Published Research
Found 53 results for Greger.
- Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum AuthorsAlexander M. Scrutton, Nayanika Sengupta, Josip Ivica, Imogen Stockwell, Sew Peak-Chew, Bishal Singh, Kunimichi Suzuki, Veronica T. Chang, Stephen H. McLaughlin, James M. Krieger, A. Radu Aricescu, Ingo H. Greger Journal Science :eaeb3577 (2025)
- Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum AuthorsScrutton A. M., Sengupta N., Ivica J., Stockwell I., Peak-Chew S., Singh B., Suzuki K., Chang V. T., McLaughlin S. H., Krieger J. M., Aricescu A. R., Greger I. H. Journal Science 391(6792):1361-1367 (2026)
- Mini analysis' misrepresents changes in synaptic properties due to incomplete event detection AuthorsGreger I.H., Watson J.F. Journal The Journal of Physiology (2025)
-
Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors
AuthorsPokharna A., Stockwell I., Ivica J., Singh B., Schwab J., Vega-Guitérrez C., Herguedas B., Cais O., Krieger J.M., Greger I.H.
Journal
Nature
645(8080):535-543 (2025)
Details
DOI10.1038/s41586-025-09325-z PMID40592473 PMCIDPMC12422969 DivisionNeurobiology, Structural Studies - Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP AuthorsFuchsberger T., Stockwell I., Woods M., Brzosko Z., Greger I.H., Paulsen O. Journal eLife 13:RP100822 (2025)
- Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization AuthorsIvica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH. Journal Nature Structural and Molecular Biology Aug 13. doi: 10.1038/s41594-024-01369-5. (2024)
- How protons shape AMPA receptor structure, function and diffusion at the synapse AuthorsGreger I.H., Ivica J. Journal Nature Structural and Molecular Biology 31, 1466–1467 (2024)
- Regulating calcium flux through AMPA glutamate receptors AuthorsGreger IH. Journal Cell Calcium Jul 30;123:102934 (2024)
- Tuning synaptic strength by regulation of AMPA glutamate receptor localization AuthorsStockwell I, Watson JF, Greger IH. Journal Bioessays e2400006 (2024)
- Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor AuthorsZhang D., Ivica J., Krieger J. M., Ho H., Yamashita K., Stockwell I., Baradaran R., Cais O., Greger I. H. Journal Nature 621(7980):877-882 (2023)
- Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics AuthorsZhang D., Lape R., Shaikh S. A., Kohegyi B. K., Watson J. F., Cais O., Nakagawa T., Greger I. H Journal Nature Communication 14(1):1659 (2023)
- Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor AuthorsHerguedas B., Kohegyi B. K., Dohrke J. N., Watson J. F., Zhang D., Ho H., Shaikh S. A., Lape R., Krieger J. M., Greger I. H. Journal Nature Communications 13(1):734 (2022)
- Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity AuthorsMatthews P. M., Pinggera A., Kampjut D., Greger I. H. Journal Neuropharmacology 197:108709. 1 October 2021 (2021)
- Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains AuthorsRajab S., Bismin L., Schwarze S., Pinggera A., Greger I. H., Neuweiler H. Journal Communications Biology 4(1):1056 (2021)
- AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions AuthorsWatson J. F., Pinggera A., Ho H., Greger I. H. Journal Nature Communications 12(1):5083 (2021)
- Gating and modulation of a hetero-octameric AMPA glutamate receptor AuthorsZhang D., Watson J. F., Matthews P. M., Cais O., Greger I. H. Journal Nature 594(7863):454-458. 17 June 2021 (2021)
- AMPA Receptors AuthorsPinggera A., Watson J. F., Greger I. H. Journal Encyclopedia of Life Sciences 1(4):635-644 (2020)
- Characterising the binding and function of TARP γ8-selective AMPA receptor modulators AuthorsDohrke J. N., Watson J. F., Birchall K., Greger I. H. Journal Journal of Biological Chemistry 295(43):14565-14577. 23 October 2020 (2020)
- An inhalation anaesthesia approach for neonatal mice allowing streamlined stereotactic injection in the brain AuthorsHo H., Fowle A., Coetzee M., Greger I. H., Watson J. F. Journal Journal of Neuroscience Methods 342:108824. 1 August 2020 (2020)
- Structural biology of glutamate receptor ion channels: towards an understanding of mechanism AuthorsGreger I. H., Mayer M. L. Journal Current Opinion in Structural Biology 57:185-195. August 2019 (2019)
- Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions AuthorsKrieger J., Lee J. Y., Greger I. H., Bahar I. Journal Neuroscience Letters 700:22-29. 1 May 2019 (2019)
-
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8
AuthorsHerguedas B., Watson J. F., Ho H, Cais O., García-Nafría J., Greger I. H.
