Published Research

Found 265 results for Gait.

• Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model AuthorsBestas B., Estupiñán H.Y., Wang Q., Kharazi S., He C., Mohammad D.K., Gupta D., Wiklander O.P.B., Lehto T., Lundin K.E., Berglöf A., Karlsson M.C.I., Abendroth F., El Andaloussi S., Gait M.J., Wood M.J.A., Leumann C.J., Stetsenko D.A., Månsson R., Wengel J., Zain R., Edvard Smith C.I. Journal RSC Chemical Biology 6(5):761-771 (2025)
  Details

  DOIdoi.org/10.1039/d4cb00312h PMID40171248 PMCIDPMC11955834 DivisionProtein & Nucleic Acid Chemistry
• Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation AuthorsGupta D., Orehek S., Turunen J., O'Donovan L., Gait M. J, El-Andaloussi S., Wood M. J. A. Journal Cells 12(18):2285 (2023)
  Details

  DOI10.3390/cells12182285 PMID37759507 PMCIDPMC10526877 DivisionProtein & Nucleic Acid Chemistry
• Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy AuthorsHammond S.M., Abendroth F., Goli L., Stoodley J., Burrell M., Thom G., Gurrell I., Ahlskog N., Gait M.J., Wood M.J., Webster C.I. Journal JCI Insight 7(24):e154142 (2022)
  Details

  DOI10.1172/jci.insight.154142 PMID36346674 PMCIDPMC7614086 DivisionProtein & Nucleic Acid Chemistry
• Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy AuthorsHammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI. Journal JCI Insight Dec 22;7(24):e154142 (2022)
  Details

  DOI10.1172/jci.insight.154142 PMID36346674 PMCIDPMC7614086 DivisionProtein & Nucleic Acid Chemistry
• Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants AuthorsPlanelles-Herrero VJ, Bittleston A, Seum C, Gaitan MG, Derivery E. Journal Nature Cell Biology 10.1038/s41556-022-01020-9 (2022)
  Details

  DOI10.1038/s41556-022-01020‑9 PMID36302967 PMCIDPMC7613801 DivisionCell Biology
• Introduction and History of the Chemistry of Nucleic Acids Therapeutics AuthorsGait M. J., Agrawal S. Journal Methods in Molecular Biology 2434:3-31 (2022)
  Details

  DOI10.1007/978-1-0716-2010-6_1 PMID35213007 PMCIDPMC7612508 DivisionProtein & Nucleic Acid Chemistry
• Dystrophin involvement in peripheral circadian SRF signalling AuthorsBetts CA, et al (including O'Donovan E., Saleh A. F., Gait M. J.) Journal Life Science Alliance 4(10):e202101014 (2021)
  Details

  DOI10.26508/lsa.202101014 PMID34389686 PMCIDPMC8363758 DivisionStructural Studies
• Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides AuthorsTone Y., Mamchaoui K., Tsoumpra M. K., Hashimoto Y., Terada R., Maruyama R., Gait M. J., Arzumanov A. A., McClorey G., Imamura M., Takeda S., Yokota T., Wood M. J. A., Mouly V., Aoki Y. Journal Nucleic Acid Therapeutics 31(2):172-181. April 2021 (2021)
  Details

  DOI10.1089/nat.2020.0907 PMID33567244 PMCIDPMC7997716 DivisionProtein & Nucleic Acid Chemistry
• Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice AuthorsKlein A. F., Varela M. A., Arandel L., Holland A., Naouar N., Arzumanov A., Seoane D., Revillod L., Bassez G., Ferry A., Jauvin D., Gourdon G., Puymirat J., Gait M. J., Furling D., Wood M. J. Journal The Journal of Clinical Investigation 129(11):4739-4744. 1 November 2019 (2019)
  Details

  DOI10.1172/JCI128205 PMID31479430 PMCIDPMC6819114 DivisionProtein & Nucleic Acid Chemistry
• Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy AuthorsHammond S. M., Abendroth F., Gait M. J., Wood M. J. A. Journal Methods in Molecular Biology 2036:221-236 (2019)
  Details

  DOI10.1007/978-1-4939-9670-4_13 PMID31410800 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment AuthorsGait M. J., Arzumanov A. A., McClorey G., Godfrey C., Betts C., Hammond S., Wood M. J. A. Journal Nucleic Acid Therapeutics 29(1):1-12. February 2019 (2019)
  Details

  DOI10.1089/nat.2018.0747 PMID30307373 PMCIDPMC6386087 DivisionProtein & Nucleic Acid Chemistry
• Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment AuthorsBetts C. A., McClorey G., Healicon R., Hammond S. M., Manzano R., Muses S., Ball V., Godfrey C., Merritt T. M., Westering T., O'Donovan L., Wells K. E., Gait M. J., Wells D. J., Tyler D., Wood M. J. Journal Human Molecular Genetics 28(3):396-406 (2019)
  Details

  DOI10.1093/hmg/ddy346 PMID30281092 PMCIDPMC6337703 DivisionProtein & Nucleic Acid Chemistry
• Memoirs Daniel McGillivray Brown. 3 February 1923—24 April 2012 AuthorsGait M. J. Journal Biographical Memoirs of Fellows of the Royal Society 66:79–100 (2018)
  Details

  DOI10.1098/rsbm.2018.0008 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy AuthorsBlain A. M., Greally E., McClorey G., Manzano R., Betts C. A., Godfrey C., O'Donovan L., Coursindel T., Gait M. J., Wood M. J., MacGowan G. A., Straub V. W. Journal PloS one 13(6):e0198897. 18 June 2018 (2018)
  Details

  DOI10.1371/journal.pone.0198897 PMID29912990 PMCIDPMC6005479 DivisionProtein & Nucleic Acid Chemistry
• Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide‑PNAs AuthorsTailhades J., Takizawa H., Gait M. J., Wellings D. A., Wade J. D., Aoki Y., Shabanpoor F. Journal Frontiers in Chemistry 5:81. 17 October 2017 (2017)
  Details

  DOI10.3389/fchem.2017.00081 PMID29094037 PMCIDPMC5651559 DivisionProtein & Nucleic Acid Chemistry
• Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy AuthorsShabanpoor F., Hammond S. M., Abendroth F., Hazell G., Wood M. J., Gait M. J. Journal Nucleic Acid Therapeutics 27(3):130-143. 1 June 2017 (2017)
  Details

  DOI10.1089/nat.2016.0652 PMID28118087 PMCIDPMC5467147 DivisionProtein & Nucleic Acid Chemistry
• ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives AuthorsHoogewijs K., James A. M., Smith R. A., Abendroth F., Gait M. J., Murphy M. P., Lightowlers R. N. Journal Interface Focus 7(2):20160117. 6 April 2017 (2017)
  Details

  DOI10.1098/rsfs.2016.0117 PMID28382203 PMCIDPMC5311907 DivisionProtein & Nucleic Acid Chemistry
• Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy AuthorsHammond S. M., Hazell G., Shabanpoor F., Saleh A. F., Bowerman M., Sleigh J. N., Meijboom K. E., Zhou H., Muntoni F., Talbot K., Gait M. J., Wood M. J. Journal Proceedings of the National Academy of Sciences of the United States of America 113(39):10962-10967. 27 September 2016 (2016)
  Details

  DOI10.1073/pnas.1605731113 PMID27621445 PMCIDPMC5047168 DivisionProtein & Nucleic Acid Chemistry
• Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry AuthorsHoogewijs K., James A. M., Smith R. A., Gait M. J., Murphy M. P., Lightowlers R. N. Journal Chembiochem : a European Journal of Chemical Biology 17(14):1312-1316 (2016)
  Details

  DOI10.1002/cbic.201600188 PMID27124570 PMCIDPMC4973694 DivisionProtein & Nucleic Acid Chemistry
• Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration AuthorsRoberts T. C., Johansson H. J., McClorey G., Godfrey C., Blomberg K. E., Coursindel T., Gait M. J., Smith C. I., Lehtiö J., Andaloussi S. E., Wood M. J. Journal Human Molecular Genetics 4(23):6756-6768. 1 December 2015 (2015)
  Details

  DOI10.1093/hmg/ddv381 PMID26385637 PMCIDPMC4634378 DivisionProtein & Nucleic Acid Chemistry
• Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics AuthorsCoenen-Stass A. M., McClorey G., Manzano R., Betts C. A., Blain A., Saleh A. F., Gait M. J., Lochmüller H., Wood M. J., Roberts T. C. Journal Scientific Reports 5:17014. 23 November 2015 (2015)
  Details

  DOI10.1038/srep17014 PMID26594036 PMCIDPMC4655324 DivisionProtein & Nucleic Acid Chemistry
• Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides AuthorsBurki U., Keane J., Blain A., O'Donovan L., Gait M. J., Laval S. H., Straub V. Journal Nucleic Acid Therapeutics 25(5):275-284. 17 September 2015 (2015)
  Details

  DOI10.1089/nat.2014.0528 PMID26176274 PMCIDPMC4576940 DivisionProtein & Nucleic Acid Chemistry
• How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse AuthorsGodfrey C., Muses S., McClorey G., Wells K. E., Coursindel T., Terry R., Betts C., Hammond S., O'Donovan L., Hildyard J., E. l. Andaloussi S., Gait M. J., Wood M. J,. Wells D. J. Journal Human Molecular Genetics 24(15):4225-4237. 1 August 2015 (2015)
  Details

  DOI10.1093/hmg/ddv155 PMID25935000 PMCIDPMC4492390 DivisionProtein & Nucleic Acid Chemistry
• Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice AuthorsLu-Nguyen N. B., Jarmin S. A., Saleh A. F., Popplewell L., Gait M. J., Dickson G. Journal Molecular Therapy 23(8):1341-1348. August 2015 (2015)
  Details

  DOI10.1038/mt.2015.88 PMID25959011 PMCIDPMC4579549 DivisionProtein & Nucleic Acid Chemistry
• Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides AuthorsEzzat K., Aoki Y., Koo T., McClorey G., Benner L., Coenen-Stass A., O'Donovan L., Lehto T., Garcia-Guerra A., Nordin J., Saleh A. F., Behlke M., Morris J., Goyenvalle A., Dugovic B., Leumann C., Gordon S., Gait M. J., El Andaloussi S., Wood M. J. Journal Nano Letters 15(7):4364-73. 8 July 2015 (2015)
  Details

  DOI10.1021/acs.nanolett.5b00490 PMID26042553 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy AuthorsBetts C. A., Saleh A. F., Carr C. A., Muses S., Wells K. E., Hammond S. M., Godfrey C., McClorey G., Woffindale C., Clarke K., Wells D. J., Gait M. J., Wood M. J. Journal Scientific Reports 5:11632. 30 June 2015 (2015)
  Details

  DOI10.1038/srep11632 PMID26113184 PMCIDPMC4586900 DivisionProtein & Nucleic Acid Chemistry
• Delivery of therapeutic oligonucleotides with cell penetrating peptides. AuthorsBoisguérin P., Deshayes S., Gait M. J., O'Donovan L., Godfrey C., Betts C. A., Wood M. J., Lebleu B. Journal Advanced Drug Delivery Reviews 87:52-67. 26 June 2015 (2015)
  Details

