Published Research

Found 356 results for Goedert.

• Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments AuthorsLövestam S., Wagstaff J. L., Katsinelos T., Shi J., Freund S. M. V., Goedert M., Scheres S. H. W. Journal Elife 14:RP104778 (2026)
  Details

  DOI10.7554/elife.104778 PMID42159330 PMCIDPMC13189620 DivisionStructural Studies
• Seeding biosensor cell line that reproduces the Alzheimer tau fold AuthorsTaxiarchis Katsinelos, Sofia Lövestam, Chao Qi, Bejamin Ryskeldi-Falcon, Jennifer A. Macdonald, Gabriel Stephenson, Bernardino Ghetti, Ann McKee, Sjors H. W. Scheres, Michel Goedert. Journal The Journal of Biological Chemistry 301(12):110952 (2025)
  Details

  DOI10.1016/j.jbc.2025.110952 PMID41260337 PMCIDPMC12765094 DivisionStructural Studies, Neurobiology
• Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments AuthorsLövestam S, Wagstaff JL, Katsinelos T, Shi J, Freund SM, Goedert M, Scheres SH Journal eLife (2025)
  Details

  DOI10.7554/eLife.104778 PMID  PMCID  DivisionStructural Studies, Neurobiology
• Distinct tau filament folds in human MAPT mutants P301L and P301T AuthorsSchweighauser M., Shi Y., Murzin A.G., Garringer H.J., Vidal R., Murrell J.R., Elena Erro M., Seelaar H., Ferrer I., van Swieten J.C., Ghetti B., Scheres S.H.W., Goedert M. Journal Nature Structural & Molecular Biology 32(8):1470-1478 (2025)
  Details

  DOI10.1038/s41594-025-01575-9 PMID40442318 PMCIDPMC12350173 DivisionStructural Studies, Neurobiology
• Identical seeding characteristics and cryo-EM filament structures in FTLD-Synuclein and typical multiple system atrophy AuthorsCullinane P.W., Yang Y., Chelban V., Yen Goh Y., Ebanks K., Curless T., Wrigley S., de Pablo-Fernández E., Holton J., Peak-Chew S., Franco C., Woerman A.L., Houlden H., Warner T.T., Scheres S.H.W., Goedert M., Jaunmuktane Z. Journal Neuropathology and Applied Neurobiology 51(2):e70013 (2025)
  Details

  DOI10.1111/nan.70013 PMID40135351 PMCIDPMC11937994 DivisionStructural Studies, Neurobiology
• Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W AuthorsQi C., Lövestam S., Murzin A.G., Peak-Chew S., Franco C., Bogdani M., Latimer C., Murrell J.R., Cullinane P.W., Jaunmuktane Z., Bird T.D., Ghetti B., Scheres S.H.W., Goedert M. Journal Nature Structural & Molecular Biology 32(7):1297-1304 (2025)
  Details

  DOI10.1038/s41594-025-01498-5 PMID40044789 PMCIDPMC12263442 DivisionStructural Studies, Neurobiology
• TMEM106B amyloid filaments in the Biondi bodies of ependymal cells AuthorsGhetti B., Schweighauser M., Jacobsen M. H., Gray D., Bacioglu M., Murzin A. G., Glazier B. S., Katsinelos T., Vidal R., Newell K. L., Gao S., Garringer H. J., Spillantini M. G., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 148(1):60 (2024)
  Details

  DOI10.1007/s00401-024-02807-w PMID39503754 PMCIDPMC11541264 DivisionNeurobiology
• Abandon the NAC in α-synuclein AuthorsGoedert M, Griesinger C, Outeiro TF, Riek R, Schröder GF, Spillantini MG. Journal The Lancet neurology Jul;23(7):669 (2024)
  Details

  DOI10.1016/S1474-4422(24)00176‑5 PMID38876744 PMCID  DivisionNeurobiology
• Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems AuthorsBacioglu M, Schweighauser M, Gray D, Lövestam S, Katsinelos T, Quaegebeur A, van Swieten J, Jaunmuktane Z, Davies SW, Scheres SHW, Goedert M, Ghetti B, Spillantini MG. Journal Acta Neuropathologica Communications Jun 17;12(1):99 (2024)
  Details

  DOI10.1186/s40478-024-01813‑z PMID38886865 PMCIDPMC11181561 DivisionStructural Studies , Neurobiology
• Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G AuthorsQi C, Kobayashi R, Kawakatsu S, Kametani F, Scheres SHW, Goedert M, Hasegawa M. Journal Acta Neuropathologica 147(1):86 (2024)
  Details

  DOI0.1007/s00401-024-02741‑x PMID38758288 PMCIDPMC7616110 DivisionStructural Studies, Neurobiology
• Disease-specific tau filaments assemble via polymorphic intermediates AuthorsLövestam S, Li D., Wagstaff J. L., Kotecha A., Kimanius D., McLaughlin S. H., Murzin A. G., Freund S. M. V, Goedert M., Scheres S. H. W. Journal Nature 625(7993):119-125 (2024)
  Details

  DOI10.1038/s41586-023-06788‑w PMID38030728 PMCIDPMC10764278 DivisionStructural Studies
• Tau and neurodegeneration AuthorsGoedert M., Crowther R. A., Scheres S. H. W., Spillantini M. G. Journal Cytoskeleton 81(1):95-102 (2024)
  Details

  DOI10.1002/cm.21812 PMID38073060 PMCIDPMC7615684 DivisionNeurobiology
• Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau AuthorsSchweighauser M., Murzin A. G., Macdonald J., Lavenir I., Crowther R. A., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica Communications 11(1):160 (2023)
  Details

  DOI10.1186/s40478-023-01658‑y PMID37798679 PMCIDPMC10552433 DivisionStructural Studies
• Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids AuthorsScheres S. H. W., Ryskeldi-Falcon B., Goedert M. Journal Nature 621(7980):701-710 (2023)
  Details

  DOI10.1038/s41586-023-06437‑2 PMID37758888 PMCID  DivisionNeurobiology
• Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration AuthorsTarutani A., Lövestam S., Zhang X., Kotecha A., Robinson A. C., Mann D. M. A., Saito Y., Murayama S., Tomita T., Goedert M., Scheres S. H. W., Hasegawa M. Journal FEBS Open bio 13(8):1394-1404 (2023)
  Details

  DOI10.1002/2211-5463.13657 PMID37337995 PMCIDPMC10392052 DivisionStructural Studies
• Mutation ∆K281 in MAPT causes Pick's disease AuthorsSchweighauser M., Garringer H. J., Klingstedt T., Nilsson K. P. R., Masuda-Suzukake M., Murrell J. R., Risacher S L., Vidal R., Scheres S. H. W., Goedert M., Ghetti B., Newell K. L. Journal Acta Neuropathologica 146(2):211-226 (2023)
  Details

  DOIdoi.org/10.1007/s00401-023-02598‑6 PMID37351604 PMCIDPMC10329087 DivisionStructural Studies
• Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains AuthorsStern A. M., Yang Y., Jin S., Yamashita K., Meunier A. L., Liu W., Cai Y., Ericsson M., Liu L., Goedert M., Scheres S. H. W., Selkoe D. J. Journal Neuron 111(13):2012-2020.e4 (2023)
  Details

  DOI10.1016/j.neuron.2023.04.007 PMID37167969 PMCIDPMC10330525 DivisionStructural Studies
• Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy AuthorsQi C., Hasegawa M., Takao M., Sakai M., Sasaki M., Mizutani M., Akagi A., Iwasaki Y., Miyahara H., Yoshida M., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica Communications 11(1):74 (2023)
  Details

  DOI10.1186/s40478-023-01565‑2 PMID37143123 PMCIDPMC10161654 DivisionStructural Studies
• Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models AuthorsMukadam A. S., Miller L. V. C., Smith A. E., Vaysburd M., Sakya S. A, Sanford S., Keeling S., Tuck B. J., Katsinelos T., Green C., Skov L., Kaalund S. S., Foss S., Mayes K., O'Connell K., Wing M., Knox C., Banbury J., Avezov E., Rowe J. B, Goedert M., Andersen J. T, James LC., McEwan W. A. Journal Science 379(6639):1336-1341 (2023)
  Details

  DOI10.1126/science. Abn1366 PMID36996217 PMCIDPMC7614512 DivisionNeurobiology
• New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy AuthorsYang Y., Garringer H. J., Shi Y., Lövestam S., Peak-Chew S., Zhang X., Kotecha A., Bacioglu M., Koto A., Takao M., Spillantini M. G., Ghetti B., Vidal R., Murzin A. G., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 145(5):561-572 (2023)
  Details

  DOI0.1007/s00401-023-02550‑8 PMID36847833 PMCIDPMC10119069 DivisionStructural Studies
• Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains AuthorsYang Y., Zhang W., Murzin A. G., Schweighauser M., Huang M., Lövestam S., Peak-Chew S. Y., Saito T., Saido T. C., Macdonald J., Lavenir I., Ghetti B., Graff C., Kumar A., Nordberg A., Goedert M., Scheres S. H. W. Journal Acta Neuropathologica 145(3):325-333 (2023)
  Details

  DOI10.1007/s00401-022-02533-1 PMID36611124 PMCIDPMC9925504 DivisionStructural Studies
• Structures of α-synuclein filaments from human brains with Lewy pathology AuthorsYang Y., Shi Y., Schweighauser M., Zhang X., Kotecha A., Murzin A.G., Garringer H.J., Cullinane P.W., Saito Y., Foroud T., Warner T.T., Hasegawa K., Vidal R., Murayama S., Revesz T., Ghetti B., Hasegawa M., Lashley T., Scheres S.H.W., Goedert M. Journal Nature 610(7933):791-795 (2022)
  Details

  DOI10.1038/s41586-022-05319‑3 PMID36108674 PMCIDPMC7613749 DivisionStructural Studies, Neurobiology
• Age-dependent formation of TMEM106B amyloid filaments in human brains AuthorsSchweighauser M., Arseni D., Bacioglu M., Huang M., Lövestam S., Shi Y., Yang Y., Zhang W., Kotecha A., Garringer H. J., Vidal R., Hallinan G. I., Newell K. L., Tarutani A., Murayama S., Miyazaki M., Saito Y., Yoshida M., Hasegawa K., Lashley T., Revesz T., Kovacs G. G., van Swieten J., Takao M., Hasegawa M., Ghetti B., Spillantini M. G., Ryskeldi-Falcon B., Murzin A. G., Goedert M., Scheres S. H. W. Journal Nature 605(7909):310-314 (2022)
  Details

  DOI10.1038/s41586-022-04650-z PMID35344985 PMCIDPMC9095482 DivisionNeurobiology, Structural Studies
• A tribute to John Q. Trojanowski (1946-2022), neuropathologist extraordinaire AuthorsGoedert M., Spillantini M. G. Journal Brain Pathology 32(3):e13066 (2022)
  Details

  DOI10.1111/bpa.13066 PMID35312135 PMCIDPMC9048512 DivisionNeurobiology
• Classification of diseases with accumulation of Tau protein AuthorsKovacs G. G., Ghetti B., Goedert M. Journal Neuropathology and Applied Neurobiology 48(3):e12792 (2022)
  Details

  DOI10.1111/nan.12792 PMID35064600 PMCIDPMC9352145 DivisionNeurobiology
• Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy AuthorsLövestam S., Koh F. A., van Knippenberg B., Kotecha A., Murzin A. G., Goedert M., Scheres S. H. W. Journal Elife 11:e76494 (2022)
  Details

  DOI10.7554/elife.76494 PMID35244536 PMCIDPMC8983045 DivisionNeurobiology, Structural Studies
• Cryo-EM structures of amyloid-β 42 filaments from human brains AuthorsYang Y., Arseni D., Zhang W., Huang M., Lövestam S., Schweighauser M., Kotecha A., Murzin A. G., Peak-Chew S. Y., Macdonald J., Lavenir I., Garringer H. J., Gelpi E., Newell K. L., Kovacs G. G., Vidal R., Ghetti B., Ryskeldi-Falcon B., Scheres S. H. W., Goedert M. Journal Science 375(6577):167-172 (2022)
  Details

  DOI10.1126/science. Abm7285 PMID35025654 PMCIDPMC7612234 DivisionStructural Studies, Neurobiology
• Cryo-EM structures of τ filaments from human brain AuthorsGoedert M. Journal Essays in Biochemistry 65(7):949-959 (2021)
  Details

  DOI10.1042/ebc20210025 PMID34846514 PMCIDPMC8709893 DivisionNeurobiology
• Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds AuthorsMacdonald J. A., Chen J. L., Masuda-Suzukake M., Schweighauser M., Jaunmuktane Z., Warner T., Holton J. L., Grossman A., Berks R., Lavenir I., Goedert M. Journal Acta Neuropathologica Communications 9(1):189 (2021)
  Details

  DOI10.1186/s40478-021-01291-7 PMID34819144 PMCIDPMC8611835 DivisionNeurobiology
• Structure-based classification of tauopathies AuthorsShi Y., Zhang W., Yang Y., Murzin A. G., Falcon B., Kotecha A., van Beers M., Tarutani A., Kametani F., Garringer H. J., Vidal R., Hallinan G. I., Lashley T., Saito Y., Murayama S., Yoshida M., Tanaka H., Kakita A., Ikeuchi T., Robinson A. C., Mann D. M. A., Kovacs G. G., Revesz T., Ghetti B., Hasegawa M., Goedert M., Scheres S. H. W. Journal Nature 598(7880):359-363 (2021)
  Details

  DOI10.1038/s41586-021-03911-7 PMID34588692 PMCIDPMC7611841 DivisionNeurobiology, Structural Studies
• Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models AuthorsMcMurray L., Macdonald J. A., Ramakrishnan N. K., Zhao Y., Williamson D. W., Tietz O., Zhou X., Kealey S., Fagan S. G., Smolek T., Cubinkova V., Žilka N., Spillantini M. G., Tolkovsky A. M., Goedert M., Aigbirhio F. I. Journal ACS Chemical Neuroscience 12(11):1885-1893. 2 June 2021 (2021)
  Details

  DOI10.1021/acschemneuro.0c00790 PMID33689290 PMCIDPMC8176454 DivisionNeurobiology
• Correction to: Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN‑1607 AuthorsShi Y., Murzin A. G., Falcon B., Epstein A., Machin J., Tempest P., Newell K. L., Vidal R., Garringer H. J., Sahara N., Higuchi M., Ghetti B., Jang M. K., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 141(6):983. June 2021 (2021)
  Details

  DOI10.1007/s00401-021-02303-5 PMID33830331 PMCIDPMC8496564 DivisionStructural Studies, Neurobiology
• Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy AuthorsLövestam S., Schweighauser M., Matsubara T., Murayama S., Tomita T., Ando T., Hasegawa K., Yoshida M., Tarutani A., Hasegawa M., Goedert M., Scheres S. H. W. Journal FEBS Open bio 11(4):999-1013. April 2021 (2021)
  Details

