Published Research
Found 268 results for Gait.
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Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model
AuthorsBestas B., Estupiรฑรกn H.Y., Wang Q., Kharazi S., He C., Mohammad D.K., Gupta D., Wiklander O.P.B., Lehto T., Lundin K.E., Berglรถf A., Karlsson M.C.I., Abendroth F., El Andaloussi S., Gait M.J., Wood M.J.A., Leumann C.J., Stetsenko D.A., Mรฅnsson R., Wengel J., Zain R., Edvard Smith C.I.
Journal
RSC Chemical Biology
6(5):761-771 (2025)
Details
DOIdoi.org/10.1039/d4cb00312h PMID40171248 PMCIDPMC11955834 DivisionProtein & Nucleic Acid Chemistry -
Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation
AuthorsGupta D., Orehek S., Turunen J., O'Donovan L., Gait M. J, El-Andaloussi S., Wood M. J. A.
Journal
Cells
12(18):2285 (2023)
Details
DOI10.3390/cells12182285 PMID37759507 PMCIDPMC10526877 DivisionProtein & Nucleic Acid Chemistry - Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division AuthorsDaeden A, Mietke A, Derivery E, Seum C, Jรผlicher F, Gonzalez-Gaitan M Journal Nature Cell Biology 25(2):235-245 (2023)
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Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy
AuthorsHammond S.M., Abendroth F., Goli L., Stoodley J., Burrell M., Thom G., Gurrell I., Ahlskog N., Gait M.J., Wood M.J., Webster C.I.
Journal
JCI Insight
7(24):e154142 (2022)
Details
DOI10.1172/jci.insight.154142 PMID36346674 PMCIDPMC7614086 DivisionProtein & Nucleic Acid Chemistry -
Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy
AuthorsHammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI.
Journal
JCI Insight
Dec 22;7(24):e154142 (2022)
Details
DOI10.1172/jci.insight.154142 PMID36346674 PMCIDPMC7614086 DivisionProtein & Nucleic Acid Chemistry - Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants AuthorsPlanelles-Herrero VJ, Bittleston A, Seum C, Gaitan MG, Derivery E. Journal Nature Cell Biology 10.1038/s41556-022-01020-9 (2022)
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Introduction and History of the Chemistry of Nucleic Acids Therapeutics
AuthorsGait M. J.,ย Agrawal S.
Journal
Methods in Molecular Biology
2434:3-31 (2022)
Details
DOI10.1007/978-1-0716-2010-6_1 PMID35213007 PMCIDPMC7612508 DivisionProtein & Nucleic Acid Chemistry - Dystrophin involvement in peripheral circadian SRF signalling AuthorsBetts CA, et al (including O'Donovan E., Saleh A. F., Gait M. J.) Journal Life Science Alliance 4(10):e202101014 (2021)
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Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides
AuthorsTone Y., Mamchaoui K., Tsoumpra M. K., Hashimoto Y., Terada R., Maruyama R., Gait M. J., Arzumanov A. A., McClorey G., Imamura M., Takeda S., Yokota T., Wood M. J. A., Mouly V., Aoki Y.
Journal
Nucleic Acid Therapeutics
31(2):172-181. April 2021 (2021)
Details
DOI10.1089/nat.2020.0907 PMID33567244 PMCIDPMC7997716 DivisionProtein & Nucleic Acid Chemistry - Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks AuthorsLรณpez-Andarias J., Saarbach J., Moreau D., Cheng Y., Derivery E., Laurent Q., Gonzรกlez-Gaitรกn M., Winssinger N., Sakai N., Matile S. Journal Journal of the American Chemical Society 142(10):4784-4792. 11 March 2020 (2020)
- Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice AuthorsKlein A. F., Varela M. A., Arandel L., Holland A., Naouar N., Arzumanov A., Seoane D., Revillod L., Bassez G., Ferry A., Jauvin D., Gourdon G., Puymirat J., Gait M. J., Furling D., Wood M. J. Journal The Journal of Clinical Investigation 129(11):4739-4744. 1 November 2019 (2019)
- Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy AuthorsHammond S. M., Abendroth F., Gait M. J., Wood M. J. A. Journal Methods in Molecular Biology 2036:221-236 (2019)
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Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment
AuthorsGait M. J., Arzumanov A. A., McClorey G., Godfrey C., Betts C., Hammond S., Wood M. J. A.
Journal
Nucleic Acid Therapeutics
29(1):1-12. February 2019 (2019)
Details
DOI10.1089/nat.2018.0747 PMID30307373 PMCIDPMC6386087 DivisionProtein & Nucleic Acid Chemistry - Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment AuthorsBetts C. A., McClorey G., Healicon R., Hammond S. M., Manzano R., Muses S., Ball V., Godfrey C., Merritt T. M., Westering T., O'Donovan L., Wells K. E., Gait M. J., Wells D. J., Tyler D., Wood M. J. Journal Human Molecular Genetics 28(3):396-406 (2019)
- Memoirs Daniel McGillivray Brown. 3 February 1923โ24 April 2012 AuthorsGait M. J. Journal Biographical Memoirs of Fellows of the Royal Society 66:79โ100 (2018)
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Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy
AuthorsBlain A. M., Greally E., McClorey G., Manzano R., Betts C. A., Godfrey C., O'Donovan L., Coursindel T., Gait M. J., Wood M. J., MacGowan G. A., Straub V. W.
Journal
PloS one
13(6):e0198897. 18 June 2018 (2018)
Details
DOI10.1371/journal.pone.0198897 PMID29912990 PMCIDPMC6005479 DivisionProtein & Nucleic Acid Chemistry -
Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide‑PNAs
AuthorsTailhades J., Takizawa H., Gait M. J., Wellings D. A., Wade J. D., Aoki Y.,
Shabanpoor F.
Journal
Frontiers in Chemistry
5:81. 17 October 2017 (2017)
Details
DOI10.3389/fchem.2017.00081 PMID29094037 PMCIDPMC5651559 DivisionProtein & Nucleic Acid Chemistry - Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s AuthorsDerivery E., Bartolami E., Matile S., Gonzalez-Gaitan M. Journal Journal of the American Chemical Society 139(30):10172-10175. 2 August 2017 (2017)
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Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy
AuthorsShabanpoor F., Hammond S. M., Abendroth F., Hazell G., Wood M. J., Gait M. J.
Journal
Nucleic Acid Therapeutics
27(3):130-143. 1 June 2017 (2017)
Details
DOI10.1089/nat.2016.0652 PMID28118087 PMCIDPMC5467147 DivisionProtein & Nucleic Acid Chemistry -
ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives
AuthorsHoogewijs K., James A. M., Smith R. A., Abendroth F., Gait M. J., Murphy M. P., Lightowlers R. N.
Journal
Interface Focus
7(2):20160117. 6 April 2017 (2017)
Details
DOI10.1098/rsfs.2016.0117 PMID28382203 PMCIDPMC5311907 DivisionProtein & Nucleic Acid Chemistry -
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy
AuthorsHammond S. M., Hazell G., Shabanpoor F., Saleh A. F., Bowerman M., Sleigh J. N., Meijboom K. E., Zhou H., Muntoni F., Talbot K., Gait M. J., Wood M. J.
Journal
Proceedings of the National Academy of Sciences of the United States of America
113(39):10962-10967. 27 September 2016 (2016)
Details
DOI10.1073/pnas.1605731113 PMID27621445 PMCIDPMC5047168 DivisionProtein & Nucleic Acid Chemistry -
Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry
AuthorsHoogewijs K., James A. M., Smith R. A., Gait M. J., Murphy M. P., Lightowlers R. N.
Journal
Chembiochem : a European Journal of Chemical Biology
17(14):1312-1316 (2016)
Details
DOI10.1002/cbic.201600188 PMID27124570 PMCIDPMC4973694 DivisionProtein & Nucleic Acid Chemistry - Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration AuthorsRoberts T. C., Johansson H. J., McClorey G., Godfrey C., Blomberg K. E., Coursindel T., Gait M. J., Smith C. I., Lehtiรถ J., Andaloussi S. E., Wood M. J. Journal Human Molecular Genetics 4(23):6756-6768. 1 December 2015 (2015)
- Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics AuthorsCoenen-Stass A. M., McClorey G., Manzano R., Betts C. A., Blain A., Saleh A. F., Gait M. J., Lochmรผller H., Wood M. J., Roberts T. C. Journal Scientific Reports 5:17014. 23 November 2015 (2015)
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Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides
AuthorsBurki U., Keane J., Blain A., O'Donovan L., Gait M. J., Laval S. H., Straub V.
Journal
Nucleic Acid Therapeutics
25(5):275-284. 17 September 2015 (2015)
Details
DOI10.1089/nat.2014.0528 PMID26176274 PMCIDPMC4576940 DivisionProtein & Nucleic Acid Chemistry - How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse AuthorsGodfrey C., Muses S., McClorey G., Wells K. E., Coursindel T., Terry R., Betts C., Hammond S., O'Donovan L., Hildyard J., E. l. Andaloussi S., Gait M. J., Wood M. J,. Wells D. J. Journal Human Molecular Genetics 24(15):4225-4237. 1 August 2015 (2015)
- Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice AuthorsLu-Nguyen N. B., Jarmin S. A., Saleh A. F., Popplewell L., Gait M. J., Dickson G. Journal Molecular Therapy 23(8):1341-1348. August 2015 (2015)
- Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides AuthorsEzzat K., Aoki Y., Koo T., McClorey G., Benner L., Coenen-Stass A., O'Donovan L., Lehto T., Garcia-Guerra A., Nordin J., Saleh A. F., Behlke M., Morris J., Goyenvalle A., Dugovic B., Leumann C., Gordon S., Gait M. J., El Andaloussi S., Wood M. J. Journal Nano Letters 15(7):4364-73. 8 July 2015 (2015)
- Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy AuthorsBetts C. A., Saleh A. F., Carr C. A., Muses S., Wells K. E., Hammond S. M., Godfrey C., McClorey G., Woffindale C., Clarke K., Wells D. J., Gait M. J., Wood M. J. Journal Scientific Reports 5:11632. 30 June 2015 (2015)
- Delivery of therapeutic oligonucleotides with cell penetrating peptides. AuthorsBoisguรฉrin P., Deshayes S., Gait M. J., O'Donovan L., Godfrey C., Betts C. A., Wood M. J., Lebleu B. Journal Advanced Drug Delivery Reviews 87:52-67. 26 June 2015 (2015)
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Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides.
AuthorsJรคrver P., Zaghloul E. M., Arzumanov A. A., Saleh A. F., McClorey G., Hammond S. M., Hรคllbrink M., Langel ร., Smith C. I., Wood M. J., Gait M. J., Andaloussi S. E.