  DOI10.1016/j. Addr.2015.02.008 PMID25747758 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides. AuthorsJärver P., Zaghloul E. M., Arzumanov A. A., Saleh A. F., McClorey G., Hammond S. M., Hällbrink M., Langel Ü., Smith C. I., Wood M. J., Gait M. J., Andaloussi S. E. Journal Nucleic Acid Therapeutics 25(2):65-77. 1 April 2015 (2015)
  Details

  DOI10.1089/nat.2014.0511 PMID25594433 PMCIDPMC4376484 DivisionProtein & Nucleic Acid Chemistry
• Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice. AuthorsBetts C. A., Saleh A. F., Carr C. A., Hammond S. M., Coenen-Stass A. M., Godfrey C., McClorey G., Varela M. A., Roberts T. C., Clarke K., Gait M. J., Wood M. J. Journal Scientific Reports 5:8986. 11 March 2015 (2015)
  Details

  DOI10.1038/srep08986 PMID25758104 PMCIDPMC4355666 DivisionProtein & Nucleic Acid Chemistry
• Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy. AuthorsO'Donovan L., Okamoto I., Arzumanov A. A., Williams D. L., Deuss P., Gait M. J. Journal Nucleic Acid Therapeutics 25(1):1-10. 19 January 2015 (2015)
  Details

  DOI10.1089/nat.2014.0512 PMID25412073 PMCIDPMC4296749 DivisionProtein & Nucleic Acid Chemistry
• Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy. AuthorsShabanpoor F., McClorey G., Saleh A. F., Järver P., Wood M. J., Gait M. J. Journal Nucleic Acids Research 43(1):29-39. 1 January 2015 (2015)
  Details

  DOI10.1093/nar/gku1256 PMID25468897 PMCIDPMC4288157 DivisionProtein & Nucleic Acid Chemistry
• Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model AuthorsBestas B., Moreno P. M., Blomberg K. E., Mohammad D. K., Saleh A. F., Sutlu T., Nordin J. Z., Guterstam P., Gustafsson M. O., Kharazi S., Piątosa B., Roberts T. C., Behlke M. A., Wood M. J., Gait M. J., Lundin K. E., El Andaloussi S., Månsson R., Berglöf A., Wengel J., Smith C. I. Journal Journal of Clinical Investigation 124(9):4067-4081. 2 September 2014 (2014)
  Details

  DOI10.1172/JCI76175 PMID25105368 PMCIDPMC4151202 DivisionProtein & Nucleic Acid Chemistry
• Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells. AuthorsLehto T., Castillo Alvarez A., Gauck S., Gait M. J., Coursindel T., Wood M. J., Lebleu B., Boisguerin P. Journal Nucleic Acids Research 42(5):3207-3217. March 2014 (2014)
  Details

  DOI10.1093/nar/gkt1220 PMID24366877 PMCIDPMC3950666 DivisionProtein & Nucleic Acid Chemistry
• A chemical view of oligonucleotides for exon skipping and related drug applications AuthorsJärver P., O'Donovan L., Gait M. J. Journal Nucleic Acid Therapeutics 24(1):37-47. February 2014 (2014)
  Details

  DOI10.1089/nat.2013.0454 PMID24171481 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo AuthorsDeuss P. J., Arzumanov A. A., Williams D. L., Gait M. J. Journal Organic & Biomolecular Chemistry 11(43):7621-7630. 21 November 2013 (2013)
  Details

  DOI10.1039/c3ob41659c PMID24105028 PMCIDPMC4002126 DivisionProtein & Nucleic Acid Chemistry
• Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry AuthorsShabanpoor F., Gait M. J. Journal Chemical Communications 49(87):10260-10262. 11 November 2013 (2013)
  Details

  DOI10.1039/c3cc46067c PMID24064913) PMCIDPMC3816334 DivisionProtein & Nucleic Acid Chemistry
• Enhanced splice correction by 3', 5'-serinol and 2'-(ω-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells AuthorsKotikam V., Arzumanov A. A., Gait M. J., Kumar V. A. Journal Artificial DNA, PNA & XNA 4(3):77-83. 1 July 2013 (2013)
  Details

  DOI10.4161/adna.27279 PMID24300385 PMCIDPMC3962517 DivisionProtein & Nucleic Acid Chemistry
• Nucleic acids: new life, new materials AuthorsGait M. J., Komiyama M., Seeman N. C., Seitz O., Micklefield J., Liu D. R. Journal Organic & Biomolecular Chemistry 11(13):2058-2059. 7 April 2013 (2013)
  Details

  DOI10.1039/c3ob90017g PMID23429691 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy AuthorsMalerba A., Kang J. K., McClorey G., Saleh A. F., Popplewell L., Gait M. J., Wood M. J., Dickson G. Journal Molecular Therapy. Nucleic Acids 1:e62. December 2012 (2012)
  Details

  DOI10.1038/mtna.2012.54 PMID23250360 PMCIDPMC3528303 DivisionProtein & Nucleic Acid Chemistry
• Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse with implications for therapy AuthorsRoberts T. C., Blomberg K. E., McClorey G., El Andaloussi S., Godfrey C., Betts C., Coursindel T., Gait M. J., Smith C. I., Wood M. J. Journal Molecular Therapy. Nucleic Acids 1:e39. August 2012 (2012)
  Details

  DOI10.1038/mtna.2012.26 PMID23344181 PMCIDPMC3437806 DivisionProtein & Nucleic Acid Chemistry
• Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment AuthorsBetts C. , Saleh A. F., Arzumanov A. A., Hammond S. M., Godfrey C., Coursindel T., Gait M. J., Wood M. J. Journal Molecular Therapy. Nucleic Acids 1:e38. August 2012 (2012)
  Details

  DOI10.1038/mtna.2012.30 PMID23344180 PMCIDPMC3438601 DivisionProtein & Nucleic Acid Chemistry
• Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA AuthorsJärver P., Coursindel T., Andaloussi S. E., Godfrey C., Wood M. J., Gait M. J. Journal Molecular Therapy. Nucleic Acids 1:e27. June 2012 (2012)
  Details

  DOI10.1038/mtna.2012.18 PMID23344079 PMCIDPMC3390225 DivisionProtein & Nucleic Acid Chemistry
• Exploiting cell surface thiols to enhance cellular uptake AuthorsTorres A. G., Gait M. J. Journal Trends in Biotechnology 30(4):185-190. April 2012 (2012)
  Details

  DOI10.1016/j.tibtech.2011.12.002 PMID22260747 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Peptide-based in vivo delivery agents for oligonucleotides and siRNA AuthorsCoursindel T., Järver P., Gait M. J. Journal Nucleic Acid Therapeutics 22(2):71-76. April 2012 (2012)
  Details

  DOI10.1089/nat.2012.0341 PMID22409235 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti‑miRs AuthorsTorres A. G., Fabani M. M., Vigorito E., Williams D., Al-Obaidi N., Wojciechowski F., Hudson R. H., Seitz O., Gait M. J. Journal Nucleic Acids Research 40(5):2152-2167. March 2012 (2012)
  Details

  DOI10.1093/nar/gkr885 PMID22070883 PMCIDPMC3300011 DivisionProtein & Nucleic Acid Chemistry
• Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2'-O-methyl oligoribonucleotides AuthorsThrelfall R. N., Torres A. G., Krivenko A., Gait M. J., Caruthers M. H. Journal Organic & Biomolecular Chemistry 10(4):746-754. 28 January 2012 (2012)
  Details

  DOI10.1039/c1ob06614e PMID22124653 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Overview of alternative oligonucleotide chemistries for exon skipping AuthorsSaleh A. F., Arzumanov A. A., Gait M. J. Journal Methods in Molecular Biology 867:365-378. 1 January 2012 (2012)
  Details

  DOI10.1007/978-1-61779-767-5_23 PMID22454073 PMCID  DivisionProtein & Nucleic Acid Chemistry
• PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation AuthorsEzzat K., El Andaloussi S., Zaghloul E. M., Lehto T., Lindberg S., Moreno P. M., Viola J. R., Magdy T., Abdo R., Guterstam P., Sillard R., Hammond S. M., Wood M. J., Arzumanov A. A., Gait M. J., Smith C. I., Hällbrink M., Langel U. Journal Nucleic Acids Research 39(12):5284-5298. July 2011 (2011)
  Details

  DOI10.1093/nar/gkr072 PMID21345932 PMCIDPMC3130259 DivisionProtein & Nucleic Acid Chemistry
• Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents AuthorsTorres A. G., Threlfall R. N., Gait M. J. Journal Artificial DNA, PNA & XNA 2(3):71-78. 1 July 2011 (2011)
  Details

  DOI10.4161/adna.17731 PMID22567190 PMCIDPMC3324337 DivisionProtein & Nucleic Acid Chemistry
• Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice AuthorsYin H., Saleh A. F., Betts C., Camelliti P., Seow Y., Ashraf S., Arzumanov A., Hammond S., Merritt T., Gait M. J., Wood M. J. Journal Molecular Therapy : the Journal of the American Society of Gene Therapy 19(7):1295-1303. July 2011 (2011)
  Details

  DOI10.1038/mt.2011.79 PMID21505427 PMCIDPMC3128823 DivisionProtein & Nucleic Acid Chemistry
• MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection AuthorsTorres A. G., Fabani M. M., Vigorito E., Gait M. J. Journal RNA 17(5):933-943. May 2011 (2011)
  Details

  DOI10.1261/rna.2533811 PMID21441346 PMCIDPMC3078742 DivisionProtein & Nucleic Acid Chemistry
• Diaphragm rescue alone prevents heart dysfunction in dystrophic mice AuthorsCrisp A., Yin H., Goyenvalle A., Betts C., Moulton H. M., Seow Y., Babbs A., Merritt T., Saleh A. F., Gait M. J., Stuckey D. J., Clarke K., Davies K. E., Wood M. J. Journal Human Molecular Genetics 20(3):413-21. 1 February 2011 (2011)
  Details

  DOI10.1093/hmg/ddq477 PMID21062902 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis and splice-redirecting activity of branched, arginine-rich peptide dendrimer conjugates of peptide nucleic acid oligonucleotides AuthorsSaleh A. F., Arzumanov A., Abes R., Owen D., Lebleu B., Gait M. J. Journal Bioconjugate Chemistry 21(10):1902-1911. 20 October 2010 (2010)
  Details

  DOI10.1021/bc100275r PMID20879728 PMCIDPMC2963316 DivisionProtein & Nucleic Acid Chemistry
• Efficient inhibition of miR-155 function in vivo by peptide nucleic acids AuthorsFabani M. M., Abreu-Goodger C., Williams D., Lyons P. A., Torres A. G., Smith K. G., Enright A. J., Gait M. J., Vigorito E. Journal Nucleic Acids Research 38(13):4466-4475. August 2010 (2010)
  Details