  DOI10.1002/2211-5463.13110 PMID33548114 PMCIDPMC8016116 DivisionNeurobiology, Structural Studies
• Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN‑1607 AuthorsShi Y., Murzin A. G., Falcon B., Epstein A., Machin J., Tempest P., Newell K. L., Vidal R., Garringer H. J., Sahara N., Higuchi M., Ghetti B., Jang M. K., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 141(5):697-708. 16 March 2021 (2021)
  Details

  DOI10.1007/s00401-021-02294-3 PMID33723967 PMCIDPMC8043864 DivisionStructural Studies, Neurobiology
• Tau Protein and Frontotemporal Dementias AuthorsGoedert M., Spillantini M. G., Falcon B., Zhang W., Newell K. L., Hasegawa M., Scheres S. H. W., Ghetti B. Journal Advances in Experimental Medicine and Biology 1281:177-199. January 2021 (2021)
  Details

  DOI10.1007/978-3-030-51140-1_12 PMID33433876 PMCID  DivisionNeurobiology, Structural Studies
• Cryo-EM structures of tau filaments AuthorsScheres S. H., Zhang W., Falcon B., Goedert M. Journal Current Opinion in Structural Biology 64:17-25. October 2020 (2020)
  Details

  DOI10.1016/j.sbi.2020.05.011 PMID32603876 PMCID  DivisionStructural Studies, Neurobiology
• Structures of α-synuclein filaments from multiple system atrophy AuthorsSchweighauser M., Shi Y., Tarutani A., Kametani F., Murzin A. G., Ghetti B., Matsubara T., Tomita T., Ando T., Hasegawa K., Murayama S., Yoshida M., Hasegawa M., Scheres S. H. W., Goedert M. Journal Nature 585(7825):464-469. 17 September 2020 (2020)
  Details

  DOI10.1038/s41586-020-2317-6 PMID32461689 PMCIDPMC7116528 DivisionStructural Studies, Neurobiology
• Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice AuthorsMasuda-Suzukake M., Suzuki G., Hosokawa M., Nonaka T., Goedert M.,Hasegawa M. Journal Brain Communications 2(2):fcaa091. 8 July 2020 (2020)
  Details

  DOI10.1093/braincomms/fcaa091 PMID33005889 PMCIDPMC7519727 DivisionNeurobiology
• Novel tau filament fold in corticobasal degeneration AuthorsZhang W., Tarutani A., Newell K. L., Murzin A. G., Matsubara T., Falcon B., Vidal R., Garringer H. J., Shi Y., Ikeuchi T., Murayama S., Ghetti B., Hasegawa M., Goedert M., Scheres S. H. W. Journal Nature 580(7802):283-287. 9 April 2020 (2020)
  Details

  DOI10.1038/s41586-020-2043‑0 PMID32050258 PMCIDPMC7148158 DivisionNeurobiology, Structural Studies
• Editorial overview: Neurobiology of disease AuthorsGoedert M., Haass C. Journal Current Opinion in Neurobiology 61:iii-iv. April 2020 (2020)
  Details

  DOI10.1016/j. Conb.2020.03.005 PMID32359783 PMCID  DivisionNeurobiology
• α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species AuthorsMorgan S. A., Lavenir I., Fan J., Masuda-Suzukake M., Passarella D., DeTure M. A., Dickson D. W., Ghetti B., Goedert M. Journal Journal of Biological Chemistry 295(19):6652-6664. 24 March 2020 (2020)
  Details

  DOI10.1074/jbc.ra119.012179 PMID32209651 PMCIDPMC7212628 DivisionNeurobiology
• Ordered Assembly of Tau Protein and Neurodegeneration AuthorsGoedert M., Spillantini M. G. Journal Advances in Experimental Medicine and Biology 1184:3-21. 25 February 2020 (2020)
  Details

  DOI10.1007/978-981-32-9358-8_1 PMID32096024 PMCID  DivisionNeurobiology
• Inhibition of synucleinopathic seeding by rationally designed inhibitors AuthorsSangwan S., Sahay S., Murray K. A., Morgan S., Guenther E. L., Jiang L., Williams C. K., Vinters H. V., Goedert M., Eisenberg D. S. Journal Elife 9:e46775. 2 January 2020 (2020)
  Details

  DOI10.7554/elife.46775 PMID31895037 PMCIDPMC6977966 DivisionNeurobiology
• Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy AuthorsKlingstedt T., Ghetti B., Holton J. L., Ling H., Nilsson K. P. R., Goedert M. Journal Acta Neuropathologica Communications 7(1):193. 3 December 2019 (2019)
  Details

  DOI10.1186/s40478-019-0840‑1 PMID31796099 PMCIDPMC6892142 DivisionNeurobiology
• Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice AuthorsLavenir I., Passarella D., Masuda-Suzukake M., Curry A., Holton J. L., Ghetti B., Goedert M. Journal Acta Neuropathologica Communications 7(1):148. 16 September 2019 (2019)
  Details

  DOI10.1186/s40478-019-0804‑5 PMID31522685 PMCIDPMC6745790 DivisionNeurobiology
• Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy AuthorsMalcolm J. C., Breuillaud L., Do Carmo S., Hall H., Welikovitch L. A., Macdonald J. A., Goedert M., Cuello A. C. Journal Neurobiology of Disease 127:323-338. July 2019 (2019)
  Details

  DOI10.1016/j.nbd.2019.03.018 PMID30905766 PMCIDPMC6597947 DivisionNeurobiology
• Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice AuthorsSkachokova Z., Martinisi A., Flach M., Sprenger F., Naegelin Y., Steiner-Monard V., Sollberger M., Monsch A. U., Goedert M., Tolnay M., Winkler D. T. Journal Acta Neuropathologica Communications 7(1):72. 7 May 2019 (2019)
  Details

  DOI10.1186/s40478-019-0725‑3 PMID31064413 PMCIDPMC6503541 DivisionNeurobiology
• Aaron Klug and the study of Alzheimer's disease AuthorsGoedert M. Journal Alzheimer's & Dementia 15(6):859-861. 19 April 2019 (2019)
  Details

  DOI10.1016/j.jalz.2019.03.001 PMID31010788 PMCIDPMC7297628 DivisionNeurobiology
• Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules AuthorsFalcon B., Zivanov J., Zhang W., Murzin A. G., Garringer H. J., Vidal R., Crowther R. A., Newell K. L., Ghetti B., Goedert M., Scheres S. H. W. Journal Nature 568(7752):420-423. April 2019 (2019)
  Details

  DOI10.1038/s41586-019-1026-5 PMID30894745 PMCIDPMC6472968 DivisionNeurobiology, Structural Studies
• Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord AuthorsMacdonald J. A., Bronner I. F., Drynan L., Fan J., Curry A., Fraser G., Lavenir I., Goedert M. Journal Acta Neuropathologica Communications 7(1):44. 18 March 2019 (2019)
  Details

  DOI10.1186/s40478-019-0695‑5 PMID30885267 PMCIDPMC6421678 DivisionNeurobiology
• Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases AuthorsZhang W., Falcon B., Murzin A. G., Fan J., Crowther R. A., Goedert M., Scheres S. H. Journal ELife 8: e43584. 5 February 2019 (2019)
  Details

  DOI10.7554/eLife.43584 PMID30720432 PMCIDPMC6375701 DivisionNeurobiology, Structural Studies
• A Conversation with Michel Goedert AuthorsGoedert M. Journal Cold Spring Harbor Symposia on Quantitative Biology 83:252-254 (2019)
  Details

  DOI10.1101/sqb.2018.83.037358 PMID30642995 PMCID  DivisionNeurobiology
• Beta-sheet assembly of Tau and neurodegeneration in Drosophila melanogaster AuthorsPassarella D., Goedert M. Journal Neurobiology of Aging 72:98-105 (2018)
  Details

  DOI10.1016/j.neurobiolaging.2018.07.022 PMID30240946 PMCIDPMC6327151 DivisionNeurobiology
• Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold AuthorsFalcon B., Zhang W., Schweighauser M., Murzin A. G., Vidal R., Garringer H. J., Ghetti B., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica 136(5):699-708. November 2018 (2018)
  Details

  DOI10.1007/s00401-018-1914-z PMID30276465 PMCIDPMC6208733 DivisionStructural Studies, Neurobiology
• Rodent models for Alzheimer disease AuthorsGötz J., Bodea L. G., Goedert M. Journal Nature Reviews. Neuroscience 19(10):583-598. October 2018 (2018)
  Details

  DOI10.1038/s41583-018-0054‑8 PMID30194347 PMCID  DivisionNeurobiology
• Structures of filaments from Pick's disease reveal a novel tau protein fold AuthorsFalcon B., Zhang W., Murzin A. G., Murshudov G., Garringer H. J., Vidal R., Crowther R. A., Ghetti B., Scheres S. H. W., Goedert M. Journal Nature 561(7721):137-140. 6 September 2018 (2018)
  Details

  DOI10.1038/s41586-018-0454-y PMID30158706 PMCIDPMC6204212 DivisionStructural Studies, Neurobiology
• Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia AuthorsBrelstaff J., Tolkovsky A. M., Ghetti B., Goedert M., Spillantini M. G. Journal Cell Reports 24(8):1939-1948.e4. 21 August 2018 (2018)
  Details

  DOI10.1016/j. Celrep.2018.07.072 PMID30134156 PMCIDPMC6161320 DivisionNeurobiology
• Ubiquitination of alpha-synuclein filaments by Nedd4 ligases AuthorsMund T., Masuda-Suzukake M., Goedert M., Pelham H. R. Journal PloS one 13(7):e0200763. 18 July 2018 (2018)
  Details

  DOI10.1371/journal.pone.0200763 PMID30021006 PMCIDPMC6051637 DivisionNeurobiology, Cell Biology
• Neurodegeneration and the ordered assembly of α-synuclein AuthorsSpillantini M. G., Goedert M. Journal Cell and Tissue Research 373(1):137-148. July 2018 (2018)
  Details

  DOI10.1007/s00441-017-2706‑9 PMID29119326 PMCIDPMC6015613 DivisionNeurobiology
• Tau filaments in neurodegenerative diseases AuthorsGoedert M. Journal FEBS Letters 592(14):2383-2391. July 2018 (2018)
  Details

  DOI10.1002/1873-3468.13108 PMID29790176 PMCID  DivisionNeurobiology
• Measurement of tau filament fragmentation provides insights into prion-like spreading AuthorsKundel F., Hong L., Falcon B., McEwan W. A., Michaels T. C. T., Meisl G., Esteras N., Abramov A. Y., Knowles T. J. P., Goedert M., Klenerman D. Journal ACS Chemical Neuroscience 9(6):1276-1282. 20 June 2018 (2018)
  Details

  DOI10.1021/acschemneuro.8b00094 PMID29590529 PMCIDPMC6014609 DivisionProtein & Nucleic Acid Chemistry, Neurobiology
• Galectin-8-mediated selective autophagy protects against seeded tau aggregation AuthorsFalcon B., Noad J., McMahon H., Randow F., Goedert M. Journal Journal of Biological Chemistry 293(7):2438-2451. 16 February 2018 (2018)
  Details

  DOI10.1074/jbc. M117.809293 PMID29282296 PMCIDPMC5818177 DivisionProtein & Nucleic Acid Chemistry, Neurobiology
• Tau Filaments and the Development of Positron Emission Tomography Tracers AuthorsGoedert M., Yamaguchi Y., Mishra S. K., Higuchi M., Sahara N. Journal Frontiers in Neurology 9:70. 15 February 2018 (2018)
  Details

  DOI10.3389/fneur.2018.00070 PMID29497399 PMCIDPMC5818396 DivisionNeurobiology
• Parkinson's disease - the story of an eponym AuthorsGoedert M., Compston A. Journal Nature Reviews. Neurology 14(1):57-62. January 2018 (2018)
  Details

  DOI10.1038/nrneurol.2017.165 PMID29217826 PMCID  DivisionNeurobiology
• Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases AuthorsGoedert M., Falcon B., Zhang W., Ghetti B., Scheres S. H. W. Journal Cold Spring Harbor Symposia on Quantitative Biology 83:163-171. January 2018 (2018)
  Details

  DOI10.1101/sqb.2018.83.037580 PMID30886056 PMCID  DivisionNeurobiology, Structural Studies
• What is the evidence that tau pathology spreads through prion-like propagation? AuthorsMudher A., Colin M., Dujardin S., Medina M., Dewachter I., Naini S. M. A., Mandelkow E. M., Mandelkow E., Buée L., Goedert M., Brion J. P. Journal Acta Neuropathologica Communications 5(1):99. 19 December 2017 (2017)
  Details

  DOI10.1186/s40478-017-0488-7 PMID29258615 PMCIDPMC5735872 DivisionNeurobiology
• The Prion-Like Behavior of Assembled Tau in Transgenic Mice AuthorsClavaguera F., Tolnay M., Goedert M. Journal Cold Spring Harbor Perspectives in Medicine 7(10). October 2017 (2017)
  Details

  DOI10.1101/cshperspect. A024372 PMID27940600 PMCID  DivisionNeurobiology
• The Transcellular Propagation and Intracellular Trafficking of α-Synuclein AuthorsTofaris G. K., Goedert M., Spillantini M. G. Journal Cold Spring Harbor Perspectives in Medicine 7(9). September 2017 (2017)
  Details

  DOI10.1101/cshperspect. A024380 PMID27920026 PMCID  DivisionNeurobiology
• Cryo-EM structures of tau filaments from Alzheimer's disease AuthorsFitzpatrick A. W. P., Falcon B., He S., Murzin A. G., Murshudov G., Garringer H. J., Crowther R. A., Ghetti B., Goedert M., Scheres S. H. W. Journal Nature 547(7662):185-190 (2017)
  Details

  DOI10.1038/nature23002 PMID28678775 PMCIDPMC5552202 DivisionNeurobiology, Structural Studies
• Propagation of Tau Aggregates and Neurodegeneration AuthorsGoedert M., Eisenberg D. S., Crowther R. A. Journal Annual Review of Neuroscience 40:189-210 (2017)
  Details

  DOI10.1146/annurev-neuro-072116‑031153 PMID28772101 PMCID  DivisionNeurobiology, Structural Studies
• Propagation of Tau aggregates AuthorsGoedert M., Spillantini M. G. Journal Molecular Brain 10(1):18. 30 May 2017 (2017)
  Details

  DOI10.1186/s13041-017-0298‑7 PMID28558799 PMCIDPMC5450399 DivisionNeurobiology
• Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration AuthorsGoedert M., Masuda-Suzukake M., Falcon B. Journal Brain: a Journal of Neurology 140(Pt 2):266-278. February 2017 (2017)
  Details