Journal
Nucleic Acid Therapeutics
25(2):65-77. 1 April 2015 (2015)
Details
DOI10.1089/nat.2014.0511 PMID25594433 PMCIDPMC4376484 DivisionProtein & Nucleic Acid Chemistry - Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice. AuthorsBetts C. A., Saleh A. F., Carr C. A., Hammond S. M., Coenen-Stass A. M., Godfrey C., McClorey G., Varela M. A., Roberts T. C., Clarke K., Gait M. J., Wood M. J. Journal Scientific Reports 5:8986. 11 March 2015 (2015)
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Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy.
AuthorsO'Donovan L., Okamoto I., Arzumanov A. A., Williams D. L., Deuss P., Gait M. J.
Journal
Nucleic Acid Therapeutics
25(1):1-10. 19 January 2015 (2015)
Details
DOI10.1089/nat.2014.0512 PMID25412073 PMCIDPMC4296749 DivisionProtein & Nucleic Acid Chemistry -
Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy.
AuthorsShabanpoor F., McClorey G., Saleh A. F., Jรคrver P., Wood M. J., Gait M. J.
Journal
Nucleic Acids Research
43(1):29-39. 1 January 2015 (2015)
Details
DOI10.1093/nar/gku1256 PMID25468897 PMCIDPMC4288157 DivisionProtein & Nucleic Acid Chemistry - Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model AuthorsBestas B., Moreno P. M., Blomberg K. E., Mohammad D. K., Saleh A. F., Sutlu T., Nordin J. Z., Guterstam P., Gustafsson M. O., Kharazi S., Piฤ tosa B., Roberts T. C., Behlke M. A., Wood M. J., Gait M. J., Lundin K. E., El Andaloussi S., Mรฅnsson R., Berglรถf A., Wengel J., Smith C. I. Journal Journal of Clinical Investigation 124(9):4067-4081. 2 September 2014 (2014)
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Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells.
AuthorsLehto T., Castillo Alvarez A., Gauck S., Gait M. J., Coursindel T., Wood M. J., Lebleu B., Boisguerin P.
Journal
Nucleic Acids Research
42(5):3207-3217. March 2014 (2014)
Details
DOI10.1093/nar/gkt1220 PMID24366877 PMCIDPMC3950666 DivisionProtein & Nucleic Acid Chemistry - A chemical view of oligonucleotides for exon skipping and related drug applications AuthorsJรคrver P., O'Donovan L., Gait M. J. Journal Nucleic Acid Therapeutics 24(1):37-47. February 2014 (2014)
- Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo AuthorsDeuss P. J., Arzumanov A. A., Williams D. L., Gait M. J. Journal Organic & Biomolecular Chemistry 11(43):7621-7630. 21 November 2013 (2013)
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Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry
AuthorsShabanpoor F., Gait M. J.
Journal
Chemical Communications
49(87):10260-10262. 11 November 2013 (2013)
Details
DOI10.1039/c3cc46067c PMID24064913) PMCIDPMC3816334 DivisionProtein & Nucleic Acid Chemistry - Enhanced splice correction by 3', 5'-serinol and 2'-(ฯ-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells AuthorsKotikam V., Arzumanov A. A., Gait M. J., Kumar V. A. Journal Artificial DNA, PNA & XNA 4(3):77-83. 1 July 2013 (2013)
- Nucleic acids: new life, new materials AuthorsGait M. J., Komiyama M., Seeman N. C., Seitz O., Micklefield J., Liu D. R. Journal Organic & Biomolecular Chemistry 11(13):2058-2059. 7 April 2013 (2013)
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Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy
AuthorsMalerba A., Kang J. K., McClorey G., Saleh A. F., Popplewell L., Gait M. J., Wood M. J., Dickson G.
Journal
Molecular Therapy. Nucleic Acids
1:e62. December 2012 (2012)
Details
DOI10.1038/mtna.2012.54 PMID23250360 PMCIDPMC3528303 DivisionProtein & Nucleic Acid Chemistry -
Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse with implications for therapy
AuthorsRoberts T. C., Blomberg K. E., McClorey G., El Andaloussi S., Godfrey C., Betts C., Coursindel T., Gait M. J., Smith C. I., Wood M. J.
Journal
Molecular Therapy. Nucleic Acids
1:e39. August 2012 (2012)
Details
DOI10.1038/mtna.2012.26 PMID23344181 PMCIDPMC3437806 DivisionProtein & Nucleic Acid Chemistry -
Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment
AuthorsBetts C. , Saleh A. F., Arzumanov A. A., Hammond S. M., Godfrey C., Coursindel T., Gait M. J., Wood M. J.
Journal
Molecular Therapy. Nucleic Acids
1:e38. August 2012 (2012)
Details
DOI10.1038/mtna.2012.30 PMID23344180 PMCIDPMC3438601 DivisionProtein & Nucleic Acid Chemistry -
Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
AuthorsJรคrver P., Coursindel T., Andaloussi S. E., Godfrey C., Wood M. J., Gait M. J.
Journal
Molecular Therapy. Nucleic Acids
1:e27. June 2012 (2012)
Details
DOI10.1038/mtna.2012.18 PMID23344079 PMCIDPMC3390225 DivisionProtein & Nucleic Acid Chemistry -
Exploiting cell surface thiols to enhance cellular uptake
AuthorsTorres A. G., Gait M. J.
Journal
Trends in Biotechnology
30(4):185-190. April 2012 (2012)
Details
DOI10.1016/j.tibtech.2011.12.002 PMID22260747 PMCID DivisionProtein & Nucleic Acid Chemistry - Peptide-based in vivo delivery agents for oligonucleotides and siRNA AuthorsCoursindel T., Jรคrver P., Gait M. J. Journal Nucleic Acid Therapeutics 22(2):71-76. April 2012 (2012)
- Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti‑miRs AuthorsTorres A. G., Fabani M. M., Vigorito E., Williams D., Al-Obaidi N., Wojciechowski F., Hudson R. H., Seitz O., Gait M. J. Journal Nucleic Acids Research 40(5):2152-2167. March 2012 (2012)
- Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2'-O-methyl oligoribonucleotides AuthorsThrelfall R. N., Torres A. G., Krivenko A., Gait M. J., Caruthers M. H. Journal Organic & Biomolecular Chemistry 10(4):746-754. 28 January 2012 (2012)
- Overview of alternative oligonucleotide chemistries for exon skipping AuthorsSaleh A. F., Arzumanov A. A., Gait M. J. Journal Methods in Molecular Biology 867:365-378. 1 January 2012 (2012)
- PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation AuthorsEzzat K., El Andaloussi S., Zaghloul E. M., Lehto T., Lindberg S., Moreno P. M., Viola J. R., Magdy T., Abdo R., Guterstam P., Sillard R., Hammond S. M., Wood M. J., Arzumanov A. A., Gait M. J., Smith C. I., Hรคllbrink M., Langel U. Journal Nucleic Acids Research 39(12):5284-5298. July 2011 (2011)
- Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents AuthorsTorres A. G., Threlfall R. N., Gait M. J. Journal Artificial DNA, PNA & XNA 2(3):71-78. 1 July 2011 (2011)
- Pip5 transduction peptides direct high efficiency oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx mice AuthorsYin H., Saleh A. F., Betts C., Camelliti P., Seow Y., Ashraf S., Arzumanov A., Hammond S., Merritt T., Gait M. J., Wood M. J. Journal Molecular Therapy : the Journal of the American Society of Gene Therapy 19(7):1295-1303. July 2011 (2011)
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MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection
AuthorsTorres A. G., Fabani M. M., Vigorito E., Gait M. J.
Journal
RNA
17(5):933-943. May 2011 (2011)
Details
DOI10.1261/rna.2533811 PMID21441346 PMCIDPMC3078742 DivisionProtein & Nucleic Acid Chemistry - Diaphragm rescue alone prevents heart dysfunction in dystrophic mice AuthorsCrisp A., Yin H., Goyenvalle A., Betts C., Moulton H. M., Seow Y., Babbs A., Merritt T., Saleh A. F., Gait M. J., Stuckey D. J., Clarke K., Davies K. E., Wood M. J. Journal Human Molecular Genetics 20(3):413-21. 1 February 2011 (2011)
- Synthesis and splice-redirecting activity of branched, arginine-rich peptide dendrimer conjugates of peptide nucleic acid oligonucleotides AuthorsSaleh A. F., Arzumanov A., Abes R., Owen D., Lebleu B., Gait M. J. Journal Bioconjugate Chemistry 21(10):1902-1911. 20 October 2010 (2010)
- Efficient inhibition of miR-155 function in vivo by peptide nucleic acids AuthorsFabani M. M., Abreu-Goodger C., Williams D., Lyons P. A., Torres A. G., Smith K. G., Enright A. J., Gait M. J., Vigorito E. Journal Nucleic Acids Research 38(13):4466-4475. August 2010 (2010)
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Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse
AuthorsYin H., Betts C., Saleh A. F., Ivanova G. D., Lee H., Seow Y., Kim D., Gait M. J., Wood M. J.
