Published Research

Found 117 results for Fersht.

• From covalent transition states in chemistry to noncovalent in biology: from β- to Φ-value analysis of protein folding AuthorsFersht A. R. Journal Quarterly Reviews of Biophysics 57:e4 (2024)
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  DOIdoi.org/10.1017/s0033583523000045 PMID38597675 PMCID  DivisionProtein & Nucleic Acid Chemistry
• AlphaFold - A Personal Perspective on the Impact of Machine Learning AuthorsFersht A. R. Journal Journal of Molecular Biology 433(20):167088. 1 October 2021 (2021)
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  DOI10.1016/j.jmb.2021.167088 PMID34087198 PMCID  DivisionProtein & Nucleic Acid Chemistry
• NF-κB Rel Subunit Exchange on a Physiological Timescale AuthorsBiancalana M., Natan E., Lenardo M. J., Fersht A. R. Journal Protein Science : a Publication of the Protein Society 30(9):1818-1832. September 2021 (2021)
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  DOI10.1002/pro.4134 PMID34089216 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm AuthorsBauer M. R., Krämer A., Settanni G., Jones R. N., Ni X., Khan Tareque R., Fersht A. R., Spencer J., Joerger A. C. Journal ACS Chemical Biology 15(3):657-668. 20 March 2020 (2020)
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  DOI10.1021/acschembio.9b00748 PMID31990523 PMCIDPMC7307883 DivisionProtein & Nucleic Acid Chemistry
• ChemBioChem@20-Some Reflections AuthorsFersht A. R., Gölitz P., Lehn J. M. Journal Chembiochem : a European Journal of Chemical Biology 21(1-2):5-6. 15 January 2020 (2020)
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  DOI10.1002/cbic.201900658 PMID31769931 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C AuthorsBauer M. R., Jones R. N., Tareque R. K., Springett B., Dingler F. A., Verduci L., Patel K. J., Fersht A. R., Joerger A. C., Spencer J. Journal Future Medicinal Chemistry 11(19):2491-2504. October 2019 (2019)
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  DOI10.4155/fmc-2019‑0181 PMID31633398 PMCIDPMC6803818 DivisionProtein & Nucleic Acid Chemistry
• SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma AuthorsGomes S., Bosco B., Loureiro J. B., Ramos H., Raimundo L., Soares J., Nazareth N., Barcherini V., Domingues L., Oliveira C., Bisio A., Piazza S., Bauer M. R., Brás J. P., Almeida M. I., Gomes C., Reis F., Fersht A. R., Inga A., Santos M. M. M., Saraiva L. Journal Cancers 11(8); E1151. August 2019 (2019)
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  DOI10.3390/cancers11081151 PMID31405179 PMCIDPMC6721528 DivisionProtein & Nucleic Acid Chemistry
• Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines AuthorsBaud M. G. J., Bauer M. R., Verduci L., Dingler F. A., Patel K. J., Horil Roy D., Joerger A. C., Fersht A. R. Journal European Journal of Medicinal Chemistry 152:101-114. 25 May 2018 (2018)
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  DOI10.1016/j.ejmech.2018.04.035 PMID29702446 PMCIDPMC5986712 DivisionProtein & Nucleic Acid Chemistry, Cell Biology, Structural Studies
• The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53 AuthorsMadan E., Parker T. M., Bauer M. R., Dhiman A., Pelham C. J., Nagane M., Kuppusamy M. L., Holmes M., Holmes T. R., Shaik K., Shee K., Kiparoidze S., Smith S. D., Park Y. A., Gomm J., Jones L. J., Tomás A. R., Cunha A. C., Selvendiran K., Hansen L. A., Fersht A. R., Hideg K., Gogna R., Kuppusamy P. Journal Journal of Biological Chemistry 293(12):4262-4276. 23 March 2018 (2018)
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  DOI10.1074/jbc. RA117.000950 PMID29382728 PMCIDPMC5868245 DivisionProtein & Nucleic Acid Chemistry
• Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: preclinical investigation with the anti-p53 drug, PK11007 AuthorsSynnott N. C., Bauer M. R., Madden S., Murray A., Klinger R., O'Donovan N., O'Connor D., Gallagher W. M., Crown J., Fersht A. R., Duffy M. J. Journal Cancer Letters 414:99-106. 1 February 2018 (2018)
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  DOI10.1016/j. Canlet.2017.09.053 PMID29069577 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Structures of closed and open conformations of dimeric human ATM AuthorsBaretić D., Pollard H. K., Fisher D. I., Johnson C. M., Santhanam B., Truman C. M., Kouba T., Fersht A. R., Phillips C., Williams R. L. Journal Science Advances 3(5):e1700933. 10 May 2017 (2017)
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  DOI10.1126/sciadv.1700933 PMID28508083 PMCIDPMC5425235 DivisionProtein & Nucleic Acid Chemistry
