophagy targets viruses and bacteria for destruction AuthorsRhinesmith T., Albecka A., James L. C. Journal Autophagy :1-2 (2026)
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  DOI10.1080/15548627.2026.2701600 PMID42418235 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid AuthorsKleinpeter A. B., Mallery D. L., Albecka A., Burdick R. C., Renner N., Klarhof J. O., Vamos B., Pathak V. K., James L. C., Freed E. O. Journal Journal of Molecular Biology :169950 (2026)
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  DOI10.1016/j.jmb.2026.169950 PMID42462964 PMCID  DivisionProtein & Nucleic Acid Chemistry
• TRIM21 induces selective autophagy of viruses and bacteria AuthorsRhinesmith T., Albecka A., Vaysburd M., Puri C., Luptak J., Boulanger J., Nguyen Le Q. M., Gratian M. J., O'Connell K., Few L., Donaldson-Wing M., Kozik P., Rubinsztein D. C., James L. C. Journal Molecular Cell 86(12):2410-2424.e10 (2026)
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  DOI10.1016/j.molcel.2026.04.031 PMID42242206 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Vaccine-induced antibodies can limit Salmonella infection in the absence of complement or macrophages AuthorsPerez-Toledo M., Aksu-Istil K., Marcial-Juarez E., Persaud R. R., Alshayea A., Jossi S. E., Carestia A., von Meijenfeld F., Botto M., James L. C., Surewaard B., Afzal Z., Shields A. M., Horsnell W. G., Lopez-Macias C., Henderson I. R., OptiVaNTS consortium, Jenne C. N., Cunningham A. F. Journal Mbio :e0284625 (2026)
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  DOI10.1128/mbio.02846‑25 PMID41738756 PMCIDPMC13059751 DivisionProtein & Nucleic Acid Chemistry
• The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid AuthorsHong J., Deshpande A., Thakare Y., Simonovsky L., Douglas A. W., Guinness C. M., Rotem-Dai N., Kortyna M. L., Klarhof J. O., Shi J., James L. C., Boecking T., Francis A. C., Rousso I., Aiken C. Journal PLoS Pathog 22(1):e1013910 (2026)
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  DOI10.1371/journal.ppat.1013910 PMID41610155 PMCIDPMC12871957 DivisionProtein & Nucleic Acid Chemistry
• How HIV-1 uses the metabolite inositol hexakisphosphate to build its capsid AuthorsJames L.C. Journal Viruses 17(5):689 (2025)
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  DOI10.3390/v17050689 PMID40431700 PMCIDPMC12115385 DivisionProtein & Nucleic Acid Chemistry
• An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models AuthorsKaren Anthi A., Kolderup A., Benno Vaage E., Bern M., Benjakul S., Tjärnhage E., Ruso-Julve F., Jensen K.R., Elisabeth Lode H., Vaysburd M., Nilsen J., Leangen Herigstad M., Aestedatter Sakya S., Tietze L., Pilati D., Nyquist-Andersen M., Dürdoop M., Tollefsrud Gjølberg T., Peng L., Foss S., Moe M.C., Low B.E., Wiles M.V., Nemazee D., Jahnsen F.L., Torgils Vaage J., Howard K.A., Sandlie I., James L.C., Grødeland G., Lund-Johansen F., Terje Andersen J. Journal Nature Communications 16(1):3999 (2025)
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  DOIdoi.org/10.1038/s41467-025-59353-6 PMID40312392 PMCIDPMC12045997 DivisionProtein & Nucleic Acid Chemistry
• UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains AuthorsKiss L., James L.C., Schulman B.A. Journal Molecular Cell 85(7):1467-1476.e6 (2025)
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  DOI10.1016/j.molcel.2025.02.021 PMID40132582 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21 AuthorsLeventhal S. S., Bisom T., Clift D., Rao D., Meade-White K., Shaia C., Murray J., Mihalakakos E. A., Hinkley T., Reynolds S. J., Best S. M., Erasmus J. H., James L. C., Feldmann H., Hawman D. W. Journal Nature Communications 15(1):9236 (2024)
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  DOI10.1038/s41467-024-53362-7 PMID39455551 PMCIDPMC11511847 DivisionProtein & Nucleic Acid Chemistry
• HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly AuthorsKleinpeter A., Mallery D. L., Renner N., Albecka A., Klarhof J. O., Freed E. O., James L. C. Journal Nature Communications 15(1):8017 (2024)
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  DOI10.1038/s41467-024-51971‑w PMID39271696 PMCIDPMC11399258 DivisionProtein & Nucleic Acid Chemistry
• Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function AuthorsMiller L. V. C., Papa G., Vaysburd M., Cheng S., Sweeney P. W., Smith A., Franco C., Katsinelos T., Huang M., Sanford S. A. I., Benn J., Farnsworth J., Higginson K., Joyner H., McEwan W. A., James L. C. Journal Cell 187(21):5967-5980.e17 (2024)
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  DOI10.1016/j. Cell.2024.08.024 PMID39276772 PMCID  DivisionProtein & Nucleic Acid Chemistry, Facilities (Mass Spec), Facilities (BSG)
• Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication AuthorsPauciullo S., Riccio A., Santopolo S., Albecka A., Papa G., James L. C., Piacentini S., Lanzilli G., Rossi A., Santoro M. G. Journal Cellular and Molecular Life Sciences : CMLS 81(1):386 (2024)
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  DOI10.1007/s00018-024-05370-5 PMID39243335 PMCIDPMC11380654 DivisionProtein & Nucleic Acid Chemistry