  DOI10.1093/nar/gkq160 PMID20223773 PMCIDPMC2910044 DivisionProtein & Nucleic Acid Chemistry
• Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse AuthorsYin H., Betts C., Saleh A. F., Ivanova G. D., Lee H., Seow Y., Kim D., Gait M. J., Wood M. J. Journal Molecular Therapy 18(4):819-827. April 2010 (2010)
  Details

  DOI10.1038/mt.2009.310 PMID20068555 PMCIDPMC2848838 DivisionProtein & Nucleic Acid Chemistry
• In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy AuthorsWang Q., Yin H., Camelliti P., Betts C., Moulton H., Lee H., Saleh A. F., Gait M. J., Wood M. J. Journal Journal of Gene Medicine 12(4):354-364. 1 April 2010 (2010)
  Details

  DOI10.1002/jgm.1446 PMID20235089 PMCID  DivisionProtein & Nucleic Acid Chemistry
• RNA-targeted splice-correction therapy for neuromuscular disease AuthorsWood M. J., Gait M. J., Yin H. Journal Brain 133(4):957-972. 1 April 2010 (2010)
  Details

  DOI10.1093/brain/awq002 PMID20150322 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cell penetrating peptides: overview and applications to the delivery of oligonucleotides AuthorsHassane F. S., Saleh A. F., Abes R., Gait, M. J., Lebleu B. Journal Cellular and Molecular Life Sciences 67(5):715-726. March 2010 (2010)
  Details

  DOI10.1007/s00018-009-0186-0 PMID19898741 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide AuthorsAnke Detzer, Marita Overhoff, Winfried Wünsche, Maria Rompf, John J. Turner, Gabriela D. Ivanova, Michael J. Gait, Georg Sczakiel Journal RNA 15(4):627-636 (2009) (2009)
  Details

  DOI10.1261/rna.1305209 PMID19228587 PMCIDPMC2661840 DivisionProtein & Nucleic Acid Chemistry
• Peptide-Based Delivery of Steric-Block PNA Oligonucleotides AuthorsSaid Abes, Gabriela D. Ivanova, Rachida Abes, Andrey A. Arzumanov, Donna Williams, David Owen, Bernard Lebleu, Michael J. Gait Journal Methods in Molecular Biology 480: 85-99 (2009)
  Details

  DOI10.1007/978-1-59745-429-2_6 PMID19085117 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Tackling antibiotic resistance: a dose of common antisense? (Editorial) AuthorsNeil Woodford, David W. Wareham, Ian Chopra, Matthew Ellington, Virve I. Enne, Heather Fairhead, William Fraser, Michael J. Gait, Peter A. Lambert, David M. Livermore, Alex J. O'Neill, Thamarai Schneiders, Davis E. Yakubu Journal Journal of Antimicrobial Chemotherapy 63(2): 225-229 (2009) (2009)
  Details

  DOI10.1093/jac/dkn467 PMID19004840 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A peptide-based dendrimer that enhances the splice-redirecting activity of PNA conjugates in cells AuthorsFatouma Said Hassane, Gabriela D. Ivanova, Eleonora Bolewska-Pedyczak, Rachida Abes, Andrey A. Arzumanov, Michael J. Gait, Bernard Lebleu, Jean Garipy Journal Bioconjugate Chemistry 20(8):1523-1530 (2009) (2009)
  Details

  DOI10.1021/bc900075p PMID19591462 PMCID  DivisionProtein & Nucleic Acid Chemistry
• miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates AuthorsFabani M. M., Gait M. J. Journal RNA 14(2):336-346 (2008)
  Details

  DOI10.1261/rna.844108 PMID18073344 PMCIDPMC2212241 DivisionProtein & Nucleic Acid Chemistry
• RNA targeting in cells by peptide conjugates of peptide nucleic acids (PNA) AuthorsG. D. Ivanova, A. A. Arzumanov, J. J. Turner, M. M. Fabani, R. Abes, B. Lebleu, M. J. Gait Journal Collection Symposium Series 10: 103-111 (2008)
  Details

  DOI  PMID  PMCID  Division 
• PNA-peptide conjugates as intracellular gene control agents AuthorsGabriela D. Ivanova, Martin M. Fabani, Andrey A. Arzumanov, Rachida Abes, Haifang Yin, Bernard Lebleu, Matthew Wood, Michael J. Gait Journal Nucleic Acids Symposium Series 52: 31-32 (2008)
  Details

  DOI  PMID18776238 PMCID  Division 
• Steric block high affinity oligonucleotide analogues: A new tool for mapping RNA-protein binding sites AuthorsDouglas Brown, Emily Joy, Jane Greatorex, Michael J. Gait, Andrew M. L. Lever Journal Nucleosides, Nucleotides and Nucleic Acids 27 (2): 196-212 (2008)
  Details

  DOI  PMID18205073 PMCID  Division 
• Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides AuthorsR. Abes, A. Arzumanov, H. Moulton, S. Abes, G. Ivanova, M. J. Gait, P. Iversen, B. Lebleu Journal Journal of Peptide Science 14 (4): 455-460 (2008)
  Details

  DOI  PMID18236382 PMCID  Division 
• Delivery of antisens oligonucleotides by arginine-rich cell penetrating peptides: design, structure-activity and applications to alter pre‑mRNA AuthorsR. Abes, H. Moulton, A. Arzumanov, S. Abes, H. Yin, G. Ivanova, F, Hassane, P. Clair, M. Wood, M. J. Gait, B. Lebleu Journal Bulletin du Cancer 95 (Sp iss): S55-S55 (2008)
  Details

  DOI  PMID  PMCID  Division 
• Peptide-Peptide Nucleic Acid Conjugates for Modulation of Gene Expression AuthorsMartin M. Fabani, Gabriela D. Ivanova, Michael J. Gait Journal In: Therapeutic Oligonucleotides (J Kurreck, ed), RSC Publishing Chapter 4: 80-102 (2008)
  Details

  DOI  PMID  PMCID  Division 
• Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle AuthorsGabriela D. Ivanova, Andrey Arzumanov, Rachida Abes, Haifang Yin, Matthew J. A. Wood, Bernard Lebleu, Michael J. Gait Journal Nucleic Acids Research 36(20): 6418-6428 (2008) (2008)
  Details

  DOI  PMID18842625 PMCID  Division 
• Cell penetrating peptide conjugates of steric block oligonucleotides AuthorsBernard Lebleu, Hong M. Moulton, Rachida Abes, Gabriela D. Ivanova, Said Abes, David A. Stein, Patrick L. Iversen, Andrey A. Arzumanov, Michael J. Gait Journal Advanced Drug Delivery Reviews 60 (4-5): 517-529 (2008)
  Details

  DOI  PMID18037527 PMCID  Division 
• Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides AuthorsSarah Resina, Said Abes, John J. Turner, Paul Prevot, Adrian Travo, Philippe Clair, Michael J. Gait, Alain R. Thierry, Bernard Lebleu Journal International Journal of Pharmaceutics 344(1 & 2): 96-102. 1 November 2007 (2007)
  Details

  DOI10.1016/j.ijpharm.2007.04.039 PMID17600642 PMCID  Division 
• Peptide conjugates of oligonucleotide analogs and siRNA for gene expression modulation AuthorsJohn J. Turner, Andrey A. Arzumanov, Gabriela Ivanova, Martin Fabani, Michael J. Gait. Journal Handbook of Cell-Penetrating Peptides, 2nd (Ed: Ulo Langel), CRC Press. 313-328 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity AuthorsJohn J. Turner, Simon W. Jones, Sterghios A. Moschos, Mark A. Lindsay, Michael J. Gait Journal Molecular BioSystems 3(1): 43-50 (2007) (2007)
  Details

  DOI10.1039/b611612d PMID17216055 PMCIDPMC2682774 DivisionProtein & Nucleic Acid Chemistry
• RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA AuthorsJohn J. Turner, Simon Jones, Martin M. Fabani, Gabriela Ivanova, Andrey A. Arzumanov, Michael J. Gait Journal Blood Cells, Molecules and Disease 38(1): 1 - 7. January - February 2007 (2007)
  Details

  DOI10.1016/j. Bcmd.2006.10.003 PMID17113327 PMCID  Division 
• Peptide-based delivery of nucleic acids : design, mechanism of uptake and applications to splice-correcting oligonucleotides AuthorsS. Abes, H. Moulton, J. Turner, P. Clair, J. P. Richard, P. Iversen, M. J. Gait, B. Lebleu Journal Biochemical Society Transactions 35(1): 53-55 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity AuthorsGabriela Ivanova, Sandrine Reigadas, Damian Ittig, Andrey Arzumanov, Marie-Line Andreola, Christian Leumann, Jean-Jacques Toulme, Michael J. Gait Journal Oligonucleotides 17(1): 54-65 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Chemical modifications to improve the cellular uptake of oligonucleotides AuthorsFrancoise Debart, Said Abes, Gaelle Deglane, Hong M. Moulton, Philippe Clair, Michael J. Gait, Jean-Jacques Vasseur, Bernard Lebleu Journal Current Topics in Medicinal Chemistry 7(7): 727-737 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Cell-penetrating-peptide-based delivery of oligonucleotides: an overview AuthorsR. Abes, A. A. Arzumanov, H. M. Moulton, S. Abes, G. D. Ivanova, P. L. Iversen, M. J. Gait, B. Lebleu Journal Biochemical Society Transactions 35(4): 775-779 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Systematic screening of LNA/2'-0-methyl chimeric derivatives of a TAR RNA aptamer AuthorsCarmelo Di Primo, Ivo Rudloff, Sandrine Reigadas, Andrey A. Arzumanov, Michael J. Gait, Jean-Jacques Toulme Journal FEBS Letters 581(4): 771-774 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide AuthorsSaid Abes, John J. Turner, Gabriela D. Ivanova, David Owen, Donna Williams, Andrey Arzumanov, Philippe Clair, Michael J. Gait, Bernard Lebleu Journal Nucleic Acids Research 35(13): 4495-4502 (2007) (2007)
  Details

  DOI  PMID  PMCID1934994 Division 
• Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity AuthorsSterghios Athanasios Moschos, Simon Wyn Jones, Mark Michael Perry, Andrew Evan Williams, Jonas Sten Erjefalt, John James Turner, Peter John Barnes, Brian Stephen Sproat, Michael John Gait, Mark Andrew Lindsay Journal Bioconjugate Chemistry 18(5): 1450-1459 (2007) (2007)
  Details

  DOI  PMID  PMCID2621305 Division 
• Synthesis of oligo-2'-0-methylribonucleotides containing [alpha]-amino acid residues in 2'-position AuthorsE. V. Kazanova, E. M. Zubin, A. V. Kachalova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya Journal Russian Chemical Bulletin, International Edition 56 : 806-814 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Comparative studies of tricyclo-DNA and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression AuthorsG. Ivanova, A. Arzumanov, M. J. Gait, S. Reigadas, J.-J. Toulme, M.-L. Andreola, D. Ittig, C. Leumann Journal Nucleosides, Nucleotides and Nucleic Acids 26(6 & 7): 747-750 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Preparation of 2'-hydrazino oligonucleotides and their reaction with aldehydes and 1,3‑diketones AuthorsT. S. Zatsepin, T. S. Oretskaya, M. J. Gait, D. A. Stetsenko. Journal Nucleosides, Nucleotides and Nucleic Acids 26(6 & 7) : 795-798 (2007) (2007)
  Details

