Published Research
Found 99 results for James L.
- How HIV-1 uses the metabolite inositol hexakisphosphate to build its capsid AuthorsJames L.C. Journal Viruses 17(5):689 (2025)
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An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models
AuthorsKaren Anthi A., Kolderup A., Benno Vaage E., Bern M., Benjakul S., Tjärnhage E., Ruso-Julve F., Jensen K.R., Elisabeth Lode H., Vaysburd M., Nilsen J., Leangen Herigstad M., Aestedatter Sakya S., Tietze L., Pilati D., Nyquist-Andersen M., Dürdoop M., Tollefsrud Gjølberg T., Peng L., Foss S., Moe M.C., Low B.E., Wiles M.V., Nemazee D., Jahnsen F.L., Torgils Vaage J., Howard K.A., Sandlie I., James L.C., Grødeland G., Lund-Johansen F., Terje Andersen J.
Journal
Nature Communications
16(1):3999 (2025)
Details
DOIdoi.org/10.1038/s41467-025-59353-6 PMID40312392 PMCIDPMC12045997 DivisionProtein & Nucleic Acid Chemistry - UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains AuthorsKiss L., James L.C., Schulman B.A. Journal Molecular Cell 85(7):1467-1476.e6 (2025)
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Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21
AuthorsLeventhal S. S., Bisom T., Clift D., Rao D., Meade-White K., Shaia C., Murray J., Mihalakakos E. A., Hinkley T., Reynolds S. J., Best S. M., Erasmus J. H., James L. C., Feldmann H., Hawman D. W.
Journal
Nature Communications
15(1):9236 (2024)
Details
DOI10.1038/s41467-024-53362-7 PMID39455551 PMCIDPMC11511847 DivisionProtein & Nucleic Acid Chemistry -
HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly
AuthorsKleinpeter A., Mallery D. L., Renner N., Albecka A., Klarhof J. O., Freed E. O., James L. C.
Journal
Nature Communications
15(1):8017 (2024)
Details
DOI10.1038/s41467-024-51971‑w PMID39271696 PMCIDPMC11399258 DivisionProtein & Nucleic Acid Chemistry -
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function
AuthorsMiller L. V. C., Papa G., Vaysburd M., Cheng S., Sweeney P. W., Smith A., Franco C., Katsinelos T., Huang M., Sanford S. A. I., Benn J., Farnsworth J., Higginson K., Joyner H., McEwan W. A., James L. C.
Journal
Cell
187(21):5967-5980.e17 (2024)
Details
DOI10.1016/j. Cell.2024.08.024 PMID39276772 PMCID DivisionProtein & Nucleic Acid Chemistry, Facilities (Mass Spec), Facilities (BSG) -
Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication
AuthorsPauciullo S., Riccio A., Santopolo S., Albecka A., Papa G., James L. C., Piacentini S., Lanzilli G., Rossi A., Santoro M. G.
Journal
Cellular and Molecular Life Sciences : CMLS
81(1):386 (2024)
Details
DOI10.1007/s00018-024-05370-5 PMID39243335 PMCIDPMC11380654 DivisionProtein & Nucleic Acid Chemistry -
Aggregate-selective removal of pathological tau by clustering-activated degraders
AuthorsBenn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA.
Journal
Science
Aug 30;385(6712):1009-1016. (2024)
Details
DOI10.1126/science. Adp5186 PMID39208111 PMCID DivisionProtein & Nucleic Acid Chemistry Neurobiology Facilities (MassSpec) -
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
AuthorsFaysal K. M. R., Walsh J. C., Renner N., Márquez C. L., Shah V. B., Tuckwell A. J., Christie M. P., Parker M. W., Turville S. G., Towers G. J., James L. C., Jacques D. A., Böcking T.
Journal
Elife
13:e83605 (2024)
Details
DOI10.7554/elife.83605 PMID38347802 PMCIDPMC10863983 DivisionProtein & Nucleic Acid Chemistry - The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology AuthorsSanford S. A. I., Miller L. V. C, Vaysburd M., Keeling S., Tuck B. J., Clark J., Neumann M., Syanda V., James L. C., McEwan W. A. Journal Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(2):1013-1025 (2024)
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Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2
AuthorsGaynor K. U., Vaysburd M., Harman M. A. J., Albecka A., Jeffrey P., Beswick P., Papa G., Chen L., Mallery D., McGuinness B., Van Rietschoten K., Stanway S., Brear P., Lulla A, Ciazynska K., Chang V. T., Sharp J., Neary M., Box H., Herriott J., Kijak E., Tatham L., Bentley E. G., Sharma P., Kirby A., Han X., Stewart J. P., Owen A., Briggs J A. G., Hyvönen M., Skynner M. J., James L. C.