  DOI10.1093/brain/aww230 PMID27658420 PMCID  DivisionNeurobiology
• Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies AuthorsGoedert M. Journal Neurodegeneration pp.12-24 (2017)
  Details

  DOI10.1002/9781118661895. Ch2 PMID  PMCID  DivisionNeurobiology
• Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation AuthorsMcEwan W. A., Falcon B., Vaysburd M., Clift D., Oblak A. L., Ghetti B., Goedert M., James L. C. Journal Proceedings of the National Academy of Sciences of the United States of America 114(3):574-579. 17 January 2017 (2017)
  Details

  DOI10.1073/pnas.1607215114 PMID28049840 PMCIDPMC5255578 DivisionProtein & Nucleic Acid Chemistry, Neurobiology
• The Synucleinopathies: Twenty Years On AuthorsGoedert M., Jakes R., Spillantini M. G. Journal Journal of Parkinson's Disease 7(s1):S51-S69. January 2017 (2017)
  Details

  DOI10.3233/jpd‑179005 PMID28282814 PMCIDPMC5345650 DivisionNeurobiology
• Co-expression of truncated and full-length tau induces severe neurotoxicity AuthorsOzcelik S., Sprenger F., Skachokova Z., Fraser G., Abramowski D., Clavaguera F., Probst A., Frank S., Müller M., Staufenbiel M., Goedert M., Tolnay M., Winkler D. T. Journal Molecular Psychiatry 21(12):1790-1798. December 2016 (2016)
  Details

  DOI10.1038/mp.2015.228 PMID26830137 PMCIDPMC5116481 DivisionNeurobiology
• Tau: From research to clinical development AuthorsHoltzman D. M., Carrillo M. C., Hendrix J. A., Bain L. J., Catafau A. M., Gault L. M., Goedert M., Mandelkow E., Mandelkow E. M., Miller D. S., Ostrowitzki S., Polydoro M., Smith S., Wittmann M., Hutton M. Journal Alzheimer's & Dementia : the Journal of the Alzheimer's Association 12(10):1033-1039. October 2016 (2016)
  Details

  DOI10.1016/j.jalz.2016.03.018 PMID27154059 PMCID  DivisionNeurobiology
• The ordered assembly of tau is the gain-of-toxic function that causes human tauopathies AuthorsGoedert M. Journal Alzheimer's & Dementia 12(10):1040-1050. October 2016 (2016)
  Details

  DOI10.1016/j.jalz.2016.09.001 PMID27686274 PMCID  DivisionNeurobiology
• Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy AuthorsMazzaro N., Barini E., Spillantini M. G., Goedert M., Medini P., Gasparini L. Journal Journal of Neuroscience 36(7):2086-2100. 17 February 2016 (2016)
  Details

  DOI10.1523/JNEUROSCI.0774-15.2016 PMID26888921 PMCIDPMC4756149 DivisionNeurobiology
• Synucleinopathies: Past, Present and Future AuthorsSpillantini M. G., Goedert M. Journal Neuropathology and Applied Neurobiology 42(1):3-5. February 2016 (2016)
  Details

  DOI10.1111/nan.12311 PMID26819143 PMCID  DivisionNeurobiology
• Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau AuthorsJackson S. J., Kerridge C., Cooper J., Cavallini A., Falcon B., Cella C. V., Landi A., Szekeres P. G., Murray T. K., Ahmed Z., Goedert M., Hutton M., O'Neill M. J., Bose S. Journal Journal of Neuroscience 36(3):762-772. 20 January 2016 (2016)
  Details

  DOI10.1523/JNEUROSCI.3542-15.2016 PMID26791207 PMCIDPMC4719013 DivisionNeurobiology
• "Why therapy development for dementia has failed in the last two decades?" AuthorsGauthier S., Albert M. , Fox N., Goedert M., Kivipelto M., Mestre-Ferrandiz J., Middleton L. T. Journal Alzheimer's & Dementia 12(1): 60–64. January 2016 (2016)
  Details

  DOI10.1016/j.jalz.2015.12.003 PMID26710325 PMCID  DivisionNeurobiology
• A Brief History of Tau AuthorsGoedert M., Spillantini M. G., Crowther R. A. Journal Clinical Chemistry 61(11):1417-1418. November 2015 (2015)
  Details

  DOI10.1373/clinchem.2015.245142 PMID26330509 PMCID  DivisionNeurobiology
• Parkinson's disease: Crystals of a toxic core AuthorsGoedert M., Cheng Y. Journal Nature 525(7570):458-459. 24 September 2015 (2015)
  Details

  DOI10.1038/nature15630 PMID26352470 PMCID  DivisionNeurobiology
• NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein AuthorsGoedert M. Journal Science 349(6248):1255555 7 August 2015 (2015)
  Details

  DOI10.1126/science.1255555 PMID26250687 PMCID  DivisionNeurobiology
• Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates AuthorsKlingstedt T., Shirani H., Mahler J., Wegenast-Braun B. M., Nyström S., Goedert M., Jucker M., Nilsson K. P. Journal Chemistry 21(25):9072-9082. 15 June 2015 (2015)
  Details

  DOI10.1002/chem.201500556 PMID26013403 PMCIDPMC4517144 DivisionNeurobiology
• PART is part of Alzheimer disease. AuthorsDuyckaerts C., Braak H., Brion J. P., Buée L., Del Tredici K., Goedert M., Halliday G., Neumann M., Spillantini M. G., Tolnay M., Uchihara T. Journal Acta Neuropathologica 129(5):749-756. May 2015 (2015)
  Details

  DOI10.1007/s00401-015-1390‑7 PMID25628035 PMCIDPMC4405349 DivisionNeurobiology
• Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging. AuthorsGhetti B., Oblak A. L., Boeve B. F., Johnson K. A., Dickerson B. C., Goedert M. Journal Neuropathology and Applied Neurobiology 41(1):24-46, 1 February 2015 (2015)
  Details

  DOI10.1111/nan.12213 PMID25556536 PMCIDPMC4329416 DivisionNeurobiology
• Conformation determines the seeding potencies of native and recombinant Tau aggregates AuthorsFalcon B., Cavallini A., Angers R., Glover S., Murray T. K., Barnham L., Jackson S., O'Neill M. J., Isaacs A. M., Hutton M. L., Szekeres P. G., Goedert M., Bose S. Journal Journal of Biological Chemistry 290(2):1049-1065. 9 January 2015 (2015)
  Details

  DOI10.1074/jbc. M114.589309 PMID25406315 PMCIDPMC4294473 DivisionNeurobiology
• Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies. AuthorsGoedert M., Falcon B., Clavaguera F., Tolnay M. Journal Current Neurology and Neuroscience Reports 14(11):495. November 2014 (2014)
  Details

  DOI10.1007/s11910-014-0495-z PMID25218483 PMCID  DivisionNeurobiology
• Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding AuthorsFlach K., Ramminger E., Hilbrich I., Arsalan-Werner A., Albrecht F., Herrmann L., Goedert M., Arendt T., Holzer M. Journal Biochimica et Biophysica Acta 1842(9):1527-1538. September 2014 (2014)
  Details

  DOI10.1016/j. Bbadis.2014.05.029 PMID24905733 PMCIDPMC4311138 DivisionNeurobiology
• A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity AuthorsAhmed Z., Cooper J., Murray T. K., Garn K., McNaughton E., Clarke H., Parhizkar S., Ward M. A., Cavallini A., Jackson S., Bose S., Clavaguera F., Tolnay M., Lavenir I., Goedert M., Hutton M L., O'Neill M. J. Journal Acta Neuropathologica 127(5):667-683. May 2014 (2014)
  Details

  DOI10.1007/s00401-014-1254-6 PMID24531916 PMCIDPMC4252866 DivisionNeurobiology
• Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA) AuthorsHerva M. E., Zibaee S., Fraser G., Barker R. A., Goedert M. , Spillantini M. G. Journal Journal of Biological Chemistry 289(17):11897-11905. 25 April 2014 (2014)
  Details

  DOI10.1074/jbc. M113.542340 PMID24584936 PMCIDPMC4002097 DivisionNeurobiology
• Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice. AuthorsClavaguera F., Hench J., Lavenir I., Schweighauser G., Frank S., Goedert M., Tolnay M. Journal Acta Neuropathologica 127(2):299-301. February 2014 (2014)
  Details

  DOI10.1007/s00401-013-1231-5 PMID24362441 PMCIDPMC4253855 DivisionNeurobiology
• The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons. AuthorsIovino M., Pfisterer U., Holton J. L., Lashley T., Swingler R. J., Calo L., Treacy R., Revesz T., Parmar M., Goedert M., Muqit M. M., Spillantini M. G. Journal Acta Neuropathologica 127(2):283-295. February 2014 (2014)
  Details

  DOI10.1007/s00401-013-1219-1 PMID24292008 PMCIDPMC3895181 DivisionNeurobiology
• Tau silencing by siRNA in the P301S mouse model of tauopathy AuthorsXu H., Rösler T. W., Carlsson T., de Andrade A., Fiala O., Hollerhage M., Oertel W. H., Goedert M., Aigner A., Höglinger G. U. Journal Current Gene Therapy 14(5):343-351. 2014 (2014)
  Details

  DOI10.2174/156652321405140926160602 PMID25687501 PMCID  DivisionNeurobiology
• Prions and the like AuthorsGoedert M. Journal Brain 137(1):301-305. 1 January 2014 (2014)
  Details

  DOI10.1093/brain/awt179 PMID  PMCID  DivisionNeurobiology
• Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice AuthorsHoffmann N. A., Dorostkar M. M., Blumenstock S., Goedert M., Herms J. Journal Acta Neuropathologica Communications 1:82. 17 December 2013 (2013)
  Details

  DOI10.1186/2051-5960-1‑82 PMID24344647 PMCIDPMC3880070 DivisionNeurobiology
• Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies AuthorsMellone M., Kestoras D., Andrews M. R., Dassie E., Crowther R. A., Stokin G. B., Tinsley J., Horne G., Goedert M., Tolkovsky A. M., Spillantini M. G. Journal Journal of Neuroscience 33(46):18175-18189. 13 November 2013 (2013)
  Details

  DOI10.1523/JNEUROSCI.4933-12.2013 PMID24227726 PMCIDPMC3828468 DivisionNeurobiology, Structural Studies
• Circadian clocks and neurodegenerative diseases: time to aggregate? AuthorsHastings M. H., Goedert M. Journal Current Opinion in Neurobiology 23(5):880-887. October 2013 (2013)
  Details

  DOI10.1016/j. Conb.2013.05.004 PMID23797088 PMCIDPMC3782660 DivisionNeurobiology
• The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates AuthorsKlingstedt T., Shirani H., Åslund K. O., Cairns N. J., Sigurdson C. J., Goedert M., Nilsson K. P. Journal Chemistry 19(31):10179-10192. 29 July 2013 (2013)
  Details

  DOI10.1002/chem.201301463 PMID23780508 PMCIDPMC3884759 DivisionNeurobiology
• Brain homogenates from human tauopathies induce tau inclusions in mouse brain AuthorsClavaguera F., Akatsu H., Fraser G., Crowther R. A., Frank S., Hench J., Probst A., Winkler D. T., Reichwald J., Staufenbiel M., Ghetti B., Goedert M., Tolnay M. Journal Proceedings of the National Academy of Sciences, USA. 110(23):9535-9540. 4 June 2013 (2013)
  Details

  DOI10.1073/pnas.1301175110 PMID23690619 PMCIDPMC3677441 DivisionNeurobiology, Structural Studies
• Tau pathology and neurodegeneration AuthorsSpillantini M. G., Goedert M. Journal Lancet Neurology 12(6):609-622. June 2013 (2013)
  Details

  DOI10.1016/S1474-4422(13)70090‑5 PMID23684085 PMCID  DivisionNeurobiology
• Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice AuthorsOzcelik S., Fraser G., Castets P., Schaeffer V., Skachokova Z., Breu K., Clavaguera F., Sinnreich M., Kappos L., Goedert M., Tolnay M., Winkler D. T. Journal PloS one 8(5):e62459. 7 May 2013 (2013)
  Details

  DOI10.1371/journal.pone.0062459 PMID23667480 PMCIDPMC3646815 DivisionNeurobiology
• "Prion-like" templated misfolding in tauopathies AuthorsClavaguera F., Lavenir I., Falcon B., Frank S., Goedert M., Tolnay M. Journal Brain Pathology 23(3):342-349. May 2013 (2013)
  Details

  DOI10.1111/bpa.12044 PMID23587140 PMCID  DivisionNeurobiology
• Parkinson's disease - the debate on the clinical phenomenology, aetiology, pathology and pathogenesis AuthorsJenner P., Morris H. R., Robbins T. W., Goedert M., Hardy J., Ben-Shlomo Y., Bolam P., Burn D., Hindle J. V., Brooks D. Journal Journal of Parkinson's Disease 3(1):1-11. 29 March 2013 (2013)
  Details

  DOI10.3233/JPD‑130175 PMID23938306 PMCID  DivisionNeurobiology
• The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1 AuthorsMorris K. L., Zibaee S., Chen L., Goedert M., Sikorski P., Serpell L. C. Journal Angewandte Chemie (International ed. in English) 52(8):2279-2283. 18 February 2013 (2013)
  Details

  DOI10.1002/anie.201207699 PMID23307646 PMCIDPMC4279883 DivisionNeurobiology
• 100 years of Lewy pathology AuthorsGoedert M., Spillantini M. G., Del Tredici K., Braak H. Journal Nature Reviews. Neurology 9(1):13-24. January 2013 (2013)
  Details

  DOI10.1038/nrneurol.2012.242 PMID23183883 PMCID  DivisionNeurobiology
• Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice AuthorsSchön C., Hoffmann N. A., Ochs S. M., Burgold S., Filser S., Steinbach S., Seeliger M. W., Arzberger T., Goedert M., Kretzschmar H. A., Schmidt B., Herms J. Journal PloS one 7(12):e53547. 31 December 2012 (2012)
  Details

  DOI10.1371/journal.pone.0053547 PMID23300938 PMCIDPMC3534024 DivisionNeurobiology
• Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy AuthorsSchaeffer V., Goedert M. Journal Autophagy 8(11):1686-1687. November 2012 (2012)
  Details

  DOI10.4161/auto.21488 PMID22874558 PMCIDPMC3494601 DivisionNeurobiology
• Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy AuthorsSchaeffer V., Lavenir I., Ozcelik S., Tolnay M., Winkler D. T., Goedert M. Journal Brain 135(Pt 7):2169-2177. July 2012 (2012)
  Details

  DOI10.1093/brain/aws143 PMID22689910 PMCIDPMC3381726 DivisionNeurobiology
• Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau AuthorsBull N. D., Guidi A., Goedert M., Martin K. R., Spillantini M. G. Journal PloS one 7(4):e34724. 4 April 2012 (2012)
  Details