Journal
Science
364(6438) eaav9011. 14 March 2019 (2019)
Details
DOI10.1126/science. Aav9011 PMID30872532 PMCIDPMC6513756 DivisionNeurobiology, Structural Studies - Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain AuthorsLee J. Y., Krieger J., Herguedas B., García-Nafría J., Dutta A., Shaikh S. A., Greger I. H., Bahar I. Journal Structure 27(2):241-252.e3. 5 February 2019 (2019)
- Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation AuthorsBuonarati O. R., Hammes E. A., Watson J. F., Greger I. H., Hell J. W. Journal Science Signaling 12(562). 1 January 2019 (2019)
- Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions AuthorsKrieger J., Lee J. Y., Greger I. H., Bahar I. Journal Neuroscience Letters e-pub: published online 23 February 2018 (2018)
- A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability AuthorsDavies B., Brown L. A., Cais O., Watson J., Clayton A. J., Chang V. T., Biggs D., Preece C., Hernandez-Pliego P., Krohn J., Bhomra A., Twigg S. R. F, Rimmer A., Kanapin A.; W. G. S. 500 Consortium, Sen A., Zaiwalla Z., McVean G., Foster R., Donnelly P., Taylor J. C., Blair E., Nutt D., Aricescu A. R., Greger I. H., Peirson S. N., Flint J., Martin H. C. Journal Human Molecular Genetics 26(20):3869-3882. 15 October 2017 (2017)
- Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins AuthorsGreger I. H., Watson J. F., Cull-Candy S. G. Journal Neuron 94(4):713-730. 17 May 2017 (2017)
- Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain AuthorsWatson J. F. Ho H., Greger I. H. Journal ELife 6: e23024. 14 March 2017 (2017)
- The dynamic AMPA receptor extracellular region: A platform for synaptic protein interactions AuthorsGarcía-Nafría J., Herguedas B., Watson J. F., Greger I. H. Journal Journal of Physiology 594(19):5449-5458. 1 October 2016 (2016)
- Structural basis for integration of GluD receptors within synaptic organizer complexes. AuthorsElegheert J., Kakegawa W., Clay J. E., Shanks N. F., Behiels E., Matsuda K., Kohda K., Miura E., Rossmann M., Mitakidis N., Motohashi J., Chang V. T., Siebold C., Greger I. H., Nakagawa T., Yuzaki M., Aricescu A. R. Journal Science 353(6296):295-299. 15 July 2016 (2016)
- IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly AuthorsGarcía-Nafría J., Watson J. F., Greger I. H. Journal Scientific Reports 6:27459. 6 June 2016 (2016)
-
Structure and organization of heteromeric AMPA-type glutamate receptors
AuthorsHerguedas B., García-Nafría J., Cais O., Fernández-Leiro R., Krieger J., Ho H., Greger I. H.
