Published Research
Found 77 results for Hegde R.
- Cotranslational membrane protein biogenesis by an EMC-bound translocon AuthorsRollins M. G., Tang J., Wan Y., Sundaram A., Wu H., Li Q., Fedry J., Hegde R. S., Ji Z., Keenan R. J. Journal Nature Structural & Molecular Biology (2026)
- Pairwise transmembrane domain insertion during multipass protein biogenesis AuthorsSmalinskaitė L., Wu H., Hegde R. S. Journal Molecular Cell :S1097-2765(26)00377-1 (2026)
- Design principles of human membrane protein topology AuthorsWu H., Hegde R. S. Journal The Journal of Cell Biology 225(8):e202604059 (2026)
- Checking in on proteostasis AuthorsSakata E., Hegde R. S., Zhao Y. G., Ito T., Radford S. E., Hatzgolou M., Jakob U., Park E., Lin Y., Deuerling E., Yang P., Choe Y. J. Journal Nature Structural & Molecular Biology 33(3):367-371 (2026)
- Global analysis of translocon remodeling during protein synthesis at the ER AuthorsSundaram A., Li Q., Wan Y., Tang J., Wu H., Smalinskaitė L., Hegde R.S., Ji Z., Keenan R.J. Journal Nature Structural & Molecular Biology (2025)
- Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control AuthorsGrabarczuk D.B., Ehrmann J.F., Murphy P., Yang W.S., Kurzbauer R., Bell L.E., Deszcz L., Neuhold J., Schleiffer A., Shulkina A., Lee J., Shin J.S., Meinhart A., Versteeg G.A., Zavodszky E., Song H.K., Hegde R.S., Clausen T. Journal Science 389(6763):909-914 (2025)
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Mechanism of chaperone recruitment and retention on mitochondrial precursors
AuthorsJuszkiewicz S., Peak-Chew S. Y., Hegde R. S.
Journal
Molecular Biology of the Cell
36(4):ar39 (2025)
Details
DOIdoi.org/10.1091/mbc. E25-01‑0035 PMID39878680 PMCIDPMC7617541 DivisionCell Biology, Facilities (Mass Spectrometry) - Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase AuthorsCarrillo Roas S., Yagita Y., Murphy P., Kurzbauer R., Clausen T., Zavodszky E., Hegde R. S. Journal Molecular Cell 85(4):815-828.e10 (2025)
- Identification of a factor that accelerates substrate release from the signal recognition particle AuthorsWang H., Hegde R. S. Journal Science 386(6725):996-1003 (2024)
- Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay AuthorsBatiuk A., Höpfler M., Almeida A. C., Teoh En-Jie D., Vadas O., Vartholomaiou E., Hegde R. S., Lin Z., Gasic I. Journal Nature Communications 15(1):9963 (2024)
- Structural analysis of the dynamic ribosome-translocon complex AuthorsLewis AJO, Zhong F, Keenan RJ, Hegde RS. Journal Elife Jun 18;13:RP95814 (2024)
- A unifying model for membrane protein biogenesis AuthorsHegde RS, Keenan RJ. Journal Nature Structural & Molecular Biology 31(7):1009-1017 (2024)
- Getting membrane proteins into shape AuthorsHegde RS. Journal Molecular Cell 84(10):1821-1823 (2024)
- Things you should learn in graduate school AuthorsHegde RS. Journal Trends in Cell Biology 34(4):269-271 (2024)
- How to enjoy and thrive in graduate school AuthorsHegde R.S. Journal Trends in Cell Biology S0962-8924(24)00027-8 (2024)
- EMC rectifies the topology of multipass membrane proteins AuthorsWu H, Smalinskaitė L, Hegde RS. Journal Nature Structural & Molecular Biology 31(1):32-41 (2024)
- Control of mRNA fate by its encoded nascent polypeptide AuthorsHöpfler M, Hegde R. S. Journal Molecular Cell 83(16):2840-2855 (2023)
- Mechanism of orphan subunit recognition during assembly quality control AuthorsYagita Y., Zavodszky E., Peak-Chew S. Y., Hegde R. S. Journal Cell 186(16):3443-3459.e24 (2023)
- Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation AuthorsHöpfler M., Absmeier E., Peak-Chew S. Y., Vartholomaiou E., Passmore L. A.,. Gasic I., Hegde R. S. Journal Molecular Cell 83(13):2290-2302.e13 (2023)
- New frontiers in quality control: the case of GPI-anchored proteins AuthorsLemus L., Hegde R. S, Goder V. Journal Nature reviews. Molecular Cell Biology (2023)
- The biogenesis of multipass membrane proteins AuthorsSmalinskaitė L, Hegde RS. Journal Cold Spring Harbor Perspectives in Biology 15(4):a041251 (2023)
- The Biogenesis of Multipass Membrane Proteins AuthorsSmalinskaitė L., Hegde R. S. Journal Cold Spring Harbor Perspectives in Biology 15(4):a041251 (2023)
- Mechanism of signal-anchor triage during early steps of membrane protein insertion AuthorsWu H., Hegde R. S. Journal Molecular Cell 83(6):961-973.e7 (2023)
- Substrate-driven assembly of a translocon for multipass membrane proteins AuthorsSundaram A, Yamsek M, Zhong F, Hooda Y, Hegde RS, Keenan RJ. Journal Nature Nov;611(7934):167-172 (2022)
- Mechanism of an intramembrane chaperone for multipass membrane proteins AuthorsSmalinskaitė L, Kim MK, Lewis AJO, Keenan RJ, Hegde RS. Journal Nature Nov;611(7934):161-166 (2022)
- The Function, Structure, and Origins of the ER Membrane Protein Complex AuthorsHegde R. S. Journal Annual Review of Biochemistry 91:651-678 (2022)
- The mechanisms of integral membrane protein biogenesis AuthorsHegde R. S., Keenan R. J. Journal Nature reviews. Molecular Cell Biology 23(2):107-124 (2022)
- A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC AuthorsLewis A. J. O., Hegde R. S. Journal BMC Biology 19(1):266 (2021)
- Identification of a quality-control factor that monitors failures during proteasome assembly AuthorsZavodszky E., Peak-Chew S. Y., Juszkiewicz S., Narvaez A. J., Hegde R. S. Journal Science 373(6558):998-1004 (2021)
- Translation stress and collided ribosomes are co-activators of cGAS AuthorsWan L., Juszkiewicz S., Blears D., Bajpe P. K., Han Z., Faull P., Mitter R., Stewart A., Snijders A. P., Hegde R. S., Svejstrup J. Q. Journal Molecular Cell 81(13):2808-2822.e10. 1 July 2021 (2021)
- An intramembrane chaperone complex facilitates membrane protein biogenesis AuthorsChitwood P. J., Hegde R. S. Journal Nature 584(7822):630-634. 27 August 2020 (2020)
- The ASC-1 Complex Disassembles Collided Ribosomes AuthorsJuszkiewicz S., Speldewinde S. H., Wan L., Svejstrup J. Q., Hegde R. S. Journal Molecular Cell 79(4):603-614.e8. 20 August 2020 (2020)
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Ribosome collisions trigger cis-acting feedback inhibition of translation initiation
AuthorsJuszkiewicz S., Slodkowicz G., Lin Z., Freire-Pritchett P., Peak-Chew S. Y., Hegde R. S.
Journal
Elife
9: e60038. 13 July 2020 (2020)
Details
DOI10.7554/elife.60038 PMID32657267 PMCIDPMC7381030 DivisionCell Biology, Structural Studies - The architecture of EMC reveals a path for membrane protein insertion AuthorsO'Donnell J. P., Phillips B. P., Yagita Y., Juszkiewicz S., Wagner A., Malinverni D., Keenan R. J., Miller E. A., Hegde R. S. Journal Elife 9: e57887. 27 May 2020 (2020)
- TTC5 mediates autoregulation of tubulin via mRNA degradation AuthorsLin Z., Gasic I., Chandrasekaran V., Peters N., Shao S., Mitchison T. J., Hegde R. S. Journal Science 367(6473):100-104. 3 January 2020 (2020)
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Mechanism of ribosome stalling during translation of a poly(A) tail
AuthorsChandrasekaran V., Juszkiewicz S., Choi J., Puglisi J. D., Brown A., Shao S., Ramakrishnan V., Hegde R. S.