  DOI  PMID  PMCID  Division 
• Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates AuthorsAbes S., Williams D., Prevot P., Thierry A.,Gait M. J., Lebleu B. Journal Journal of Controlled Release 110(3):595-604. 21 February 2006 (2006)
  Details

  DOI10.1016/j.jconrel.2005.10.026 PMID16377019 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Inhibition of HIV-1 replication by oligonucleotide analogues directed to the packaging signal and trans-activating response region AuthorsDouglas E. Brown, Andrey Arzumanov, Sana Syed, Michael J. Gait, Andrew M. Lever Journal Antiviral Chemistry and Chemotherapy 17 : 1-9 (2006) (2006 )
  Details

  DOI  PMID  PMCID  Division 
• Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA : chemistry and cell delivery AuthorsJohn J. Turner, Martin Fabani, Andrey A. Arzumanov, Gabriela Ivanova, Michael J. Gait Journal Biochimica et Biophysica Acta 1758 : 290-300 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides AuthorsNatalia N. Dioubankova, Andrei D. Malakhov, Dmitry A. Stetsenko, Michael J. Gait, Vladimar A. Korshun Journal Tetrahedron 62 : 6762-6773 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis of 2'-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3‑diketones AuthorsTimofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya, Dmitry A. Stetsenko Journal Tetrahedron Letters 47 : 5515-5518 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Anti-HIV activity of steric block oligonucleotides AuthorsGabriela Ivanova, Andrey A. Arzumanov, John J. Turner, Sandrine Reigadas, Jean-Jacques Toulme, Douglas E. Brown, Andrew M. L. Lever, Michael J. Gait Journal Ann. N. Y. Acad. Sci 1082 : 103-115 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Oligonucleotide analogs as antiviral agents AuthorsMartin M. Fabani, John J. Turner, Michael J. Gait Journal Current Opinion in Molecular Therapeutics 8: 108-114 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Disulfide conjugation of peptides to oligonucleotides and their analogs AuthorsJohn J. Turner, Donna Williams, David Owen, Michael J. Gait Journal Current Protocols in Nucleic Acid Chemistry Supplement 24: 4.28.1-4.28.21 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Peptide conjugates of oligonucleotide analogs and siRNA for gene expression modulation AuthorsJohn J. Turner, Andrey A. Arzumanov, Gabriela Ivanova, Martin Fabani, Michael J. Gait Journal Handbook of Cell-Penetrating Peptides, 2nd ed (Ed: Ulo Langel), CRC Press pp.313-328 (2006) (2006)
  Details

  DOI  PMID  PMCID  Division 
• Syntheses and oligonucleotide incorporation of nucleoside analogues containing pendant imidazolyl or amino functionalities - the search for sequence-specific artificial ribonucleases AuthorsHolmes S. C., Gait M. J. Journal European Journal of Organic Chemistry 24 : 5171-5183. December 2005 (2005)
  Details

  DOI10.1002/ejoc.200500413 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Chemical methods for peptide-oligonucleotide conjugate synthesis AuthorsStetsenko D. A., Gait M. J. Journal Methods in Molecular Biology (Oligonucleotide Synthesis: Methods and Applications, Edited by P. Herdewijn) 288: 205-224. January 2005 (2005)
  Details

  DOI10.1385/1-59259-823-4:205 PMID15333905 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis of DNA conjugates by solid-phase fragment condensation via aldehyde-nucleophile coupling AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya Journal Tetrahedron Letters 46: 3191-3195 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Use of carbonyl group addition-elimination reactions for synthesis of nucleic acid conjugates AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya Journal Bioconjugate Chemistry 16 : 471-489 (2005) (2005 )
  Details

  DOI  PMID  PMCID  Division 
• Oligonucleotides containing 2'-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2'-aldehyde oligonucleotides for chemoselective ligation AuthorsEugeny M. Zubin, Dmitry A. Stetsenko, Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya Journal Bioorganic and Medicinal Chemistry 13 : 4912-4920 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis and properties of oligodeoxyribonucleotides containing 2'-0-(2,3-dihydroxypropyl)-and 2'-0-(2-oxoethyl)arabinouridine residues AuthorsT. S. Zatsepin, Yu. M. Ivanova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya Journal Russian Chemical Bulletin, International Edition 54 : 238-246 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification AuthorsMing Jiang, Andrey A. A. Arzumanov, Michael J. Gait, Jo Milner Journal Nucleic Acids Research 33 : e151 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Inhibition of HIV-1 TAT-dependent trans-activation by steric block oligonucleotide analogues containing amino modifications AuthorsIvanova G. D., Arzumanov A. A., Babu B. R., Karla N., Sweedler D.,Beigelman L., Wengel J., Gait M. J. Journal Collection Symposium Series 7:367-371 (2005) (2005)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA AuthorsGaelle Kolb, Sandrine Reigadas, Claudine Boiziau, Arthur van Aerschot, Andrey Arzumanov, Michael J. Gait, Piet Herdewijn, Jean-Jacques Toulme Journal Biochemistry 44: 2926-2933 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides AuthorsJohn J Turner, Andrey A. Arzumanov, Michael J. Gait Journal Nucleic Acids Research 33: 27-42 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Antiviral activity of steric-block oligonucleotides targeting the HIV-1 trans-activation repsonse and packaging signal stem-loop RNAs AuthorsBrown D., Arzumanov A. A., Turner J. J., Stetsenko D. A., Lever A. M. L., Gait M. J. Journal Nucleosides, Nucleotides, and Nucleic Acids 24(5-7):393-396. January 2005 (2005)
  Details

  DOI10.1081/ncn‑200059813 PMID16247957 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Incorporation of side-chain groups of basic amino acids into oligonucleotides via the 2'-position of uridine AuthorsEugeny M. Zubin, Dmitry A. Stetsenko, Anna V. Kachalova, Michael J. Gait, Tatiana S. Oretskaya Journal Nucleic Acids Symposium Series No. 49: 347-348 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents AuthorsT. S. Zatsepin, J. J. Turner, T. S. Oretskaya, M. J. Gait Journal Current Pharmaceutical Design 11: 3639-3654 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• 2'-hydrazine oligonucleotides: synthesis and efficient conjugation with aldehydes AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya Journal Nucleic Acids Symposium Series No.49: 133-134 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells AuthorsJohn J. Turner, Gabriela D. Ivanova, Birgit Verbeure, Donna Williams, Andrey A. Arzumanov, Said Abes, Bernard Lebleu, Michael J. Gait Journal Nucleic Acids Research 33: 6837-6849 (2005) (2005)
  Details

  DOI  PMID  PMCID  Division 
• Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers AuthorsRoss M. F., Filipovska A., Smith R. A. J., Gait M. J., Murphy M. P. Journal Biochemical Journal 383(Pt. 3):457-468. November 2004 (2004)
  Details

  DOI10.1042/bj20041095 PMID15270716 PMCIDPMC1133738 DivisionProtein & Nucleic Acid Chemistry
• Targeting the A site of RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics AuthorsAbelian A., Walsh A. P., Lentzen G., Aboul-Ela F., Gait M. J. Journal Biochemical Journal 383(Pt 2):201-208 (2004) (2004)
  Details

  DOI10.1042/BJ20040246 PMID15294017 PMCIDPMC1134060 DivisionProtein & Nucleic Acid Chemistry
• Oligonucleotides with 2'-O-carboxymethyl group: synthesis and 2'-conjugation via amide bond formation on solid phase AuthorsKachalova A., Zubin E., Stetsenko D., Gait M. J., Oretskaya T. Journal Org. Biomol. Chem. 2(19):2793-2797 (2004) (2004)
  Details

  DOI10.1039/b409496d PMID15455151 PMCIDPMC1388261 DivisionProtein & Nucleic Acid Chemistry
• Efficient conjugation and preferential DNA binding of oligonucleotides containing 2'-O-(2-oxoethyl)arabinouridine AuthorsZatsepin T. S., Ivanova Y. M., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Tetrahedron Letters 45(39): 7327-7330. 20 September 2004 (2004)
  Details

  DOI10.1016/j.tetlet.2004.08.006 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• 2'-functionalized nucleic acids as structural tools in molecular biology AuthorsZatsepin T. S., Gait M. J., Oretskaya T. S. Journal IUBMB Life 56(4):209-214. April 2004 (2004)
  Details

  DOI10.1080/15216540410001710570 PMID15230348 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis of oligonucleotide 2'-conjugates via amide bond formation in solution AuthorsKachalova A. V., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Bioorganic & Medicinal Chemistry Letters 14(3):801-804 (2004) (2004)
  Details

  DOI10.1016/j. Bmcl.2003.10.069 PMID14741293 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A new solid support for synthesis of oligonucleotide 3'-carbazates - useful intermediates for chemoselective ligation AuthorsDmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait Journal Innovation and Perspectives in Solid Phase Synthesis and Combinational Libraries. (Edited by R. Epton) pp.297-300 (2004) (2004)
  Details

  DOI  PMID  PMCID  Division 
• Chemoselective ligation of oligonucleotides modified with reactive groups AuthorsAnna V. Kachalova, Eugeny M. Zubin, Timofei S. Zatsepin, Yulia V. Agapkina, Yulia M. Ivanova, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya Journal Innovation and Perspectives in Solid Phase Synthesis and Combinational Libraries. (Edited by R. Epton) pp.255-260 (2004) (2004)
  Details