Journal
Molecular Therapy
18(4):819-827. April 2010 (2010)
Details
DOI10.1038/mt.2009.310 PMID20068555 PMCIDPMC2848838 DivisionProtein & Nucleic Acid Chemistry - In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy AuthorsWang Q., Yin H., Camelliti P., Betts C., Moulton H., Lee H., Saleh A. F., Gait M. J., Wood M. J. Journal Journal of Gene Medicine 12(4):354-364. 1 April 2010 (2010)
- RNA-targeted splice-correction therapy for neuromuscular disease AuthorsWood M. J., Gait M. J., Yin H. Journal Brain 133(4):957-972. 1 April 2010 (2010)
- Cell penetrating peptides: overview and applications to the delivery of oligonucleotides AuthorsHassane F. S., Saleh A. F., Abes R., Gait, M. J., Lebleu B. Journal Cellular and Molecular Life Sciences 67(5):715-726. March 2010 (2010)
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Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide
AuthorsAnke Detzer, Marita Overhoff, Winfried Wรผnsche, Maria Rompf, John J. Turner, Gabriela D. Ivanova, Michael J. Gait, Georg Sczakiel
Journal
RNA
15(4):627-636 (2009) (2009)
Details
DOI10.1261/rna.1305209 PMID19228587 PMCIDPMC2661840 DivisionProtein & Nucleic Acid Chemistry - Peptide-Based Delivery of Steric-Block PNA Oligonucleotides AuthorsSaid Abes, Gabriela D. Ivanova, Rachida Abes, Andrey A. Arzumanov, Donna Williams, David Owen, Bernard Lebleu, Michael J. Gait Journal Methods in Molecular Biology 480: 85-99 (2009)
- Tackling antibiotic resistance: a dose of common antisense? (Editorial) AuthorsNeil Woodford, David W. Wareham, Ian Chopra, Matthew Ellington, Virve I. Enne, Heather Fairhead, William Fraser, Michael J. Gait, Peter A. Lambert, David M. Livermore, Alex J. O'Neill, Thamarai Schneiders, Davis E. Yakubu Journal Journal of Antimicrobial Chemotherapy 63(2): 225-229 (2009) (2009)
- A peptide-based dendrimer that enhances the splice-redirecting activity of PNA conjugates in cells AuthorsFatouma Said Hassane, Gabriela D. Ivanova, Eleonora Bolewska-Pedyczak, Rachida Abes, Andrey A. Arzumanov, Michael J. Gait, Bernard Lebleu, Jean Garipy Journal Bioconjugate Chemistry 20(8):1523-1530 (2009) (2009)
- miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates AuthorsFabani M. M., Gait M. J. Journal RNA 14(2):336-346 (2008)
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RNA targeting in cells by peptide conjugates of peptide nucleic acids (PNA)
AuthorsG. D. Ivanova, A. A. Arzumanov, J. J. Turner, M. M. Fabani, R. Abes, B. Lebleu, M. J. Gait
Journal
Collection Symposium Series
10: 103-111 (2008)
Details
DOI PMID PMCID Division - PNA-peptide conjugates as intracellular gene control agents AuthorsGabriela D. Ivanova, Martin M. Fabani, Andrey A. Arzumanov, Rachida Abes, Haifang Yin, Bernard Lebleu, Matthew Wood, Michael J. Gait Journal Nucleic Acids Symposium Series 52: 31-32 (2008)
- Steric block high affinity oligonucleotide analogues: A new tool for mapping RNA-protein binding sites AuthorsDouglas Brown, Emily Joy, Jane Greatorex, Michael J. Gait, Andrew M. L. Lever Journal Nucleosides, Nucleotides and Nucleic Acids 27 (2): 196-212 (2008)
- Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides AuthorsR. Abes, A. Arzumanov, H. Moulton, S. Abes, G. Ivanova, M. J. Gait, P. Iversen, B. Lebleu Journal Journal of Peptide Science 14 (4): 455-460 (2008)
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Delivery of antisens oligonucleotides by arginine-rich cell penetrating peptides: design, structure-activity and applications to alter pre‑mRNA
AuthorsR. Abes, H. Moulton, A. Arzumanov, S. Abes, H. Yin, G. Ivanova, F, Hassane, P. Clair, M. Wood, M. J. Gait, B. Lebleu
Journal
Bulletin du Cancer
95 (Sp iss): S55-S55 (2008)
Details
DOI PMID PMCID Division -
Peptide-Peptide Nucleic Acid Conjugates for Modulation of Gene Expression
AuthorsMartin M. Fabani, Gabriela D. Ivanova, Michael J. Gait
Journal
In: Therapeutic Oligonucleotides (J Kurreck, ed), RSC Publishing
Chapter 4: 80-102 (2008)
Details
DOI PMID PMCID Division - Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle AuthorsGabriela D. Ivanova, Andrey Arzumanov, Rachida Abes, Haifang Yin, Matthew J. A. Wood, Bernard Lebleu, Michael J. Gait Journal Nucleic Acids Research 36(20): 6418-6428 (2008) (2008)
- Cell penetrating peptide conjugates of steric block oligonucleotides AuthorsBernard Lebleu, Hong M. Moulton, Rachida Abes, Gabriela D. Ivanova, Said Abes, David A. Stein, Patrick L. Iversen, Andrey A. Arzumanov, Michael J. Gait Journal Advanced Drug Delivery Reviews 60 (4-5): 517-529 (2008)
- Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides AuthorsSarah Resina, Said Abes, John J. Turner, Paul Prevot, Adrian Travo, Philippe Clair, Michael J. Gait, Alain R. Thierry, Bernard Lebleu Journal International Journal of Pharmaceutics 344(1 & 2): 96-102. 1 November 2007 (2007)
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Peptide conjugates of oligonucleotide analogs and siRNA for gene expression modulation
AuthorsJohn J. Turner, Andrey A. Arzumanov, Gabriela Ivanova, Martin Fabani, Michael J. Gait.
Journal
Handbook of Cell-Penetrating Peptides, 2nd (Ed: Ulo Langel), CRC Press.
313-328 (2007) (2007)
Details
DOI PMID PMCID Division - MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity AuthorsJohn J. Turner, Simon W. Jones, Sterghios A. Moschos, Mark A. Lindsay, Michael J. Gait Journal Molecular BioSystems 3(1): 43-50 (2007) (2007)
- RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA AuthorsJohn J. Turner, Simon Jones, Martin M. Fabani, Gabriela Ivanova, Andrey A. Arzumanov, Michael J. Gait Journal Blood Cells, Molecules and Disease 38(1): 1 - 7. January - February 2007 (2007)
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Peptide-based delivery of nucleic acids : design, mechanism of uptake and applications to splice-correcting oligonucleotides
AuthorsS. Abes, H. Moulton, J. Turner, P. Clair, J. P. Richard, P. Iversen, M. J. Gait, B. Lebleu
Journal
Biochemical Society Transactions
35(1): 53-55 (2007) (2007)
Details
DOI PMID PMCID Division -
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity
AuthorsGabriela Ivanova, Sandrine Reigadas, Damian Ittig, Andrey Arzumanov, Marie-Line Andreola, Christian Leumann, Jean-Jacques Toulme, Michael J. Gait
Journal
Oligonucleotides
17(1): 54-65 (2007) (2007)
Details
DOI PMID PMCID Division -
Chemical modifications to improve the cellular uptake of oligonucleotides
AuthorsFrancoise Debart, Said Abes, Gaelle Deglane, Hong M. Moulton, Philippe Clair, Michael J. Gait, Jean-Jacques Vasseur, Bernard Lebleu
Journal
Current Topics in Medicinal Chemistry
7(7): 727-737 (2007) (2007)
Details
DOI PMID PMCID Division -
Cell-penetrating-peptide-based delivery of oligonucleotides: an overview
AuthorsR. Abes, A. A. Arzumanov, H. M. Moulton, S. Abes, G. D. Ivanova, P. L. Iversen, M. J. Gait, B. Lebleu
Journal
Biochemical Society Transactions
35(4): 775-779 (2007) (2007)
Details
DOI PMID PMCID Division -
Systematic screening of LNA/2'-0-methyl chimeric derivatives of a TAR RNA aptamer
AuthorsCarmelo Di Primo, Ivo Rudloff, Sandrine Reigadas, Andrey A. Arzumanov, Michael J. Gait, Jean-Jacques Toulme
Journal
FEBS Letters
581(4): 771-774 (2007) (2007)
Details
DOI PMID PMCID Division - Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide AuthorsSaid Abes, John J. Turner, Gabriela D. Ivanova, David Owen, Donna Williams, Andrey Arzumanov, Philippe Clair, Michael J. Gait, Bernard Lebleu Journal Nucleic Acids Research 35(13): 4495-4502 (2007) (2007)
- Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity AuthorsSterghios Athanasios Moschos, Simon Wyn Jones, Mark Michael Perry, Andrew Evan Williams, Jonas Sten Erjefalt, John James Turner, Peter John Barnes, Brian Stephen Sproat, Michael John Gait, Mark Andrew Lindsay Journal Bioconjugate Chemistry 18(5): 1450-1459 (2007) (2007)
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Synthesis of oligo-2'-0-methylribonucleotides containing [alpha]-amino acid residues in 2'-position
AuthorsE. V. Kazanova, E. M. Zubin, A. V. Kachalova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya
Journal
Russian Chemical Bulletin, International Edition
56 : 806-814 (2007) (2007)
Details
DOI PMID PMCID Division -
Comparative studies of tricyclo-DNA and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression
AuthorsG. Ivanova, A. Arzumanov, M. J. Gait, S. Reigadas, J.-J. Toulme, M.-L. Andreola, D. Ittig, C. Leumann
Journal
Nucleosides, Nucleotides and Nucleic Acids
26(6 & 7): 747-750 (2007) (2007)
Details
DOI PMID PMCID Division -
Preparation of 2'-hydrazino oligonucleotides and their reaction with aldehydes and 1,3‑diketones
AuthorsT. S. Zatsepin, T. S. Oretskaya, M. J. Gait, D. A. Stetsenko.
Journal
Nucleosides, Nucleotides and Nucleic Acids
26(6 & 7) : 795-798 (2007) (2007)
Details
DOI PMID PMCID Division -
Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates
AuthorsAbes S., Williams D., Prevot P., Thierry A.,Gait M. J., Lebleu B.
Journal
Journal of Controlled Release
110(3):595-604. 21 February 2006 (2006)
Details
DOI10.1016/j.jconrel.2005.10.026 PMID16377019 PMCID DivisionProtein & Nucleic Acid Chemistry -
Inhibition of HIV-1 replication by oligonucleotide analogues directed to the packaging signal and trans-activating response region
AuthorsDouglas E. Brown, Andrey Arzumanov, Sana Syed, Michael J. Gait, Andrew M. Lever
Journal
Antiviral Chemistry and Chemotherapy
17 : 1-9 (2006) (2006 )
Details
DOI PMID PMCID Division -
Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA : chemistry and cell delivery
AuthorsJohn J. Turner, Martin Fabani, Andrey A. Arzumanov, Gabriela Ivanova, Michael J. Gait
Journal
Biochimica et Biophysica Acta
1758 : 290-300 (2006) (2006)
Details
DOI PMID PMCID Division -
Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides
AuthorsNatalia N. Dioubankova, Andrei D. Malakhov, Dmitry A. Stetsenko, Michael J. Gait, Vladimar A. Korshun
Journal
Tetrahedron
62 : 6762-6773 (2006) (2006)
Details
DOI PMID PMCID Division -
Synthesis of 2'-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3‑diketones
AuthorsTimofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya, Dmitry A. Stetsenko
Journal
Tetrahedron Letters
47 : 5515-5518 (2006) (2006)
Details
DOI PMID PMCID Division -
Anti-HIV activity of steric block oligonucleotides
AuthorsGabriela Ivanova, Andrey A. Arzumanov, John J. Turner, Sandrine Reigadas, Jean-Jacques Toulme, Douglas E. Brown, Andrew M. L. Lever, Michael J. Gait
Journal
Ann. N. Y. Acad. Sci
1082 : 103-115 (2006) (2006)
Details
DOI PMID PMCID Division -
Oligonucleotide analogs as antiviral agents
AuthorsMartin M. Fabani, John J. Turner, Michael J. Gait
Journal
Current Opinion in Molecular Therapeutics
8: 108-114 (2006) (2006)
Details
DOI PMID PMCID Division -
Disulfide conjugation of peptides to oligonucleotides and their analogs
AuthorsJohn J. Turner, Donna Williams, David Owen, Michael J. Gait
Journal
Current Protocols in Nucleic Acid Chemistry
Supplement 24: 4.28.1-4.28.21 (2006) (2006)
Details
DOI PMID PMCID Division -
Peptide conjugates of oligonucleotide analogs and siRNA for gene expression modulation
AuthorsJohn J. Turner, Andrey A. Arzumanov, Gabriela Ivanova, Martin Fabani, Michael J. Gait
Journal
Handbook of Cell-Penetrating Peptides, 2nd ed (Ed: Ulo Langel), CRC Press
pp.313-328 (2006) (2006)
Details
DOI PMID PMCID Division - Syntheses and oligonucleotide incorporation of nucleoside analogues containing pendant imidazolyl or amino functionalities - the search for sequence-specific artificial ribonucleases AuthorsHolmes S. C., Gait M. J. Journal European Journal of Organic Chemistry 24 : 5171-5183. December 2005 (2005)
- Chemical methods for peptide-oligonucleotide conjugate synthesis AuthorsStetsenko D. A., Gait M. J. Journal Methods in Molecular Biology (Oligonucleotide Synthesis: Methods and Applications, Edited by P. Herdewijn) 288: 205-224. January 2005 (2005)
-
Synthesis of DNA conjugates by solid-phase fragment
condensation via aldehyde-nucleophile coupling
AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya
Journal
Tetrahedron Letters
46: 3191-3195 (2005) (2005)
Details
DOI PMID PMCID Division -
Use of carbonyl group addition-elimination reactions for synthesis of nucleic acid conjugates
AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya
Journal
Bioconjugate Chemistry
16 : 471-489 (2005) (2005 )
Details
DOI PMID PMCID Division -
Oligonucleotides containing 2'-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2'-aldehyde oligonucleotides for chemoselective ligation
AuthorsEugeny M. Zubin, Dmitry A. Stetsenko, Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya
Journal
Bioorganic and Medicinal Chemistry
13 : 4912-4920 (2005) (2005)
Details
DOI PMID PMCID Division -
Synthesis and properties of oligodeoxyribonucleotides containing 2'-0-(2,3-dihydroxypropyl)-and 2'-0-(2-oxoethyl)arabinouridine residues
AuthorsT. S. Zatsepin, Yu. M. Ivanova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya
Journal
Russian Chemical Bulletin, International Edition
54 : 238-246 (2005) (2005)
Details
DOI PMID PMCID Division -
A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification
AuthorsMing Jiang, Andrey A. A. Arzumanov, Michael J. Gait, Jo Milner
Journal
Nucleic Acids Research
33 : e151 (2005) (2005)
Details
DOI PMID PMCID Division -
Inhibition of HIV-1 TAT-dependent trans-activation by steric block oligonucleotide analogues containing amino modifications
AuthorsIvanova G. D., Arzumanov A. A., Babu B. R., Karla N., Sweedler D.,Beigelman L., Wengel J., Gait M. J.