• Aggregate-selective removal of pathological tau by clustering-activated degraders AuthorsBenn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Journal Science Aug 30;385(6712):1009-1016. (2024)
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  DOI10.1126/science. Adp5186 PMID39208111 PMCID  DivisionProtein & Nucleic Acid Chemistry Neurobiology Facilities (MassSpec)
• Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure AuthorsFaysal K. M. R., Walsh J. C., Renner N., Márquez C. L., Shah V. B., Tuckwell A. J., Christie M. P., Parker M. W., Turville S. G., Towers G. J., James L. C., Jacques D. A., Böcking T. Journal eLife 13:e83605 (2024)
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  DOI10.7554/elife.83605 PMID38347802 PMCIDPMC10863983 DivisionProtein & Nucleic Acid Chemistry
• The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology AuthorsSanford S. A. I., Miller L. V. C, Vaysburd M., Keeling S., Tuck B. J., Clark J., Neumann M., Syanda V., James L. C., McEwan W. A. Journal Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(2):1013-1025 (2024)
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  DOI10.1002/alz.13493 PMID37849026 PMCIDPMC10916982 DivisionProtein & Nucleic Acid Chemistry
• Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2 AuthorsGaynor K. U., Vaysburd M., Harman M. A. J., Albecka A., Jeffrey P., Beswick P., Papa G., Chen L., Mallery D., McGuinness B., Van Rietschoten K., Stanway S., Brear P., Lulla A, Ciazynska K., Chang V. T., Sharp J., Neary M., Box H., Herriott J., Kijak E., Tatham L., Bentley E. G., Sharma P., Kirby A., Han X., Stewart J. P., Owen A., Briggs J A. G., Hyvönen M., Skynner M. J., James L. C. Journal Nature Communications 14(1):3583 (2023)
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  DOI10.1038/s41467-023-39158-1 PMID37328472 PMCIDPMC10275983 DivisionProtein & Nucleic Acid Chemistry
• Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates AuthorsKiss L., Rhinesmith T., Luptak J., Dickson C. F., Weidenhausen J., Smyly S., Yang J. C., Maslen S. L., Sinning I., Neuhaus D., Clift D., James L. C. Journal Nature Communications 14(1):2160 (2023)
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  DOI 10.1038/s41467-023-37504-x PMID37061529 PMCIDPMC10105713 DivisionProtein & Nucleic Acid Chemistry
• Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding AuthorsStacey J. C. V., Tan A., Lu J. M., James L. C., Dick R. A., Briggs J. A. G. Journal Proceedings of the National Academy of Sciences of the United States of America, 120(16):e2220557120 (2023)
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  DOI10.1073/pnas.2220557120 PMID37040417 PMCIDPMC10120081 DivisionStructural Studies
• Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models AuthorsMukadam A. S., Miller L. V. C., Smith A. E., Vaysburd M., Sakya S. A, Sanford S., Keeling S., Tuck B. J., Katsinelos T., Green C., Skov L., Kaalund S. S., Foss S., Mayes K., O'Connell K., Wing M., Knox C., Banbury J., Avezov E., Rowe J. B, Goedert M., Andersen J. T, James LC., McEwan W. A. Journal Science 379(6639):1336-1341 (2023)
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  DOI10.1126/science. Abn1366 PMID36996217 PMCIDPMC7614512 DivisionNeurobiology
• IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing AuthorsPapa G., Albecka A., Mallery D., Vaysburd M., Renner N., James L. C. Journal EMBO Reports 24(5):e56275 (2023)
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  DOI 10.15252/embr.202256275 PMID36970882 PMCIDPMC10157305 DivisionProtein & Nucleic Acid Chemistry
• HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly AuthorsRenner N, Kleinpeter A, Mallery DL, Albecka A, Rifat Faysal KM, Böcking T, Saiardi A, Freed EO, James LC Journal Nature Structural and Molecular Biology 30(3):370-382 (2023)
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  DOI10.1038/s41594-022-00887‑4 PMID36624347 PMCIDPMC7614341 DivisionProtein & Nucleic Acid Chemistry
• Evasion of cGAS and TRIM5 defines pandemic HIV AuthorsZuliani-Alvarez L, Govasli ML, Rasaiyaah J, Monit C, Perry SO, Sumner RP, McAlpine-Scott S, Dickson C, Rifat Faysal KM, Hilditch L, Miles RJ, Bibollet-Ruche F, Hahn BH, Boecking T, Pinotsis N, James LC, Jacques DA, Towers GJ. Journal Nature Microbiology Nov;7(11):1762-1776 (2022)
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  DOI10.1038/s41564-022-01247‑0 PMID36289397 PMCIDPMC9613477 DivisionProtein & Nucleic Acid Chemistry
• A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling AuthorsMersmann SF, Johns E, Yong T, McEwan WA, James LC, Cohen EAK, Grove J. Journal Scientific Reports Oct 14;12(1):17286 (2022)
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  DOI10.1038/s41598-022-20506‑y PMID36241663 PMCIDPMC9568568 DivisionProtein & Nucleic Acid Chemistry
• TRIM7 restricts coxsackievirus and norovirus infection by detecting the C-terminal glutamine generated by 3C protease processing AuthorsLuptak J., Mallery D. L., Jahun A. S., Albecka A., Clift D., Ather O., Slodkowicz G., Goodfellow I., James L. C. Journal Viruses 14(8):1610 (2022)
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  DOI10.3390/v14081610 PMID35893676 PMCIDPMC9394474 DivisionProtein & Nucleic Acid Chemistry