  DOI  PMID  PMCID  Division 
• Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues AuthorsMichael J. Gait Journal CMLS Cellular and Molecular Life Sciences 60: 844-853 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Steric inhibition of human immunodeficiency virus type-1 Tat-dependent trans-activation in vitro and in cells by oligonucleotides containing 2'-O-methyl G-clamp ribonucleoside analogues AuthorsStephen C. Holmes, Andrey A. Arzumanov, Michael J. Gait Journal Nucleic Acids Research 31: 2759-2768 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis of peptide and reporter conjugates of oligonucleotide analogues AuthorsDmitri A. Stetsenko, Donna Williams, David Owen, Michael J. Gait Journal Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Peptides, Proteins and Nucleic Acids. Small Molecule Organic Chemical Diversity. (Collected Papers Seventh International Symposium 2002) [Editor: Roger Epton], Mayflower Worldwide Limited pp.5-8 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• LNA and alpha-L-LNA: towards therapeutic applications AuthorsJesper Wengel, Birte Vester, Lars Bo Lundberg, Stephen Douthwaite, Mads D. Sorensen, B. Ravindra Babu, Michael J. Gait, Andrey Arzumanov, Michael Petersen, Jakob T. Nielsen Journal Nucleosides, Nucleotides & Nucleic Acids 22: 601-604 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• The synthesis of 2'-O-methyl G-clamp containing oligonucleotides and their inhibition of the HIV-1 Tat-TAR interaction AuthorsStephen C. Holmes, Michael J. Gait Journal Nucleosides, Nucleotides & Nucleic Acids 22: 1259-1262 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• 1,2-diol and hydrazide phosphoramidites for solid-phase synthesis and chemoselective ligation of 2'-modified oligonucleotides AuthorsEugeny M. Zubin, Dmitry A. Stetsenko, Tatiana S. Oretskaya, Michael J. Gait Journal Nucleosides, Nucleotides & Nucleic Acids 22: 1375-1378 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Total stepwise solid-phase peptide-oligonucleotide conjugate synthesis on macroporous polystyrene AuthorsDmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait Journal Nucleosides, Nucleotides & Nucleic Acids 22: 1379-1382 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis of 2'-modified oligonucleotides containing aldehyde or ethylenediamine groups AuthorsT. S. Zatsepin, E. A. Romanova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya Journal Nucleosides, Nucleotides & Nucleic Acids 22: 1383-1385 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Uridine 2'-carbamates: facile tools for oligonucleotide 2'-functionalization AuthorsVladimir A. Korshun, Dmitry A. Stetsenko, Michael J. Gait Journal Current Protocols in Nucleic Acid Chemistry Suppl 15: 4.21.1-4.21.26 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Pyrenemethyl ara-uridine-2'-carbamate: a strong interstrand excimer in the major groove of a DNA duplex AuthorsNatalia N. Dioubankova, Andrei D. Malakhov, Dmitry A. Stetsenko, Michael J. Gait, Pavel E. Volynsky, Roman G. Efremov, Vladimir A. Korshun Journal ChemBioChem 4: 841-847 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues AuthorsAndrey Arzumanov, Dmitry A. Stetsenko, Andrey D. Malakhov, Stefanie Reichelt, Mads D. Sorensen, B. Ravindra Babu, Jesper Wengel, Michael J. Gait Journal Oligonucleotides 13: 435-453 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Solid phase synthesis and chromatographic characteristics of nucleophilic agents conjugated with oligonucleotides containing 5'-terminal carboxyl group AuthorsA. V. Kachalova, V. N. Tashlitsky, D. A. Stetsenko, E. A. Romanova, M. J. Gait, T. S. Oretskaya Journal Russian Journal of Bioorganic Chemistry 29: 274-280 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake AuthorsJean Philippe Richard, Kamran Melikov, Eric Vives, Corinne Ramos, Birgit Verbeure, Mike J. Gait, Leonid V. Chernomordik, Bernard Lebleu Journal Journal of Biological Chemistry 278: 585-590 (2003) (2003)
  Details

  DOI  PMID  PMCID  Division 
• 2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription AuthorsDarfeuille F., Arzumanov A., Gait M. J., Di Primo C., Toulme J-J. Journal Biochemistry 41(40):12186-12192 (2002) (2002)
  Details

  DOI10.1021/bi025974d PMID12356320 PMCID  Division 
• Novel uridin-2'-yl carbamates: synthesis, incorporation into oligodeoxyribonucleotides, and remarkable fluorescence properties of 2'-pyren-1‑ylmethylcarbamate AuthorsKorshun V. A., Stetsenko D. A., Gait M. J. Journal J. Chem. Soc., Perkin Trans 1 pp.1092-1104 (2002) (2002)
  Details

  DOI10.1039/B111434B PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• (R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides AuthorsNatalia N. Dioubankova, Andrey D. Malakhov, Dmitry A. Stetsenko, Vladimir A. Korshun, Michael J. Gait Journal Organic Letters 4: 4607-4610 (2002) (2002)
  Details

  DOI  PMID  PMCID  Division 
• A new and efficient method for synthesis of 5'-conjugates of oligonucleotides through amide-bond formation on solid phase AuthorsAnna V. Kachalova, Dmitry A. Stetsenko, Elena A. Romanova, Vadim N. Tashlitsky, Michael J. Gait, Tatiana S. Oretskaya Journal Helvetica Chimica Acta 85: 2409-2416 (2002) (2002)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2'-aldehydes through thiazolidine, oxime, and hydrazine linkages AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Andrey A. Arzumanov, Elena A. Romanova, Michael J. Gait, Tatiana S. Oretskaya Journal Bioconjugate Chemistry 13: 822-830 (2002) (2002)
  Details

  DOI  PMID  PMCID  Division 
• Total stepwise solid-phase synthesis of oligonucleoitde-(3'-->N)-peptide AuthorsDmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait Journal Organic Letters 4: 3259-3262 (2002) (2002)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis of 2'-modified oligonucleotides and their conjugates AuthorsTatiana S. Oretskaya, Timofei S. Zatsepin, Evgeny M. Zubin, Anna V. Kachalova, Elena A. Romanova, Dmitry A. Stetsenko, Michael J. Gait Journal Collection Symposium Series 5: 145-149 (2002) (2002)
  Details

  DOI  PMID  PMCID  Division 
• Loop-loop interaction of HIV-1 TAR RNA with N3' --> P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription AuthorsFabien Darfeuille, Andrey Arzumanov, Sergei Gryaznov, Michael J. Gait, Carmelo Di Primo, Jean-Jacques Toulme Journal Proceedings of the National Academy of Sciences, USA 99: 9709-9714 (2002) (2002)
  Details

  DOI  PMID  PMCID  Division 
• Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration AuthorsStolze K., Holmes S. C., Earnshaw D. J., Singh M., Stetsenko D.,Williams D., Gait M. J. Journal Bioorganic & Medicinal Chemistry Letters 11(23):3007-3010 (2001) (2001)
  Details

  DOI10.1016/S0960-894X(01)00608-4 PMID11714598 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A convenient solid-phase method for synthesis of 3'-conjugates of oligonucleotides AuthorsStetsenko D. A., Gait M. J. Journal Bioconjugate Chemistry 12(4):576-586 (2001) (2001)
  Details

  DOI10.1021/bc000157g PMID11459463 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A new 'native ligation' procedure for peptide-oligonucleotide conjugation AuthorsStetsenko D. A., Gait M. J. Journal Nucleosides, Nucleotides & Nucleic Acids 20(4-7):801-804 (2001) (2001)
  Details

  DOI10.1081/NCN‑100002433 PMID11563119 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction AuthorsArzumanov A., Walsh A. P., Liu X., Rajwanshi V. K., Wengel J., Gait M. J. Journal Nucleosides, Nucleotides & Nucleic Acids 20(4-7):471-480 (2001) (2001)
  Details

  DOI10.1081/NCN‑100002321 PMID11563062 PMCID  DivisionProtein & Nucleic Acid Chemistry
• ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities AuthorsDan Grisaru, Varda Deutsch, Michael Shapira, Marjorie Pick, Meira Sternfeld, Naomi Melamed-Book, Daniela Kaufer, Nilly Galyam, Michael J. Gait, David Owen, Joseph B. Lessing, Amiram Eldor, Hermona Soreq Journal Molecular Medicine 7(2):93-105 (2001) (2001)
  Details

  DOI10.1007/BF03401943 PMID11471550 PMCIDPMC1950016 DivisionProtein & Nucleic Acid Chemistry
• Aminoglycosides and cleavage of the hairpin ribozyme AuthorsEarnshaw D. J., Gait M. J. Journal RNA-binding antibiotics. Edited by Renee Schroeder and Mary G Wallis pp.35-55 (2001) (2001)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis and properties of modified oligodeoxyribonucleotides containing 2'-0-(2,3-dihydroxypropyl)uridine and 2'-0-(2-oxoethyl)uridine AuthorsZatsepin T. S., Kachalova A. V., Romanova E. A., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Russian Journal of Bioorganic Chemistry 27:39-44. January 2001 (2001)
  Details

  DOI10.1023/a:1009579002330 PMID11255642 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis of peptide-oligonucleotide conjugates: application to basic peptides AuthorsStetsenko D. A., Williams D., Gait M. J. Journal Nucleic Acids Research Supplement 1: 153-154 (2001) (2001)
  Details

  DOI  PMID12836310 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Inhibition of HIV-1 Tat-dependent Trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides AuthorsArzumanov A., Walsh A. P., Rajwanshi V. K., Kumar R., Wengel J., Gait M. J. Journal Biochemistry 40(48):14645-14654 (2001) (2001)
  Details

  DOI10.1021/bi011279e PMID11724578 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Peptide conjugates of oligonucleotides as enhanced antisense agents AuthorsStetsenko D. A., Arzumanov A. A., Korshun V. A., Gait M. J. Journal Molecular Biology 34: 852-859. November 2000 (2000)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Efficient conjugation of peptides to oligonucleotides by native ligation AuthorsStetsenko D. A., Gait M. J. Journal Journal of Organic Chemistry 65(16):4900-4908 (2000) (2000)
  Details

  DOI10.1021/jo000214z PMID10956469 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Use of the fluorescent nucleoside analogue benzo[g]quinazoline 2'-O-methyl-beta-D-ribofuranoside to monitor the binding of the HIV-1 Tat protein or of antisense oligonucleotides to the TAR RNA stem‑loop AuthorsArzumanov A., Godde F., Moreau S., Toulme J-J., Weeds A., Gait M. J. Journal Helvetica Chimica Acta 83(7): 1424-1436. 5 July 2000 (2000)
  Details

  DOI10.1002/1522-2675(20000705)83:7<1424::AID-HLCA1424>3.0. CO;2-D PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides AuthorsEarnshaw D. J., Hamm M. L., Piccirilli J. A., Karpeisky A., Beigelman L., Ross B. S., Manoharan M., Gait M. J. Journal Biochemistry 39(21):6410-6421 (2000) (2000)
  Details

  DOI10.1021/bi992974d PMID10828955 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position AuthorsKachalova A. V., Zatsepin T. S., Romanova E. A., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Nucleosides, Nucleotides and Nucleic Acids 19(10-12):1693-1707 (2000) (2000)
  Details

  DOI10.1080/15257770008045453 PMID11200266 PMCID  DivisionProtein & Nucleic Acid Chemistry
• New phosphoramidite reagents for the synthesis of oligonucleotides containing a cysteine residue useful in peptide conjugation AuthorsStetsenko D. A., Gait M. J. Journal Nucleosides, Nucleotides and Nucleic Acids 19(10-12):1751-1764 (2000) (2000)
  Details

  DOI10.1080/15257770008045457 PMID11200270 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthetic hairpin ribozymes for analysis of structure, function, and ionic co‑factors AuthorsEarnshaw D. J., Gait M. J. Journal Ribozyme Biochemistry and Biotechnology. Edited by Guido Krupp and Rajesh K. Gaur pp.227-253 (2000) (2000)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthetic hairpin ribozymes for analysisof structure, function, and ionic co‑factors AuthorsEarnshaw D. J., Gait M. J. Journal Ribozyme Biochemistry and Biotechnology. Edited by Guido Krupp and Rajesh K. Gaur pp.227-253 (2000) (2000)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• The harpin ribozyme: the roles of ions in RNA cleavage AuthorsEarnshaw D. J., Gait M. J. Journal Nucleic Acids Symposium Series No.42: 273-274 (1999) (1999)
  Details