Journal
Collection Symposium Series
7:367-371 (2005) (2005)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry -
Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA
AuthorsGaelle Kolb, Sandrine Reigadas, Claudine Boiziau, Arthur van Aerschot, Andrey Arzumanov, Michael J. Gait, Piet Herdewijn, Jean-Jacques Toulme
Journal
Biochemistry
44: 2926-2933 (2005) (2005)
Details
DOI PMID PMCID Division -
Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides
AuthorsJohn J Turner, Andrey A. Arzumanov, Michael J. Gait
Journal
Nucleic Acids Research
33: 27-42 (2005) (2005)
Details
DOI PMID PMCID Division - Antiviral activity of steric-block oligonucleotides targeting the HIV-1 trans-activation repsonse and packaging signal stem-loop RNAs AuthorsBrown D., Arzumanov A. A., Turner J. J., Stetsenko D. A., Lever A. M. L., Gait M. J. Journal Nucleosides, Nucleotides, and Nucleic Acids 24(5-7):393-396. January 2005 (2005)
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Incorporation of side-chain groups of basic amino acids into oligonucleotides via the 2'-position of uridine
AuthorsEugeny M. Zubin, Dmitry A. Stetsenko, Anna V. Kachalova, Michael J. Gait, Tatiana S. Oretskaya
Journal
Nucleic Acids Symposium Series
No. 49: 347-348 (2005) (2005)
Details
DOI PMID PMCID Division -
Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents
AuthorsT. S. Zatsepin, J. J. Turner, T. S. Oretskaya, M. J. Gait
Journal
Current Pharmaceutical Design
11: 3639-3654 (2005) (2005)
Details
DOI PMID PMCID Division -
2'-hydrazine oligonucleotides: synthesis and efficient conjugation with aldehydes
AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya
Journal
Nucleic Acids Symposium Series
No.49: 133-134 (2005) (2005)
Details
DOI PMID PMCID Division -
Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells
AuthorsJohn J. Turner, Gabriela D. Ivanova, Birgit Verbeure, Donna Williams, Andrey A. Arzumanov, Said Abes, Bernard Lebleu, Michael J. Gait
Journal
Nucleic Acids Research
33: 6837-6849 (2005) (2005)
Details
DOI PMID PMCID Division - Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers AuthorsRoss M. F., Filipovska A., Smith R. A. J., Gait M. J., Murphy M. P. Journal Biochemical Journal 383(Pt. 3):457-468. November 2004 (2004)
- Targeting the A site of RNA of the Escherichia coli ribosomal 30 S subunit by 2'-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics AuthorsAbelian A., Walsh A. P., Lentzen G., Aboul-Ela F., Gait M. J. Journal Biochemical Journal 383(Pt 2):201-208 (2004) (2004)
- Oligonucleotides with 2'-O-carboxymethyl group: synthesis and 2'-conjugation via amide bond formation on solid phase AuthorsKachalova A., Zubin E., Stetsenko D., Gait M. J., Oretskaya T. Journal Org. Biomol. Chem. 2(19):2793-2797 (2004) (2004)
- Efficient conjugation and preferential DNA binding of oligonucleotides containing 2'-O-(2-oxoethyl)arabinouridine AuthorsZatsepin T. S., Ivanova Y. M., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Tetrahedron Letters 45(39): 7327-7330. 20 September 2004 (2004)
- 2'-functionalized nucleic acids as structural tools in molecular biology AuthorsZatsepin T. S., Gait M. J., Oretskaya T. S. Journal IUBMB Life 56(4):209-214. April 2004 (2004)
- Synthesis of oligonucleotide 2'-conjugates via amide bond formation in solution AuthorsKachalova A. V., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Bioorganic & Medicinal Chemistry Letters 14(3):801-804 (2004) (2004)
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A new solid support for synthesis of oligonucleotide 3'-carbazates - useful intermediates for chemoselective ligation
AuthorsDmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait
Journal
Innovation and Perspectives in Solid Phase Synthesis and Combinational Libraries. (Edited by R. Epton)
pp.297-300 (2004) (2004)
Details
DOI PMID PMCID Division -
Chemoselective ligation of oligonucleotides modified with reactive groups
AuthorsAnna V. Kachalova, Eugeny M. Zubin, Timofei S. Zatsepin, Yulia V. Agapkina, Yulia M. Ivanova, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya
Journal
Innovation and Perspectives in Solid Phase Synthesis and Combinational Libraries. (Edited by R. Epton)
pp.255-260 (2004) (2004)
Details
DOI PMID PMCID Division -
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues
AuthorsMichael J. Gait
Journal
CMLS Cellular and Molecular Life Sciences
60: 844-853 (2003) (2003)
Details
DOI PMID PMCID Division -
Steric inhibition of human immunodeficiency virus type-1 Tat-dependent trans-activation in vitro and in cells by oligonucleotides containing 2'-O-methyl G-clamp ribonucleoside analogues
AuthorsStephen C. Holmes, Andrey A. Arzumanov, Michael J. Gait
Journal
Nucleic Acids Research
31: 2759-2768 (2003) (2003)
Details
DOI PMID PMCID Division -
Synthesis of peptide and reporter conjugates of oligonucleotide analogues
AuthorsDmitri A. Stetsenko, Donna Williams, David Owen, Michael J. Gait
Journal
Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Peptides, Proteins and Nucleic Acids. Small Molecule Organic Chemical Diversity. (Collected Papers Seventh International Symposium 2002) [Editor: Roger Epton], Mayflower Worldwide Limited
pp.5-8 (2003) (2003)
Details
DOI PMID PMCID Division -
LNA and alpha-L-LNA: towards therapeutic applications
AuthorsJesper Wengel, Birte Vester, Lars Bo Lundberg, Stephen Douthwaite, Mads D. Sorensen, B. Ravindra Babu, Michael J. Gait, Andrey Arzumanov, Michael Petersen, Jakob T. Nielsen
Journal
Nucleosides, Nucleotides & Nucleic Acids
22: 601-604 (2003) (2003)
Details
DOI PMID PMCID Division -
The synthesis of 2'-O-methyl G-clamp containing oligonucleotides and their inhibition of the HIV-1 Tat-TAR interaction
AuthorsStephen C. Holmes, Michael J. Gait
Journal
Nucleosides, Nucleotides & Nucleic Acids
22: 1259-1262 (2003) (2003)
Details
DOI PMID PMCID Division -
1,2-diol and hydrazide phosphoramidites for solid-phase synthesis and chemoselective ligation of 2'-modified oligonucleotides
AuthorsEugeny M. Zubin, Dmitry A. Stetsenko, Tatiana S. Oretskaya, Michael J. Gait
Journal
Nucleosides, Nucleotides & Nucleic Acids
22: 1375-1378 (2003) (2003)
Details
DOI PMID PMCID Division -
Total stepwise solid-phase peptide-oligonucleotide conjugate synthesis on macroporous polystyrene
AuthorsDmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait
Journal
Nucleosides, Nucleotides & Nucleic Acids
22: 1379-1382 (2003) (2003)
Details
DOI PMID PMCID Division -
Synthesis of 2'-modified oligonucleotides containing aldehyde or ethylenediamine groups
AuthorsT. S. Zatsepin, E. A. Romanova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya
Journal
Nucleosides, Nucleotides & Nucleic Acids
22: 1383-1385 (2003) (2003)
Details
DOI PMID PMCID Division -
Uridine 2'-carbamates: facile tools for oligonucleotide 2'-functionalization
AuthorsVladimir A. Korshun, Dmitry A. Stetsenko, Michael J. Gait
Journal
Current Protocols in Nucleic Acid Chemistry
Suppl 15: 4.21.1-4.21.26 (2003) (2003)
Details
DOI PMID PMCID Division -
Pyrenemethyl ara-uridine-2'-carbamate: a strong interstrand excimer in the major groove of a DNA duplex
AuthorsNatalia N. Dioubankova, Andrei D. Malakhov, Dmitry A. Stetsenko, Michael J. Gait, Pavel E. Volynsky, Roman G. Efremov, Vladimir A. Korshun
Journal
ChemBioChem
4: 841-847 (2003) (2003)
Details
DOI PMID PMCID Division -
A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues
AuthorsAndrey Arzumanov, Dmitry A. Stetsenko, Andrey D. Malakhov, Stefanie Reichelt, Mads D. Sorensen, B. Ravindra Babu, Jesper Wengel, Michael J. Gait
Journal
Oligonucleotides
13: 435-453 (2003) (2003)
Details
DOI PMID PMCID Division -
Solid phase synthesis and chromatographic characteristics of nucleophilic agents conjugated with oligonucleotides containing 5'-terminal carboxyl group
AuthorsA. V. Kachalova, V. N. Tashlitsky, D. A. Stetsenko, E. A. Romanova, M. J. Gait, T. S. Oretskaya
Journal
Russian Journal of Bioorganic Chemistry
29: 274-280 (2003) (2003)