Journal
Nature Communications
14(1):3583 (2023)
Details
DOI10.1038/s41467-023-39158-1 PMID37328472 PMCIDPMC10275983 DivisionProtein & Nucleic Acid Chemistry -
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates
AuthorsKiss L., Rhinesmith T., Luptak J., Dickson C. F., Weidenhausen J., Smyly S., Yang J. C., Maslen S. L., Sinning I., Neuhaus D., Clift D., James L. C.
Journal
Nature Communications
14(1):2160 (2023)
Details
DOI 10.1038/s41467-023-37504-x PMID37061529 PMCIDPMC10105713 DivisionProtein & Nucleic Acid Chemistry - Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding AuthorsStacey J. C. V., Tan A., Lu J. M., James L. C., Dick R. A., Briggs J. A. G. Journal Proceedings of the National Academy of Sciences of the United States of America, 120(16):e2220557120 (2023)
- Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models AuthorsMukadam A. S., Miller L. V. C., Smith A. E., Vaysburd M., Sakya S. A, Sanford S., Keeling S., Tuck B. J., Katsinelos T., Green C., Skov L., Kaalund S. S., Foss S., Mayes K., O'Connell K., Wing M., Knox C., Banbury J., Avezov E., Rowe J. B, Goedert M., Andersen J. T, James LC., McEwan W. A. Journal Science 379(6639):1336-1341 (2023)
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IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing
AuthorsPapa G., Albecka A., Mallery D., Vaysburd M., Renner N., James L. C.
Journal
EMBO Reports
24(5):e56275 (2023)
Details
DOI 10.15252/embr.202256275 PMID36970882 PMCIDPMC10157305 DivisionProtein & Nucleic Acid Chemistry -
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
AuthorsRenner N, Kleinpeter A, Mallery DL, Albecka A, Rifat Faysal KM, Böcking T, Saiardi A, Freed EO, James LC
Journal
Nature Structural and Molecular Biology
30(3):370-382 (2023)
Details
DOI10.1038/s41594-022-00887‑4 PMID36624347 PMCIDPMC7614341 DivisionProtein & Nucleic Acid Chemistry -
Evasion of cGAS and TRIM5 defines pandemic HIV
AuthorsZuliani-Alvarez L, Govasli ML, Rasaiyaah J, Monit C, Perry SO, Sumner RP, McAlpine-Scott S, Dickson C, Rifat Faysal KM, Hilditch L, Miles RJ, Bibollet-Ruche F, Hahn BH, Boecking T, Pinotsis N, James LC, Jacques DA, Towers GJ.
Journal
Nature Microbiology
Nov;7(11):1762-1776 (2022)
Details
DOI10.1038/s41564-022-01247‑0 PMID36289397 PMCIDPMC9613477 DivisionProtein & Nucleic Acid Chemistry -
A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling
AuthorsMersmann SF, Johns E, Yong T, McEwan WA, James LC, Cohen EAK, Grove J.
Journal
Scientific Reports
Oct 14;12(1):17286 (2022)
Details
DOI10.1038/s41598-022-20506‑y PMID36241663 PMCIDPMC9568568 DivisionProtein & Nucleic Acid Chemistry - TRIM7 restricts coxsackievirus and norovirus infection by detecting the C-terminal glutamine generated by 3C protease processing AuthorsLuptak J., Mallery D. L., Jahun A. S., Albecka A., Clift D., Ather O., Slodkowicz G., Goodfellow I., James L. C. Journal Viruses 14(8):1610 (2022)
- The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21 AuthorsKiss L., James L. C. Journal Seminars in Cell & Developmental Biology 126:99-107 (2022)
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Cholesterol determines the cytosolic entry and seeded aggregation of tau
AuthorsTuck B.J., Miller L.V.C., Katsinelos T., Smith A.E., Wilson E.L., Keeling S., Cheng S., Vaysburd M.J., Knox C., Tredgett L., Metzakopian E., James L. C., McEwan W.A.
Journal
Cell Reports
39(5):110776 (2022)
Details
DOI10.1016/j.Celrep.2022.110776 PMID35508140 PMCIDPMC9108550 DivisionProtein & Nucleic Acid Chemistry -
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge
AuthorsFoss S., Jonsson A., Bottermann M., Watkinson R., Lode H. E., McAdam M. B., Michaelsen T. E., Sandlie I., James L. C., Andersen J. T.
Journal
Science Immunology
7(70):eabj1640 (2022)
Details
DOI10.1126/sciimmunol. Abj1640 PMID35486676 PMCIDPMC7614286 DivisionProtein & Nucleic Acid Chemistry -
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
AuthorsMeng B, et al (including Papa G., Mallery D. L., James L. C.)
Journal
Nature
603(7902):706-714 (2022)
Details
DOI10.1038/s41586-022-04474-x PMID35104837 PMCIDPMC8942856 DivisionProtein & Nucleic Acid Chemistry -
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
AuthorsMlcochova P., et al (Including Papa G., Albecka A., James L. C.)