Journal
Nature Structural & Molecular Biology
26(12):1132-1140. December 2019 (2019)
Details
DOI10.1038/s41594-019-0331-x PMID31768042 PMCIDPMC6900289 DivisionCell Biology, Structural Studies - Recognition and Degradation of Mislocalized Proteins in Health and Disease AuthorsHegde R. S., Zavodszky E. Journal Cold Spring Harbor Perspectives in Biology 11(11). 1 November 2019 (2019)
- Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy. AuthorsVerhagen J. M. A., van den Born M., van der Linde H. C., G. J. Nikkels P, Verdijk R. M., Kivlen M. H., van Unen L. M. A., Baas A. F., Ter Heide H., van Osch-Gevers L., Hoogeveen-Westerveld M., Herkert J. C., Bertoli-Avella A. M., van Slegtenhorst M. A., Wessels M. W., Verheijen F. W., Hassel D., Hofstra R. M. W., Hegde R. S., van Hasselt P. M., van Ham T. J., van de Laar I. M. B. H. Journal Circulation. Genomic and Precision Medicine 12(9):397-406. September 2019 (2019)
- Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors AuthorsZavodszky E., Hegde R. S. Journal eLife 8: e46740. 16 May 2019 (2019)
- The Role of EMC during Membrane Protein Biogenesis AuthorsChitwood P. J., Hegde R. S. Journal Trends in Cell Biology 29(5):371-384. May 2019 (2019)
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Activation of GCN2 by the ribosomal P‑stalk
AuthorsInglis A. J., Masson G. R., Shao S., Perisic O., McLaughlin S. H., Hegde R. S., Williams R. L.
Journal
Proceedings of the National Academy of Sciences of the United States of America
116(11):4946-4954. 12 March 2019 (2019)
Details
DOI10.1073/pnas.1813352116 PMID30804176 PMCIDPMC6421407 DivisionCell Biology, Protein & Nucleic Acid Chemistry - The ER membrane protein complex (EMC) promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis AuthorsVolkmar N., Thezenas M. L., Louie S. M., Juszkiewicz S., Nomura D. K., Hegde R. S., Kessler B. M., Christianson J. C. Journal Journal of Cell Science 132(2). 15 January 2019 (2019)
- EMC Is Required to Initiate Accurate Membrane Protein Topogenesis AuthorsChitwood P. J., Juszkiewicz S., Guna A., Shao S., Hegde R. S. Journal Cell 175(6):1507-1519. 26 November 2018 (2018)
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ZNF598 Is a Quality Control Sensor of Collided Ribosomes
AuthorsJuszkiewicz S., Chandrasekaran V., Lin Z., Kraatz S., Ramakrishnan V., Hegde R. S.
Journal
Molecular Cell
72(3):469-481.e7. 1 October 2018 (2018)
Details
DOI10.1016/j.molcel.2018.08.037 PMID30293783 PMCIDPMC6224477 DivisionStructural Studies, Cell Biology - Quality Control of Orphaned Proteins AuthorsJuszkiewicz S., Hegde R. S. Journal Molecular Cell 71(3):443-457. 2 August 2018 (2018)
- Transmembrane domain recognition during membrane protein biogenesis and quality control AuthorsGuna A., Hegde R. S. Journal Current Biology 28(8):R498-R511. 1 April 2018 (2018)
- The ER membrane protein complex is a transmembrane domain insertase AuthorsGuna A., Volkmar N., Christianson J. C., Hegde R. S. Journal Science 359(6374):470-473. 26 January 2018 (2018)
- Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum AuthorsAnghel S. A., McGilvray P. T., Hegde R. S., Keenan R. J. Journal Cell Reports 21(13):3708-3716. 26 December 2017 (2017)
- UBE2O is a quality control factor for orphans of multiprotein complexes AuthorsYanagitani K., Juszkiewicz S., Hegde R. S. Journal Science 357(6350):472-475. 4 August 2017 (2017)
- Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination AuthorsJuszkiewicz S., Hegde R. S. Journal Molecular Cell 65(4):743-750.e4 (2017)
- IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses AuthorsChen C., Itakura E., Nelson G. M., Sheng M., Laurent P., Fenk L. A., Butcher R. A., Hegde R. S., de Bono M. Journal Nature 542(7639):43-48. 2 February 2017 (2017)
- Mechanistic basis for a molecular triage reaction AuthorsShao S., Rodrigo-Brenni M. C., Kivlen M. H., Hegde R. S. Journal Science 355(6322):298-302. 20 January 2017 (2017)
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Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes
AuthorsShao S., Murray J., Brown A., Taunton J., Ramakrishnan V., Hegde R. S.