Details
DOI PMID PMCID Division -
Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake
AuthorsJean Philippe Richard, Kamran Melikov, Eric Vives, Corinne Ramos, Birgit Verbeure, Mike J. Gait, Leonid V. Chernomordik, Bernard Lebleu
Journal
Journal of Biological Chemistry
278: 585-590 (2003) (2003)
Details
DOI PMID PMCID Division - 2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription AuthorsDarfeuille F., Arzumanov A., Gait M. J., Di Primo C., Toulme J-J. Journal Biochemistry 41(40):12186-12192 (2002) (2002)
- Novel uridin-2'-yl carbamates: synthesis, incorporation into oligodeoxyribonucleotides, and remarkable fluorescence properties of 2'-pyren-1‑ylmethylcarbamate AuthorsKorshun V. A., Stetsenko D. A., Gait M. J. Journal J. Chem. Soc., Perkin Trans 1 pp.1092-1104 (2002) (2002)
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(R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides
AuthorsNatalia N. Dioubankova, Andrey D. Malakhov, Dmitry A. Stetsenko, Vladimir A. Korshun, Michael J. Gait
Journal
Organic Letters
4: 4607-4610 (2002) (2002)
Details
DOI PMID PMCID Division -
A new and efficient method for synthesis of 5'-conjugates of oligonucleotides through amide-bond formation on solid phase
AuthorsAnna V. Kachalova, Dmitry A. Stetsenko, Elena A. Romanova, Vadim N. Tashlitsky, Michael J. Gait, Tatiana S. Oretskaya
Journal
Helvetica Chimica Acta
85: 2409-2416 (2002) (2002)
Details
DOI PMID PMCID Division -
Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2'-aldehydes through thiazolidine, oxime, and hydrazine linkages
AuthorsTimofei S. Zatsepin, Dmitry A. Stetsenko, Andrey A. Arzumanov, Elena A. Romanova, Michael J. Gait, Tatiana S. Oretskaya
Journal
Bioconjugate Chemistry
13: 822-830 (2002) (2002)
Details
DOI PMID PMCID Division -
Total stepwise solid-phase synthesis of oligonucleoitde-(3'-->N)-peptide
AuthorsDmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait
Journal
Organic Letters
4: 3259-3262 (2002) (2002)
Details
DOI PMID PMCID Division -
Synthesis of 2'-modified oligonucleotides and their conjugates
AuthorsTatiana S. Oretskaya, Timofei S. Zatsepin, Evgeny M. Zubin, Anna V. Kachalova, Elena A. Romanova, Dmitry A. Stetsenko, Michael J. Gait
Journal
Collection Symposium Series
5: 145-149 (2002) (2002)
Details
DOI PMID PMCID Division -
Loop-loop interaction of HIV-1 TAR RNA with N3' --> P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription
AuthorsFabien Darfeuille, Andrey Arzumanov, Sergei Gryaznov, Michael J. Gait, Carmelo Di Primo, Jean-Jacques Toulme
Journal
Proceedings of the National Academy of Sciences, USA
99: 9709-9714 (2002) (2002)
Details
DOI PMID PMCID Division -
Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration
AuthorsStolze K., Holmes S. C., Earnshaw D. J., Singh M., Stetsenko D.,Williams D., Gait M. J.
Journal
Bioorganic & Medicinal Chemistry Letters
11(23):3007-3010 (2001) (2001)
Details
DOI10.1016/S0960-894X(01)00608-4 PMID11714598 PMCID DivisionProtein & Nucleic Acid Chemistry - A convenient solid-phase method for synthesis of 3'-conjugates of oligonucleotides AuthorsStetsenko D. A., Gait M. J. Journal Bioconjugate Chemistry 12(4):576-586 (2001) (2001)
- A new 'native ligation' procedure for peptide-oligonucleotide conjugation AuthorsStetsenko D. A., Gait M. J. Journal Nucleosides, Nucleotides & Nucleic Acids 20(4-7):801-804 (2001) (2001)
- Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction AuthorsArzumanov A., Walsh A. P., Liu X., Rajwanshi V. K., Wengel J., Gait M. J. Journal Nucleosides, Nucleotides & Nucleic Acids 20(4-7):471-480 (2001) (2001)
- ARP, a peptide derived from the stress-associated acetylcholinesterase variant, has hematopoietic growth promoting activities AuthorsDan Grisaru, Varda Deutsch, Michael Shapira, Marjorie Pick, Meira Sternfeld, Naomi Melamed-Book, Daniela Kaufer, Nilly Galyam, Michael J. Gait, David Owen, Joseph B. Lessing, Amiram Eldor, Hermona Soreq Journal Molecular Medicine 7(2):93-105 (2001) (2001)
-
Aminoglycosides and cleavage of the hairpin ribozyme
AuthorsEarnshaw D. J., Gait M. J.
Journal
RNA-binding antibiotics. Edited by Renee Schroeder and Mary G Wallis
pp.35-55 (2001) (2001)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry - Synthesis and properties of modified oligodeoxyribonucleotides containing 2'-0-(2,3-dihydroxypropyl)uridine and 2'-0-(2-oxoethyl)uridine AuthorsZatsepin T. S., Kachalova A. V., Romanova E. A., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Russian Journal of Bioorganic Chemistry 27:39-44. January 2001 (2001)
- Synthesis of peptide-oligonucleotide conjugates: application to basic peptides AuthorsStetsenko D. A., Williams D., Gait M. J. Journal Nucleic Acids Research Supplement 1: 153-154 (2001) (2001)
- Inhibition of HIV-1 Tat-dependent Trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides AuthorsArzumanov A., Walsh A. P., Rajwanshi V. K., Kumar R., Wengel J., Gait M. J. Journal Biochemistry 40(48):14645-14654 (2001) (2001)
-
Peptide conjugates of oligonucleotides as enhanced antisense agents
AuthorsStetsenko D. A., Arzumanov A. A., Korshun V. A., Gait M. J.
Journal
Molecular Biology
34: 852-859. November 2000 (2000)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry - Efficient conjugation of peptides to oligonucleotides by native ligation AuthorsStetsenko D. A., Gait M. J. Journal Journal of Organic Chemistry 65(16):4900-4908 (2000) (2000)
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Use of the fluorescent nucleoside analogue benzo[g]quinazoline 2'-O-methyl-beta-D-ribofuranoside to monitor the binding of the HIV-1 Tat protein or of antisense oligonucleotides to the TAR RNA stem‑loop
AuthorsArzumanov A., Godde F., Moreau S., Toulme J-J., Weeds A., Gait M. J.
Journal
Helvetica Chimica Acta
83(7): 1424-1436. 5 July 2000 (2000)
Details
DOI10.1002/1522-2675(20000705)83:7<1424::AID-HLCA1424>3.0. CO;2-D PMID PMCID DivisionProtein & Nucleic Acid Chemistry, Cell Biology - Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides AuthorsEarnshaw D. J., Hamm M. L., Piccirilli J. A., Karpeisky A., Beigelman L., Ross B. S., Manoharan M., Gait M. J. Journal Biochemistry 39(21):6410-6421 (2000) (2000)
- Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position AuthorsKachalova A. V., Zatsepin T. S., Romanova E. A., Stetsenko D. A., Gait M. J., Oretskaya T. S. Journal Nucleosides, Nucleotides and Nucleic Acids 19(10-12):1693-1707 (2000) (2000)
- New phosphoramidite reagents for the synthesis of oligonucleotides containing a cysteine residue useful in peptide conjugation AuthorsStetsenko D. A., Gait M. J. Journal Nucleosides, Nucleotides and Nucleic Acids 19(10-12):1751-1764 (2000) (2000)
-
Synthetic hairpin ribozymes for analysis of structure, function, and ionic co‑factors
AuthorsEarnshaw D. J., Gait M. J.
Journal
Ribozyme Biochemistry and Biotechnology. Edited by Guido Krupp and Rajesh K. Gaur
pp.227-253 (2000) (2000)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry -
Synthetic hairpin ribozymes for analysisof structure, function, and ionic co‑factors
AuthorsEarnshaw D. J., Gait M. J.
Journal
Ribozyme Biochemistry and Biotechnology. Edited by Guido Krupp and Rajesh K. Gaur
pp.227-253 (2000) (2000)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry - The harpin ribozyme: the roles of ions in RNA cleavage AuthorsEarnshaw D. J., Gait M. J. Journal Nucleic Acids Symposium Series No.42: 273-274 (1999) (1999)
- Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA AuthorsBeatrice Mestre, Andrey Arzumanov, Mohinder Singh, Florence Boulme, Simon Litvak, Michael J. Gait Journal Biochimica et Biophysica Acta (BBA) 1445(1):86-98 (1999) (1999)
- Studies towards the synthesis of peptide-oligonucleotide conjugates AuthorsPeyrottes S., Mestre B., Burlina F., Gait M. J. Journal Nucleosides & Nucleotides 18: 1443-1448 (1999) (1999)
-
Inhibition of the HIV-1 Tat protein-TAR RNA interaction by 2'-O-Methyl oligoribonucleotides
AuthorsArzumanov A., Gait M. J.