Journal
Nature
599(7883):114-119 (2021)
Details
DOI10.1038/s41586-021-03944‑y PMID34488225 PMCIDPMC8566220 DivisionProtein & Nucleic Acid Chemistry -
Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
AuthorsCattin-Ortolá J., Welch L. G., Maslen S. L., Papa G., James L. C., Munro S.
Journal
Nature Communications
12(1):5333 (2021)
Details
DOI10.1038/s41467-021-25589-1 PMID34504087 PMCIDPMC8429659 DivisionProtein & Nucleic Acid Chemistry, Cell Biology -
SARS-CoV-2 spike protein stabilized in the closed state induces potent neutralizing responses
AuthorsCarnell G. W., Ciazynska K. A., Wells D. A., Xiong X., Aguinam E. T., McLaughlin S. H., Mallery D., Ebrahimi S., Ceron-Gutierrez L., Asbach B., Einhauser S., Wagner R., James L. C., Doffinger R., Heeney J. L., Briggs J. A. G.
Journal
Journal of Virology
95(15):e0020321. August 2021 (2021)
Details
DOI10.1128/jvi.00203‑21 PMID33963055 PMCIDPMC8274612 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
AuthorsMiller L. V. C., Mukadam A. S., Durrant C. S., Vaysburd M. J., Katsinelos T., Tuck B. J., Sanford S., Sheppard O., Knox C., Cheng S., James L. C., Coleman M. P., McEwan W. A.
Journal
Acta Neuropathologica Communications
9(1):41. 12 March 2021 (2021)
Details
DOI10.1186/s40478-021-01141-6 PMID33712082 PMCIDPMC7953780 DivisionProtein & Nucleic Acid Chemistry -
A stable immature lattice packages IP6 for HIV capsid maturation
AuthorsMallery D. L., Kleinpeter A. B., Renner N., Faysal K. M. R., Novikova M., Kiss L., Wilson M. S. C., Ahsan B., Ke Z., Briggs J. A. G., Saiardi A., Böcking T., Freed E. O., James L. C.
Journal
Science Advances
7(11): eabe4716. 10 March 2021 (2021)
Details
DOI10.1126/sciadv. Abe4716 PMID33692109 PMCIDPMC7946374 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity
AuthorsCaddy S. L., Vaysburd M., Papa G., Wing M., O'Connell K., Stoycheva D., Foss S., Terje Andersen J., Oxenius A., James L. C.
Journal
EMBO Journal
40(5):e106228. 1 March 2021 (2020)
Details
DOI10.15252/embj.2020106228 PMID33258165 PMCIDPMC7917548 DivisionProtein & Nucleic Acid Chemistry -
Target-induced clustering activates Trim-Away of pathogens and proteins
AuthorsZeng J., Santos A. F., Mukadam A. S., Osswald M., Jacques D. A., Dickson C. F., McLaughlin S. H., Johnson C. M., Kiss L. ., Luptak J., Renner N., Vaysburd M., McEwan W. A., Morais-de-Sá E., Clift D., James L. C.
Journal
Nature Structural & Molecular Biology
28(3):278-289. March 2021 (2021)
Details
DOI10.1038/s41594-021-00560‑2 PMID33633400 PMCIDPMC7611929 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
AuthorsKiss L., Clift D., Renner N., Neuhaus D., James L. C.
Journal
Nature Communications
12(1):1220. 22 February 2021 (2021)
Details
DOI10.1038/s41467-021-21443‑6 PMID33619271 PMCIDPMC7900206 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly
AuthorsRenner N., Mallery D. L., Faysal K. M. R., Peng W., Jacques D. A., Böcking T., James L. C.
Journal
Plos Pathogens
17(2):e1009164. 1 February 2021 (2021)
Details
DOI10.1371/journal.ppat.1009164 PMID33524070 PMCIDPMC7850482 DivisionProtein & Nucleic Acid Chemistry -
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
AuthorsPapa G., Mallery D. L., Albecka A., Welch L. G., Cattin-Ortolá J., Luptak J., Paul D., McMahon H. T., Goodfellow I. G., Carter A., Munro S., James L. C.
Journal
Plos Pathogens
17(1):e1009246. 25 January 2021 (2021)
Details
DOI10.1371/journal.ppat.1009246 PMID33493182 PMCIDPMC7861537 DivisionProtein & Nucleic Acid Chemistry, Neurobiology, Cell Biology, Structural Studies -
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids
AuthorsPellegrini L., Albecka A., Mallery D. L., Kellner M. J., Paul D., Carter A. P., James L. C., Lancaster M. A.
Journal
Cell Stem Cell
27(6):951-961.e5. 3 December 2020 (2020)
Details
DOI10.1016/j.stem.2020.10.001 PMID33113348 PMCIDPMC7553118 DivisionStructural Studies, Protein & Nucleic Acid Chemistry, Cell Biology -
A thermostable, closed SARS-CoV-2 spike protein trimer
AuthorsXiong X., Qu K., Ciazynska K. A., Hosmillo M., Carter A. P., Ebrahimi S., Ke Z., Scheres S. H. W., Bergamaschi L., Grice G. L., Zhang Y.; CITIID-NIHR COVID-19 BioResource Collaboration, Nathan J. A., Baker S., James L. C., Baxendale H. E., Goodfellow I., Doffinger R., Briggs J. A. G.