  DOI10.1371/journal.pone.0034724 PMID22496848 PMCIDPMC3319610 DivisionNeurobiology
• Frontotemporal dementia: implications for understanding Alzheimer disease AuthorsGoedert M., Ghetti B., Spillantini M. G. Journal Cold Spring Harbor Perspectives in Medicine 2(2):a006254. February 2012 (2012)
  Details

  DOI10.1101/cshperspect. A006254 PMID22355793 PMCIDPMC3281593 DivisionNeurobiology
• Phosphorylation of microtubule-associated protein tau by AMPK-related kinases AuthorsYoshida H., Goedert M. Journal Journal of Neurochemistry 120(1):165-176. January 2012 (2012)
  Details

  DOI10.1111/j.1471-4159.2011.07523.x PMID21985311 PMCID  DivisionNeurobiology
• Pathogenesis of the tauopathies AuthorsGoedert M., Spillantini M. G. Journal Journal of Molecular Neuroscience 45(3):425-431. November 2011 (2011)
  Details

  DOI10.1007/s12031-011-9593-4 PMID21785996 PMCID  DivisionNeurobiology
• Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability AuthorsGasparini L., Crowther R. A., Martin K. R., Berg N., Coleman M., Goedert M., Spillantini M. G. Journal Neurobiology of Aging 32(3):419-433. March 2011 (2011)
  Details

  DOIdoi:10.1016/j.neurobiolaging PMID19356824 PMCID  DivisionNeurobiology, Structural Studies
• Human beta-synuclein rendered fibrillogenic by designed mutations AuthorsZibaee S., Fraser G., Jakes R., Owen D., Serpell L. C., Crowther R. A., Goedert M. Journal Journal of Biological Chemistry 285(49):38555-38567 3 December 2010 (2010)
  Details

  DOI10.1074/jbc. M110.160721 PMID20833719 PMCIDPMC2992288 DivisionNeurobiology, Protein and Nucleic Acid Chemistry, Structural Studies
• Cell-mediated neuroprotection in a mouse model of human tauopathy AuthorsHampton D. W., Webber D. J., Bilican B., Goedert M., Spillantini M. G., Chandran S. Journal Journal of Neuroscience 30(30):9973-9983. 28 July 2010 (2010)
  Details

  DOI10.1523/JNEUROSCI.0834-10.2010 PMID20668182 PMCID  DivisionNeurobiology
• SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease AuthorsGarcia-Reitböck P., Anichtchik O., Bellucci A., Iovino M., Ballini C., Fineberg E., Ghetti B., Della Corte L., Spano P., Tofaris G. K., Goedert M., Spillantini M. G. Journal Brain 133(7):2032-2044. 9 July 2010 (2010)
  Details

  DOI10.1093/brain/awq132 PMID20534649 PMCIDPMC2892942 DivisionNeurobiology
• The propagation of prion-like protein inclusions in neurodegenerative diseases AuthorsGoedert M., Clavaguera F., Tolnay M. Journal Trends in Neurosciences 33(7):317-325. 1 July 2010 (2010)
  Details

  DOI10.1016/j.tins.2010.04.003 PMID20493564 PMCID  DivisionNeurobiology
• Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease AuthorsCoomaraswamy J., Kilger E., Wölfing H., Schäfer C., Kaeser S. A., Wegenast-Braun B. M., Hefendehl J. K., Wolburg H., Mazzella M., Ghiso J., Goedert M., Akiyama H., Garcia-Sierra F., Wolfer D. P., Mathews P. M., Jucker M. Journal Proceedings of the National Academy of Sciences, USA 107(17):7969-7974. 27 April 2010 (2010)
  Details

  DOI10.1073/pnas.1001056107 PMID20385796 PMCIDPMC2867864 DivisionNeurobiology
• Early behavioural markers of disease in P301S tau transgenic mice AuthorsScattoni M. L., Gasparini L., Alleva E., Goedert M., Calamandrei G., Spillantini M. G. Journal Behavioural Brain Research 208(1):250-257. 17 March 2010 (2010)
  Details

  DOI10.1016/j. Bbr.2009.12.002 PMID20004218 PMCID  DivisionNeurobiology
• A role for FKBP52 in Tau protein function AuthorsChambraud B., Sardin E., Giustiniani J., Dounane O., Schumacher M., Goedert M., Baulieu E. E. Journal Proceedings of the National Academy of Sciences, USA 107(6):2658-2663. 9 February 2010 (2010)
  Details

  DOI10.1073/pnas.0914957107 PMID20133804 PMCIDPMC2823896 DivisionNeurobiology
• Invited review: Prion-like transmission and spreading of tau pathology. AuthorsClavaguera F., Hench J., Goedert M., Tolnay M. Journal Neuropathology and Applied Neurobiology 41(1):47-58. 1 February 2010 (2015)
  Details

  DOI10.1111/nan.12197 PMID25399729 PMCID  DivisionNeurobiology
• Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies AuthorsMasami Masudaa, Masato Hasegawaa, Takashi Nonakaa, Takayuki Oikawaa, Motokuni Yonetania, Yoshiki Yamaguchic, Koichi Katoc, Shin-ichi Hisanagab, Michel Goedert Journal FEBS Letters 583(4):787-91 (2009) (2009)
  Details

  DOI10.1016/j.febslet.2009.01.037 PMID19183551 PMCID  DivisionNeurobiology
• Transmission and spreading of tauopathy in transgenic mouse brain AuthorsFlorence Clavaguera, Tristan Bolmont, R. Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K. Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolnay Journal Nature Cell Biology 11(7):909-913 (2009) (2009)
  Details

  DOI10.1038/ncb1901 PMID19503072 PMCID  DivisionStructural Studies, Neurobiology
• Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models AuthorsMakiko Yamashita, Takashi Nonaka, Tetsuaki Arai, Fuyuki Kametani, Vladimir L. Buchman, Natalia Ninkina, Sergey O. Bachurin, Haruhiko Akiyama, Michel Goedert, Masato Hasegawa Journal FEBS Letters 583(14):2419-2424 (2009) (2009)
  Details

  DOI10.1016/j.febslet.2009.06.042 PMID19560462 PMCID  DivisionNeurobiology
• Oskar Fischer and the study of dementia AuthorsGoedert M. Journal Brain : a Journal of Neurology 132(Pt 4):1102-1111. April 2008 (2008)
  Details

  DOI10.1093/brain/awn256 PMID18952676 PMCIDPMC2668940 DivisionNeurobiology
• Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy AuthorsPatrice Delobel, Isabelle Lavenir, Graham Fraser, Esther Ingram, Max Holzer, Bernardino Ghetti, Maria Grazia Spillantini, R. Anthony Crowther, and Michel Goedert Journal American Journal of Pathology 172 (1): 123-131 (2008)
  Details

  DOI  PMID18079436 PMCIDPMC2189621 Division 
• Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl- 4-hydroxy)styrylbenzene] AuthorsAna Velasco, Graham Fraser, Patrice Delobel, Bernardino Ghetti, Isabelle Lavenir, Michel Goedert Journal FEBS Letters 582 (6): 901-906 (2008)
  Details

  DOI  PMID18291106 PMCIDPMC2726283 Division 
• In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain AuthorsLiang Ye, Ana Velasco, Graham Fraser, Thomas G Beach, Lucia Sue, Tracy Osredkar, Vincenzo Libri, Maria Grazia Spillantini, Michel Goedert, Andrew Lockhart Journal Journal of Neurochemistry 105 (4): 1428-1437 (2008)
  Details

  DOI10.1111/j.1471-4159.2008.05245.x PMID18221373 PMCIDPMC2408655 Division 
• The value of incomplete mouse models of Alzheimer's disease AuthorsRebecca Radde, Cecilia Duma, Michel Goedert, Mathias Jucker Journal European Journal of Nuclear Medicine and Molecular Imaging 35 (sup 1): S70-S74 (2008)
  Details

  DOI  PMID18270700 PMCID  Division 
• White Matter Taupathy With Globular Glial Inclusions: A District Sporadic Frontotemporal Lobar Degeneration AuthorsGabor G. Kovacs, Katalin Majtenyi, Salvatore Spina, Jill R. Murrell, Ellen Gelpi, Romana Hoftberger, Graham Fraser, Anthony Crowther, Michel Goedert, Herbert Budka, Bernardino Ghetti Journal Journal of Neuropathology & Experimental Neurology 67 (10): 963-975 (2008)
  Details

  DOI  PMID18800011 PMCIDPMC2785030 Division 
• The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family AuthorsSalvatore Spina, Martin R. Farlow, Frederick W. Unverzagt, David A. Kareken, Jill R. Murrell, Graham Fraser, Francine Epperson, R. Anthony Crowther, Maria G. Spillantini, Michel Goedert, Bernardino Ghetti Journal Brain 131 (Pt 1): 72-89 (2008)
  Details

  DOI  PMID18065436 PMCID PMC2702832 Division 
• Alois Alzheimer : His life and times AuthorsMichel Goedert, Bernardino Ghetti Journal Brain Pathology 17 : 57-62 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Interaction of tau protein with the dynactin complex AuthorsEnrico Magnani, Juan Fan, Laura Gasparini, Matthew Golding, Meredith Williams, Giampietro Schiavo, Michel Goedert, Linda A. Amos, Maria Grazia Spillantini Journal EMBO Journal 26(21): 4546-4554 (2007) (2007)
  Details

  DOI  PMID  PMCID2063488 Division 
• Sequence determinants for amyloid fibrillogenesis of human alpha‑synuclein AuthorsShahin Zibaee, Ross Jakes, Graham Fraser, Louise C. Serpell, R. Anthony Crowther, Michel Goedert Journal Journal of Molecular Biology 374(2): 454-464 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily AuthorsKanwar Virdee, Hirotaka Yoshida, Sew Peak-Chew, Michel Goedert Journal FEBS Letters 581(14): 2657-2662 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Tau proteins and the dementias AuthorsMichel Goedert, Maria Grazia Spillantini Journal The Dementias 2 (J. H. Growdon, M. N. Rossoe, eds) 99-111 (2007)
  Details

  DOI  PMID  PMCID  Division 
• Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha‑synucleinopathies AuthorsAasami Ishii, Takashi Nonakaa, Sayuri Taniguchi, Taro Saito, Tetsuaki Arai, David Mann, Takeshi Iwatsubo, Shin-ichi Hisanaga, Michel Goedert, Masato Hasegawa Journal FEBS Letters 581(24): 4711-4717 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• The novel Tau mutation G335S: clinical, neuropathological and molecular characterization AuthorsSalvatore Spina, Jill R. Murrell, Hirotaka Yoshida, Bernardino Ghetti, Niamh Bermingham, Brian Sweeney, Stephen R. Dlouhy, R. Anthony Crowther, Michel Goedert, Catherine Keohane Journal Acta Neuropathol. (Berl.) 113(4): 461-470 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclei, ABeta, and tau using the amino acid sequence alone AuthorsShahin Zibaee, O. Sumner Makin, Michel Goedert, Louise C. Serpell Journal Protein Science 16(5): 906-918 (2007) (2007)
  Details

  DOI  PMID  PMCID2206631 Division 
• Introduction to Symposium: Tau protein and neurodegeneration AuthorsBernardino Ghetti, Michel Goedert Journal Brain Pathology 17(1): 56(2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Inherited and sporadic tauopathies AuthorsM. G. Spillantini, M. Goedert Journal In: Parkinson's disease and movement disorders. 5th edition (J. Jankovic & E. Tolosa, eds) Lippincott Williams & Wilkins pp.203-212 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Alpha- synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation AuthorsKerensa Broersen, Daan van den Brink, Graham Fraser, Michel Goedert, Bazbek Davletov Journal Biochemistry 45(51):15610-15616 (2006) (2006)
  Details

  DOI10.1021/bi061743l PMID17176082 PMCID  DivisionNeurobiology
• A century of Alzheimer's disease AuthorsGoedert M., Spillantini M. G. Journal Science 314(5800):777-781 (2006) (2006)
  Details

  DOI10.1126/science.1132814 PMID17082447 PMCID  DivisionNeurobiology
• Tau protein, the paired helical filament and Alzheimer's disease AuthorsGoedert M., Klug A., Crowther R. A. Journal Journal of Alzheimer's Disease 9(3 suppl):195-207. August 2006 (2006)
  Details

  DOI  PMID16914859 PMCID  DivisionNeurobiology, Structural Studies
• Cell-cycle markers in a transgenic mouse model of human tauopathy. Increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 AuthorsDelobel P., Lavenir I., Ghetti B., Holzer M., Goedert M. Journal American Journal of Pathology 168(3):878-887. March 2006 (2006)
  Details

  DOI10.2353/ajpath.2006.050540 PMID16507903 PMCIDPMC1606514 DivisionNeurobiology
• Neurodegenerative alpha-synucleinopathies and tauopathies AuthorsGoedert M., Spillantini M. G. Journal Basic Neurochemistry: Molecular, Cellular and Medical Aspects (Elsevier Inc for American Society of Neurochemistry) pp.745-759 (2006) (2006)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology
• Synuclein proteins of the Pufferfish Fugu rubripes: sequences and functional characterization AuthorsHirotaka Yoshida, Molly Craxton, Ross Jakes, Shahin Zibaee, Richard Tavare, Graham Fraser, Louise C. Serpell, Bazbek Davletov, R. Anthony Crowther, Michel Goedert Journal Biochemistry 45: 2599-2607 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Cysteine misincorporation in baterially expressed human alpha‑synuclein AuthorsMasami Masuda, Naoshi Dohmae, Takashi Nonaka, Takayuki Oikawa, Shin-ichi Hisanaga, Michel Goedert, Masato Hasegawa Journal FEBS Letters 580 : 1775-1779 (2006) (2006 )
  Details

  DOI  PMID  PMCID  Division 
• Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein (1-120) : implications for Lewy body disorders AuthorsGeorge K. Tofaris, Pablo Garcia Reitbock, Trevor Humby, Sarah L. Lambourne, Mark O'Connell, Bernardino Ghetti, Helen Gossage, Piers C. Emson, Lawrence S. Wilkinson, Michel Goedert, Maria Grazia Spillantini Journal The Journal of Neuroscience 26 : 3942-3950 (2006) (2006 )
  Details

  DOI  PMID  PMCID  Division 
• Small molecule inhibitors of alpha-synuclein filament assembly AuthorsMasami Masuda, Nobuyuki Suzuki, Sayuri Taniguchi, Takayuki Oikawa, Takashi Nonaka, Takeshi Iwatsubo, Shin-ichi Hisanaga, Michel Goedert, Masato Hasegawa Journal Biochemistry 45 : 6085-6094 (2006). (2006 )
  Details