Journal
Collection Symposium Series
2: 168-174 (1999) (1999)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry -
Site-specific cross-linking of amino acids in the basic region of human immunodeficiency virus type 1 Tat peptide to chemically modified TAR RNA duplexes
AuthorsMark A. Farrow, Fareed Aboul-ela, David Owen, Alexander Karpeisky, Leonid Beigelman, Michael J. Gait
Journal
Biochemistry
37: 3096-3108 (1998) (1998)
Details
DOI PMID PMCID Division -
Applications of chemically synthesized RNA
AuthorsMichael J. Gait, David J. Earnshaw, Mark A. Farrow, Jan H. Fogg, Richard L. Grenfell, Nikolai A. Naryshkin, Terence V. Smith
Journal
Applications of Chemically Sunthesized RNA (Book)
pp.1-36 (1998) (1998)
Details
DOI PMID PMCID Division -
Incorporation of modified nucleotides into RNA for studies on RNA structure, function and intermolecular interactions
AuthorsRobert A. Zimmermann, Michael J. Gait, Melissa J. Moore
Journal
Modification and Editing of RNA . Edited by Henri Grosjean and Rob Benne
pp.59-84 (1998) (1998)
Details
DOI PMID PMCID Division -
Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions
AuthorsDavid J. Earnshaw, Michael J. Gait
Journal
Nucleic Acids Research
26: 5551-5561 (1998) (1998)
Details
DOI PMID PMCID Division -
Modified oligoribonucleotides as site-specific probes of RNA structure and function
AuthorsDavid J. Earnshaw, Michael J. Gait
Journal
Biopolymers (Nucleic Acid Sciences)
48: 39-55 (1998) (1998)
Details
DOI PMID PMCID Division -
The synthesis of peptide-oligonucleotide conjugates by a fragment coupling approach
AuthorsSuzanne Peyrottes, Beatrice Mestre, Fabienne Burlina, Michael J. Gait
Journal
Tetrahedron
54: 12513-12522 (1998) (1998)
Details
DOI PMID PMCID Division -
Covalent RNA-peptide binding in a specific complex using oligoribonucleotide N-hydroxybenzotriazole esters
AuthorsE. A. Taran, M. G. Ivanovskaya, M. J. Gait, Z. A. Shabarova
Journal
Molecular Biology
32: 697-703 (1998) (1998)
Details
DOI PMID PMCID Division - RNA recognition and regulation of HIV-1 gene expression by viral factor Tat AuthorsNaryshkin N. A., Gait M. J., Ivanovskaya M. G. Journal Biochemistry Moscow 63(5):489-503 (1998) (1998)
-
Chemical cross-linking of the human immunodeficiency virus type 1 Tat protein to synthetic models of the RNA recognition sequence TAR containing site-specific trisubstituted pyrophosphate analogues
AuthorsNikolai A. Naryshkin, Mark A. Farrow, Marina G. Ivanovskaya, Tanya S. Oretskaya, Zoe A. Shabarova, Michael J. Gait
Journal
Biochemistry
36: 3496-3505 (1997) (1997)
Details
DOI PMID PMCID Division -
Solid phase synthesis of oligoribonucleotides containing site-specific modifications
AuthorsSabine Schmidt, Richard L. Grenfell, Jan Fogg, Terry V. Smith, Jane A. Grasby, Karin Mersmann, Michael J. Gait
Journal
Innovations and Perspectives in Solid Phase Synthesis and Combinatorial Libraries. Edited by R. Epton
pp.11-18 (1997) (1997)
Details
DOI PMID PMCID Division -
Inter-domain cross-linking and molecular modelling of the hairpin ribozyme
AuthorsDavid J. Earnshaw, Benoit Masquida, Sabine Muller, Snorri Th. Sigurdsson, Fritz Eckstein, Eric Westhof, Michael J. Gait
Journal
Journal of Molecular Biology
274: 197-212 (1997) (1997)
Details
DOI PMID PMCID Division -
Progress toward the structure and therapeutic use of the hairpin ribozyme
AuthorsDavid J. Earnshaw, Michael J. Gait
Journal
Antisense & Nucleic Acid Drug Development
7: 403-411 (1997) (1997)
Details
DOI PMID PMCID Division -
Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex
AuthorsKeen N. J., Gait M. J., Karn J.
Journal
Proceedings of the National Academy of Sciences, USA
93(6):2505-2510. 19 March 1996 (1996)
Details
DOI10.1073/pnas.93.6.2505 PMID8637904 PMCIDPMC39827 DivisionProtein & Nucleic Acid Chemistry -
Control of transcriptional elongation by the human immunodeficiency virus Tat protein
AuthorsJonathan Karn, Mark J. Churcher, Karola Rittner, Nicholas J. Keen, Michael J. Gait
Journal
Eukaryotic Gene Transcription. Edited by Stephen Goodbourn
pp.254-286 (1996) (1996)
Details
DOI PMID PMCID Division -
Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs
AuthorsIvan Mikaelian, Marion Krieg, Michael J. Gait, Jonathan Karn
Journal
Journal of Molecular Biology
257: 246-264 (1996) (1996)
Details
DOI PMID PMCID Division -
Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure
AuthorsSabine Schmidt, Leonid Beigelman, Alexander Karpeisky, Nassim Usman, Ulrik S. Sorensen, Michael J. Gait
Journal
Nucleic Acids Research
24: 573-581 (1996) (1996)
Details
DOI PMID PMCID Division -
Synthesis and properties of mixed ribo- and deoxyribooligonucleotide duplexes containing an internucleotide trisubstituted pyrophosphate bond
AuthorsN. A. Naryshkin, M. G. Ivanovskaya, T. S. Oretskaya, E. M. Volkov, M. J. Gait, Z. A. Shabarova
Journal
Russian Journal of Bioorganic Chemistry
22: 592-598 (1996) (1996)
Details
DOI PMID PMCID Division -
Probing the tertiary structure of the hairpin ribozyme by chemical crosslinking
AuthorsSabine Schmidt, David J. Earnshaw, Snorri Th. Sigurdsson, Fritz Eckstein, Michael J. Gait
Journal
Collect. Czech. Chem. Commun.
61: S276-S279 (1996) (1996)
Details
DOI PMID PMCID Division -
Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA
AuthorsJane A. Grasby, Karin Mersmann, Mohinder Singh, Michael J. Gait
Journal
Biochemistry
34: 4068-4076 (1995) (1995)
Details
DOI PMID PMCID Division -
The human immunodeficiency virus long terminal repeat includes a specialised initiator element which is required for Tat-responsive transcription
AuthorsKarola Rittner, Mark J. Churcher, Michael J. Gait, Jonathan Karn
Journal
Journal of Molecular Biology
248: 562-580 (1995) (1995)
Details
DOI PMID PMCID Division -
The RNA element encoded by the trans-activation-responsive region of human immunodeficiency virus type 1 is functional when displaced downstream of the start of transcription
AuthorsMark J. Churcher, Anthony D. Lowe, Michael J. Gait, Jonathan Karn
Journal
Proceedings of the National Academy of Sciences, USA
92: 2408-2412 (1995) (1995)
Details
DOI PMID PMCID Division -
Control of human immunodeficiency virus gene expression by the RNA-binding proteins tat and rev
AuthorsJonathan Karn. Michael J. Gait, Mark J. Churcher, Derek A. Mann, Ivan Mikaelian, Clare Pritchard
Journal
RNA Protein: Interactions. Frontiers in Molecular Biology. Edited by. S Goodbourn
pp.192-220 (1995) (1995)
Details
DOI PMID PMCID Division -
Rapid crystallization of chemically synthesized hammerhead RNAs using a double screening procedure
AuthorsWilliam G. Scott, John T. Finch, Richard Grenfell, Jan Fogg, Terry Smith, Michael J. Gait, Aaron Klug
Journal
Journal of Molecular Biology
250: 327-332 (1995) (1995)
Details
DOI PMID PMCID Division -
Synthetic ribonucleotide analogues for RNA structure-function studies
AuthorsMichael J. Gait, Jane A. Grasby, Jonathan Karn, Karin Mersmann, Clare E. Pritchard
Journal
Nucleosides & Nucleotides
14: 1133-1144 (1995) (1995)
Details
DOI PMID PMCID Division -
Synthesis and applications of oligoribonucleotides containing N4‑methylcytidine
AuthorsJane A. Grasby, Mohinder Singh, Jonathan Karn, Michael J. Gait
Journal
Nucleosides and Nucleotides
14: 1129-1132 (1995) (1995)
Details
DOI PMID PMCID Division -
Progress in anti-HIV structure-based drug design
AuthorsMichael J. Gait, Jonathan Karn
Journal
Trends in Biotechnology
13: 430-438 (1995) (1995)
Details
DOI PMID PMCID Division -
RNA binding assays for the regulatory proteins Tat and Rev
AuthorsJ. Karn, M. J. Churcher, K. Rittner, A. Kelley, P. J. G. Butler, D. A. Mann, M. J. Gait
Journal
HIV: A Practical Approach. Vol. 2 Biochemistry, Molecular Biology and Drug Design. Edited by J. Karn
pp.147-165 (1995) (1995)
Details
DOI PMID PMCID Division -
Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins
AuthorsClare E. Pritchard, Jane A. Grasby, Francois Hamy, Anthony M. Zacharek, Mohinder Singh, Jonathan Karn, Michael J. Gait
Journal
Nucleic Acids Research
22: 2592-2600 (1994) (1994)
Details
DOI PMID PMCID Division -
A molecular rheostat. Co-operative rev binding to Stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression
AuthorsDerek A. Mann, Ivan Mikaelian, Rodney W. Zemmel, Sheila M. Green, Anthony D. Lowe, Tominori Kimura, Mohinder Singh, P. Jonathan G. Butler, Michael J. Gait, Jonathan Karn
Journal
Journal of Molecular Biology
241: 193-207 (1994) (1994)
Details
DOI PMID PMCID Division -
Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis
AuthorsJ. A. Grasby, M. J. Gait
Journal
Biochimie
76: 1233-1234 (1994) (1994)
Details
DOI PMID PMCID Division -
Applications of synthetic oligoribonucleotide analogues in studies of RNA structure and function
AuthorsJane A. Grasby, Clare E. Pritchard, Michael J. Gait
Journal
Proc. Indian Acad. Sci. (Chem. Sci.)