Journal
Nature Structural & Molecular Biology
27(10):934-941. October 2020 (2020)
Details
DOI10.1038/s41594-020-0478‑5 PMID32737467 PMCIDPMC7116388 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant
AuthorsMlcochova P., Collier D., Ritchie A., Assennato S. M., Hosmillo M., Goel N., Meng B., Chatterjee K., Mendoza V., Temperton N., Kiss L., James L. C., Ciazynska K. A., Xiong X., Briggs J. A. G., Nathan J. A., Mescia F., Bergamaschi L., Zhang H., Barmpounakis P., Demeris N., Skells R., Lyons P. A., Bradley J., Baker S., Allain J. P., Smith K. G. C, Bousfield R., Wilson M., Sparkes D., Amoroso G., Gkrania-Klotsas E., Hardwick S., Boyle A., Goodfellow I., Gupta R. K.; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration.
Journal
Cell reports. Medicine
1(6):100099. 22 September 2020 (2020)
Details
DOI10.1016/j.xcrm.2020.100099 PMID32905045 PMCIDPMC7462534 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
Intracellular antibody immunity and its applications
AuthorsZeng J., James L. C.
Journal
Plos Pathogens
16(8):e1008657. 6 August 2020 (2020)
Details
DOI10.1371/journal.ppat.1008657 PMID32760166 PMCIDPMC7410306 DivisionProtein & Nucleic Acid Chemistry -
Intracellular neutralisation of rotavirus by VP6-specific IgG
AuthorsCaddy S. L., Vaysburd M., Wing M., Foss S., Andersen J. T., O'Connell K., Mayes K., Higginson K., Iturriza-Gómara M., Desselberger U., James L. C.
Journal
Plos Pathogens
16(8):e1008732. 4 August 2020 (2020)
Details
DOI10.1371/journal.ppat.1008732 PMID32750093 PMCIDPMC7428215 DivisionProtein & Nucleic Acid Chemistry -
Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication
AuthorsMallery D. L., Faysal K. M. R., Kleinpeter A., Wilson M. S. C., Vaysburd M.,
Fletcher A. J., Novikova M., Böcking T., Freed E. O., Saiardi A., James L. C.
Journal
Cell Reports
29(12):3983-3996.e4. 17 December 2019 (2019)
Details
DOI10.1016/j. Celrep.2019.11.050 PMID31851928 PMCIDPMC6931105 DivisionProtein & Nucleic Acid Chemistry -
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
AuthorsLabzin L. I., Bottermann M., Rodriguez-Silvestre P., Foss S., Andersen J. T., Vaysburd M., Clift D., James L. C.
Journal
EMBO Journal
38(21):e101365. 4 November 2019 (2019)
Details
DOI10.15252/embj.2018101365 PMID31468569 PMCIDPMC6826209 DivisionProtein & Nucleic Acid Chemistry -
Rare missense variants in the human cytosolic antibody receptor preserve antiviral function
AuthorsZeng J., Slodkowicz G., James L. C.
Journal
ELife
8: e48339. 15 October 2019 (2019)
Details
DOI10.7554/eLife.48339 PMID31613747 PMCIDPMC6794091 DivisionProtein & Nucleic Acid Chemistry -
A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases
AuthorsKiss L., Zeng J., Dickson C. F., Mallery D. L., Yang J. C., McLaughlin S. H., Boland A., Neuhaus D., James L. C.
Journal
Nature Communications
10(1):4502. 3 October 2019 (2019)
Details
DOI10.1038/s41467-019-12388‑y PMID31582740 PMCIDPMC6776665 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
TRIM21-From Intracellular Immunity to Therapy
AuthorsFoss S., Bottermann M., Jonsson A., Sandlie I., James L. C., Andersen J. T.
Journal
Frontiers in Immunology
10:2049. 28 August 2019 (2019)
Details
DOI10.3389/fimmu.2019.02049 PMID31555278 PMCIDPMC6722209 DivisionProtein & Nucleic Acid Chemistry - Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid AuthorsJames L. C., Böcking T. Journal Cell Host & Microbe 26(2):151-153. 14 August 2019 (2019)
- The HIV-1 Capsid: More than Just a Delivery Package AuthorsJames L. C. Journal Advances in Experimental Medicine and Biology 1215:69-83. July 2019 (2019)
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Complement C4 Prevents Viral Infection through Capsid Inactivation
AuthorsBottermann M., Foss S., Caddy S. L., Clift D., van Tienen L. M., Vaysburd M., Cruickshank J., O'Connell K., Clark J., Mayes K., Higginson K., Lode H. E., McAdam M. B., Sandlie I., Andersen J. T., James L. C.