  DOI  PMID  PMCID  Division 
• Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38(delta) or JNK2 in the presence of heparin generates the AT100 epitope AuthorsHirotaka Yoshida, Michel Goedert Journal Journal of Neurochemistry 99 : 154 - 164 (2006) (2006 )
  Details

  DOI  PMID  PMCID  Division 
• Frontotemporal lobar degeneration through loss of progranulin function AuthorsMichel Goedert, Maria Grazia Spillantini Journal Brain 129: 2808-2810 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Mutations in the tau gene (MAPT) in FTDP-17: the family with multiple system tauopathy with presenile dementia (MSTD) AuthorsMaria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin Farlow, Aaron Klug, Bernardino Ghetti Journal Journal of Alzheimer's Disease 9(3 suppl): 373-380 (2006) (2006)
  Details

  DOI  PMID16914875 PMCID  DivisionNeurobiology
• The Alzheimer tangle - 100 years on AuthorsMichel Goedert, Maria Grazia Spillantini, Bernardino Ghetti, R. Anthony Crowther, Aaron Klug Journal Alzheimer: 100 Years and Beyond (Ed: Jucker et al) Spinger-Verlag, 2006 297-308 (2006)
  Details

  DOI10.1007/978-3-540-37652-1_38 PMID  PMCID  DivisionNeurobiology
• Tau gene mutations and their effects AuthorsGoedert M. Journal Movement Disorders 20 : S45-S52. August 2005 (2005 )
  Details

  DOI10.1002/mds.20539 PMID16092090 PMCID  DivisionNeurobiology
• p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP AuthorsSabio G., Arthur J. S. C., Kuma Y., Peggie M., Carr J., Murray-Tair V., Centeno F., Goedert M., Morrice N. A., Cuenda A. Journal EMBO Journal 24(6):1134-1145. 23 March 2005 (2005)
  Details

  DOI10.1038/sj.emboj.7600578 PMID15729360 PMCIDPMC556394 DivisionNeurobiology
• Mutations causing neurodegenerative tauopathies AuthorsMichel Goedert, Ross Jakes Journal Biochimica et Biophysica Acta 1739: 240-250 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly AuthorsCarmen Feijoo, David G. Campbell, Ross Jakes, Michel Goedert, Ana Cuenda Journal Journal of Cell Science 118: 397-408 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins AuthorsSayuri Taniguchi, Nobuyuki Suzuki, Masami Masuda, Shin-ichi Hisanaga, Takeshi Iwatsubo, Michel Goedert, Masato Hasegawa Journal Journal of Biological Chemistry 280 : 7614-7623 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the aplha-synuclein gene AuthorsKeiji Yamaguchi, Elizabeth J. Cochran, Jill R. Murrell, Mihael H. Polymeropoulos, Kathleen M. Shannon, R. Anthony Crowther, Michel Goedert, Bernardino Ghetti Journal Acta Neuropathologica 110 : 298-305 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Neurodegenerative alpha‑synucleinopathies AuthorsMichel Goedert, Maria Grazia Spillantini Journal Current Clinical Neurology: Atypical Parkinsonian Disorders (Edited by I. Litvan) pp.77-94 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein AuthorsBellucci A., Westwood A. J., Ingram E., Casamenti F., Goedert M., Spillantini M. G. Journal American Journal of Pathology 165(5):1643-1652. November 2004 (2004)
  Details

  DOI10.1016/S0002-9440(10)63421-9 PMID15509534 PMCIDPMC1618683 DivisionNeurobiology
• Tau gene (MAPT) sequence variation among primates AuthorsHolzer M., Craxton M., Jakes R., Arendt T., Goedert M. Journal Gene 341: 313-322. 27 October 2004 (2004)
  Details

  DOI10.1016/j.gene.2004.07.013 PMID15474313 PMCID  DivisionNeurobiology
• Mutation E46K increases phospholipid binding and assembly into filaments of human alpha‑synuclein AuthorsChoi W., Zibaee S., Jakes R., Serpell L. C., Davletov B., Crowther R. A., Goedert M. Journal FEBS Letters 576(3):363-368. 22 October 2004 (2004)
  Details

  DOI10.1016/j.febslet.2004.09.038 PMID15498564 PMCID  DivisionNeurobiology, Structural Studies
• Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK) AuthorsYoshida H., Hastie C. J., McLauchlan H., Cohen P., Goedert M. Journal Journal of Neurochemistry 90(2):352-358. July 2004 (2004)
  Details

  DOI10.1111/j.1471-4159.2004.02479.x PMID15228592 PMCID  DivisionNeurobiology
• Tau protein and neurodegeneration AuthorsGoedert M. Journal Seminars in Cell & Developmental Biology 15(1):45-49. February 2004 (2004)
  Details

  DOI10.1016/j.semcdb.2003.12.015 PMID15036206 PMCID  DivisionNeurobiology
• Alpha-synuclein and neurodegeneration AuthorsMichel Goedert Journal Primer on the Autonomic Nervous System (Editor in Chief David Robertson) pp.204-207 (2004) (2004)
  Details

  DOI  PMID  PMCID  Division 
• Early-onset dementia with Lewy bodies AuthorsMasaki Takao, Bernardino Ghetti, Hirotaka Yoshida, Pedro Piccardo, Yolanda Narain, Jill R. Murrell, Ruben Vidal, Bradley S. Glazier, Ross Jakes, Miho Tsutsui, Maria Grazia Spillantini, R. Anthony Crowther, Michel Goedert, Atsuo Koto Journal Brain Pathol 14: 137-147 (2004) (2004)
  Details

  DOI  PMID  PMCID  Division 
• Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2 AuthorsGuadalupe Sabio, Suzana Reuver, Carmen Feijoo, Masato Hasegawa, Gareth M. Thomas, Francisco Centeno, Sven Kuhlendahl, Sergio Leal-Ortiz, Michel Goedert, Craig Garner, Ana Cuenda Journal Biochemical Journal 380: 19-30 (2004) (2004)
  Details

  DOI  PMID  PMCID  Division 
• GSK3 inhibitors: development and therapeutic potential AuthorsPhilip Cohen, Michel Goedert Journal Nature Reviews Drug Discovery 3: 479-487 (2004) (2004)
  Details

  DOI  PMID  PMCID  Division 
• Repeat motifs of tau bind to the insides of microtubules in the absence of taxol AuthorsKar S., Fan J., Smith M. J., Goedert M., Amos L. A. Journal EMBO Journal 22(1):70-77. 2 January 2003 (2003)
  Details

  DOI10.1093/emboj/cdg001 PMID12505985 PMCIDPMC140040 DivisionNeurobiology; Structural Studies
• Introduction to the tauopathies AuthorsMichel Goedert Journal Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Editor: Dennis Dickson) ISN Neuropath Press, Basel pp.82-85 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• The neurobiology of the tauopathies AuthorsMaria Grazia Spillantini, Michel Goedert Journal Disorders of Brain and Mind 2 (Eds: Maria A. Ron, Trevor W. Robbins) Cambridge University Press pp.245-261 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure AuthorsJohn Berriman, Louise C. Serpell, Keith A. Oberg, Anthony L. Fink, Michel Goedert, R. Anthony Crowther Journal Proceedings of the National Academy of Sciences, USA 100: 9034-9038 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R AuthorsEsther van Herpen, Sonia M. Rosso, Lies-Anne Serverijnen, Hirotaka Yoshida, Guido Breedveld, Raoul van de Graaf, Wouter Kamphorst, Rivka Ravid, Rob Willemsen, Dennis Dooijes, Danielle Majoor-Krakauer, Johan M. Kros, R. Anthony Crowther, Michel Goedert, Peter Heutink, John C. van Swieten Journal Ann. Neurol. 54: 573-581 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Relevance of mutations in Tau for understanding the tauopathies AuthorsMichel Goedert Journal Curr. Med. Chem. – Immun., Endoc. & Metab. Agents 3: 341-348 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Neurodegenerative tauopathy in the worm AuthorsMichel Goedert Journal Proceedings of the National Academy of Sciences, USA 100: 9653-9655 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats AuthorsYoshida H., Goedert M. Journal Biochemistry 41(51):15203-15211 (2002) (2002)
  Details

  DOI10.1021/bi026464m PMID12484758 PMCID  DivisionNeurobiology
• Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein AuthorsAllen B., Ingram E., Takao M., Smith M. j., Jakes R., Virdee K., Yoshida H., Holzer M., Craxton M., Emson P. C., Atzori C., Migheli A., Crowther R. A., Ghetti B., Spillantini M. G., Goedert M. Journal Journal of Neuroscience 22(21):9340-9351 (2002) (2002)
  Details

  DOI10.1523/jneurosci.22-21-09340.2002 PMID12417659 PMCIDPMC6758022 DivisionNeurobiology
• Proteasomal degradation of tau protein AuthorsDavid D. C., Layfield R., Serpell L., Narain Y., Goedert M., Spillantini M. G. Journal Journal of Neurochemistry 83(1):176-185. October 2002 (2002)
  Details

  DOI10.1046/j.1471-4159.2002.01137.x PMID12358741 PMCID  DivisionNeurobiology
• Biophysical properties of the synucleins and their propensities to fibrilate. Inhibition of alpha-synuclein assenbly by beta- and gamma‑synucleins AuthorsVladimir N. Uversky, Jie Li, Pierre Souillac, Ian S. Millett, Sebastian Doniach, Ross Jakes, Michel Goedert, Anthony L. Fink Journal Journal of Biological Chemistry 277(14):11970-11978. 5 April 2002 (2002 )
  Details

  DOI10.1074/jbc. M109541200 PMID11812782 PMCID  Division 
• Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells AuthorsBuée-Scherrer V., Goedert M. Journal FEBS Letters 515(1-3):151-154. 27 March 2002 (2002)
  Details

  DOI10.1016/s0014-5793(02)02460-2 PMID11943212 PMCID  DivisionNeurobiology
• Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation AuthorsDelobel P., Flament S., Hamdane M., Jakes R., Rousseau A., Delacourte A., Vilain J-P., Goedert M., Buee L. Journal Journal of Biological Chemistry 277(11):9199-9205. 15 March 2002 (2002)
  Details

  DOI10.1074/jbc.m107716200 PMID11756436 PMCID  DivisionNeurobiology
• A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease AuthorsRosso S. M., van Herpen E., Deelen W., Kamphorst W., Severijnen L-A., Willemsen R., Ravid R., Niermeijer M. F., Dooijes D., Smith M. J., Goedert M., Heutink P., van Swieten J. C. Journal Ann. Neurol. 51(3):373-376. March 2002 (2002)
  Details

  DOI10.1002/ana.10140 PMID11891833 PMCID  DivisionNeurobiology
• Functional effects of tau gene mutations N296 and N296H AuthorsYoshida H., Crowther R. A., Goedert M. Journal Journal of Neurochemistry 80(3):548-551. February 2002 (2002)
  Details

  DOI10.1046/j.0022-3042.2001.00729.x PMID11906000 PMCID  DivisionStructural Studies, Neurobiology
• A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins AuthorsSyme C. D., Blanch E. W., Holt C., Jakes R., Goedert M., Hecht L., Barron L. D. Journal Eur. J. Biochem. 269(1):148-156. January 2002 (2002)
  Details

  DOI10.1046/j.0014-2956.2001.02633.x PMID11784308 PMCID  DivisionNeurobiology
• Tau and Parkinson disease AuthorsSpillantini M. G., Goedert M. Journal JAMA 286(18):2324-2326 (2001) (2001)
  Details

  DOI10.1001/jama.286.18.2324 PMID11710900 PMCID  DivisionNeurobiology
• Pick's disease associated with the novel Tau gene mutation K369I AuthorsNeumann M., Schulz-Schaeffer W., Crowther R. A., Smith M. J., Spillantini M G., Goedert M., Kretzschmar H. Journal Annals of Neurology 50(4):503-513 (2001) (2001)
  Details

  DOI10.1002/ana.1223 PMID11601501 PMCID  DivisionStructural Studies, Neurobiology
• Regulation of alternative splicing of human Tau exon 10 by phosphorylation of splicing factors AuthorsHartmann A. M., Rujescu D., Giannakouros T., Nikolakaki E., Goedert M., Mandelkow E-M., Gao Q. S.., Andreadis A., Stamm S. Journal Molecular and Cellular Neuroscience 18(1):80-90 (2001) (2001)
  Details

  DOI10.1006/mcne.2001.1000 PMID11461155 PMCID  DivisionNeurobiology
• Alpha-synuclein and neurodegenerative diseases AuthorsGoedert M. Journal Nature Reviews Neurosience 2(7):492-501 (2001) (2001)
  Details

  DOI10.1038/35081564 PMID11433374 PMCID  DivisionNeurobiology
• Parkinson's disease and other α-synucleinopathies AuthorsMichel Goedert Journal Clin. Chem. Lab. Med. 39: 308-312 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy as α−synucleinopathies AuthorsMichel Goedert, Ross Jakes, R. Anthony Crowther, Maria Grazia Spillantini Journal Methods in Molecular Medicine: Parkinson's Disease: Methods and Protocols. Edited by M. M. Mouradian 62: 33-59 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• Tau gene mutations and neurodegeneration AuthorsMichel Goedert, Maria Grazia Spillantini Journal Biochemical Society Symposium: Neural Signal Transduction and Alzheimer's Disease 67: 59-71 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• From genetics to pathology: tau and α-synuclein assemblies in neurodegenerative diseases AuthorsMichel Goedert, Maria Grazia Spillantini, Louise C. Serpell, John Berriman, Michael J. Smith, Ross Jakes, R. Anthony Crowther Journal Phil. Trans. R. Soc. Lond. B 356: 213-227 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• Alzheimer disease and the frontotemporal dementias: Diseases with cerebral deposition of fibrillar proteins AuthorsP. H. St George-Hyslop, L. A. Farrer, M. Goedert Journal The Metabolic & Molecular Bases of Inherited Diease. 8th ed. Edited by Charles R. Scriver, Arthur L. Beaudet, William S. Sly, David Valle 4: 5875-5899 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• Tau mutations altering splicing of tau exon 10 in japanese frontotemporal dementia AuthorsMinoru Yasuda, Junichi Takamatsu, Osamu Komure, Sadako Kuno, Ian D'Souza, Toshio Kawamata, Masato Hasegawa, Takeshi Iwatubo, Parvoneh Poorkaj, Michel Goedert, Gerard D. Schellenberg, Chikako Tanaka Journal Neuroscientific Basis of Dementia. Editied by C. Tanaka, P. L. McGeer, Y. Ihara pp.81-84 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• The kinase DYRK phosphorylates protein-synthesis initiation factor elF2Bε at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase AuthorsYvonne L. Woods, Philip Cohen, Walter Becker, Ross Jakes, Michel Goedert, Xuemin Wang, Christopher G. Proud Journal Biochemical Journal 355: 609-615 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• Neurodegenerative tauopathies AuthorsVirginia M-Y. Lee, Michel Goedert, John Q. Trojanowski Journal Annu. Rev. Neurosci. 24: 1121-1159 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• The significance of tau and α-synuclein inclusions in neurodegenerative diseases AuthorsMichel Goedert Journal Current Opinion in Genetics & Development 11: 343-351 (2001) (2001)
  Details