• The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21 AuthorsKiss L., James L. C. Journal Seminars in Cell & Developmental Biology 126:99-107 (2022)
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  DOI10.1016/j.semcdb.2021.11.005 PMID34823983 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cholesterol determines the cytosolic entry and seeded aggregation of tau AuthorsTuck B.J., Miller L.V.C., Katsinelos T., Smith A.E., Wilson E.L., Keeling S., Cheng S., Vaysburd M.J., Knox C., Tredgett L., Metzakopian E., James L. C., McEwan W.A. Journal Cell Reports 39(5):110776 (2022)
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  DOI10.1016/j.Celrep.2022.110776 PMID35508140 PMCIDPMC9108550 DivisionProtein & Nucleic Acid Chemistry
• Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge AuthorsFoss S., Jonsson A., Bottermann M., Watkinson R., Lode H. E., McAdam M. B., Michaelsen T. E., Sandlie I., James L. C., Andersen J. T. Journal Science Immunology 7(70):eabj1640 (2022)
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  DOI10.1126/sciimmunol. Abj1640 PMID35486676 PMCIDPMC7614286 DivisionProtein & Nucleic Acid Chemistry
• Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity AuthorsMeng B, Abdullahi A, Ferreira IATM, Goonawardane N, Saito A, Kimura I, Yamasoba D, Gerber PP, Fatihi S, Rathore S, Zepeda SK, Papa G, Kemp SA, Ikeda T, Toyoda M, Tan TS, Kuramochi J, Mitsunaga S, Ueno T, Shirakawa K, Takaori-Kondo A, Brevini T, Mallery DL, Charles OJ; CITIID-NIHR BioResource COVID-19 Collaboration; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ecuador-COVID19 Consortium; Bowen JE, Joshi A, Walls AC, Jackson L, Martin D, Smith KGC, Bradley J, Briggs JAG, Choi J, Madissoon E, Meyer KB, Mlcochova P, Ceron-Gutierrez L, Doffinger R, Teichmann SA, Fisher AJ, Pizzuto MS, de Marco A, Corti D, Hosmillo M, Lee JH, James LC, Thukral L, Veesler D, Sigal A, Sampaziotis F, Goodfellow IG, Matheson NJ, Sato K, Gupta RK. Journal Nature 603(7902):706-714 (2022)
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  DOI10.1038/s41586-022-04474-x PMID35104837 PMCIDPMC8942856 DivisionProtein & Nucleic Acid Chemistry
• SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion AuthorsMlcochova P., et al (Including Papa G., Albecka A., James L. C.) Journal Nature 599(7883):114-119 (2021)
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  DOI10.1038/s41586-021-03944‑y PMID34488225 PMCIDPMC8566220 DivisionProtein & Nucleic Acid Chemistry
• Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation AuthorsCattin-Ortolá J., Welch L. G., Maslen S. L., Papa G., James L. C., Munro S. Journal Nature Communications 12(1):5333 (2021)
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  DOI10.1038/s41467-021-25589-1 PMID34504087 PMCIDPMC8429659 DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• SARS-CoV-2 spike protein stabilized in the closed state induces potent neutralizing responses AuthorsCarnell G. W., Ciazynska K. A., Wells D. A., Xiong X., Aguinam E. T., McLaughlin S. H., Mallery D., Ebrahimi S., Ceron-Gutierrez L., Asbach B., Einhauser S., Wagner R., James L. C., Doffinger R., Heeney J. L., Briggs J. A. G. Journal Journal of Virology 95(15):e0020321. August 2021 (2021)
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  DOI10.1128/jvi.00203‑21 PMID33963055 PMCIDPMC8274612 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue AuthorsMiller L. V. C., Mukadam A. S., Durrant C. S., Vaysburd M. J., Katsinelos T., Tuck B. J., Sanford S., Sheppard O., Knox C., Cheng S., James L. C., Coleman M. P., McEwan W. A. Journal Acta Neuropathologica Communications 9(1):41. 12 March 2021 (2021)
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  DOI10.1186/s40478-021-01141-6 PMID33712082 PMCIDPMC7953780 DivisionProtein & Nucleic Acid Chemistry
• A stable immature lattice packages IP6 for HIV capsid maturation AuthorsMallery D. L., Kleinpeter A. B., Renner N., Faysal K. M. R., Novikova M., Kiss L., Wilson M. S. C., Ahsan B., Ke Z., Briggs J. A. G., Saiardi A., Böcking T., Freed E. O., James L. C. Journal Science Advances 7(11): eabe4716. 10 March 2021 (2021)
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  DOI10.1126/sciadv. Abe4716 PMID33692109 PMCIDPMC7946374 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity AuthorsCaddy S. L., Vaysburd M., Papa G., Wing M., O'Connell K., Stoycheva D., Foss S., Terje Andersen J., Oxenius A., James L. C. Journal EMBO Journal 40(5):e106228. 1 March 2021 (2021)
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  DOI10.15252/embj.2020106228 PMID33258165 PMCIDPMC7917548 DivisionProtein & Nucleic Acid Chemistry
• Target-induced clustering activates Trim-Away of pathogens and proteins AuthorsZeng J., Santos A. F., Mukadam A. S., Osswald M., Jacques D. A., Dickson C. F., McLaughlin S. H., Johnson C. M., Kiss L. ., Luptak J., Renner N., Vaysburd M., McEwan W. A., Morais-de-Sá E., Clift D., James L. C. Journal Nature Structural & Molecular Biology 28(3):278-289. March 2021 (2021)
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  DOI10.1038/s41594-021-00560‑2 PMID33633400 PMCIDPMC7611929 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination AuthorsKiss L., Clift D., Renner N., Neuhaus D., James L. C. Journal Nature Communications 12(1):1220. 22 February 2021 (2021)