  DOI10.1093/nass/42.1.273 PMID10780485 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA AuthorsBeatrice Mestre, Andrey Arzumanov, Mohinder Singh, Florence Boulme, Simon Litvak, Michael J. Gait Journal Biochimica et Biophysica Acta (BBA) 1445(1):86-98 (1999) (1999)
  Details

  DOI10.1016/S0167-4781(99)00019‑6 PMID10209261 PMCID  Division 
• Studies towards the synthesis of peptide-oligonucleotide conjugates AuthorsPeyrottes S., Mestre B., Burlina F., Gait M. J. Journal Nucleosides & Nucleotides 18: 1443-1448 (1999) (1999)
  Details

  DOI10.1080/07328319908044748 PMID  PMCID  Division 
• Inhibition of the HIV-1 Tat protein-TAR RNA interaction by 2'-O-Methyl oligoribonucleotides AuthorsArzumanov A., Gait M. J. Journal Collection Symposium Series 2: 168-174 (1999) (1999)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Site-specific cross-linking of amino acids in the basic region of human immunodeficiency virus type 1 Tat peptide to chemically modified TAR RNA duplexes AuthorsMark A. Farrow, Fareed Aboul-ela, David Owen, Alexander Karpeisky, Leonid Beigelman, Michael J. Gait Journal Biochemistry 37: 3096-3108 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Applications of chemically synthesized RNA AuthorsMichael J. Gait, David J. Earnshaw, Mark A. Farrow, Jan H. Fogg, Richard L. Grenfell, Nikolai A. Naryshkin, Terence V. Smith Journal Applications of Chemically Sunthesized RNA (Book) pp.1-36 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Incorporation of modified nucleotides into RNA for studies on RNA structure, function and intermolecular interactions AuthorsRobert A. Zimmermann, Michael J. Gait, Melissa J. Moore Journal Modification and Editing of RNA . Edited by Henri Grosjean and Rob Benne pp.59-84 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions AuthorsDavid J. Earnshaw, Michael J. Gait Journal Nucleic Acids Research 26: 5551-5561 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Modified oligoribonucleotides as site-specific probes of RNA structure and function AuthorsDavid J. Earnshaw, Michael J. Gait Journal Biopolymers (Nucleic Acid Sciences) 48: 39-55 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• The synthesis of peptide-oligonucleotide conjugates by a fragment coupling approach AuthorsSuzanne Peyrottes, Beatrice Mestre, Fabienne Burlina, Michael J. Gait Journal Tetrahedron 54: 12513-12522 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• Covalent RNA-peptide binding in a specific complex using oligoribonucleotide N-hydroxybenzotriazole esters AuthorsE. A. Taran, M. G. Ivanovskaya, M. J. Gait, Z. A. Shabarova Journal Molecular Biology 32: 697-703 (1998) (1998)
  Details

  DOI  PMID  PMCID  Division 
• RNA recognition and regulation of HIV-1 gene expression by viral factor Tat AuthorsNaryshkin N. A., Gait M. J., Ivanovskaya M. G. Journal Biochemistry Moscow 63(5):489-503 (1998) (1998)
  Details

  DOI  PMID9632883 PMCID  Division 
• Chemical cross-linking of the human immunodeficiency virus type 1 Tat protein to synthetic models of the RNA recognition sequence TAR containing site-specific trisubstituted pyrophosphate analogues AuthorsNikolai A. Naryshkin, Mark A. Farrow, Marina G. Ivanovskaya, Tanya S. Oretskaya, Zoe A. Shabarova, Michael J. Gait Journal Biochemistry 36: 3496-3505 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Solid phase synthesis of oligoribonucleotides containing site-specific modifications AuthorsSabine Schmidt, Richard L. Grenfell, Jan Fogg, Terry V. Smith, Jane A. Grasby, Karin Mersmann, Michael J. Gait Journal Innovations and Perspectives in Solid Phase Synthesis and Combinatorial Libraries. Edited by R. Epton pp.11-18 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Inter-domain cross-linking and molecular modelling of the hairpin ribozyme AuthorsDavid J. Earnshaw, Benoit Masquida, Sabine Muller, Snorri Th. Sigurdsson, Fritz Eckstein, Eric Westhof, Michael J. Gait Journal Journal of Molecular Biology 274: 197-212 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Progress toward the structure and therapeutic use of the hairpin ribozyme AuthorsDavid J. Earnshaw, Michael J. Gait Journal Antisense & Nucleic Acid Drug Development 7: 403-411 (1997) (1997)
  Details

  DOI  PMID  PMCID  Division 
• Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex AuthorsKeen N. J., Gait M. J., Karn J. Journal Proceedings of the National Academy of Sciences, USA 93(6):2505-2510. 19 March 1996 (1996)
  Details

  DOI10.1073/pnas.93.6.2505 PMID8637904 PMCIDPMC39827 DivisionProtein & Nucleic Acid Chemistry
• Control of transcriptional elongation by the human immunodeficiency virus Tat protein AuthorsJonathan Karn, Mark J. Churcher, Karola Rittner, Nicholas J. Keen, Michael J. Gait Journal Eukaryotic Gene Transcription. Edited by Stephen Goodbourn pp.254-286 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs AuthorsIvan Mikaelian, Marion Krieg, Michael J. Gait, Jonathan Karn Journal Journal of Molecular Biology 257: 246-264 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure AuthorsSabine Schmidt, Leonid Beigelman, Alexander Karpeisky, Nassim Usman, Ulrik S. Sorensen, Michael J. Gait Journal Nucleic Acids Research 24: 573-581 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis and properties of mixed ribo- and deoxyribooligonucleotide duplexes containing an internucleotide trisubstituted pyrophosphate bond AuthorsN. A. Naryshkin, M. G. Ivanovskaya, T. S. Oretskaya, E. M. Volkov, M. J. Gait, Z. A. Shabarova Journal Russian Journal of Bioorganic Chemistry 22: 592-598 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Probing the tertiary structure of the hairpin ribozyme by chemical crosslinking AuthorsSabine Schmidt, David J. Earnshaw, Snorri Th. Sigurdsson, Fritz Eckstein, Michael J. Gait Journal Collect. Czech. Chem. Commun. 61: S276-S279 (1996) (1996)
  Details

  DOI  PMID  PMCID  Division 
• Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA AuthorsJane A. Grasby, Karin Mersmann, Mohinder Singh, Michael J. Gait Journal Biochemistry 34: 4068-4076 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• The human immunodeficiency virus long terminal repeat includes a specialised initiator element which is required for Tat-responsive transcription AuthorsKarola Rittner, Mark J. Churcher, Michael J. Gait, Jonathan Karn Journal Journal of Molecular Biology 248: 562-580 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• The RNA element encoded by the trans-activation-responsive region of human immunodeficiency virus type 1 is functional when displaced downstream of the start of transcription AuthorsMark J. Churcher, Anthony D. Lowe, Michael J. Gait, Jonathan Karn Journal Proceedings of the National Academy of Sciences, USA 92: 2408-2412 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Control of human immunodeficiency virus gene expression by the RNA-binding proteins tat and rev AuthorsJonathan Karn. Michael J. Gait, Mark J. Churcher, Derek A. Mann, Ivan Mikaelian, Clare Pritchard Journal RNA Protein: Interactions. Frontiers in Molecular Biology. Edited by. S Goodbourn pp.192-220 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Rapid crystallization of chemically synthesized hammerhead RNAs using a double screening procedure AuthorsWilliam G. Scott, John T. Finch, Richard Grenfell, Jan Fogg, Terry Smith, Michael J. Gait, Aaron Klug Journal Journal of Molecular Biology 250: 327-332 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Synthetic ribonucleotide analogues for RNA structure-function studies AuthorsMichael J. Gait, Jane A. Grasby, Jonathan Karn, Karin Mersmann, Clare E. Pritchard Journal Nucleosides & Nucleotides 14: 1133-1144 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis and applications of oligoribonucleotides containing N4‑methylcytidine AuthorsJane A. Grasby, Mohinder Singh, Jonathan Karn, Michael J. Gait Journal Nucleosides and Nucleotides 14: 1129-1132 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Progress in anti-HIV structure-based drug design AuthorsMichael J. Gait, Jonathan Karn Journal Trends in Biotechnology 13: 430-438 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• RNA binding assays for the regulatory proteins Tat and Rev AuthorsJ. Karn, M. J. Churcher, K. Rittner, A. Kelley, P. J. G. Butler, D. A. Mann, M. J. Gait Journal HIV: A Practical Approach. Vol. 2 Biochemistry, Molecular Biology and Drug Design. Edited by J. Karn pp.147-165 (1995) (1995)
  Details

  DOI  PMID  PMCID  Division 
• Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins AuthorsClare E. Pritchard, Jane A. Grasby, Francois Hamy, Anthony M. Zacharek, Mohinder Singh, Jonathan Karn, Michael J. Gait Journal Nucleic Acids Research 22: 2592-2600 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• A molecular rheostat. Co-operative rev binding to Stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression AuthorsDerek A. Mann, Ivan Mikaelian, Rodney W. Zemmel, Sheila M. Green, Anthony D. Lowe, Tominori Kimura, Mohinder Singh, P. Jonathan G. Butler, Michael J. Gait, Jonathan Karn Journal Journal of Molecular Biology 241: 193-207 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis AuthorsJ. A. Grasby, M. J. Gait Journal Biochimie 76: 1233-1234 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• Applications of synthetic oligoribonucleotide analogues in studies of RNA structure and function AuthorsJane A. Grasby, Clare E. Pritchard, Michael J. Gait Journal Proc. Indian Acad. Sci. (Chem. Sci.) 106: 1003-1022 (1994) (1994)
  Details

  DOI  PMID  PMCID  Division 
• 7-deazaadenosine: oligoribonucleotide building block synthesis and autocatalytic hydrolysis of base-modified hammerhead ribozymes AuthorsSeela F., Mersmann K., Grasby J. A., Gait M. J. Journal Helvetica Chimica Acta 76(5): 1809-1820. 11 August 1993 (1993)
  Details

  DOI10.1002/hlca.19930760502 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• RNA recognition by the human immuno-deficiency virus Tat and Rev proteins AuthorsGait M. J., Karn J. Journal Trends in Biochemical Sciences 18(7):255-259. July 1993 (1993)
  Details