  DOI  PMID  PMCID  Division 
• Human Tau transgenic mice. Towards an animal model for neuro- and glialfibrillary lesion formation AuthorsGötz J., Tolnay M., Barmettler R., Ferrari A., Burki K., Goedert M., Probst A., Nitsch R. M. Journal Neuropathology and Genetics of Dementia. Edited by Tolnay and Probst pp. 71-83 (2001) (2001)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology
• Tau gene mutations and Tau pathology in frontotemporal dementia and parkinsonism linked to chromosome 17 AuthorsSpillantini M. G., Goedert M. Journal Neuropathology and Genetics of Dementia. Edited by Tolnay and Probst pp.21-37 (2001) (2001)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology
• Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease AuthorsGoedert M., Spillantini M. G. Journal Biochimica et Biophysica Acta 1502(1):110-121 (2000) (2000)
  Details

  DOI10.1016/s0925-4439(00)00037‑5 PMID10899436 PMCID  DivisionNeurobiology
• Abnormal tau-containing filaments in neurodegenerative diseases AuthorsCrowther R. A., Goedert M. Journal Journal of Structural Biology 130(2-3):271-279 (2000) (2000)
  Details

  DOI10.1006/jsbi.2000.4270 PMID10940231 PMCID  DivisionStructural Studies, Neurobiology
• Tau mutations in familial frontotemporal dementia AuthorsSpillantini M. G., Goedert M. Journal Brain 123 ( Pt 5):857-859 (2000) (2000)
  Details

  DOI10.1093/brain/123.5.857 PMID10775532 PMCID  DivisionNeurobiology
• Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation AuthorsSerpell L. C., Berriman J., Jakes R., Goedert M., Crowther R. A. Journal Proceedings of the National Academy of Sciences, USA 97(9):4897-4902 (2000) (2000)
  Details

  DOI10.1073/pnas.97.9.4897 PMID10781096 PMCIDPMC18329 DivisionNeurobiology, Structural Studies
• Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes AuthorsDuff K., Knight H., Refolo L. M., Sanders S., Yu X., Picciano M., Malester B., Hutton M., Adamson J., Goedert M., Burki K., Davies P. Journal Neurobiology of Diseases 7(2):87-98 (2000) (2000)
  Details

  DOI10.1006/nbdi.1999.0279 PMID10783293 PMCID  DivisionNeurobiology
• A novel mutation at position+12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD‑Kumamoto) AuthorsYasuda M., Takamatsu J., D'Souza I., Crowther R. A., Kawamata T.,Hasegawa M., Hasegawa H., Spillantini M. G., Tanimukai S., Poorkaj P.,Varani L., Varani G., Iwatsubo T., Goedert M., Schellenberg G. D.,Tanaka C. Journal Annals of Neurology 47(4):422-429 (2000) (2000)
  Details

  DOI10.1002/1531-8249(200004)47:4<422::aid-ana4>3.0. Co;2‑g PMID10762152 PMCID  DivisionStructural Studies, Neurobiology
• Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein AuthorsProbst A., Gotz J., Wiederhold K. H., Tolnay M., Mistl C., Jaton A. L., Hong M., Ishihara T., Lee V. M-Y., Trojanowski J. Q., Jakes R., Crowther R. A., Spillantini M. G., Burki K., Goedert M. Journal Acta Neuropathol. 99(5):469-481 (2000) (2000)
  Details

  DOI10.1007/s004010051148 PMID10805089 PMCID  DivisionNeurobiology, Structural Studies
• Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‑17) AuthorsSpillantini M. G., Van Swieten V. C., Goedert M. Journal Neurogenetics 2(4):193-205. March 2000 (2000)
  Details

  DOI10.1007/pl00022972 PMID10983715 PMCID  DivisionNeurobiology
• A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease AuthorsGiasson B. I., Jakes R., Goedert M., Duda J. E., Leight S., Trojanowski J. Q., Lee V. M. Y. Journal Journal of Neuroscience Research 59(4):528-533 (2000) (2000)
  Details

  DOI10.1002/(sici)1097-4547(20000215)59:4<528::aid-jnr8>3.0. Co;2‑0 PMID10679792 PMCID  DivisionNeurobiology
• Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics AuthorsVarani L., Spillantini M. G., Goedert M., Varani G. Journal Nucleic Acids Research 28(3):710-719 (2000) (2000)
  Details

  DOI10.1093/nar/28.3.710 PMID10637322 PMCIDPMC102548 DivisionNeurobiology
• Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7 AuthorsYvonne Fleming, Christopher G. Armstrong, Nick Morrice, Andrew Paterson, Michel Goedert, Philip Cohen Journal Biochemical Journal 352: 145-154 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies AuthorsMaria Grazia Spillantini, Hirotaka Yoshida, Claudia Rizzini, Peter L. Lantos, Nadeem Khan, Martin N. Rossor, Michel Goedert, Jeremy Brown Journal Annals of Neurology 48: 939-943 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy AuthorsMaria Grazia Spillantini, Michel Goedert Journal Annals of the New York Academy of Sciences 920 (The Molecular Basis of Dementia): 16-27 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly AuthorsMichael J. Smith, R. Anthony Crowther, Michel Goedert Journal FEBS Letters 484: 265-270 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain AuthorsR. Anthony Crowther, Susan E. Daniel, Michel Goedert Journal Neuroscience Letters 292: 128-130 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• Tau gene mutation K257T causes a tauopathy similar to Pick's disease AuthorsClaudia Rizzini, Michel Goedert, John R. Hodges, Michael J. Smith, Ross Jakes, Richard Hills, John H. Xuereb, R. Anthony Crowther, Maria Grazia Spillantini Journal Journal of Neuropathology and Experimental Neurology 59: 990-1001 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• In vivo analysis of wild-type and FTDP-17 tau transgenic mice AuthorsJ. Gotz, R. Barmettler, A. Ferrari, M. Goedert, A. Probst, R. M. Nitsch Journal Annals of the New York Academy of Sciences 920 (The Molecular Basis of Dementia): 126-133 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• Tau gene mutations in frontotemporal dementia and Parkinsonism linked to chromsome 17 (FTDP‑17) AuthorsMichel Goedert, Bernardino Ghetti, Maria Grazia Spillantini Journal Annals of the New York Academy of Sciences 920 (The Molecular Basis of Dementia): 74-83 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and Parkinsonism linked to chromosome 17 mutations AuthorsMichel Goedert, Sivapong Satumtira, Ross Jakes, Michael J. Smith, Craig Kamibayashi, Charles L. White III, Estelle Sontag Journal Journal of Neurochemistry 75: 2155-2162 (2000) (2000)
  Details

  DOI  PMID  PMCID  Division 
• Tauopathies and alpha‑synucleinopathies AuthorsGoedert M., Spillantini M. G. Journal Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders. Edited by V. Lee at al pp.65-86 (2000) (2000)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology
• Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusion and axonal deposits AuthorsMurrell J. R., Spillantini M. G., Zolo P., Guazzelli M., Smith M. J.,Hasegawa M., Redi F., Crowther A., Pietrini P., Ghetti B., Goedert M. Journal Journal of Neuropathology and Experimental Neurology 58(12):1207-1226 (1999) (1999)
  Details

  DOI10.1097/00005072-199912000‑00002 PMID10604746 PMCID  DivisionNeurobiology, Structural Studies
• Alternative splicing of synaptotagmins involving transmembrane exon skipping AuthorsCraxton M., Goedert M. Journal FEBS Letters 460(3):417-422 (1999) (1999)
  Details

  DOI10.1016/s0014-5793(99)01382-4 PMID10556508 PMCID  DivisionNeurobiology
• Tau protein and the paired helical filament of Alzheimer's disease AuthorsGoedert M., Klug A. Journal Brain Research Bulletin 50(5-6):469-470. November-December 1999 (1999)
  Details

  DOI10.1016/S0361-9230(99)00138-0 PMID10643488 PMCID  DivisionNeurobiology, Structural Studies
• Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways AuthorsBorsch-Haubold A. G., Ghomashchi F., Pasquet S., Goedert M., Cohen P., Gelb M. H., Watson S. P. Journal European Journal of Biochemistry 265(1):195-203 . October 1999 (1999)
  Details

  DOI10.1046/j.1432-1327.1999.00722.x PMID10491174 PMCID  DivisionNeurobiology
• A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of Axin and beta‑catenin AuthorsThomas G. M., Frame S., Goedert M., Nathke I., Polakis P., Cohen P. Journal FEBS Letters 458(2):247-251. 17 September 1999 (1999)
  Details

  DOI10.1016/S0014-5793(99)01161‑8 PMID10481074 PMCID  DivisionNeurobiology
• Paradoxical activation of Raf by a novel Raf Inhibitor AuthorsClare A. Hall-Jackson, Patrick A. Eyers, Philip Cohen, Michel Goedert, F. Tom Boyle, Neil Hewitt, Helen Plant, Philip Hedge Journal Chemistry & Biology 6(8):559-568 (1999) (1999)
  Details

  DOI10.1016/S1074-5521(99)80088‑X PMID10421767 PMCID  DivisionNeurobiology
• Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17 AuthorsVarani L., Hasegawa M., Spillantini M. G., Smith M. J., Murrell J. R., Ghetti B., Klug A., Goedert M., Varani G. Journal Proceedings of the National Academy of Sciences, USA 96(14):8229-8234. 6 July 1999 (1999)
  Details

  DOI10.1073/pnas.96.14.8229 PMID10393977 PMCIDPMC22217 DivisionStructural Studies, Neurobiology
• Epitope mapping of LB509, a monoclonal antibody directed against human alpha‑synuclein AuthorsRoss Jakes, R. Anthony Crowther, Virginia M.-Y. Lee, John Q. Trojanowski, Takeshi Iwatsubo, Michel Goedert Journal Neuroscience Letters 269(1):13-16 (1999) (1999)
  Details

  DOI10.1016/S0304-3940(99)00411‑5 PMID10821633 PMCID  Division 
• Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha‑synucleinopathies AuthorsMichel Goedert Journal Phil. Trans. R. Soc. Lond. B 354(1386):1101-1118 (1999) (1999)
  Details

  DOI10.1098/rstb.1999.0466 PMID10434313 PMCIDPMC1692614 DivisionNeurobiology
• Pinning down phosphorylated tau AuthorsGoedert M. Journal Nature 399(6738):739-740 (1999) (1999)
  Details

  DOI10.1038/21550 PMID10391237 PMCID  DivisionNeurobiology
• Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in Tau AuthorsBugiani O., Murrell J. R., Giaccone G., Hasegawa M., Ghigo G., Tabaton M., Morbin M., Primavera A., Carella F., Solaro C., Grisoli M., Savoiardo M., Spillantini M. G., Tagliavini F., Goedert M., Ghetti B. Journal Journal of Neuropathology and Experimental Neurology 58(6):667-677 (1999) (1999)
  Details

  DOI10.1097/00005072-199906000‑00011 PMID10374757 PMCID  DivisionNeurobiology
• Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580 AuthorsPatrick A. Eyers, Paul van den IJssel, Roy A. Quinlan, Michel Goedert, Philip Cohen Journal FEBS Letters 451(2):191-196 (1999) (1999)
  Details

  DOI10.1016/S0014-5793(99)00552‑9 PMID10371163 PMCID  DivisionNeurobiology
• Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments AuthorsMichel Goedert, Ross Jakes, R. Anthony Crowther Journal FEBS Letters 450(3):306-311 (1999) (1999)
  Details

  DOI10.1016/S0014-5793(99)00508‑6 PMID10359094 PMCID  Division 
• Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia AuthorsSpillantini M. G., Tolnay M., Love S., Goedert M. Journal Acta Neuropathol 97(6):585-594 (1999) (1999)
  Details

  DOI10.1007/s004010051034 PMID10378377 PMCID  DivisionNeurobiology
• Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1‑syntrophin AuthorsMasato Hasegawa, Ana Cuenda, Maria Grazia Spillantini, Gareth M. Thomas, Valerie Buee-Scherrer, Philip Cohen, Michel Goedert Journal Journal of Biological Chemistry 274(18):12626-12631 (1999) (1999)
  Details

  DOI10.1074/jbc.274.18.12626 PMID10212242 PMCID  DivisionNeurobiology
• Tau gene mutation in familial progressive subcortical gliosis AuthorsM. Goedert, M. G. Spillantini, R. A. Crowther, S. G. Chen, P. Parchi, M. Tabaton, D. J. Lanska, W. R. Markesbery, K. C. Wilhelmsen, D. W. Dickson, R. B. Petersen, P. Gambetti Journal Nature Medicine 5(4):454-457 (1999) (1999)
  Details

  DOI10.1038/7454 PMID10202939 PMCID  DivisionNeurobiology
• Tau pathology in a family with dementia and a P301L mutation in Tau AuthorsSuzanne S. Mirra, Jill R. Murrell, Marla Gearing, Maria G. Spillantini, Michel Goedert, Anthony Crowther, Allan I. Levey, Randi Jones, Joanne Green, John M. Shoffner, Bruce H. Wainer, Marie L. Schmidt, John Q. Trojanowski, Bernardino Ghetti Journal Journal of Neuropathology and Experimental Neurology 58(4):335-345 (1999) (1999)
  Details

  DOI10.1097/00005072-199904000‑00004 PMID10218629 PMCID  Division 
• Effect of SB 203580 on the activity of c-Raf in vitro and in vivo AuthorsClare A. Hall-Jackson, Michel Goedert, Philip Hedge, Philip Cohen Journal Oncogene 18(12):2047-2054 (1999) (1999)
  Details

  DOI10.1038/sj.onc.1202603 PMID10321729 PMCID  DivisionNeurobiology
• High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands AuthorsRizzu P., Van Swieten J. C., Joosse M., Hasegawa M., Stevens M., Tibben A., Niermeijer M. F., Hillebrand M., Ravid R., Oostra B. A., Goedert M., van Duijn C. M., Heutink P. Journal Am. J. Hum. Genet. 64(2):414-421 (1999) (1999)
  Details

  DOI10.1086/302256 PMID9973279 PMCIDPMC1377751 DivisionNeurobiology
• FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10 AuthorsMasato Hasegawa, Michael J. Smith, Masaaki Iijima, Takeshi Tabira, Michel Goedert Journal FEBS Letters 443(2):93-96 (1999) (1999)
  Details

  DOI10.1016/S0014-5793(98)01696-2 PMID9989582 PMCID  DivisionNeurobiology
• The tauopathies. Toward an experimental animal model AuthorsGoedert M., Hasegawa M. Journal American Journal of Pathology 154(1):1-6 (1999) (1999)
  Details