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  DOI10.1038/s41467-021-21443‑6 PMID33619271 PMCIDPMC7900206 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly AuthorsRenner N., Mallery D. L., Faysal K. M. R., Peng W., Jacques D. A., Böcking T., James L. C. Journal Plos Pathogens 17(2):e1009164. 1 February 2021 (2021)
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  DOI10.1371/journal.ppat.1009164 PMID33524070 PMCIDPMC7850482 DivisionProtein & Nucleic Acid Chemistry
• Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion AuthorsPapa G., Mallery D. L., Albecka A., Welch L. G., Cattin-Ortolá J., Luptak J., Paul D., McMahon H. T., Goodfellow I. G., Carter A., Munro S., James L. C. Journal Plos Pathogens 17(1):e1009246. 25 January 2021 (2021)
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  DOI10.1371/journal.ppat.1009246 PMID33493182 PMCIDPMC7861537 DivisionProtein & Nucleic Acid Chemistry, Neurobiology, Cell Biology, Structural Studies
• SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids AuthorsPellegrini L., Albecka A., Mallery D. L., Kellner M. J., Paul D., Carter A. P., James L. C., Lancaster M. A. Journal Cell Stem Cell 27(6):951-961.e5. 3 December 2020 (2020)
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  DOI10.1016/j.stem.2020.10.001 PMID33113348 PMCIDPMC7553118 DivisionStructural Studies, Protein & Nucleic Acid Chemistry, Cell Biology
• A thermostable, closed SARS-CoV-2 spike protein trimer AuthorsXiong X., Qu K., Ciazynska K. A., Hosmillo M., Carter A. P., Ebrahimi S., Ke Z., Scheres S. H. W., Bergamaschi L., Grice G. L., Zhang Y.; CITIID-NIHR COVID-19 BioResource Collaboration, Nathan J. A., Baker S., James L. C., Baxendale H. E., Goodfellow I., Doffinger R., Briggs J. A. G. Journal Nature Structural & Molecular Biology 27(10):934-941. October 2020 (2020)
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  DOI10.1038/s41594-020-0478‑5 PMID32737467 PMCIDPMC7116388 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant AuthorsMlcochova P., Collier D., Ritchie A., Assennato S. M., Hosmillo M., Goel N., Meng B., Chatterjee K., Mendoza V., Temperton N., Kiss L., James L. C., Ciazynska K. A., Xiong X., Briggs J. A. G., Nathan J. A., Mescia F., Bergamaschi L., Zhang H., Barmpounakis P., Demeris N., Skells R., Lyons P. A., Bradley J., Baker S., Allain J. P., Smith K. G. C, Bousfield R., Wilson M., Sparkes D., Amoroso G., Gkrania-Klotsas E., Hardwick S., Boyle A., Goodfellow I., Gupta R. K.; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration. Journal Cell reports. Medicine 1(6):100099. 22 September 2020 (2020)
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  DOI10.1016/j.xcrm.2020.100099 PMID32905045 PMCIDPMC7462534 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Intracellular antibody immunity and its applications AuthorsZeng J., James L. C. Journal Plos Pathogens 16(8):e1008657. 6 August 2020 (2020)
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  DOI10.1371/journal.ppat.1008657 PMID32760166 PMCIDPMC7410306 DivisionProtein & Nucleic Acid Chemistry
• Intracellular neutralisation of rotavirus by VP6-specific IgG AuthorsCaddy S. L., Vaysburd M., Wing M., Foss S., Andersen J. T., O'Connell K., Mayes K., Higginson K., Iturriza-Gómara M., Desselberger U., James L. C. Journal Plos Pathogens 16(8):e1008732. 4 August 2020 (2020)
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  DOI10.1371/journal.ppat.1008732 PMID32750093 PMCIDPMC7428215 DivisionProtein & Nucleic Acid Chemistry
• Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication AuthorsMallery D. L., Faysal K. M. R., Kleinpeter A., Wilson M. S. C., Vaysburd M., Fletcher A. J., Novikova M., Böcking T., Freed E. O., Saiardi A., James L. C. Journal Cell Reports 29(12):3983-3996.e4. 17 December 2019 (2019)
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  DOI10.1016/j. Celrep.2019.11.050 PMID31851928 PMCIDPMC6931105 DivisionProtein & Nucleic Acid Chemistry
• Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection AuthorsLabzin L. I., Bottermann M., Rodriguez-Silvestre P., Foss S., Andersen J. T., Vaysburd M., Clift D., James L. C. Journal EMBO Journal 38(21):e101365. 4 November 2019 (2019)
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  DOI10.15252/embj.2018101365 PMID31468569 PMCIDPMC6826209 DivisionProtein & Nucleic Acid Chemistry
• Rare missense variants in the human cytosolic antibody receptor preserve antiviral function AuthorsZeng J., Slodkowicz G., James L. C. Journal ELife 8: e48339. 15 October 2019 (2019)
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  DOI10.7554/eLife.48339 PMID31613747 PMCIDPMC6794091 DivisionProtein & Nucleic Acid Chemistry
• A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases AuthorsKiss L., Zeng J., Dickson C. F., Mallery D. L., Yang J. C., McLaughlin S. H., Boland A., Neuhaus D., James L. C. Journal Nature Communications 10(1):4502. 3 October 2019 (2019)