Journal
Cell Host & Microbe
25(4):617-629.e7. 10 April 2019 (2019)
Details
DOI10.1016/j. Chom.2019.02.016 PMID30926239 PMCIDPMC6461443 DivisionProtein & Nucleic Acid Chemistry -
Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling
AuthorsFletcher A. J., Vaysburd M., Maslen S., Zeng J., Skehel J. M., Towers G. J., James L. C.
Journal
Cell Host & Microbe
24(6):761-775.e6. 12 December 2018 (2018)
Details
DOI10.1016/j. Chom.2018.10.007 PMID30503508 PMCIDPMC6299210 DivisionProtein & Nucleic Acid Chemistry, Cell Biology - IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating AuthorsDick R. A., Mallery D. L., Vogt V. M., James L. C. Journal Viruses 10(11). 15 November 2018 (2018)
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TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination
AuthorsBottermann M., Foss S., van Tienen L. M., Vaysburd M., Cruickshank J., O'Connell K., Clark J., Mayes K., Higginson K., Hirst J. C., McAdam M. B., Slodkowicz G., Hutchinson E., Kozik P., Andersen J. T., James L. C.
Journal
Proceedings of the National Academy of Sciences of the United States of America
115(41):10440-10445. 9 October 2018 (2018)
Details
DOI10.1073/pnas.1806314115 PMID30209217 PMCIDPMC6187179 DivisionProtein & Nucleic Acid Chemistry -
Acute and rapid degradation of endogenous proteins by Trim‑Away
AuthorsClift D., So C., McEwan W. A., James L. C., Schuh M.
Journal
Nature Protocols
13(10):2149-2175. October 2018 (2018)
Details
DOI10.1038/s41596-018-0028‑3 PMID30250286 PMCID DivisionProtein & Nucleic Acid Chemistry, Cell Biology -
The Human Immunodeficiency Virus Capsid Is More Than Just a Genome Package
AuthorsJames L. C., Jacques D. A.
Journal
Annual Review of Virology
5(1):209-225. September 2018 (2018)
Details
DOI10.1146/annurev-virology-092917‑043430 PMID30052493 PMCID DivisionProtein & Nucleic Acid Chemistry -
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
AuthorsMallery D. L., Márquez C. L., McEwan W. A., Dickson C., Jacques D. A., Anandapadamanaban M., Bichel K., Towers G. J., Saiardi A., Böcking T., James L. C.
Journal
ELife
7: e35335. 31 May 2018 (2018)
Details
DOI10.7554/eLife.35335 PMID29848441 PMCIDPMC6039178 DivisionProtein & Nucleic Acid Chemistry -
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21
AuthorsDickson C., Fletcher A. J., Vaysburd M., Yang J. C., Mallery D. L., Zeng J., Johnson C. M., McLaughlin S. H., Skehel M., Maslen S., Cruickshank J., Huguenin-Dezot N., Chin J. W., Neuhaus D., James L. C.
Journal
eLife
7: e32660. 18 April 2017 (2018)
Details
DOI10.7554/eLife.32660 PMID29667579 PMCIDPMC5906095 DivisionCell Biology, Protein & Nucleic Acid Chemistry, Structural Studies -
Intracellular Antiviral Immunity
AuthorsBottermann M., James L. C.
Journal
Advances in Virus Research
100:309-354. 16 February 2018 (2018)
Details
DOI10.1016/bs. Aivir.2018.01.002 PMID29551141 PMCIDPMC7172442 DivisionProtein & Nucleic Acid Chemistry -
Characterization of innate immune viral sensors in patients following allogeneic hematopoietic stem cell transplantation
AuthorsCaddy S. L., Wang M., Krishnamurthy P., Uttenthal B., Chandra A., Crawley C., James L. C.
Journal
Innate Immunity
24(2):112-121. February 2018 (2018)
Details
DOI10.1177/1753425918757898 PMID29433372 PMCIDPMC6830896 DivisionProtein & Nucleic Acid Chemistry -
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein
AuthorsKhamina K., Lercher A., Caldera M., Schliehe C., Vilagos B., Sahin M., Kosack L., Bhattacharya A., Májek P., Stukalov A., Sacco R., James L. C., Pinschewer D. D., Bennett K. L., Menche J., Bergthaler A.
Journal
PLoS Pathogens
13(12):e1006758. 20 December 2017 (2017)
Details
DOI10.1371/journal.ppat.1006758 PMID29261807 PMCIDPMC5738113 DivisionProtein & Nucleic Acid Chemistry -
A Method for the Acute and Rapid Degradation of Endogenous Proteins
AuthorsClift D., McEwan W. A., Labzin L. I., Konieczny V., Mogessie B., James L. C., Schuh M.