  DOI10.1016/S0002-9440(10)65242‑X PMID9916910 PMCIDPMC1853453 DivisionNeurobiology
• Filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases AuthorsM. Goedert, R. A. Crowther, R. Jakes, M. Hasegawa, M. J. Smith, J. R. Murrell, B. Ghetti, M. G. Spillantini Journal Alzheimer's Disease and Related Disorders. Edited by K. Iqbal, D. F. Swaab, B. Winbald, H. M. Wisniewski pp.245-258 (1999) (1999)
  Details

  DOI  PMID  PMCID  Division 
• Tau proteins AuthorsHasegawa M., Goedert M. Journal Recent Advances in Alzheimer's Disease Research. Edited by Y. Ihaia pp.81-93 (1999) (1999)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology
• Tau protein pathology in neurodegenerative diseases AuthorsSpillantini M. G., Goedert M. Journal Trends in Neurosciences 21(10):428-433 (1998) (1998)
  Details

  DOI10.1016/S0166-2236(98)01337‑X PMID9786340 PMCID  DivisionNeurobiology
• Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia AuthorsTrojanowski J. Q., Goedert M., Iwatsubo T., Lee V. M-Y. Journal Cell Death and Differentiation 5(10):832-837 (1998) (1998)
  Details

  DOI10.1038/sj. Cdd.4400432 PMID10203692 PMCID  DivisionNeurobiology
• Mutation in the tau gene in familial multiple system tauopathy with presenile dementia AuthorsSpillantini M. G., Murrell J. R., Goedert M., Farlow M. R., Klug A., Ghetti B. Journal Proceedings of the National Academy of Sciences, USA 95(13):7737-7741. 23 June 1998 (1998)
  Details

  DOI10.1073/pnas.95.13.7737 PMID9636220 PMCIDPMC22742 DivisionNeurobiology, Structural Studies
• Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution AuthorsPatrick A. Eyers, Molly Craxton, Nick Morrice, Philip Cohen, Michel Goedert Journal Chemistry & Biology 5: 321-328 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Alpha-synuclein and the Lewy body AuthorsMichel Goedert, Ross Jakes, Maria Grazia Spillantini Journal NeuroScience News 1: 47-52 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies AuthorsMaria Grazia Spillantini, R. Anthony Crowther, Ross Jakes, Masato Hasegawa, Michel Goedert Journal Proceedings of the National Academy of Sciences, USA 95: 6469-6473 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinase AuthorsZhong Qi, Xiaodong Zhu, Michel Goedert, Donald J. Fujita, Jerry H. Wang Journal FEBS Letters 324: 227-230 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases AuthorsM. Goedert, R. Jakes, R. A. Crowther, M. Hasegawa, M. J. Smith, M. G. Spillantini Journal Biochemical Society Transactions 26: 463-471 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid AuthorsPhilip Cohen, Michel Goedert Journal Chemistry & Biology 5(7):R161-4 (1998) (1998)
  Details

  DOI10.1016/S1074-5521(98)90068‑0 PMID9662509 PMCID  Division 
• Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies AuthorsSpillantini M. G., Crowther R. A., Jakes R., Cairns N., Lantos P. L., Goedert M. Journal Neuroscience Letters 251(3):205-208 (1998) (1998)
  Details

  DOI10.1016/S0304-3940(98)00504‑7 PMID9726379 PMCID  DivisionNeurobiology
• Synthetic filaments assembled from C-terminally truncated alpha‑synuclein AuthorsR. Anthony Crowther, Ross Jakes, Maria Grazia Spillantini, Michel Goedert Journal FEBS Letters 436: 309-312 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Lewy body diseases and multiple system atrophy as alpha‑synucleinopathies AuthorsM. Goedert, M. G. Spillantini Journal Molecular Psychiatry 3: 462-465 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Neurofibrillary pathology of Alzheimer's disease and other taupathies AuthorsMichel Goedert Journal Progress in Brain Research 117: 287-306 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Filamentous nerve cell inclusions in neurodegenerative diseases AuthorsMichel Goedert, Maria Grazia Spillantini, Stephen W. Davies Journal Current Opinion in Neurobiology 8: 619-632 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Tau mutations cause frontotemporal dementias AuthorsMichel Goedert, R. Anthony Crowther, Maria Grazia Spillantini Journal Neuron 21: 955-958 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly AuthorsMasato Hasegawa, Michael J,Smith, Michel Goedert Journal FEBS Letters 437: 207-210 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Binding of alpha-Synuclein to brain vesicles is abolished by familial Parkinson's disease mutation AuthorsPoul H. Jensen, Morten S. Nielsen, Ross Jakes, Carlos G. Dotti, Michel Goedert Journal Journal of Biological Chemistry 273: 26292-26294 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro AuthorsSean Lawler, Yvonne Fleming, Michel Goedert, Philip Cohen Journal Current Biology 8: 1387-1390 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• alpha-Synuclein in Lewy bodies AuthorsMaria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert Journal Nature 388(6645):839-840. 28 August 1997 (1997)
  Details

  DOI10.1038/42166 PMID9278044 PMCID  DivisionNeurobiology
• Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDA Component and age-related biochemical modifications AuthorsN. Sergeant, J.-P. David, M. Goedert, R. Jakes, P. Vermersch, L. Buee, D. Lefranc, A. Wattez, A. Delacourte Journal Journal of Neurochemistry 69(2):834-844. August 1997 (1997)
  Details

  DOI10.1046/j.1471-4159.1997.69020834.x PMID9231745 PMCID  Division 
• Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases AuthorsMichel Goedert, Ana Cuenda, Molly Craxton, Ross Jakes, Philip Cohen Journal EMBO Journal 16(12):3563-3571. 15 June 1997 (1997)
  Details

  DOI10.1093/emboj/16.12.3563 PMID9218798 PMCIDPMC1169981 DivisionNeurobiology
• Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases AuthorsMichel Goedert, Masato Hasegawa, Ross Jakes, Sean Lawler, Ana Cuenda, Philip Cohen Journal FEBS Letters 409(1):57-62. 2 June 1997 (1997)
  Details

  DOI10.1016/S0014-5793(97)00483-3 PMID9199504 PMCID  Division 
• Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridisation AuthorsM. Goedert, J. Hasegawa, M. Craxton, M. A. Leversha, S. Clegg Journal Genomics 41(3):501-502. 1 May 1997 (1997)
  Details

  DOI10.1006/geno.1997.4633 PMID9169156 PMCID  Division 
• Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments AuthorsMaria Grazia Spillantini, Michel Goedert, R. Anthony Crowther, Jill R. Murrell, Martin R. Farlow, Bernardino Ghetti Journal Proceedings of the National Academy of Sciences, USA 94: 4113-4118. 15 April 1997 (1997)
  Details

  DOI10.1073/pnas.94.8.4113 PMID9108114 PMCIDPMC20577 DivisionNeurobiology
• Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons AuthorsM. Tolnay, M. G. Spillantini, M. Goedert, J. Ulrich, D. Langui, A. Probst Journal Acta Neuropathol. 93(5):477-484 (1997)
  Details

  DOI10.1007/s004010050642 PMID9144586 PMCID  DivisionNeurobiology
• The neurofibrillary pathology of Alzheimer's disease AuthorsGoedert M. Journal The Neuroscientist 3(2): 131-141 (1997) (1997)
  Details

  DOI10.1177/107385849700300212 PMID  PMCID  DivisionNeurobiology
• Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38) AuthorsAna Cuenda, Philip Cohen, Valerie Buee-Scherrer, Michel Goedert Journal EMBO Journal 16(2):295-305. 15 January 1997 (1997)
  Details

  DOI10.1093/emboj/16.2.295 PMID9029150 PMCIDPMC1169636 Division 
• Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location AuthorsMolly Craxton, Anne Olsen, Michel Goedert Journal Genomics 42: 165-169 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• The neurofibrillary pathology of Alzheimer's disease AuthorsMichel Goedert, John Q. Trojanowski, Virginia M.-Y. Lee Journal The Molecular and Genetic Basis of Neurological Diseases, 2nd edition. Edited by Rosenberg et al. pp.613-627 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Characterization of familial multiple system tauopathy with pre-senile dementia AuthorsM. G. Spillantini, M. Goedert, R. A. Crowther, J. R. Murrell, M. R. Farlow, B. Ghetti Journal Alzheimer's Disease: Biology, Diagnosis and Therapeutics. Edited by K. Iqbal, B. Winbald, T. Nishimura, M. Takeda, H. M. Wisniewski pp.213-223 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• The awakening of alpha‑synuclein AuthorsMichel Goedert Journal Nature 388: 232-233 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Alzheimer-like changes in microtubule-associated protein tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation AuthorsMasato Hasegawa, R. Anthony Crowther, Ross Jakes, Michel Goedert Journal Journal of Biological Chemistry 272: 33118-33124 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• SKK4, a novel activator of stress-activated protein kinase-1 AuthorsSean Lawler, Ana Cuenda, Michel Goedert, Philip Cohen Journal FEBS Letters 414: 153-158 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17 AuthorsJ. R. Murrell, D. Koller, T. Foroud, M. Goedert, M. G. Spillantini, H. J. Edenberg, M. R. Farlow, B. Ghetti Journal Am. J. Hum. Genet. 61: 1131-1138 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• tau Protein and the neurofibrillary pathology of Alzheimer's disease AuthorsGoedert M., Trojanowski J. Q., Lee V. M-Y. Journal Molecular Mechanisms of Dementia. Edited by W. Wasco and R. E. Tanzi pp.199-218 (1997) (1997)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology
• PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhaditis elegans AuthorsGoedert M., Baur C. P., Ahringer J., Jakes R., Hasegawa M., Spillantini M. G., Smith M. J., Hill F. Journal Journal of Cell Science 109 ( Pt 11):2661-2672. November 1996 (1996)
  Details

  DOI  PMID8937984 PMCID  DivisionNeurobiology
• Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans AuthorsGoedert M., Jakes R., Spillantini M. G., Hasegawa M., Smith M. J., Crowther R. A. Journal Nature 383(6600):550-553. 10 October 1996 (1996)
  Details

  DOI10.1038/383550a0 PMID8849730 PMCID  DivisionNeurobiology, Structural Studies
• Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser‑356 AuthorsLitersky J. M., Johnson G. V. W., Jakes R., Goedert M., Lee M., Seubert P. Journal Biochemical Journal 316( Pt 2):655-660. June 1996 (1996)
  Details

  DOI10.1042/bj3160655 PMID8687413 PMCIDPMC1217397 DivisionNeurobiology
• SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases AuthorsStephan Mertens, Molly Craxton, Michel Goedert Journal FEBS Letters 383(3):273-276. April 1996 (1996)
  Details

  DOI 10.1016/0014-5793(96)00255-4 PMID8925912 PMCID  Division 
• Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization AuthorsM. Goedert, S. Marsh, N. Carter Journal Genomics 32(1):173-175. 15 February 1996 (1996)
  Details

  DOI10.1006/geno.1996.0102 PMID8786116 PMCID  Division 
• Expression of APP in transgenic mice: a comparison of neuron-specific promoters AuthorsKerstin Andra, Dorothee Abramowski, Mairead Duke, Alphonse Probst, Karl-Heinz Wiederhold, Kurt Burki, Michel Goedert, Bernd Sommer, Matthias Staufenbiel Journal Neurobiology of Aging 17: 183-190 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease AuthorsV. Buee-Scherrer, O. Condamines, C. Mourton-Gilles, R. Jakes, M. Goedert, B. Pau, A. Delacourte Journal Molecular Brain Research 39: 79-88 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP AuthorsBernardino Ghetti, Pedro Piccardo, Maria Grazia Spillantini, Yousuke Ichimiya, Monica Porro, Francesco Perini, Tetsuyuki Kitamoto, Jun Tateishi, Charles Seiler, Blas Frangione, Orso Bugiani, Giorgio Giaccone, Frances Prelli, Michel Goedert, Stephen R. Dloughy, Fabrizio Tagliavini Journal Proceedings of the National Academy of Sciences, USA 93: 744-748 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Tau protein and the neurofibrillary pathology of Alzheimer's disease AuthorsM. Goedert Journal Annals of the New York Academy of Sciences. (The Neurobiology of Alzheimer's Disease) 777:121-131. January 1996 (1996)
  Details

  DOI10.1111/j.1749-6632.1996.tb34410.x PMID8624074 PMCID  Division 
• Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein AuthorsM. Hasegawa, R. Jakes, R. A. Crowther, V. M.-Y. Lee, Y. Ihara, M. Goedert Journal FEBS Letters 384: 25-30 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism AuthorsA. D. Roses, G. Einstein, J. Gilbert, M. Goedert, S-H. Han, D. Huang, C. Hulette, E. Masliah, M. A. Pericak-Vance, A. M. Sauders, D. E. Schmechel, W. J. Strittmattter, K. H. Weisgraber, P.-T. Xi Journal Annals of the New York Academy of Sciences. (The Neurobiology of Alzheimer's disease) 777: 146-157 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles AuthorsM. G. Spillantini, R. A. Crowther, M. Goedert Journal Acta Neuropathol. 92: 42-48 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Molecular dissection of the neurofibrillary lesions of Alzheimer's Disease AuthorsM. Goedert, M. G. Spillantini, M. Hasegawa, R. Jakes, R. A. Crowther, A. Klug Journal Cold Spring Harbor Symposia on Quantitative Biology LXI: 565-573 (1996) (1996)
  Details

  DOI  PMID9246483 PMCID  Division 
• tau Protein and the neurofibrillary pathology of Alzheimer's disease AuthorsMichel Goedert, John Q. Trojanowski, Virginia M.-Y. Lee Journal Molecular Mechanisms of Dementia. Edited by W. Wasco and R. E. Tanzi pp.199-218 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment AuthorsA. Probst, M. Tolnay, D. Langui, M. Goedert, M. G. Spillantini Journal Acta Neuropathol. 92: 588-596 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Molecular dissection of the paired helical filament AuthorsGoedert M., Spillantini M. G., Jakes R., Crowther R. A., Vanmechelen E., Probst A., Gotz J., Burki K., Cohen P. Journal Neurobiology of Aging 16(3):325-334. May-June 1995 (1995)
  Details