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  DOI10.1038/s41467-019-12388‑y PMID31582740 PMCIDPMC6776665 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• TRIM21-From Intracellular Immunity to Therapy AuthorsFoss S., Bottermann M., Jonsson A., Sandlie I., James L. C., Andersen J. T. Journal Frontiers in Immunology 10:2049. 28 August 2019 (2019)
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  DOI10.3389/fimmu.2019.02049 PMID31555278 PMCIDPMC6722209 DivisionProtein & Nucleic Acid Chemistry
• Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid AuthorsJames L. C., Böcking T. Journal Cell Host & Microbe 26(2):151-153. 14 August 2019 (2019)
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  DOI10.1016/j. Chom.2019.07.011 PMID31415744 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The HIV-1 Capsid: More than Just a Delivery Package AuthorsJames L. C. Journal Advances in Experimental Medicine and Biology 1215:69-83. July 2019 (2019)
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  DOI10.1007/978-3-030-14741-9_4 PMID31317496 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Complement C4 Prevents Viral Infection through Capsid Inactivation AuthorsBottermann M., Foss S., Caddy S. L., Clift D., van Tienen L. M., Vaysburd M., Cruickshank J., O'Connell K., Clark J., Mayes K., Higginson K., Lode H. E., McAdam M. B., Sandlie I., Andersen J. T., James L. C. Journal Cell Host & Microbe 25(4):617-629.e7. 10 April 2019 (2019)
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  DOI10.1016/j. Chom.2019.02.016 PMID30926239 PMCIDPMC6461443 DivisionProtein & Nucleic Acid Chemistry
• Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling AuthorsFletcher A. J., Vaysburd M., Maslen S., Zeng J., Skehel J. M., Towers G. J., James L. C. Journal Cell Host & Microbe 24(6):761-775.e6. 12 December 2018 (2018)
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  DOI10.1016/j. Chom.2018.10.007 PMID30503508 PMCIDPMC6299210 DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating AuthorsDick R. A., Mallery D. L., Vogt V. M., James L. C. Journal Viruses 10(11). 15 November 2018 (2018)
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  DOI10.3390/v10110640 PMID30445742 PMCIDPMC6267275 DivisionProtein & Nucleic Acid Chemistry
• TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination AuthorsBottermann M., Foss S., van Tienen L. M., Vaysburd M., Cruickshank J., O'Connell K., Clark J., Mayes K., Higginson K., Hirst J. C., McAdam M. B., Slodkowicz G., Hutchinson E., Kozik P., Andersen J. T., James L. C. Journal Proceedings of the National Academy of Sciences of the United States of America 115(41):10440-10445. 9 October 2018 (2018)
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  DOI10.1073/pnas.1806314115 PMID30209217 PMCIDPMC6187179 DivisionProtein & Nucleic Acid Chemistry
• Acute and rapid degradation of endogenous proteins by Trim‑Away AuthorsClift D., So C., McEwan W. A., James L. C., Schuh M. Journal Nature Protocols 13(10):2149-2175. October 2018 (2018)
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  DOI10.1038/s41596-018-0028‑3 PMID30250286 PMCID  DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• The Human Immunodeficiency Virus Capsid Is More Than Just a Genome Package AuthorsJames L. C., Jacques D. A. Journal Annual Review of Virology 5(1):209-225. September 2018 (2018)
  Details

  DOI10.1146/annurev-virology-092917‑043430 PMID30052493 PMCID  DivisionProtein & Nucleic Acid Chemistry
• IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis AuthorsMallery D. L., Márquez C. L., McEwan W. A., Dickson C., Jacques D. A., Anandapadamanaban M., Bichel K., Towers G. J., Saiardi A., Böcking T., James L. C. Journal ELife 7: e35335. 31 May 2018 (2018)
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• Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21 AuthorsDickson C., Fletcher A. J., Vaysburd M., Yang J. C., Mallery D. L., Zeng J., Johnson C. M., McLaughlin S. H., Skehel M., Maslen S., Cruickshank J., Huguenin-Dezot N., Chin J. W., Neuhaus D., James L. C. Journal eLife 7: e32660. 18 April 2017 (2018)
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• Intracellular Antiviral Immunity AuthorsBottermann M., James L. C. Journal Advances in Virus Research 100:309-354. 16 February 2018 (2018)
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• Characterization of innate immune viral sensors in patients following allogeneic hematopoietic stem cell transplantation AuthorsCaddy S. L., Wang M., Krishnamurthy P., Uttenthal B., Chandra A., Crawley C., James L. C. Journal Innate Immunity 24(2):112-121. February 2018 (2018)
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• Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein AuthorsKhamina K., Lercher A., Caldera M., Schliehe C., Vilagos B., Sahin M., Kosack L., Bhattacharya A., Májek P., Stukalov A., Sacco R., James L. C., Pinschewer D. D., Bennett K. L., Menche J., Bergthaler A. Journal PLoS Pathogens 13(12):e1006758. 20 December 2017 (2017)
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• A Method for the Acute and Rapid Degradation of Endogenous Proteins AuthorsClift D., McEwan W. A., Labzin L. I., Konieczny V., Mogessie B., James L. C., Schuh M. Journal Cell 171(7):1692-1706.e18. 14 December 2017 (2017)