  DOI10.1016/0968-0004(93)90176‑n PMID8212135 PMCID  DivisionProtein & Nucleic Acid Chemistry
• High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region AuthorsMark J. Churcher, Christina Lamont, Francois Hamy, Colin Dingwall, Sheila M. Green, Anthony D. Lowe, P. Jonathan G. Butler, Michael J. Gait, Jonathan Karn Journal Journal of Molecular Biology 230: 90-110 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Oligoribonucleotides AuthorsMichael J. Gait Journal Antisense Research and Applications. Edited by Stanley T. Crooke and Bernard Lebleu pp.289-301 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA AuthorsFrancois Hamy, Ulysse Asseline, Jane Grasby, Shigenori Iwai, Clare Pritchard, George Slim, P. Jonathan G. Butler, Jonathan Karn, Michael J. Gait Journal Journal of Molecular Biology 230: 111-123 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• HIV gene regulatory proteins tat and rev and their interactions wi th synthetic RNA AuthorsUlysse Asseline, Jane Grasby, Francois Hamy, Shigenori Iwai, Derek A. Mann, Clare Pritchard, Jonathan Karn, Michael J. Gait Journal Nucleic Acids Symposium Series No. 29 pp.113-114 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage AuthorsJane A. Grasby, P. Jonathan G. Butler, Michael J. Gait Journal Nucleic Acids Research 21: 4444-4450 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro AuthorsMaria A. Graeble, Mark J. Churcher, Anthony D. Lowe, Michael J. Gait, Jonathan Karn Journal Proceedings of the National Academy of Sciences, USA 90: 6184-6188 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region AuthorsMark J. Churcher, Christina Lamont, Francois Hamy, Colin Dingwall, Sheila M. Green, Anthony D. Lowe, P. Jonathan G. Butler, Michael J. Gait, Jonathan Karn Journal Journal of Molecular Biology 230: 90-110 (1993) (1993)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis and applications of oligoribonucleotides containing guanosine analogues AuthorsGrasby J. A., Pritchard C. E., Mersmann K., Seela F., Gait M. J. Journal Collect. Czech. Chem. Commun. 58 (Special Issue): 154-157 (1993) (1993)
  Details

  DOI10.1135/cccc1993s154 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• In situ hybridization with biotinylated probes AuthorsPiers C. Emson, Michael J. Gait Journal In situ Hybridization. A Practical Approach. Edited by D. G. Wilkinson pp.45-59 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage AuthorsGeorge Slim, Michael J. Gait Journal Biochemical and Biophysical Reseach Communications 183: 605-609 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein AuthorsShigenori Iwai, Clare Pritchard, Derek A. Mann, Jonathan Karn, Michael J. Gait Journal Nucleic Acids Research 20: 6465-6472 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• Recognition of the high affinity binding site in rev-response element RNA by the Human Immunodeficiency Virus type-1 rev protein AuthorsShigenori Iwai, Clare Pritchard, Derek A. Mann, Jonathan Karn, Michael J. Gait Journal Nucleic Acids Research 20: 6465-6472 (1992) (1992)
  Details

  DOI  PMID  PMCID  Division 
• DNA/RNA synthesis and labelling AuthorsMichael J. Gait Journal Current Opinion in Biotechnology 2: 61-68 (1991) (1991)
  Details

  DOI  PMID  PMCID  Division 
• Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes AuthorsGeorge Slim, Michael J. Gait Journal Nucleic Acids Research 19: 1183-1188 (1991 ) (1991)
  Details

  DOI  PMID  PMCID  Division 
• Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich 'bubble' located within the rev-responsive region of viral mRNAs AuthorsShaun Heaphy, John T. Finch, Michael J. Gait, Jonathan Karn, Mohinder Singh Journal Proceedings of the National Academy of Sciences, USA 88: 7366-7370 (1991 ) (1991)
  Details

  DOI  PMID  PMCID  Division 
• Oligoribonucleotide synthesis AuthorsGait M. J., Pritchard C., Slim G. Journal Oligoribonucleotide Synthesis and Analogues: A Practical Approach (Book) pp.25-48 (1991) (1991)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Regulation of HIV-1 gene expression by the RNA-binding proteins tat and rev AuthorsJ. Karn, C. Dingwall, M. J. Gait, S. Heaphy, M. A. Skinner Journal Nucleic Acids and Molecular Biology. Edited by F. Eckstein and D. M. J. Lilley Volume 5: 194-218 (1991) (1991)
  Details

  DOI  PMID  PMCID  Division 
• 3'/5'-regioselectivity of introduction of the 9-fluorenyl-methoxycarbonyl group to 2'-O-tetrahydropyran-2-yl- and 2'-O-(4-methoxytetrahydropyran-4-yl-)-nucleosides: useful intermediates for solid-phase-RNA‑synthesis AuthorsLehmann C., Xu Y. Z., Christodoulou C., Gait M. J., Van Meervelt L., Moore M., Kennard O. Journal Nucleosides & Nucleotides 10: 1599-1614 (1991) (1991)
  Details

  DOI10.1080/07328319108046684 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Trans-activation requires the binding of the HIV-1 tat protein to TAR RNA AuthorsDingwall C., Ernberg I., Gait M. J., Heaphy S., Karn J., Skinner M. Journal Advances in Molecular Biology and Targeted Treatment for AIDS (Edited by A. Kumar) pp.133-143 (1991) (1991)
  Details

  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure AuthorsColin Dingwall, Ingemar Ernberg, Michael J. Gait, Sheila M. Green, Shaun Heaphy, Jonathan Karn, Anthony D. Lowe, Mohinder Singh, Michael A. Skinner Journal EMBO Journal 9: 4145-4153 (1990 ) (1990)
  Details

  DOI  PMID  PMCID  Division 
• Biotinyl and phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides AuthorsKonrad Misiura, Ian Durrant, Michael R. Evans, Michael J. Gait Journal Nucleic Acids Research 18: 4345-4354 (1990) (1990)
  Details

  DOI  PMID  PMCID  Division 
• HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region AuthorsShaun Heaphy, Colin Dingwall, Ingemar Ernberg, Michael J. Gait, Sheila M. Green, Jonathan Karn, Anthony D. Lowe, Mohinder Singh, Michael A. Skinner Journal Cell 60: 685-693 (1990 ) (1990)
  Details

  DOI  PMID  PMCID  Division 
• Simultaneous visualization of vasopressin and oxytocin mRNA-containing neurons in the hypothalamus using non-radioactive in situ hybridization histochemistry AuthorsIchimiya Y., Emson P. C., Christodoulou C. Gait M. J., Ruth J. L. Journal Journal of Neuroendocrinology 1(2):73-75. April 1989 (1989)
  Details

  DOI10.1111/j.1365-2826.1989.tb00081.x PMID19210460 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5'-hydroxyl protection AuthorsChristian Lehmann, Yao-Zhong Xu, Chris Christodoulou, Zu-Kun Tan, Michael J. Gait Journal Nucleic Acids Research 17: 2379-2390 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• Solid-phase synthesis of oligoribonucleotides AuthorsYao-Zhong Xu, Christian Lehmann, George Slim, Chris Christodoulou, Zu-Kun Tan, Michael J. Gait Journal Nucleic Acids Research Symposium Series No. 21: 39-40 (1989) (1989)
  Details

  DOI  PMID2608470 PMCID  Division 
• Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro AuthorsColin Dingwall, Ingemar Ernberg, Michael J. Gait, Sheila M. Green, Shaun Heaphy, Jonathan Karn, Anthony D. Lowe, Mohinder Singh, Michael A. Skinner, Robert Valerio Journal Proceedings of the National Academy of Sciences, USA 86: 6925-6929 (1989) (1989)
  Details

  DOI  PMID  PMCID  Division 
• Nonradioactive methods of in Situ hybridization: visualization of neuroendocrine mRNA AuthorsEmson P. C., Arai H., Agrawal S., Christodoulou C., Gait M. J. Journal Methods in Enzymology 168: 753-761. January 1989 (1989)
  Details

  DOI10.1016/0076-6879(89)68056‑1 PMID2725321 PMCID  DivisionProtein & Nucleic Acid Chemistry
• In situ hybridization histochemistry: localisation of vasopressin mRNA in rat brain using a biotinylated oligonucleotide probe AuthorsArai H., Emson P. C., Agrawal S., Christodoulou C., Gait M. J. Journal Molecular Brain Research 464(1):63-69. August 1988 (1988)
  Details

  DOI10.1016/0169-328x(88)90019-8 PMID3179745 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Nucleotide and deduced amino acid sequence of stp: the bacteriophage T4 anticodon nuclease gene AuthorsDaphne Chapman, Ilan Morad, Gabriel Kaufmann, Michael J. Gait, Lori Jorissen, Larry Snyder Journal Journal of Molecular Biology 199: 373-377 (1988) (1988)
  Details

  DOI  PMID  PMCID  Division 
• Cloning and expression in E. Coli of a synthetic gene for the bacteriocidal protein caltrin/seminalplasmin AuthorsHeaphy S., Singh M., Gait M. J. Journal Protein Engineering 1(5):425-431. October 1987 (1987)
  Details

  DOI10.1093/protein/1.5.425 PMID3334097 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Sequential NMR assignments of labile protons in DNA using two-dimensional nuclear-Overhauser-enhancement spectroscopy with three jump-and-return pulse sequences AuthorsOtting G., Grütter R., Leupin W., Minganti C., Ganesh K. N., Sproat B. S.,Gait M. J., Wüthrich K. Journal Eur. J. Biochem 166(1):215-220. July 1987 (1987)
  Details

  DOI10.1111/j.1432-1033.1987.tb13504.x PMID3036520 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Effect of single amino acid changes in the region of the adenylylation site of T4 RNA ligase AuthorsShaun Heaphy, Mohinder Singh, Michael J. Gait Journal Biochemistry 26: 1688-1696 (1987) (1987)
  Details

  DOI  PMID  PMCID  Division 
• A new 5'-protecting group for use in solid-phase synthesis of oligoribonucleotides AuthorsChris Christodoulou, Sudhir Agrawal, Michael J. Gait Journal Nucleosides & Nucleotides 6: 341-344 (1987) (1987)
  Details

  DOI  PMID  PMCID  Division 
• Progress towards solid-phase synthesis of oligoribonucleotides AuthorsChris Christodoulou, Sudhir Agrawal, Michael J. Gait Journal Biophosphates and Their Analogues - Synthesis, Structure, Metabolism and Activity. Edited by K. S. Bruzik and W. J. Stec pp.99-106 (1987) (1987)
  Details

  DOI  PMID  PMCID  Division 
• Efficient methods for attaching non-radioactive labels to the 5' ends of synthetic oligodeoxyribonucleotides AuthorsSudhir Agrawal, Chris Christodoulou, Michael J. Gait Journal Nucleic Acids Research 14(15):6227-6245 (1986) (1986)
  Details

  DOI10.1093/nar/14.15.6227 PMID3748808 PMCIDPMC311633 DivisionProtein & Nucleic Acid Chemistry
• Incompatibility of acid-labiIe 2' and 5' protecting groups for solid-phase synthesis of oligoribonucleotides AuthorsChris Christodoulou, Sudhir Agrawal, Michael J. Gait Journal Tetrahedron Letters 27: 1521-1522 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division 
• Site-directed mutagenesis as a means of studying the enzyme T4 RNA ligase AuthorsHeaphy S., Singh M., Gait M. J. Journal Biochemical Society Transactions 14: 1220-1221 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division 
• The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron AuthorsBritt-Marie Sjoberg, Solveig Hahne, Catherine Z. Mathews, Christopher K. Mathews, Keith N. Rand, Michael J. Gait Journal EMBO Journal 5: 2031-2036 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division 
• Oligonucleotide-directed misincorporation mutagenesis on single-stranded DNA templates AuthorsMohinder Singh, Shaun Heaphy, Michael J. Gait Journal Protein Engineering 1: 75-76 (1986) (1986)
  Details