Journal
Cell
171(7):1692-1706.e18. 14 December 2017 (2017)
Details
DOI10.1016/j. Cell.2017.10.033 PMID29153837 PMCIDPMC5733393 DivisionProtein & Nucleic Acid Chemistry - Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity AuthorsBottermann M., Lode H. E., Watkinson R. E, Foss S., Sandlie I., Andersen J. T., James L. C. Journal Scientific Reports 7:45418. 6 April 2017 (2017)
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Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
AuthorsMcEwan W. A., Falcon B., Vaysburd M., Clift D., Oblak A. L., Ghetti B., Goedert M., James L. C.
Journal
Proceedings of the National Academy of Sciences of the United States of America
114(3):574-579. 17 January 2017 (2017)
Details
DOI10.1073/pnas.1607215114 PMID28049840 PMCIDPMC5255578 DivisionProtein & Nucleic Acid Chemistry, Neurobiology - Antibody-antigen kinetics constrain intracellular humoral immunity AuthorsBottermann M., Lode H. E., Watkinson R. E., Foss S., Sandlie I., Andersen J. T., James L. C. Journal Scientific Reports 6:37457. 24 November 2016 (2016)
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HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
AuthorsJacques D. A., McEwan W. A., Hilditch L., Price A. J., Towers G. J., James L. C.
Journal
Nature
536(7616):349-353. 18 August 2016 (2016)
Details
DOI10.1038/nature19098 PMID27509857 PMCIDPMC4998957 DivisionProtein & Nucleic Acid Chemistry -
Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21
AuthorsFletcher A. J., James L. C.
Journal
Journal of Virology
90(10):4856-4859. May 2016 (2016)
Details
DOI10.1128/JVI.00050‑16 PMID26937031 PMCIDPMC4859718 DivisionProtein & Nucleic Acid Chemistry -
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
AuthorsFoss S., Watkinson R. E., Grevys A., McAdam M. B., Bern M., Høydahl L. S., Dalhus B., Michaelsen T. E., Sandlie I., James L. C., Andersen J. T.
Journal
Journal of Immunology
196(8):3452-3459. 15 April 2016 (2016)
Details
DOI10.4049/jimmunol.1502601 PMID26962230 PMCIDPMC4977002 DivisionProtein & Nucleic Acid Chemistry -
Structural and mechanistic insights into the regulation of the fundamental Rho-regulator RhoGDIα by lysine acetylation
AuthorsKuhlmann N., Wroblowski S., Knyphausen P., de Boor S., Brenig J., Zienert A. Y., Meyer-Teschendorf K., Praefcke G. J., Nolte H., Krüger M., Schacherl M., Baumann U., James L. C., Chin J. W., Lammers M.
Journal
Journal of Biological Chemistry
291(11):5484-5499. 11 March 2016 (2016)
Details
DOI10.1074/jbc. M115.707091 PMID26719334 PMCIDPMC4786691 DivisionProtein & Nucleic Acid Chemistry - TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity AuthorsFoss S., Watkinson R., Sandlie I., James L. C., Andersen J. T. Journal Immunological Reviews 268(1):328-339. November 2015 (2015)
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TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus
AuthorsWatkinson R. E., McEwan W. A., Tam J. C., Vaysburd M., James L. C.
Journal
PLoS Pathogens
11(10):e1005253. 27 October 2015 (2015)
Details
DOI10.1371/journal.ppat.1005253 PMID26506431 PMCIDPMC4624778 DivisionProtein & Nucleic Acid Chemistry -
HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry
AuthorsZhou J., Price A. J., Halambage U. D., James L. C., Aiken C.
Journal
Journal of Virology
89(17):9068-9079. September 2015 (2015)
Details
DOI10.1128/JVI.00340‑15 PMID26109731 PMCIDPMC4524096 DivisionProtein & Nucleic Acid Chemistry -
Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21
AuthorsFletcher A. J., Mallery D. L., Watkinson R. E., Dickson C. F., James L. C.
Journal
Proceedings of the National Academy of Sciences of the United States of America
112(32):10014-10019. 11 August 2015 (2015)
Details
DOI10.1073/pnas.1507534112 PMID26150489 PMCIDPMC4538650 DivisionProtein & Nucleic Acid Chemistry -
Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin
AuthorsRhodes D. A., Chen H. C., Price A. J., Keeble A. H., Davey M. S., James L. C., Eberl M., Trowsdale J.
Journal
Journal of Immunology
194(5):2390-2398. 1 March 2015 (2015)
Details
DOI10.4049/jimmunol.1401064 PMID25637025 PMCIDPMC4337483 DivisionProtein & Nucleic Acid Chemistry - TRIM21-Dependent Intracellular Antibody Neutralization of Virus Infection. AuthorsMcEwan W. A., James L. C. Journal Progress in Molecular Biology and Translational Science 129:167-187, 1 January 2015 (2015)
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Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly
AuthorsPrice A. J., Jacques D. A., McEwan W. A., Fletcher A. J., Essig S., Chin J. W., Halambage U. D., Aiken C., James L. C.