  DOI10.1016/0197-4580(95)00017‑9 PMID7566342 PMCID  DivisionNeurobiology, Structural Studies
• Tau protein in Alzheimer's disease AuthorsM. Goedert, R. Jakes, M. G. Spillantini, R. A. Crowther, P. Cohen, E. Vanmechelen, A. Probst, J. Gotz, K. Burki Journal Biochemical Society Transactions 23: 80-85 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain AuthorsMolly Craxton, Michel Goedert Journal FEBS Letters 361: 196-200 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Molecular dissection of the neurofibrillary lesions of Alzheimer's disease AuthorsM. Goedert Journal Arzneimittel-Forschung/Drug Research 45: 403-409 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform AuthorsJurgen Gotz, Alphonse Probst, Maria Grazia Spillantini, Thomas Schafer, Ross Jakes, Kurt Burki, Michel Goedert Journal EMBO Journal 14: 1304-1313 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205 AuthorsM. Goedert, R. Jakes, E. Vanmechelen Journal Neuroscience Letters 189: 167-170 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Molecular dissection of the paired helical filament AuthorsM. Goedert, M. G. Spillantini, R. Jakes, R. A. Crowther, P. Cohen, E. Vanmechelen, A. Probst, J. Gotz, K. Burki Journal Research Advances in Alzheimer's Disease and Related Disorders. Edited by K. Iqbal et al pp. 493-502 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Characterisation of an antibody relevant to the neuropathology of Alzheimer disease AuthorsR. Jakes, C. R. Harrington, M. G. Spillantini, M. Goedert, A. Klug Journal Alzheimer Disease and Associated Disorders 9: 47-51 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Apolipoprotein E and Alzheimer's Disease AuthorsA. D. Roses, A. M. Saunders, E. H. Corder, N. J. Risch, J. L. Haines, M. A. Pericak-Vance, S.-H. Han, G. Einstein, C. Hulette, D. E. Schmechel, M. Goedert, R. Jakes, L.-M. Dong, K. H. Weisgraber, M. Holsti, D. Huang, W. J. Strittmatter Journal Research Advances in Alzheimer's Disease and Related Disorders. Edited by K. Iqbal et al pp.85-96 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau AuthorsPeter Seubert, Madhumalti Mawal-Dewan, Robin Barbour, Ross Jakes, Michel Goedert, Gail V. W. Jonhson, Joel M. Litersky, Dale Schenk, Ivan Lieberburg, John Q. Trojanowski, Virginia M.-Y. Lee Journal Journal of Biological Chemistry 270: 18917-18922 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35 AuthorsMaria Grazia Spillantini, Aspasia Divane, Michel Goedert Journal Genomics 27: 379-381 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Glycogen synthase kinase-3beta phosphorylates tau protein at multiple sites in intact cells AuthorsBrian R. Sperber, Susan Leight, Michel Goedert, V. M.-Y. Lee Journal Neuroscience Letters 197: 149-153 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Protein phosphatase 2A is the major enzyme in Brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase AuthorsM. Goedert, R. Jakes, Z. Qi, J. H. Wang, P. Cohen Journal Journal of Neurochemistry 65: 2804-2807 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Identification of two distinct synucleins from human brain AuthorsJakes R., Spillantini M. G., Goedert M. Journal FEBS Letters 345(1):27-32. 23 May 1994 (1994)
  Details

  DOI10.1016/0014-5793(94)00395‑5 PMID8194594 PMCID  DivisionNeurobiology
• Assembly of Alzheimer-like filaments from full-length tau protein AuthorsCrowther R. A., Olesen O. F., Smith M. J., Jakes R., Goedert M. Journal FEBS Letters 337(2):135-138. 10 January 1994 (1994)
  Details

  DOI10.1016/0014-5793(94)80260-2 PMID8287967 PMCID  DivisionStructural Studies, Neurobiology
• Assembly of Alzheimer-like filaments from full-length tau protein AuthorsCrowther R. A., Olesen O. F., Smith M. J., Jakes R., Goedert M. Journal FEBS Letters 337(2):135-138. 10 January 1994 (1994)
  Details

  DOI10.1016/0014-5793(94)80260‑2 PMID8287967 PMCID  DivisionStructural Studies, Neurobiology
• Tau protein and Alzheimer's disease AuthorsGoedert M., Jakes R., Spillantini M. G., Crowther R. A. Journal Microtubules pp.183-200 (1994) (1994)
  Details

  DOI  PMID  PMCID  DivisionNeurobiology, Structural Studies
• Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein AuthorsMichel Goedert, Ross Jakes, R. Anthony Crowther, Philip Cohen, Eugeen Vanmechelen, Marc Vandermeeren, Patrick Cras Journal Biochemical Journal 301: 871-877 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Risky apolipoprotein in brain AuthorsMichel Goedert, Warren J. Strittmatter, Allen D. Roses Journal Nature 372: 45-46 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease AuthorsDavid Y. Huang, Michel Goedert, Ross Jakes, Karl H. Weisgraber, Craig C. Garner, Ann M. Saunders, Margaret A. Pericak-Vance, Donald E. Schmechel, Allen D. Roses, Warren J. Strittmatter Journal Neuroscience Letters 182: 55-58 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404 AuthorsL. Otvos Jr., L. Feiner, E. Lang, G. I. Szendrei, M. Goedert, V. M-Y. Lee Journal Journal of Neuroscience Research 39: 669-673 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer Disease AuthorsWarren J. Strittmatter, Ann M. Saunders, Michel Goedert, Karl H. Weisgraber, Li-Ming Dong, Ross Jakes, David Y. Huang, Margaret Pericak-Vance, Donald Schmechel, Allen D. Roses Journal Proceedings of the National Academy of Sciences, USA 91: 11183-11186 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype AuthorsWarren J. Strittmatter, Karl H. Weisgraber, Michel Goedert, Ann M. Saunders, David Huang, Elizabeth H. Corder, Li-Ming Dong, Ross Jakes, Mark J. Alberts, John R. Gilbert, Seol-Heui Han, Christine Hulette, Gillian Einstein, Donald E. Schmechel, Margaret A. Pericak-Vance, Allen D. Roses Journal Experimental Neurology 125 (2): 172-4 (1994)
  Details

  DOI  PMID  PMCID  Division 
• The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development AuthorsGoedert M., Jakes R., Crowther R. A., Six J., Lubke U., Vandermeeren M.,Cras P., Trojanowski J. Q., Lee V. M. Y. Journal Proceedings of the National Academy of Sciences USA 90: 5066-5070. 1 June 1993 (1993)
  Details

  DOI10.1073/pnas.90.11.5066 PMID8506352 PMCIDPMC46655 DivisionNeurobiology
• Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord AuthorsJae Hong Lee, Michel Goedert, William D. Hill, Virginia M.-Y. Lee, John Q. Trojanowski Journal Experimental Neurology 121: 93-105 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding AuthorsGregory T. Bramblett, Michel Goedert, Ross Jakes, Sandra E. Merrick, John Q. Trojanowski, Virginia M.-Y. Lee Journal Neuron 10: 1089-1099 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Tau protein and the neurofibrillary pathology of Alzheimer's disease AuthorsMichel Goedert Journal Trends in Neurosciences 16: 460-465 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Human tau isoforms confer distinct morphological and functional properties to stably transfected fibroblasts AuthorsMathew M. S. Lo, Ann W. Fieles, Tyrrell E. Norris, Pauline G. Dargis, Claudia B. Caputo, Clay W. Scott, Virginia M.-Y. Lee, Michel Goedert Journal Molecular Brain Research 20: 209-220 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• PHFtau (A68): from pathological marker to potential mediator of neuronal dysfunction and degeneration in Alzheimer's disease AuthorsJohn Q. Trojanowski, Marie L. Schmidt, Ryong-Woon Shin, Gregory T. Bramblett, Michel Goedert, Virginia M.-Y. Lee Journal Clinical Neuroscience 1: 184-191 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region AuthorsBiernat J., Mandelkow E. M., Schröter C., Lichtenberg-Kraag B., Steiner B., Berling B., Meyer H., Mercken M., Vandermeeren A., Goedert M., Mandelkow E. Journal EMBO Journal 11(4):1593-1597. April 1992 (1992)
  Details

  DOI  PMID1563356 PMCIDPMC556608 DivisionNeurobiology
• p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphates 2A1 AuthorsMichel Goedert, E. Suzanne Cohen, Ross Jakes, Philip Cohen Journal FEBS Letters 312: 95-99 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• Construction and characterization of a yeast artificial chromosome library containing 1.5 equivalents of human chromosome 21 AuthorsM.-C. Potier, W. L. Kuo, A. Dutriaux, J. Gray, M. Goedert Journal Genomics 14: 481-483 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms AuthorsM. Goedert, M. G. Spillantini, N. J. Cairns, R. A. Crowther Journal Neuron 8: 159-168 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system AuthorsM. Goedert, M. G. Spillantini, R. A. Crowther Journal Proceedings of the National Academy of Sciences, USA 89: 1983-1987 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease AuthorsR. A. Crowther, O. F. Olesen, R. Jakes, M. Goedert Journal FEBS Letters 309: 199-202 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease AuthorsGoedert G., Sisodia S. S., Price D. L. Journal Current Opinion in Neurobiology 1(3):441-447. October 1991 (1991)
  Details

  DOI10.1016/0959-4388(91)90067-h PMID1821689 PMCID  DivisionNeurobiology
• Tau proteins and neurofibrillary degeneration AuthorsGoedert M., Spillantini M. G., Crowther R. A. Journal Brain Pathology 1(4):279-286. July 1991 (1991)
  Details

  DOI10.1111/j.1750-3639.1991.tb00671.x PMID1669718 PMCID  DivisionNeurobiology, Structural Studies
• Molecular characterization of microtubule-associated proteins tau and MAP2 AuthorsM. Goedert, R. A. Crowther, C. C. Garner Journal Trends in Neurosciences 14: 193-199 (1991 ) (1991)
  Details

  DOI  PMID  PMCID  Division 
• Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau AuthorsM. Goedert, M. G. Spillantini, R. Jakes Journal Neuroscience Letters 126: 149-154 (1991 ) (1991)
  Details

  DOI  PMID  PMCID  Division 
• Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles AuthorsSteiner B., Mandelkow E. M., Biernat J., Gustke N., Meyer H. E., Schmidt B., Mieskes G., Söling H. D., Drechsel D., Kirschner M. W., Goedert M., Mandelkow E. Journal EMBO Journal 9(11):3539-3544. November 1990 (1990)
  Details

  DOI  PMID2120043 PMCIDPMC552103 DivisionNeurobiology
• Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease AuthorsSpillantini M. G., Goedert M., Jakes R., Klug A. Journal Proceedings of the National Academy of Sciences, USA 87(10):3947-3951. 1 May 1990 (1990)
  Details

  DOI10.1073/pnas.87.10.3947 PMID2111023 PMCIDPMC54021 DivisionNeurobiology, Structural Studies
• Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease AuthorsSpillantini M. G., Goedert M., Jakes R., Klug A. Journal Proceedings of the National Academy of Sciences, USA 87(10):3952-3956 (1990) (1990)
  Details

  DOI10.1073/pnas.87.10.3952 PMID1692627 PMCIDPMC54022 DivisionNeurobiology, Structural Studies
• Molecular neuropathology of Alzheimer's disease: In situ hybridization studies AuthorsGoedert M., Spillantini M. G. Journal Cellular and Molecular Neurobiology 10(1):159-174. March 1990 (1990)
  Details

  DOI10.1007/bf00733642 PMID2110505 PMCID  DivisionNeurobiology
• Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization AuthorsMichel Goedert, Ross Jakes Journal EMBO Journal 9: 4225-4230 (1990) (1990)
  Details

  DOI  PMID  PMCID  Division 
• Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain AuthorsGoedert M., Spillantini M. G., Potier M. C., Ulrich J., Crowther R. A. Journal EMBO Journal 8(2):393-399. 1 February 1989 (1989)
  Details

  DOI10.1002/j.1460-2075.1989.tb03390.x PMID2498079 PMCIDPMC400819 DivisionNeurobiology, Structural Studies
• Nerve growth factor receptor mRNA distribution inhuman brain: normal levels in basal forebrain in Alzheimer's disease AuthorsGoedert M., Fine A., Dawbarn D., . Wilcock G. K., Chao M. V. Journal Molecular Brain Research 5(1):1-7. January 1989 (1989)
  Details

  DOI10.1016/0169-328x(89)90011‑9 PMID2538704 PMCID  DivisionNeurobiology
• Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease AuthorsM. Goedert, M. G. Spillantini, R. Jakes, D. Rutherford, R. A. Crowther Journal Neuron 3: 519-526 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• Characterization of molecular pathology of Alzheimer's disease AuthorsMichel Goedert Journal Methods in Neurosciences 1: 425-443 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression AuthorsM. G. Spillantini, L. Aloe, E. Alleva, R. De Simone, M. Goedert, R. Levi-Montalcini Journal Proceedings of the National Academy of Sciences, USA 86: 8555-8559 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• Expression and cellular localization of amyloid beta-protein precursor transcripts in normal human brain and in Alzheimer's disease AuthorsM. G. Spillantini, S. P. Hunt, J. Ulrich, M. Goedert Journal Molecular Brain Research 6: 143-150 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• The repeat region of microtubule-associated protein Tau forms part of the core of the paired helical filament of Alzheimer's disease AuthorsTony Crowther, Michel Goedert, Claude M. Wischik Journal Annals of Medicine 21: 127-132 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule -associated protein tau AuthorsM. Goedert, C. M. Wischik, R. A. Crowther, J. E. Walker, A. Klug Journal Proceedings of the National Academy of Sciences, USA 85: 4051-4055 (1988) (1988)
  Details

  DOI  PMID  PMCID  Division 
• Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau AuthorsM. Goedert, C. M. Wischik, R. A. Crowther, J. E. Walker, A. Klug Journal Proceedings of the National Academy of Sciences, USA 85: 4051-4055 (1988) (1988)
  Details

  DOI  PMID  PMCID  Division 
• The cellular localization of preprotachykinin A messenger RNA in the bovine nervous system AuthorsM. Goedert, S. P. Hunt Journal Neuroscience 22: 983-992 (1987) (1987)
  Details

  DOI  PMID2446201 PMCID  Division 
• The cellular localization of preprotachykinin A messenger RNA in the bovine nervous system AuthorsM. Goedert, S. P. Hunt Journal Neuroscience 22: 983-992 (1987) (1987)
  Details

  DOI  PMID2446201 PMCID  Division 
• Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease AuthorsMichel Goedert Journal EMBO Journal 6: 3627-3632 (1987) (1987)
  Details

  DOI  PMID  PMCID  Division 
• Molecular cloning of the chicken nerve growth factor gene: mRNA distribution in developing and adult tissues AuthorsMichel Goedert Journal Biochemical and Biophysical Research Communications 141: 1116-1122 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division 
• Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease AuthorsM. Goedert, A. Fine, S. P. Hunt, A. Ullrich Journal Molecular Brain Research 1: 85-92 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division 
• The cellular localization of preprotachykinin, preproenkephalin A and beta prepronerve growth factor mRNA AuthorsMichel Goedert, Stephen P. Hunt Journal In Situ Hybridization in Brain. Edited by George R. Uhl pp.151-169 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division