  DOI  PMID  PMCID  Division 
• Location of the adenylylation site in T4 RNA ligase AuthorsHans C. Thogersen, Morris, H. R., Keith N. Rand, Michael J. Gait Journal European Journal of Biochemisty 147: 325-329 (1985) (1985)
  Details

  DOI  PMID  PMCID  Division 
• Comparison of controlled pore glass and Kieselguhr-polydimethylacrylamide composite as supports for solid-phase synthesis of 23-residue oligodeoxyribonucleotides in milligram amounts AuthorsCarlo Minganti, K. N. Ganesh, Brian S. Sproat, Michael J. Gait Journal Analytical Biochemistry 147: 63-74 (1985) (1985)
  Details

  DOI  PMID  PMCID  Division 
• Chemical synthesis of a gene for somatomedin C AuthorsBrian S. Sproat, Michael J. Gait Journal Nucleic Acids Research 13: 2959-2977 (1985) (1985)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides VIII. An improved procedure for solid-phase oligodeoxyribonucleotide synthesis using a controlled pore glass support and phosphotriester chemistry AuthorsB. S. Sproat, C. Minganti, M. J. Gait Journal Nucleosides & Nucleotides 4: 139-142 (1985) (1985)
  Details

  DOI  PMID  PMCID  Division 
• T4RNA ligase: new structural studies on an unusual but useful enzyme AuthorsK. N. Rand, M. Singh, H. C. Thogersen, M. J. Gait Journal Proc. Int. Symp. Biomol. Struct. Interactions, Suppl. J. Biosci. 8: 89-106 (1985) (1985)
  Details

  DOI  PMID  PMCID  Division 
• Sequence and cloning of bacteriophage T4 gene 63 encoding RNA ligase and tail fibre attachment activities AuthorsK. N. Rand, M. J. Gait Journal EMBO Journal 3: 397-402 (1984) (1984)
  Details

  DOI  PMID  PMCID  Division 
• Synthetic donor and acceptor splice sites function in a RNA polymerase B (II) transcription unit AuthorsG. Rautmann, H. W. D. Matthes, M. J. Gait, R. Breathnach Journal EMBO Journal 3: 2021-2028 (1984) (1984)
  Details

  DOI  PMID  PMCID  Division 
• A new selective phage cloning vector, lambda2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI AuthorsJonathan Karn, Hans W. D. Matthes, Michael J. Gait, Sydney Brenner Journal Gene 32: 217-224 (1984) (1984)
  Details

  DOI  PMID  PMCID  Division 
• Continuous-flow phosphotriester method for solid-phase synthesis of oligodeoxyribonucleotides AuthorsM. J. Gait, H. W. D. Matthes, M. Singh, B. S. Sproat, R. Titmas Journal Cold Spring Harbor Symposia on Quantitative Biology XLVII: 393-401 (1983) (1983)
  Details

  DOI  PMID  PMCID  Division 
• The antitumor drug cis-[Pt(NH3)2Cl2] forms an intrastrand d(GpG) cross-link upon reaction with [d(ApGpGpCpCpT)]2 AuthorsCaradonna J. P., Lippard S. J., Gait M. J., Singh M. Journal Journal of the American Chemical Society 104: 5793-5795. 1 October 1982 (1982)
  Details

  DOI10.1021/ja00385a044 PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Synthesis of oligodeoxyribonucleotides by a continuous-flow, solid-phase method using phosphotriester intermediates AuthorsMichael J. Gait, Hans W. D. Matthes, Mohinder Singh, Richard C. Titmas Journal Journal of the Chemical Society. Chemical Communications pp.37-40 (1982) (1982)
  Details

  DOI  PMID  PMCID  Division 
• Chicken histone H5: selection of a cDNA recombinant using an extended synthetic primer AuthorsP. A. Krieg, A. J. Robins, M. J. Gait, R. C. Titmas, J. R. E. Wells Journal Nucleic Acids Research 10: 1495-1502 (1982) (1982)
  Details

  DOI  PMID  PMCID  Division 
• Nucleotide sequence of tobacco mosaic virus RNA AuthorsP. Goelet, G. P. Lomonossoff, P. J. G. Butler, M. E. Akam, M. J. Gait, J. Karn Journal Proceedings of the National Academy of Sciences, USA 79: 5818-5822 (1982) (1982)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides. VII. Solid phase synthesis of oligodeoxyribonucleotides by a continuous flow phosphotriester method on a kieselguhr-polyamide support AuthorsMichael J. Gait, Hans W. D. Matthes, Mohinder Singh, Brian S. Sproat, Richard C. Titmas Journal Nucleic Acids Research 10: 6243-6254 (1982) (1982)
  Details

  DOI  PMID  PMCID  Division 
• Synthesis of oligodeoxyribonucleotides by a continuous flow, phosphotriester method on a kieselguhr/polyamide support AuthorsMichael J. Gait, Hans W. D. Matthes, Mohinder Singh, Brian S. Sproat, Richard C. Titmas Journal Chemical and Enzymatic Synthesis of Gene Fragments. Edited by H. G. Gassen and Anne Lang pp.2-42 (1982) (1982)
  Details

  DOI  PMID  PMCID  Division 
• The use of synthetic oligodeoxynucleotide primers in cloning and sequencing segment 8 of influenza virus (A/PR/8/34) AuthorsGreg Winter, Stan Fields, Michael J. Gait, George G. Brownlee Journal Nucleic Acids Research 9: 237-245 (1981) (1981)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides VI. Efficient, mechanised synthesis of heptadeca-deoxyribonucleotides by an improved solid phase phosphotriester route AuthorsMary Lynn Duckworth, Michael J. Gait, Philip Goelet, Guo Fang Hong, Mohinder Singh, Richard C. Titmas Journal Nucleic Acids Research 9: 1691-1706 (1981) (1981)
  Details

  DOI  PMID  PMCID  Division 
• Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing AuthorsPamela H. Hamlyn, Michael J. Gait, Cesar Milstein Journal Nucleic Acids Research 9: 4485-4494 (1981) (1981)
  Details

  DOI  PMID  PMCID  Division 
• A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2 AuthorsS. Anderson, M. J. Gait, L. Mayol, I. G. Young Journal Nucleic Acids Research 8: 1731-1743 (1980) (1980)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates AuthorsM. J. Gait, M. Singh, R. C. Sheppard, M. D. Edge, A. R. Greene, G. R. Heathcliffe, T. C. Atkinson, C. R. Newton, A. F. Markham Journal Nucleic Acids Research 8: 1081-1096 (1980) (1980)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides V. Further studies in solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates AuthorsM. J. Gait, S. G. Popov, M. Singh, R. C. Titmas Journal Nucleic Acids Research Symposium Series 7: 243-257 (1980) (1980)
  Details

  DOI  PMID  PMCID  Division 
• Comparison of rates of phosphotriester formation and sulphonation by coupling agents in oligodeoxyribonucleotide synthesis by the phosphotriester method AuthorsM. J. Gait, S. G. Popov Journal Tetrahedron Letters 21: 2841-2842 (1980) (1980)
  Details

  DOI  PMID  PMCID  Division 
• Polymer-supported synthesis of oligonucleotides AuthorsM. J. Gait Journal Polymer-supported Reactions in Organic Synthesis. Edited by P. Hodge and D. C. Sherrington pp.435-456 (1980) (1980)
  Details

  DOI  PMID  PMCID  Division 
• Biological chemistry. Part (ii) Nucleic acids. (b) Oligonucleotides and polynucleotides AuthorsM. J. Gait Journal Annual Reports B 1980. The Royal Society of Chemistry pp.310-322 (1980) (1980)
  Details

  DOI  PMID  PMCID  Division 
• The polyamide method of solid phase peptide and oligonucleotide synthesis AuthorsAtherton E., Gait M. J., Sheppard R. C., Williams B. J. Journal Bioorganic Chemistry 8: 351-370 (1979) (1979)
  Details

  DOI  PMID  PMCID  Division 
• Easily prepared polar support for solid phase peptide and oligonucleotide synthesis. Preparation of substance P and a nonadeoxyribonucleotide AuthorsReza Arshady, Eric Atherton, Michael J. Gait, Karen Lee, Robert C. Sheppard Journal Journal of the Chemical Society. Chemical Communications pp.423-425 (1979) (1979)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides III. Effect of added carboxylate ion on the efficiency of internucleotide bond formation. Solid-phase synthesis of the dodecanucleotide d(pT-A-A-C-T-G-C-T-C-A-C‑T) AuthorsM. J. Gait, R. C. Sheppard Journal Nucleic Acids Research 6: 1259-1268 (1979) (1979)
  Details

  DOI  PMID  PMCID  Division 
• Rapid chemical synthesis and circular dichroism properties of some 2'-5'-linked oligoriboadenylates AuthorsA. F. Markham, R. A. Porter, M. J. Gait, R. C. Sheppard, I. M. Kerr Journal Nucleic Acids Research 6: 2569-2582 (1979) (1979)
  Details

  DOI  PMID  PMCID  Division 
• Biological Chemistry. Part (v) Nucleic Acids. (b) Oligonucleotides and polynucleotides AuthorsGait M. J. Journal Royal Society of Chemistry: Annual Reports B 76: pp.462-471 (1979) (1979)
  Details

  DOI10.1039/OC9797600462 PMID  PMCID  Division 
• Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing AuthorsPamela H. Hamlyn, George G. Brownlee, Chen-Chi Cheng, Michael J. Gait, Cesar Milstein Journal Cell 15: 1067-1075 (1978) (1978)
  Details

  DOI  PMID  PMCID  Division 
• Solid-phase oligonucleotide synthesis: a renaissance AuthorsGait M. J., Sheppard R. C. Journal Nucleic Acids Research Special Publication 4: s79-s83. 1 January 1978 (1978)
  Details

  DOI10.1093/nar/1.suppl_1.s79 PMID  PMCIDPMC6581299 DivisionProtein & Nucleic Acid Chemistry
• Rapid synthesis of oligodeoxyribonucleotides: a new solid-phase method AuthorsM. J. Gait, R. C. Sheppard Journal Nucleic Acids Research 4: 1135-1158 (1977) (1977)
  Details

  DOI  PMID  PMCID  Division 
• Rapid synthesis of oligodeoxyribonucleotides II. Machine-aided solid-phase syntheses of two nonanucleotides and an octanucleotide AuthorsM. J. Gait, R. C. Sheppard Journal Nucleic Acids Research 4: 4391-4410 (1977) (1977)
  Details

  DOI  PMID  PMCID  Division 
• A polyamide support for oligonucleotide synthesis AuthorsM. J. Gait, R. C. Sheppard Journal Journal of the American Chemical Society 98: 8514-8516 (1976) (1976)
  Details

  DOI  PMID  PMCID  Division