106: 1003-1022 (1994) (1994)
Details
DOI PMID PMCID Division - 7-deazaadenosine: oligoribonucleotide building block synthesis and autocatalytic hydrolysis of base-modified hammerhead ribozymes AuthorsSeela F., Mersmann K., Grasby J. A., Gait M. J. Journal Helvetica Chimica Acta 76(5): 1809-1820. 11 August 1993 (1993)
- RNA recognition by the human immuno-deficiency virus Tat and Rev proteins AuthorsGait M. J., Karn J. Journal Trends in Biochemical Sciences 18(7):255-259. July 1993 (1993)
-
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region
AuthorsMark J. Churcher, Christina Lamont, Francois Hamy, Colin Dingwall, Sheila M. Green, Anthony D. Lowe, P. Jonathan G. Butler, Michael J. Gait, Jonathan Karn
Journal
Journal of Molecular Biology
230: 90-110 (1993) (1993)
Details
DOI PMID PMCID Division -
Oligoribonucleotides
AuthorsMichael J. Gait
Journal
Antisense Research and Applications. Edited by Stanley T. Crooke and Bernard Lebleu
pp.289-301 (1993) (1993)
Details
DOI PMID PMCID Division -
Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA
AuthorsFrancois Hamy, Ulysse Asseline, Jane Grasby, Shigenori Iwai, Clare Pritchard, George Slim, P. Jonathan G. Butler, Jonathan Karn, Michael J. Gait
Journal
Journal of Molecular Biology
230: 111-123 (1993) (1993)
Details
DOI PMID PMCID Division -
HIV gene regulatory proteins tat and rev and their interactions wi th synthetic RNA
AuthorsUlysse Asseline, Jane Grasby, Francois Hamy, Shigenori Iwai, Derek A. Mann, Clare Pritchard, Jonathan Karn, Michael J. Gait
Journal
Nucleic Acids Symposium Series No. 29
pp.113-114 (1993) (1993)
Details
DOI PMID PMCID Division -
The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage
AuthorsJane A. Grasby, P. Jonathan G. Butler, Michael J. Gait
Journal
Nucleic Acids Research
21: 4444-4450 (1993) (1993)
Details
DOI PMID PMCID Division -
Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro
AuthorsMaria A. Graeble, Mark J. Churcher, Anthony D. Lowe, Michael J. Gait, Jonathan Karn
Journal
Proceedings of the National Academy of Sciences, USA
90: 6184-6188 (1993) (1993)
Details
DOI PMID PMCID Division -
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region
AuthorsMark J. Churcher, Christina Lamont, Francois Hamy, Colin Dingwall, Sheila M. Green, Anthony D. Lowe, P. Jonathan G. Butler, Michael J. Gait, Jonathan Karn
Journal
Journal of Molecular Biology
230: 90-110 (1993) (1993)
Details
DOI PMID PMCID Division - Synthesis and applications of oligoribonucleotides containing guanosine analogues AuthorsGrasby J. A., Pritchard C. E., Mersmann K., Seela F., Gait M. J. Journal Collect. Czech. Chem. Commun. 58 (Special Issue): 154-157 (1993) (1993)
-
In situ hybridization with biotinylated probes
AuthorsPiers C. Emson, Michael J. Gait
Journal
In situ Hybridization. A Practical Approach. Edited by D. G. Wilkinson
pp.45-59 (1992) (1992)
Details
DOI PMID PMCID Division -
The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage
AuthorsGeorge Slim, Michael J. Gait
Journal
Biochemical and Biophysical Reseach Communications
183: 605-609 (1992) (1992)
Details
DOI PMID PMCID Division -
Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein
AuthorsShigenori Iwai, Clare Pritchard, Derek A. Mann, Jonathan Karn, Michael J. Gait
Journal
Nucleic Acids Research
20: 6465-6472 (1992) (1992)
Details
DOI PMID PMCID Division -
Recognition of the high affinity binding site in rev-response element RNA by the Human Immunodeficiency Virus type-1 rev protein
AuthorsShigenori Iwai, Clare Pritchard, Derek A. Mann, Jonathan Karn, Michael J. Gait
Journal
Nucleic Acids Research
20: 6465-6472 (1992) (1992)
Details
DOI PMID PMCID Division -
DNA/RNA synthesis and labelling
AuthorsMichael J. Gait
Journal
Current Opinion in Biotechnology
2: 61-68 (1991) (1991)
Details
DOI PMID PMCID Division -
Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes
AuthorsGeorge Slim, Michael J. Gait
Journal
Nucleic Acids Research
19: 1183-1188 (1991 )
(1991)
Details
DOI PMID PMCID Division -
Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich 'bubble' located within the rev-responsive region of viral mRNAs
AuthorsShaun Heaphy, John T. Finch, Michael J. Gait, Jonathan Karn, Mohinder Singh
Journal
Proceedings of the National Academy of Sciences, USA
88: 7366-7370 (1991 )
(1991)
Details
DOI PMID PMCID Division -
Oligoribonucleotide synthesis
AuthorsGait M. J., Pritchard C., Slim G.
Journal
Oligoribonucleotide Synthesis and Analogues: A Practical Approach (Book)
pp.25-48 (1991)
(1991)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry -
Regulation of HIV-1 gene expression by the RNA-binding proteins tat and rev
AuthorsJ. Karn, C. Dingwall, M. J. Gait, S. Heaphy, M. A. Skinner
Journal
Nucleic Acids and Molecular Biology. Edited by F. Eckstein and D. M. J. Lilley
Volume 5: 194-218 (1991)
(1991)
Details
DOI PMID PMCID Division - 3'/5'-regioselectivity of introduction of the 9-fluorenyl-methoxycarbonyl group to 2'-O-tetrahydropyran-2-yl- and 2'-O-(4-methoxytetrahydropyran-4-yl-)-nucleosides: useful intermediates for solid-phase-RNA‑synthesis AuthorsLehmann C., Xu Y. Z., Christodoulou C., Gait M. J., Van Meervelt L., Moore M., Kennard O. Journal Nucleosides & Nucleotides 10: 1599-1614 (1991) (1991)
-
Trans-activation requires the binding of the HIV-1 tat protein to TAR RNA
AuthorsDingwall C., Ernberg I., Gait M. J., Heaphy S., Karn J., Skinner M.
Journal
Advances in Molecular Biology and Targeted Treatment for AIDS (Edited by A. Kumar)
pp.133-143 (1991) (1991)
Details
DOI PMID PMCID DivisionProtein & Nucleic Acid Chemistry -
HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure
AuthorsColin Dingwall, Ingemar Ernberg, Michael J. Gait, Sheila M. Green, Shaun Heaphy, Jonathan Karn, Anthony D. Lowe, Mohinder Singh, Michael A. Skinner
Journal
EMBO Journal
9: 4145-4153 (1990 )
(1990)
Details
DOI PMID PMCID Division -
Biotinyl and phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides
AuthorsKonrad Misiura, Ian Durrant, Michael R. Evans, Michael J. Gait
Journal
Nucleic Acids Research
18: 4345-4354 (1990)
(1990)
Details
DOI PMID PMCID Division -
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region
AuthorsShaun Heaphy, Colin Dingwall, Ingemar Ernberg, Michael J. Gait, Sheila M. Green, Jonathan Karn, Anthony D. Lowe, Mohinder Singh, Michael A. Skinner
Journal
Cell
60: 685-693 (1990 ) (1990)
Details
DOI PMID PMCID Division -
Simultaneous visualization of vasopressin and oxytocin mRNA-containing neurons in the hypothalamus using non-radioactive in situ hybridization histochemistry
AuthorsIchimiya Y., Emson P. C., Christodoulou C. Gait M. J., Ruth J. L.
Journal
Journal of Neuroendocrinology
1(2):73-75. April 1989 (1989)
Details
DOI10.1111/j.1365-2826.1989.tb00081.x PMID19210460 PMCID DivisionProtein & Nucleic Acid Chemistry -
Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5'-hydroxyl protection
AuthorsChristian Lehmann, Yao-Zhong Xu, Chris Christodoulou, Zu-Kun Tan, Michael J. Gait
Journal
Nucleic Acids Research
17: 2379-2390 (1989) (1989)
Details
DOI PMID PMCID Division - Solid-phase synthesis of oligoribonucleotides AuthorsYao-Zhong Xu, Christian Lehmann, George Slim, Chris Christodoulou, Zu-Kun Tan, Michael J. Gait Journal Nucleic Acids Research Symposium Series No. 21: 39-40 (1989) (1989)
-
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro
AuthorsColin Dingwall, Ingemar Ernberg, Michael J. Gait, Sheila M. Green, Shaun Heaphy, Jonathan Karn, Anthony D. Lowe, Mohinder Singh, Michael A. Skinner, Robert Valerio
Journal
Proceedings of the National Academy of Sciences, USA
86: 6925-6929 (1989) (1989)
Details
DOI PMID PMCID Division - Nonradioactive methods of in Situ hybridization: visualization of neuroendocrine mRNA AuthorsEmson P. C., Arai H., Agrawal S., Christodoulou C., Gait M. J. Journal Methods in Enzymology 168: 753-761. January 1989 (1989)
- In situ hybridization histochemistry: localisation of vasopressin mRNA in rat brain using a biotinylated oligonucleotide probe AuthorsArai H., Emson P. C., Agrawal S., Christodoulou C., Gait M. J. Journal Molecular Brain Research 464(1):63-69. August 1988 (1988)
-
Nucleotide and deduced amino acid sequence of stp: the bacteriophage T4 anticodon nuclease gene
AuthorsDaphne Chapman, Ilan Morad, Gabriel Kaufmann, Michael J. Gait, Lori Jorissen, Larry Snyder
Journal
Journal of Molecular Biology
199: 373-377 (1988) (1988)
Details
DOI PMID PMCID Division - Cloning and expression in E. Coli of a synthetic gene for the bacteriocidal protein caltrin/seminalplasmin AuthorsHeaphy S., Singh M., Gait M. J. Journal Protein Engineering 1(5):425-431. October 1987 (1987)
-
Sequential NMR assignments of labile protons in DNA using two-dimensional nuclear-Overhauser-enhancement spectroscopy with three jump-and-return pulse sequences
AuthorsOtting G., Grรผtter R., Leupin W., Minganti C., Ganesh K. N., Sproat B. S.,Gait M. J., Wรผthrich K.
Journal
Eur. J. Biochem
166(1):215-220. July 1987 (1987)
Details
DOI10.1111/j.1432-1033.1987.tb13504.x PMID3036520 PMCID DivisionProtein & Nucleic Acid Chemistry -
Effect of single amino acid changes in the region of the adenylylation site of T4 RNA ligase
AuthorsShaun Heaphy, Mohinder Singh, Michael J. Gait
Journal
Biochemistry
26: 1688-1696 (1987) (1987)
Details
DOI PMID PMCID Division -
A new 5'-protecting group for use in solid-phase synthesis of oligoribonucleotides
AuthorsChris Christodoulou, Sudhir Agrawal, Michael J. Gait
Journal
Nucleosides & Nucleotides
6: 341-344 (1987) (1987)
Details
DOI PMID PMCID Division -
Progress towards solid-phase synthesis of oligoribonucleotides
AuthorsChris Christodoulou, Sudhir Agrawal, Michael J. Gait
Journal
Biophosphates and Their Analogues - Synthesis, Structure, Metabolism and Activity. Edited by K. S. Bruzik and W. J. Stec
pp.99-106 (1987) (1987)
Details
DOI PMID PMCID Division -
Efficient methods for attaching non-radioactive labels to the 5' ends of synthetic oligodeoxyribonucleotides
AuthorsSudhir Agrawal, Chris Christodoulou, Michael J. Gait
Journal
Nucleic Acids Research
14(15):6227-6245 (1986) (1986)
Details
DOI10.1093/nar/14.15.6227 PMID3748808 PMCIDPMC311633 DivisionProtein & Nucleic Acid Chemistry -
Incompatibility of acid-labiIe 2' and 5' protecting groups for solid-phase synthesis of oligoribonucleotides
AuthorsChris Christodoulou, Sudhir Agrawal, Michael J. Gait
Journal
Tetrahedron Letters
27: 1521-1522 (1986) (1986)
Details
DOI PMID PMCID Division -
Site-directed mutagenesis as a means of studying the enzyme T4 RNA ligase
AuthorsHeaphy S., Singh M., Gait M. J.