Journal
Cell
167(5):1229-1240.e15. 17 November 2016 (2016)
Details
DOI10.1016/j. Cell.2016.10.046 PMID27863242 PMCIDPMC5119991 DivisionStructural Studies, Cell Biology - Toward a structural understanding of co-translational protein translocation AuthorsVoorhees R. M., Hegde R. S. Journal Current Opinion in Cell Biology 41:91-99. August 2016 (2016)
- Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation AuthorsItakura E., Zavodszky E., Shao S., Wohlever M. L., Keenan R. J., Hegde R. S. Journal Molecular Cell 63(1):21-33. 7 July 2016 (2016)
- Target Selection during Protein Quality Control AuthorsShao S., Hegde R. S. Journal Trends in Biochemical Sciences 41(2):124-137. February 2016 (2016)
- Structure of the Sec61 channel opened by a signal sequence AuthorsVoorhees R. M., Hegde R. S. Journal Science 351(6268):88-9. 1 January 2016 (2016)
- Ribosome-associated protein quality control AuthorsBrandman O., Hegde R. S. Journal Nature Structural & Molecular Biology 23(1):7-15. January 2016 (2016)
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Structural basis for stop codon recognition in eukaryotes
AuthorsBrown A., Shao S., Murray J., Hegde R. S., Ramakrishnan V.
Journal
Nature
524(7566):493-496. 27 August 2015 (2015)
Details
DOI10.1038/nature14896 PMID26245381 PMCIDPMC4591471 DivisionStructural Studies; Cell Biology - Structures of the scanning and engaged states of the mammalian SRP-ribosome complex AuthorsVoorhees R. M., Hegde R. S. Journal ELife 4: e09315. 9 July 2015 (2015)
- The Ribosome Quality Control Pathway can Access Nascent Polypeptides Stalled at the Sec61 Translocon Authorsvon der Malsburg K., Shao S., Hegde R. S. Journal Molecular Biology of the Cell 26(12):2168-2180. 15 June 2015 (2015)
- Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. AuthorsMateja A., Paduch M., Chang H. Y., Szydlowska A., Kossiakoff A. A., Hegde R. S., Keenan R. J. Journal Science 347(6226):1152-1155. 6 March 2015 (2015)
- Structure and assembly pathway of the ribosome quality control complex. AuthorsShao S., Brown A., Santhanam B., Hegde R. S. Journal Molecular Cell 57(3):433-444, 8 January 2015 (2015)
- Cell Biology. Local synthesis and disposal Authors Shao S., Hegde R. S. Journal Science 346(6210):701-702. 7 November 2014 (2014)
- Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors AuthorsShao S., Hegde R. S. Journal Molecular Cell 55(6):880-890. 18 September 2014 (2014)
- ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway AuthorsSatpute-Krishnan P., Ajinkya M., Bhat S., Itakura E., Hegde R. S., Lippincott-Schwartz J. Journal Cell 158(3):522-533. 31 July 2014 (2014)
- Msp1: patrolling mitochondria for lost proteins AuthorsHegde R. S. Journal EMBO Journal 33(14):1509-1510. 17 July 2014 (2014)
- Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6 AuthorsRodrigo-Brenni M. C., Gutierrez E., Hegde R. S. Journal Molecular Cell 55(2):227-237. 17 July 2014 (2014)
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Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution
AuthorsVoorhees R. M., Fernández I. S., Scheres S. H., Hegde R. S.
Journal
Cell
157(7):1632-1643. 19 June 2014 (2014)
Details
DOI10.1016/j. Cell.2014.05.024 PMID24930395 PMCIDPMC4081569 DivisionCell Biology, Structural Studies - An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism. AuthorsChen C., Itakura E., Weber K. P., Hegde R. S., de Bono M. Journal PLoS Genetics 10(3):e1004082. March 2014 (2014)
- An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate AuthorsMackinnon A. L., Paavilainen V. O., Sharma A., Hegde R. S., Taunton J. Journal ELife 3:e01483. 4 February 2014 (2014)
- Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER AuthorsZhang Z. R., Bonifacino J. S., Hegde R. S. Journal Cell 54(3):609-622. 1 August 2013 (2013)
- Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation AuthorsShao S., von der Malsburg K., Hegde R. S. Journal Molecular Cell 50(5):637-648. 6 June 2013 (2013)
- Design principles of protein biosynthesis-coupled quality control AuthorsRodrigo-Brenni M. C., Hegde R. S. Journal Developmental Cell 23(5):896-907. 13 November 2012 (2012)
- A calmodulin-dependent translocation pathway for small secretory proteins AuthorsShao S., Hegde R. S. Journal Cell 147(7):1576-1588. 23 December 2011 (2011)
- Tail-anchored membrane protein insertion into the endoplasmic reticulum AuthorsHegde R. S., Keenan R. J. Journal Nature Reviews. Molecular Cell Biology 12(12):787-798. December 2011 (2011)
- A conserved archaeal pathway for tail-anchored membrane protein insertion AuthorsSherrill J., Mariappan M., Dominik P., Hegde R. S., Keenan R. J. Journal Traffic 12(9):1119-1123. September 2011 (2011)