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  DOI10.1016/j. Cell.2017.10.033 PMID29153837 PMCIDPMC5733393 DivisionProtein & Nucleic Acid Chemistry
• Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity AuthorsBottermann M., Lode H. E., Watkinson R. E, Foss S., Sandlie I., Andersen J. T., James L. C. Journal Scientific Reports 7:45418. 6 April 2017 (2017)
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  DOI10.1038/srep45418 PMID28382939 PMCIDPMC5382576 DivisionProtein & Nucleic Acid Chemistry
• Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation AuthorsMcEwan W. A., Falcon B., Vaysburd M., Clift D., Oblak A. L., Ghetti B., Goedert M., James L. C. Journal Proceedings of the National Academy of Sciences of the United States of America 114(3):574-579. 17 January 2017 (2017)
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  DOI10.1073/pnas.1607215114 PMID28049840 PMCIDPMC5255578 DivisionProtein & Nucleic Acid Chemistry, Neurobiology
• Antibody-antigen kinetics constrain intracellular humoral immunity AuthorsBottermann M., Lode H. E., Watkinson R. E., Foss S., Sandlie I., Andersen J. T., James L. C. Journal Scientific Reports 6:37457. 24 November 2016 (2016)
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  DOI10.1038/srep37457 PMID27881870 PMCIDPMC5121590 DivisionProtein & Nucleic Acid Chemistry
• HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis AuthorsJacques D. A., McEwan W. A., Hilditch L., Price A. J., Towers G. J., James L. C. Journal Nature 536(7616):349-353. 18 August 2016 (2016)
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  DOI10.1038/nature19098 PMID27509857 PMCIDPMC4998957 DivisionProtein & Nucleic Acid Chemistry
• Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21 AuthorsFletcher A. J., James L. C. Journal Journal of Virology 90(10):4856-4859. May 2016 (2016)
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• TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity AuthorsFoss S., Watkinson R. E., Grevys A., McAdam M. B., Bern M., Høydahl L. S., Dalhus B., Michaelsen T. E., Sandlie I., James L. C., Andersen J. T. Journal Journal of Immunology 196(8):3452-3459. 15 April 2016 (2016)
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• Structural and mechanistic insights into the regulation of the fundamental Rho-regulator RhoGDIα by lysine acetylation AuthorsKuhlmann N., Wroblowski S., Knyphausen P., de Boor S., Brenig J., Zienert A. Y., Meyer-Teschendorf K., Praefcke G. J., Nolte H., Krüger M., Schacherl M., Baumann U., James L. C., Chin J. W., Lammers M. Journal Journal of Biological Chemistry 291(11):5484-5499. 11 March 2016 (2016)
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  DOI10.1074/jbc. M115.707091 PMID26719334 PMCIDPMC4786691 DivisionProtein & Nucleic Acid Chemistry
• TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity AuthorsFoss S., Watkinson R., Sandlie I., James L. C., Andersen J. T. Journal Immunological Reviews 268(1):328-339. November 2015 (2015)
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  DOI10.1111/imr.12363 PMID26497531 PMCIDPMC4670481 DivisionProtein & Nucleic Acid Chemistry
• TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus AuthorsWatkinson R. E., McEwan W. A., Tam J. C., Vaysburd M., James L. C. Journal PLoS Pathogens 11(10):e1005253. 27 October 2015 (2015)
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  DOI10.1371/journal.ppat.1005253 PMID26506431 PMCIDPMC4624778 DivisionProtein & Nucleic Acid Chemistry
• HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry AuthorsZhou J., Price A. J., Halambage U. D., James L. C., Aiken C. Journal Journal of Virology 89(17):9068-9079. September 2015 (2015)
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  DOI10.1128/JVI.00340‑15 PMID26109731 PMCIDPMC4524096 DivisionProtein & Nucleic Acid Chemistry
• Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21 AuthorsFletcher A. J., Mallery D. L., Watkinson R. E., Dickson C. F., James L. C. Journal Proceedings of the National Academy of Sciences of the United States of America 112(32):10014-10019. 11 August 2015 (2015)
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  DOI10.1073/pnas.1507534112 PMID26150489 PMCIDPMC4538650 DivisionProtein & Nucleic Acid Chemistry
• Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin AuthorsRhodes D. A., Chen H. C., Price A. J., Keeble A. H., Davey M. S., James L. C., Eberl M., Trowsdale J. Journal Journal of Immunology 194(5):2390-2398. 1 March 2015 (2015)
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  DOI10.4049/jimmunol.1401064 PMID25637025 PMCIDPMC4337483 DivisionProtein & Nucleic Acid Chemistry
• TRIM21-Dependent Intracellular Antibody Neutralization of Virus Infection. AuthorsMcEwan W. A., James L. C. Journal Progress in Molecular Biology and Translational Science 129:167-187, 1 January 2015 (2015)
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  DOI10.1016/bs.pmbts.2014.10.006 PMID25595804 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly AuthorsPrice A. J., Jacques D. A., McEwan W. A., Fletcher A. J., Essig S., Chin J. W., Halambage U. D., Aiken C., James L. C. Journal PLoS Pathogens 10(10):e1004459. 30 October 2014 (2014)