Journal
PLoS Pathogens
10(10):e1004459. 30 October 2014 (2014)
Details
DOI10.1371/journal.ppat.1004459 PMID25356722 PMCIDPMC4214760 DivisionProtein & Nucleic Acid Chemistry -
Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells
AuthorsBidgood S. R., Tam J. C., McEwan W. A., Mallery D. L., James L. C.
Journal
Proceedings of the National Academy of Sciences, USA
111(37):13463-13468. 16 September 2014 (2014)
Details
DOI10.1073/pnas.1410980111 PMID25169018 PMCIDPMC4169910 DivisionProtein & Nucleic Acid Chemistry -
Intracellular sensing of complement C3 activates cell autonomous immunity
AuthorsTam J. C., Bidgood S. R., McEwan W. A., James L. C.
Journal
Science
345(6201):1256070. 5 September 2014 (2014)
Details
DOI10.1126/science.1256070 PMID25190799 PMCIDPMC4172439 DivisionProtein & Nucleic Acid Chemistry - Intracellular antibody immunity and the cytosolic Fc receptor TRIM21 AuthorsJames L. C. Journal Current Topics in Microbiology and Immunology 382:51-66. 12 August 2014 (2014)
- Intracellular antibody immunity AuthorsWatkinson R. E., McEwan W. A., James L. C. Journal Journal of Clinical Immunology 34 Suppl 1:S30-4. July 2014 (2014)
- Antibody- and TRIM21-dependent intracellular restriction of Salmonella enterica AuthorsRakebrandt N., Lentes S., Neumann H., James L. C., Neumann-Staubitz P. Journal Pathogens and Disease 72(2):131-137. 27 June 2014 (2014)
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HIV-1 evades innate immune recognition through specific cofactor recruitment
AuthorsRasaiyaah J., Tan C. P., Fletcher A. J., Price A. J., Blondeau C., Hilditch L., Jacques D. A., Selwood D. L., James L. C., Noursadeghi M., Towers G. J.
Journal
Nature
503(7476):402-405. 21 November 2013 (2013)
Details
DOI10.1038/nature12769 PMID24196705 PMCIDPMC3928559 DivisionProtein & Nucleic Acid Chemistry -
HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358
AuthorsBichel K., Price A. J., Schaller T., Towers G. J., Freund S. M., James L. C.
Journal
Retrovirology
10:81. 31 July 2013 (2013)
Details
DOI 10.1186/1742-4690-10‑81 PMID23902822 PMCIDPMC3750474 DivisionProtein & Nucleic Acid Chemistry - Intracellular antibody receptor TRIM21 prevents fatal viral infection AuthorsVaysburd M., Watkinson R. E., Cooper H., Reed M., O'Connell K., Smith J., Cruickshanks J., James L. C. Journal Proceedings of the National Academy of Sciences, USA. 110(30):12397-12401. 23 July 2013 (2013)
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Simultaneous neutralization and innate immune detection of a replicating virus by TRIM21
AuthorsWatkinson R. E., Tam J. C., Vaysburd M. J., James L. C.
Journal
Journal of Virology
87(13):7309-7313. July 2013 (2013)
Details
DOI10.1128/JVI.00647‑13 PMID23596308 PMCIDPMC3700317 DivisionProtein & Nucleic Acid Chemistry - Cellular self-defense: how cell-autonomous immunity protects against pathogens AuthorsRandow F., MacMicking J. D., James L. C. Journal Science 340(6133):701-706. 10 May 2013 (2013)
- Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 AuthorsMcEwan W. A., Tam J. C., Watkinson R. E., Bidgood S. R., Mallery D. L., James L. C. Journal Nature Immunology 14(4):327-336. April 2013 (2013)
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The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import
AuthorsVeillette M., Bichel K., Pawlica P., Freund S. M., Plourde M. B., Pham Q. T., Reyes-Moreno C., James L. C., Berthoux L.
Journal
Retrovirology
10:25. 28 February 2013 (2013)
Details
DOI10.1186/1742-4690-10‑25 PMID23448277 PMCIDPMC3598646 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization
AuthorsHauler F., Mallery D. L., McEwan W. A., Bidgood S. R., James L. C.
Journal
Proceedings of the National Academy of Sciences, USA
109(48):19733-19738. 27 November 2012 (2012)
Details
DOI10.1073/pnas.1210659109 PMID23091005 PMCIDPMC3511720 DivisionProtein & Nucleic Acid Chemistry -
CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication
AuthorsPrice A. J., Fletcher A. J., Schaller T., Elliott T., Lee K., Kewalramani V. N., Chin J. W., Towers G. J., James L. C.
Journal
PLoS Pathogens
8(8):e1002896. 30 August 2012 (2012)
Details
DOI10.1371/journal.ppat.1002896 PMID22956906 PMCIDPMC3431306 DivisionProtein & Nucleic Acid Chemistry -
Regulation of Virus Neutralization and the Persistent Fraction by TRIM21
AuthorsMcEwan W. A., Hauler F., Williams C. R., Bidgood S. R., Mallery D. L., Crowther R. A., James L. C.