• Multisite aggregation of p53 and implications for drug rescue AuthorsWang G., Fersht A. R. Journal Proceedings of the National Academy of Sciences of the United States of America 114(13):E2634-E2643. 28 March 2017 (2017)
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  DOI10.1073/pnas.1700308114 PMID28292898 PMCIDPMC5380089 DivisionProtein & Nucleic Acid Chemistry
• Design of a molecular support for cryo-EM structure determination AuthorsMartin T. G., Bharat T. A., Joerger A. C., Bai X. C., Praetorius F., Fersht A. R., Dietz H., Scheres S. H. Journal Proceedings of the National Academy of Sciences of the United States of America 113(47):E7456-E7463. 22 November 2016 (2016)
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  DOI10.1073/pnas.1612720113 PMID27821763 PMCIDPMC5127339 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells AuthorsBauer M. R., Joerger A. C., Fersht A. R. Journal Proceedings of the National Academy of Sciences of the United States of America 113(36):E5271-80. 6 September 2016 (2016)
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  DOI10.1073/pnas.1610421113 PMID27551077 PMCIDPMC5018792 DivisionProtein & Nucleic Acid Chemistry
• An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein AuthorsBromley D., Bauer M. R., Fersht A. R., Daggett V. Journal Protein Engineering, Design & Selection : PEDS 29(9):377-390. September 2016 (2016)
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  DOI10.1093/protein/gzw035 PMID27503952 PMCIDPMC5001139 DivisionProtein & Nucleic Acid Chemistry
• Harnessing fluorine-sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs AuthorsBauer M. R., Jones R. N., Baud M. G., Wilcken R., Boeckler F. M., Fersht A. R., Joerger A. C., Spencer J. Journal ACS Chemical Biology 11(8):2265-2274. 19 August 2016 (2016)
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  DOI10.1021/acschembio.6b00315 PMID27267810 PMCIDPMC4994063 DivisionProtein & Nucleic Acid Chemistry
• The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches AuthorsJoerger A. C., Fersht A. R. Journal Annual Review of Biochemistry 85:375-404 June 2016 (2016)
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  DOI10.1146/annurev-biochem-060815‑014710 PMID27145840 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Experimental and theoretical evaluation of the ethynyl moiety as a halogen bioisostere AuthorsWilcken R., Zimmermann M. O., Bauer M. R., Rutherford T. J., Fersht A. R.., Joerger A. C., Boeckler F. M. Journal ACS Chemical Biology 10(12):2725-2732. 18 December 2015 (2015)
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  DOI10.1021/acschembio.5b00515 PMID26378745 PMCIDPMC4836799 DivisionProtein & Nucleic Acid Chemistry
• Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53 AuthorsJoerger A. C., Bauer M. R., Wilcken R., Baud M. G., Harbrecht H., Exner T. E., Boeckler F. M., Spencer J., Fersht A. R. Journal Structure 23(12):2246-2255. 1 December 2015 (2015)
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  DOI10.1016/j.str.2015.10.016 PMID26636255 PMCIDPMC4671956 DivisionProtein & Nucleic Acid Chemistry
• Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation AuthorsNasedkin A., Marcellini M., Religa T. L,. Freund S. M., Menzel A., Fersht A. R., Jemth P., van der Spoel D., Davidsson J. Journal PloS one 10(5):e0125662. 6 May 2015 (2015)
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  DOI10.1371/journal.pone.0125662 PMID25946337 PMCIDPMC4422743 DivisionProtein & Nucleic Acid Chemistry
• Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis. AuthorsWang G., Fersht A. R. Journal Proceedings of the National Academy of Sciences of the United States of America 112(8):2437-2442. 24 February 2015 (2015)
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  DOI10.1073/pnas.1500243112 PMID25675526 PMCIDPMC4345617 DivisionProtein & Nucleic Acid Chemistry
• Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding. AuthorsWang G., Fersht A. R. Journal Proceedings of the National Academy of Sciences of the United States of America 112(8):2443-2448. 24 February 2015 (2015)
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  DOI10.1073/pnas.1500262112 PMID25675527 PMCIDPMC4345553 DivisionProtein & Nucleic Acid Chemistry
• Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel laureates in chemistry AuthorsFersht A. R. Journal Proceedings of the National Academy of Sciences, USA 110(49):19656-19657. 3 December 2013 (2013)
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  DOI10.1073/pnas.1320569110 PMID24277833 PMCIDPMC3856823 DivisionProtein & Nucleic Acid Chemistry