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  DOI10.1371/journal.ppat.1004459 PMID25356722 PMCIDPMC4214760 DivisionProtein & Nucleic Acid Chemistry
• Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells AuthorsBidgood S. R., Tam J. C., McEwan W. A., Mallery D. L., James L. C. Journal Proceedings of the National Academy of Sciences, USA 111(37):13463-13468. 16 September 2014 (2014)
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  DOI10.1073/pnas.1410980111 PMID25169018 PMCIDPMC4169910 DivisionProtein & Nucleic Acid Chemistry
• Intracellular sensing of complement C3 activates cell autonomous immunity AuthorsTam J. C., Bidgood S. R., McEwan W. A., James L. C. Journal Science 345(6201):1256070. 5 September 2014 (2014)
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  DOI10.1126/science.1256070 PMID25190799 PMCIDPMC4172439 DivisionProtein & Nucleic Acid Chemistry
• Intracellular antibody immunity and the cytosolic Fc receptor TRIM21 AuthorsJames L. C. Journal Current Topics in Microbiology and Immunology 382:51-66. 12 August 2014 (2014)
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  DOI10.1007/978-3-319-07911-0_3 PMID25116095 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Intracellular antibody immunity AuthorsWatkinson R. E., McEwan W. A., James L. C. Journal Journal of Clinical Immunology 34 Suppl 1:S30-4. July 2014 (2014)
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  DOI10.1007/s10875-014-0017-4 PMID24722852 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Antibody- and TRIM21-dependent intracellular restriction of Salmonella enterica AuthorsRakebrandt N., Lentes S., Neumann H., James L. C., Neumann-Staubitz P. Journal Pathogens and Disease 72(2):131-137. 27 June 2014 (2014)
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  DOI10.1111/2049-632X.12192 PMID24920099 PMCID  DivisionProtein & Nucleic Acid Chemistry
• HIV-1 evades innate immune recognition through specific cofactor recruitment AuthorsRasaiyaah J., Tan C. P., Fletcher A. J., Price A. J., Blondeau C., Hilditch L., Jacques D. A., Selwood D. L., James L. C., Noursadeghi M., Towers G. J. Journal Nature 503(7476):402-405. 21 November 2013 (2013)
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  DOI10.1038/nature12769 PMID24196705 PMCIDPMC3928559 DivisionProtein & Nucleic Acid Chemistry
• HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358 AuthorsBichel K., Price A. J., Schaller T., Towers G. J., Freund S. M., James L. C. Journal Retrovirology 10:81. 31 July 2013 (2013)
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  DOI 10.1186/1742-4690-10‑81 PMID23902822 PMCIDPMC3750474 DivisionProtein & Nucleic Acid Chemistry
• Intracellular antibody receptor TRIM21 prevents fatal viral infection AuthorsVaysburd M., Watkinson R. E., Cooper H., Reed M., O'Connell K., Smith J., Cruickshanks J., James L. C. Journal Proceedings of the National Academy of Sciences, USA. 110(30):12397-12401. 23 July 2013 (2013)
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  DOI10.1073/pnas.1301918110 PMID23840060 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Simultaneous neutralization and innate immune detection of a replicating virus by TRIM21 AuthorsWatkinson R. E., Tam J. C., Vaysburd M. J., James L. C. Journal Journal of Virology 87(13):7309-7313. July 2013 (2013)
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  DOI10.1128/JVI.00647‑13 PMID23596308 PMCIDPMC3700317 DivisionProtein & Nucleic Acid Chemistry
• Cellular self-defense: how cell-autonomous immunity protects against pathogens AuthorsRandow F., MacMicking J. D., James L. C. Journal Science 340(6133):701-706. 10 May 2013 (2013)
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  DOI10.1126/science.1233028 PMID23661752 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 AuthorsMcEwan W. A., Tam J. C., Watkinson R. E., Bidgood S. R., Mallery D. L., James L. C. Journal Nature Immunology 14(4):327-336. April 2013 (2013)
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  DOI10.1038/ni.2548 PMID23455675 PMCIDPMC3672961 DivisionProtein & Nucleic Acid Chemistry
• The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import AuthorsVeillette M., Bichel K., Pawlica P., Freund S. M., Plourde M. B., Pham Q. T., Reyes-Moreno C., James L. C., Berthoux L. Journal Retrovirology 10:25. 28 February 2013 (2013)
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  DOI10.1186/1742-4690-10‑25 PMID23448277 PMCIDPMC3598646 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization AuthorsHauler F., Mallery D. L., McEwan W. A., Bidgood S. R., James L. C. Journal Proceedings of the National Academy of Sciences, USA 109(48):19733-19738. 27 November 2012 (2012)
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  DOI10.1073/pnas.1210659109 PMID23091005 PMCIDPMC3511720 DivisionProtein & Nucleic Acid Chemistry
• CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication AuthorsPrice A. J., Fletcher A. J., Schaller T., Elliott T., Lee K., Kewalramani V. N., Chin J. W., Towers G. J., James L. C. Journal PLoS Pathogens 8(8):e1002896. 30 August 2012 (2012)
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  DOI10.1371/journal.ppat.1002896 PMID22956906 PMCIDPMC3431306 DivisionProtein & Nucleic Acid Chemistry