Journal
Biochemical Society Transactions
14: 1220-1221 (1986) (1986)
Details
DOI PMID PMCID Division -
The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron
AuthorsBritt-Marie Sjoberg, Solveig Hahne, Catherine Z. Mathews, Christopher K. Mathews, Keith N. Rand, Michael J. Gait
Journal
EMBO Journal
5: 2031-2036 (1986) (1986)
Details
DOI PMID PMCID Division -
Oligonucleotide-directed misincorporation mutagenesis on single-stranded DNA templates
AuthorsMohinder Singh, Shaun Heaphy, Michael J. Gait
Journal
Protein Engineering
1: 75-76 (1986) (1986)
Details
DOI PMID PMCID Division -
Location of the adenylylation site in T4 RNA ligase
AuthorsHans C. Thogersen, Morris, H. R., Keith N. Rand, Michael J. Gait
Journal
European Journal of Biochemisty
147: 325-329 (1985) (1985)
Details
DOI PMID PMCID Division -
Comparison of controlled pore glass and Kieselguhr-polydimethylacrylamide composite as supports for solid-phase synthesis of 23-residue oligodeoxyribonucleotides in milligram amounts
AuthorsCarlo Minganti, K. N. Ganesh, Brian S. Sproat, Michael J. Gait
Journal
Analytical Biochemistry
147: 63-74 (1985) (1985)
Details
DOI PMID PMCID Division -
Chemical synthesis of a gene for somatomedin C
AuthorsBrian S. Sproat, Michael J. Gait
Journal
Nucleic Acids Research
13: 2959-2977 (1985) (1985)
Details
DOI PMID PMCID Division -
Rapid synthesis of oligodeoxyribonucleotides VIII. An improved procedure for solid-phase oligodeoxyribonucleotide synthesis using a controlled pore glass support and phosphotriester chemistry
AuthorsB. S. Sproat, C. Minganti, M. J. Gait
Journal
Nucleosides & Nucleotides
4: 139-142 (1985) (1985)
Details
DOI PMID PMCID Division -
T4RNA ligase: new structural studies on an unusual but useful enzyme
AuthorsK. N. Rand, M. Singh, H. C. Thogersen, M. J. Gait
Journal
Proc. Int. Symp. Biomol. Struct. Interactions, Suppl. J. Biosci.
8: 89-106 (1985) (1985)
Details
DOI PMID PMCID Division -
Sequence and cloning of bacteriophage T4 gene 63 encoding RNA ligase and tail fibre attachment activities
AuthorsK. N. Rand, M. J. Gait
Journal
EMBO Journal
3: 397-402 (1984) (1984)
Details
DOI PMID PMCID Division -
Synthetic donor and acceptor splice sites function in a RNA polymerase B (II) transcription unit
AuthorsG. Rautmann, H. W. D. Matthes, M. J. Gait, R. Breathnach
Journal
EMBO Journal
3: 2021-2028 (1984) (1984)
Details
DOI PMID PMCID Division -
A new selective phage cloning vector, lambda2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI
AuthorsJonathan Karn, Hans W. D. Matthes, Michael J. Gait, Sydney Brenner
Journal
Gene
32: 217-224 (1984) (1984)
Details
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Continuous-flow phosphotriester method for solid-phase synthesis of oligodeoxyribonucleotides
AuthorsM. J. Gait, H. W. D. Matthes, M. Singh, B. S. Sproat, R. Titmas
Journal
Cold Spring Harbor Symposia on Quantitative Biology
XLVII: 393-401 (1983) (1983)
Details
DOI PMID PMCID Division - The antitumor drug cis-[Pt(NH3)2Cl2] forms an intrastrand d(GpG) cross-link upon reaction with [d(ApGpGpCpCpT)]2 AuthorsCaradonna J. P., Lippard S. J., Gait M. J., Singh M. Journal Journal of the American Chemical Society 104: 5793-5795. 1 October 1982 (1982)
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Synthesis of oligodeoxyribonucleotides by a continuous-flow, solid-phase method using phosphotriester intermediates
AuthorsMichael J. Gait, Hans W. D. Matthes, Mohinder Singh, Richard C. Titmas
Journal
Journal of the Chemical Society. Chemical Communications
pp.37-40 (1982) (1982)
Details
DOI PMID PMCID Division -
Chicken histone H5: selection of a cDNA recombinant using an extended synthetic primer
AuthorsP. A. Krieg, A. J. Robins, M. J. Gait, R. C. Titmas, J. R. E. Wells
Journal
Nucleic Acids Research
10: 1495-1502 (1982) (1982)
Details
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Nucleotide sequence of tobacco mosaic virus RNA
AuthorsP. Goelet, G. P. Lomonossoff, P. J. G. Butler, M. E. Akam, M. J. Gait, J. Karn
Journal
Proceedings of the National Academy of Sciences, USA
79: 5818-5822 (1982) (1982)
Details
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Rapid synthesis of oligodeoxyribonucleotides. VII. Solid phase synthesis of oligodeoxyribonucleotides by a continuous flow phosphotriester method on a kieselguhr-polyamide support
AuthorsMichael J. Gait, Hans W. D. Matthes, Mohinder Singh, Brian S. Sproat, Richard C. Titmas
Journal
Nucleic Acids Research
10: 6243-6254 (1982) (1982)
Details
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Synthesis of oligodeoxyribonucleotides by a continuous flow, phosphotriester method on a kieselguhr/polyamide support
AuthorsMichael J. Gait, Hans W. D. Matthes, Mohinder Singh, Brian S. Sproat, Richard C. Titmas
Journal
Chemical and Enzymatic Synthesis of Gene Fragments. Edited by H. G. Gassen and Anne Lang
pp.2-42 (1982) (1982)
Details
DOI PMID PMCID Division -
The use of synthetic oligodeoxynucleotide primers in cloning and sequencing segment 8 of influenza virus (A/PR/8/34)
AuthorsGreg Winter, Stan Fields, Michael J. Gait, George G. Brownlee
Journal
Nucleic Acids Research
9: 237-245 (1981) (1981)
Details
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Rapid synthesis of oligodeoxyribonucleotides VI. Efficient, mechanised synthesis of heptadeca-deoxyribonucleotides by an improved solid phase phosphotriester route
AuthorsMary Lynn Duckworth, Michael J. Gait, Philip Goelet, Guo Fang Hong, Mohinder Singh, Richard C. Titmas
Journal
Nucleic Acids Research
9: 1691-1706 (1981) (1981)
Details
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Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing
AuthorsPamela H. Hamlyn, Michael J. Gait, Cesar Milstein
Journal
Nucleic Acids Research
9: 4485-4494 (1981) (1981)
Details
DOI PMID PMCID Division -
A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2
AuthorsS. Anderson, M. J. Gait, L. Mayol, I. G. Young
Journal
Nucleic Acids Research
8: 1731-1743 (1980) (1980)
Details
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Rapid synthesis of oligodeoxyribonucleotides IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates
AuthorsM. J. Gait, M. Singh, R. C. Sheppard, M. D. Edge, A. R. Greene, G. R. Heathcliffe, T. C. Atkinson, C. R. Newton, A. F. Markham
Journal
Nucleic Acids Research
8: 1081-1096 (1980) (1980)
Details
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Rapid synthesis of oligodeoxyribonucleotides V. Further studies in solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates
AuthorsM. J. Gait, S. G. Popov, M. Singh, R. C. Titmas
Journal
Nucleic Acids Research Symposium Series
7: 243-257 (1980) (1980)
Details
DOI PMID PMCID Division -
Comparison of rates of phosphotriester formation and sulphonation by coupling agents in oligodeoxyribonucleotide synthesis by the phosphotriester method
AuthorsM. J. Gait, S. G. Popov
Journal
Tetrahedron Letters
21: 2841-2842 (1980) (1980)
Details
DOI PMID PMCID Division -
Polymer-supported synthesis of oligonucleotides
AuthorsM. J. Gait
Journal
Polymer-supported Reactions in Organic Synthesis. Edited by P. Hodge and D. C. Sherrington
pp.435-456 (1980) (1980)
Details
DOI PMID PMCID Division -
Biological chemistry. Part (ii) Nucleic acids. (b) Oligonucleotides and polynucleotides
AuthorsM. J. Gait
Journal
Annual Reports B 1980. The Royal Society of Chemistry
pp.310-322 (1980) (1980)
Details
DOI PMID PMCID Division -
The polyamide method of solid phase peptide and oligonucleotide synthesis
AuthorsAtherton E., Gait M. J., Sheppard R. C., Williams B. J.
Journal
Bioorganic Chemistry
8: 351-370 (1979) (1979)
Details
DOI PMID PMCID Division -
Easily prepared polar support for solid phase peptide and oligonucleotide synthesis. Preparation of substance P and a nonadeoxyribonucleotide
AuthorsReza Arshady, Eric Atherton, Michael J. Gait, Karen Lee, Robert C. Sheppard
Journal
Journal of the Chemical Society. Chemical Communications
pp.423-425 (1979) (1979)
Details
DOI PMID PMCID Division -
Rapid synthesis of oligodeoxyribonucleotides III. Effect of added carboxylate ion on the efficiency of internucleotide bond formation. Solid-phase synthesis of the dodecanucleotide d(pT-A-A-C-T-G-C-T-C-A-C‑T)
AuthorsM. J. Gait, R. C. Sheppard
Journal
Nucleic Acids Research
6: 1259-1268 (1979) (1979)
Details
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Rapid chemical synthesis and circular dichroism properties of some 2'-5'-linked oligoriboadenylates
AuthorsA. F. Markham, R. A. Porter, M. J. Gait, R. C. Sheppard, I. M. Kerr
Journal
Nucleic Acids Research
6: 2569-2582 (1979) (1979)
Details
DOI PMID PMCID Division - Biological Chemistry. Part (v) Nucleic Acids. (b) Oligonucleotides and polynucleotides AuthorsGait M. J. Journal Royal Society of Chemistry: Annual Reports B 76: pp.462-471 (1979) (1979)
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Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing
AuthorsPamela H. Hamlyn, George G. Brownlee, Chen-Chi Cheng, Michael J. Gait, Cesar Milstein
Journal
Cell
15: 1067-1075 (1978) (1978)
Details
DOI PMID PMCID Division - Solid-phase oligonucleotide synthesis: a renaissance AuthorsGait M. J., Sheppard R. C. Journal Nucleic Acids Research Special Publication 4: s79-s83. 1 January 1978 (1978)
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Rapid synthesis of oligodeoxyribonucleotides: a new solid-phase method
AuthorsM. J. Gait, R. C. Sheppard
Journal
Nucleic Acids Research
4: 1135-1158 (1977) (1977)
Details
DOI PMID PMCID Division -
Rapid synthesis of oligodeoxyribonucleotides II. Machine-aided solid-phase syntheses of two nonanucleotides and an octanucleotide
AuthorsM. J. Gait, R. C. Sheppard
Journal
Nucleic Acids Research
4: 4391-4410 (1977) (1977)
Details
DOI PMID PMCID Division -
A polyamide support for oligonucleotide synthesis
AuthorsM. J. Gait, R. C. Sheppard
Journal
Journal of the American Chemical Society
98: 8514-8516 (1976) (1976)
Details
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