Journal
Science
352(6285): aad3873. 29 April 2016 (2016)
Details
DOI10.1126/science. Aad3873 PMID26966189 PMCIDPMC4852135 DivisionNeurobiology; Structural Studies - Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains AuthorsKrieger J., Bahar I., Greger I. H. Journal Biophysical Journal 109(6):1136-1148. 15 September 2015 (2015)
- Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences AuthorsDutta A., Krieger J., Lee J. Y., Garcia-Nafria J., Greger I. H., Bahar I. Journal Structure 23(9):1692-1704. 1 September 2015 (2015)
- Factors influencing success of clinical genome sequencing across a broad spectrum of disorders AuthorsTaylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G Journal Nature Genetics 47(7):717-726. July 2015 (2015)
- Mapping the interaction sites between AMPA receptors and TARPs reveals a role for the receptor N-terminal domain in channel gating AuthorsCais O., Herguedas B., Krol K., Cull-Candy SG., Farrant M., Greger I. H. Journal Cell Reports 9(2):728-740. 23 October 2014 (2014)
- Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3 AuthorsShanks N. F., Cais O., Maruo T., Savas J. N., Zaika E. I., Azumaya C. M., Yates J. R. 3rd, Greger I., Nakagawa T. Journal Journal of Neuroscience 34(36):12104-12120. 3 September 2014 (2014)
- Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system AuthorsPenn A. C., Balik A., Greger I. H. Journal Frontiers in Neuroscience 7:61. 18 April 2013 (2013)
- Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing AuthorsPenn A. C , Balik A , Greger I. H. Journal Nucleic Acids Research 41(2):1113-1123. January 2013 (2013)
- Activity-regulated RNA editing in select neuronal subfields in hippocampus AuthorsBalik A. , Penn A. C., Nemoda Z., Greger I. H. Journal Nucleic Acids Research 41(2):1124-1134. January 2013 (2013)
- Receptor heteromeric assembly-how it works and why it matters: the case of ionotropic glutamate receptors AuthorsHerguedas B., Krieger J., Greger I. H. Journal Progress in Molecular Biology and Translational Science 117:361-386. 2013 (2013)
- Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain AuthorsPenn A. C., Balik A., Wozny C., Cais O., Greger I. H. Journal Neuron 76(3):503-510. 8 November 2012 (2012)
- Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains AuthorsDutta A., Shrivastava I. H., Sukumaran M., Greger I. H., Bahar I. Journal Structure 20(11):1838-1849. 7 November 2012 (2012)
- Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L AuthorsShanks N. F., Savas J. N., Maruo T., Cais O., Hirao A., Oe S., Ghosh A., Noda Y., Greger I. H., Yates J. R. 3rd, Nakagawa T. Journal Cell Reports 1(6):590-598. 28 June 2012 (2012)
- AMPA receptor assembly: atomic determinants and built-in modulators AuthorsSukumaran M., Penn A. C., Greger I. H. Journal Advances in Experimental Medicine and Biology 970:241-264. 2012 (2012)
-
Intrinsic motions in the N-terminal domain of an ionotropic glutamate receptor detected by fluorescence correlation spectroscopy
AuthorsJensen M. H., Sukumaran M., Johnson C. M., Greger I. H., Neuweiler H.
Journal
Journal of Molecular Biology
414(1):96-105. 18 November 2011 (2011)
Details
DOI10.1016/j.jmb.2011.09.037 PMID22001020 PMCID DivisionNeurobiology, Protein & Nucleic Acid Chemistry -
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers
AuthorsRossmann M., Sukumaran M., Penn A. C., Veprintsev D. B., Babu M. M., Greger I. H.
Journal
EMBO Journal
30(5):959-971. 2 March 2011 (2011)
Details
DOI10.1038/emboj.2011.16 PMID21317873 PMCIDPMC3049212 DivisionNeurobiology, Structural Studies - Dynamics and allosteric potential of the AMPA receptor N-terminal domain AuthorsSukumaran M., Rossmann M., Shrivastava I., Dutta A., Bahar I., Greger I. H. Journal EMBO Journal 30(5):972-982. 2 March 2011 (2011)
- Sculpting AMPA receptor formation and function by alternative RNA processing AuthorsAndrew C. Penn, Ingo H. Greger Journal RNA Biology 6(5):517-521 (2009) (2009)
- Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum AuthorsAndrew C Penn, Stephen R Williams, Ingo H Greger Journal EMBO Journal 27 (22): 3056-3068 (2008)
-
AMPA receptor biogenesis and trafficking
AuthorsIngo H. Greger, Jose A Esteban
Journal
Current Opinion in Neurobiology
17(3): 289-297 (2007) (2007)
Details
DOI PMID PMCID Division -
Molecular determinants of AMPA receptor subunit assembly
AuthorsIngo H. Greger, Edward B. Ziff, Andrew C. Penn
Journal
Trends in Neurosciences
30(8): 407-416 (2007) (2007)
Details
DOI PMID PMCID Division -
Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis
AuthorsIngo H. Greger, Pearl Akamine, Latika Khatri, Edward B. Ziff
Journal
Neuron
51 : 85-97 (2006). (2006 )
Details
DOI PMID PMCID Division