Journal
Journal of Virology
86(16):8482-8491. August 2012 (2012)
Details
DOI10.1128/JVI.00728‑12 PMID22647693 PMCIDPMC3421726 DivisionProtein & Nucleic Acid Chemistry; Structural Studies - Diverse HIV viruses are targeted by a conformationally dynamic antiviral AuthorsCaines M. E., Bichel K., Price A. J., McEwan W. A., Towers G. J., Willett B. J., Freund S. M., James L. C. Journal Nature Structural & Molecular Biology 19(4):411-416. April 2012 (2012)
- Intracellular antibody-mediated immunity and the role of TRIM21 AuthorsMcEwan W. A., Mallery D. L., Rhodes D. A., Trowsdale J., James L. C. Journal BioEssays 33(11):803-809. November 2011 (2011)
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HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2
AuthorsOcwieja K. E., Brady T. L., Ronen K., Huegel A., Roth S. L., Schaller T., James L. C., Towers G. J., Young J. A., Chanda S. K., König R., Malani N., Berry C. C., Bushman F. D.
Journal
PLoS Pathogens
7(3):e1001313. March 2011 (2011)
Details
DOI10.1371/journal.ppat.1001313 PMID21423673 PMCIDPMC3053352 DivisionProtein & Nucleic Acid Chemistry -
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
AuthorsMallery D. L., McEwan W. A., Bidgood S. R., Towers G. J., Johnson C. M., James L. C.
Journal
Proceedings of the National Academy of Sciences, USA
107(46):19985-19990. 16 November 2010 (2010)
Details
DOI10.1073/pnas.1014074107 PMID21045130 PMCIDPMC2993423 DivisionProtein & Nucleic Acid Chemistry -
Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion
AuthorsDietrich I., Macintyre A., McMonagle E., Price A. J., James L. C., McEwan W. A., Hosie M. J., Willett B. J.
Journal
Journal of Virology
84(17):8980-8985. 1 September 2010 (2010)
Details
DOI10.1128/JVI.00858‑10 PMID20554781 PMCIDPMC2919025 DivisionProtein & Nucleic Acid Chemistry -
Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity
AuthorsYlinen L. M., Price A. J., Rasaiyaah J., Hué S., Rose N. J., Marzetta F., James L. C., Towers G. J.
Journal
PLoS Pathogens
6(8):e1001062. 19 August 2010 (2010)
Details
DOI10.1371/journal.ppat.1001062 PMID20808866 PMCIDPMC2924388 DivisionProtein & Nucleic Acid Chemistry -
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex
AuthorsJackson L. P., Kelly B. T., McCoy A. J., Gaffry T., James L. C., Collins B. M., Höning S., Evans P. R., Owen D. J.
Journal
Cell
141(7):1220-1229. 25 June 2010 (2010)
Details
DOI10.1016/j. Cell.2010.05.006 PMID20603002 PMCIDPMC3655264 DivisionProtein & Nucleic Acid Chemistry, Structural Studies -
Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization
AuthorsLammers M., Neumann H., Chin J. W., James L. C.
Journal
Nature Chemical Biology
6(5):331-337. 1 May 2010 (2010)
Details
DOI10.1038/nchembio.342 PMID20364129 PMCIDPMC3867001 DivisionProtein & Nucleic Acid Chemistry -
Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D
AuthorsYlinen L. M. J., Schaller T., Price A., Fletcher A. J., Noursadeghi M., James L. C., Towers G. J.
Journal
Journal of Virology
83(4):2044-2047. February 2009 (2009)
Details
DOI10.1128/JVI.01876‑08 PMID19073742 PMCIDPMC2643744 DivisionProtein & Nucleic Acid Chemistry -
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved
AuthorsKeeble A. H., Khan Z., Forster A., James L. C.
Journal
Proceedings of the National Academy of Sciences of the United States of America
105(16):6045-6050. 22 April 2008 (2008)
Details
DOI10.1073/pnas.0800159105 PMID18420815 PMCIDPMC2329685 DivisionProtein & Nucleic Acid Chemistry - Beta-edge interactions in a pentadecameric human antibody Vk domain AuthorsJames L. C., Jones P. C., McCoy A., Tennent G. A., Pepys M. B., Famm K., Winter G. Journal Journal of Molecular Biology 367(3):603-608. 30 March 2007 (2007)
- Structural basis for PRYSPRY-mediated TRIM function AuthorsJames L. C., Keeble, A. H. Khan Z., Rhodes D. A,, Trowsdale J. Journal Proc. Natl. Acad . Sci. U. S. A. 104(15): 6200-6205 (2007) (2007)
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Erratum: 1.9 angstom structure of the therapeutic antibody CAMPATH-1H Fab in complex with a synthetic peptide antigen
AuthorsJames L. C., Hale G., Waldmann H., Bloomer A. C.
Journal
Journal of Molecular Biology
292: 1161 (1999) (1999)
Details
DOI PMID PMCID Division