• Regulation of Virus Neutralization and the Persistent Fraction by TRIM21 AuthorsMcEwan W. A., Hauler F., Williams C. R., Bidgood S. R., Mallery D. L., Crowther R. A., James L. C. Journal Journal of Virology 86(16):8482-8491. August 2012 (2012)
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  DOI10.1128/JVI.00728‑12 PMID22647693 PMCIDPMC3421726 DivisionProtein & Nucleic Acid Chemistry; Structural Studies
• Diverse HIV viruses are targeted by a conformationally dynamic antiviral AuthorsCaines M. E., Bichel K., Price A. J., McEwan W. A., Towers G. J., Willett B. J., Freund S. M., James L. C. Journal Nature Structural & Molecular Biology 19(4):411-416. April 2012 (2012)
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  DOI10.1038/nsmb.2253 PMID22407016 PMCIDPMC3407371 DivisionProtein & Nucleic Acid Chemistry
• Intracellular antibody-mediated immunity and the role of TRIM21 AuthorsMcEwan W. A., Mallery D. L., Rhodes D. A., Trowsdale J., James L. C. Journal BioEssays 33(11):803-809. November 2011 (2011)
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  DOI10.1002/bies.201100093 PMID22006823 PMCID  DivisionProtein & Nucleic Acid Chemistry
• HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 AuthorsOcwieja K. E., Brady T. L., Ronen K., Huegel A., Roth S. L., Schaller T., James L. C., Towers G. J., Young J. A., Chanda S. K., König R., Malani N., Berry C. C., Bushman F. D. Journal PLoS Pathogens 7(3):e1001313. March 2011 (2011)
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  DOI10.1371/journal.ppat.1001313 PMID21423673 PMCIDPMC3053352 DivisionProtein & Nucleic Acid Chemistry
• Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21) AuthorsMallery D. L., McEwan W. A., Bidgood S. R., Towers G. J., Johnson C. M., James L. C. Journal Proceedings of the National Academy of Sciences, USA 107(46):19985-19990. 16 November 2010 (2010)
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  DOI10.1073/pnas.1014074107 PMID21045130 PMCIDPMC2993423 DivisionProtein & Nucleic Acid Chemistry
• Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion AuthorsDietrich I., Macintyre A., McMonagle E., Price A. J., James L. C., McEwan W. A., Hosie M. J., Willett B. J. Journal Journal of Virology 84(17):8980-8985. 1 September 2010 (2010)
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  DOI10.1128/JVI.00858‑10 PMID20554781 PMCIDPMC2919025 DivisionProtein & Nucleic Acid Chemistry
• Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity AuthorsYlinen L. M., Price A. J., Rasaiyaah J., Hué S., Rose N. J., Marzetta F., James L. C., Towers G. J. Journal PLoS Pathogens 6(8):e1001062. 19 August 2010 (2010)
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  DOI10.1371/journal.ppat.1001062 PMID20808866 PMCIDPMC2924388 DivisionProtein & Nucleic Acid Chemistry
• A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex AuthorsJackson L. P., Kelly B. T., McCoy A. J., Gaffry T., James L. C., Collins B. M., Höning S., Evans P. R., Owen D. J. Journal Cell 141(7):1220-1229. 25 June 2010 (2010)
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  DOI10.1016/j. Cell.2010.05.006 PMID20603002 PMCIDPMC3655264 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization AuthorsLammers M., Neumann H., Chin J. W., James L. C. Journal Nature Chemical Biology 6(5):331-337. 1 May 2010 (2010)
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  DOI10.1038/nchembio.342 PMID20364129 PMCIDPMC3867001 DivisionProtein & Nucleic Acid Chemistry
• Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D AuthorsYlinen L. M. J., Schaller T., Price A., Fletcher A. J., Noursadeghi M., James L. C., Towers G. J. Journal Journal of Virology 83(4):2044-2047. February 2009 (2009)
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  DOI10.1128/JVI.01876‑08 PMID19073742 PMCIDPMC2643744 DivisionProtein & Nucleic Acid Chemistry
• TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved AuthorsKeeble A. H., Khan Z., Forster A., James L. C. Journal Proceedings of the National Academy of Sciences of the United States of America 105(16):6045-6050. 22 April 2008 (2008)
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  DOI10.1073/pnas.0800159105 PMID18420815 PMCIDPMC2329685 DivisionProtein & Nucleic Acid Chemistry
• Beta-edge interactions in a pentadecameric human antibody Vk domain AuthorsJames L. C., Jones P. C., McCoy A., Tennent G. A., Pepys M. B., Famm K., Winter G. Journal Journal of Molecular Biology 367(3):603-608. 30 March 2007 (2007)
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  DOI10.1016/j.jmb.2006.10.093 PMID17292396 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structural basis for PRYSPRY-mediated TRIM function AuthorsJames L. C., Keeble, A. H. Khan Z., Rhodes D. A,, Trowsdale J. Journal Proc. Natl. Acad . Sci. U. S. A. 104(15): 6200-6205 (2007) (2007)
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• Erratum: 1.9 angstom structure of the therapeutic antibody CAMPATH-1H Fab in complex with a synthetic peptide antigen AuthorsJames L. C., Hale G., Waldmann H., Bloomer A. C. Journal Journal of Molecular Biology 292: 1161 (1999) (1999)
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