• MDMX contains an autoinhibitory sequence element AuthorsBista M., Petrovich M., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 110(44):17814-17819. 29 October 2013 (2013)
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  DOI10.1073/pnas.1317398110 PMID24127580 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Small molecule induced reactivation of mutant p53 in cancer cells AuthorsLiu X., Wilcken R., Joerger A. C., Chuckowree I. S., Amin J., Spencer J., Fersht A. R. Journal Nucleic Acids Research 41(12):6034-6044. July 2013 (2013)
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  DOI10.1093/nar/gkt305 PMID23630318 PMCIDPMC3695503 DivisionProtein & Nucleic Acid Chemistry
• Don't waste good methods on bad buffers and ambiguous data AuthorsHuang F., Johnson C. M., Petrovich M., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 110(5):E331-2. 29 January 2013 (2013)
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  DOI10.1073/pnas.1217840110 PMID23329326 PMCIDPMC3562816 DivisionProtein & Nucleic Acid Chemistry
• Intrinsically disordered p53 and its complexes populate compact conformations in the gas phase AuthorsPagel K., Natan E., Hall Z., Fersht A. R., Robinson C. V. Journal Angewandte Chemie (International ed. in English) 52(1):361-365. 2 January 2013 (2013)
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  DOI10.1002/anie.201203047 PMID22777995 PMCID  DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Evaluating Drosophila p53 as a model system for studying cancer mutations AuthorsHerzog G., Joerger A. C., Shmueli M. D., Fersht A. R., Gazit E., Segal D. Journal Journal of Biological Chemistry 287(53):44330-44337. 28 December 2012 (2012)
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  DOI10.1074/jbc. M112.417980 PMID23135266 PMCIDPMC3531747 DivisionProtein & Nucleic Acid Chemistry
• Chemical physics of protein folding AuthorsWolynes P. G., Eaton W. A., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 109(44):17770-17771. 30 October 2012 (2012)
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  DOI10.1073/pnas.1215733109 PMID23112193 PMCIDPMC3497751 DivisionProtein & Nucleic Acid Chemistry
• Stability of p53 homologs AuthorsBrandt T., Kaar J. L., Fersht A. R., Veprintsev D. B. Journal PloS one 7(10):e47889. 24 October 2012 (2012)
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  DOI10.1371/journal.pone.0047889 PMID23112865 PMCIDPMC3480436 DivisionProtein & Nucleic Acid Chemistry
• Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 AuthorsVogel S. M., Bauer M. R., Joerger A. C., Wilcken R., Brandt T., Veprintsev D. B., Rutherford T. J., Fersht A. R., Boeckler F. M. Journal Proceedings of the National Academy of Sciences, USA 109(42):16906-16910. 16 October 2012 (2012)
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  DOI10.1073/pnas.1215060109 PMID23035244 PMCIDPMC3479485 DivisionProtein & Nucleic Acid Chemistry
• Sequence-dependent sliding kinetics of p53 AuthorsLeith J. S., Tafvizi A., Huang F., Uspal W. E., Doyle P. S., Fersht A. R., Mirny L. A., van Oijen A. M . Journal Proceedings of the National Academy of Sciences, USA 109(41):16552-16557. 9 October 2012 (2012)
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  DOI10.1073/pnas.1120452109 PMID23012405 PMCIDPMC3478643 DivisionProtein & Nucleic Acid Chemistry
• Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy AuthorsBista M., Freund S. M., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 109(39):15752-15756. 25 September 2012 (2012)
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  DOI10.1073/pnas.1214176109 PMID22972749 PMCIDPMC3465378 DivisionProtein & Nucleic Acid Chemistry
• In support of the BMRB AuthorsMarkley J. L. ... Fersht A. ... Neuhaus D. Journal Nature Structural & Molecular Biology 19(9):854-860. September 2012 (2012)
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  DOI10.1038/nsmb.2371 PMID22955930 PMCID  DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• First-order rate-determining aggregation mechanism of p53 and its implications AuthorsWang G., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA. 109(34):13590-13595. 21 August 2012 (2012)
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  DOI10.1073/pnas.1211557109 PMID22869710 PMCIDPMC3427100 DivisionProtein & Nucleic Acid Chemistry
• Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition AuthorsWilcken R., Wang G., Boeckler F. M., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 109(34):13584-13589. 21 August 2012 (2012)
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  DOI10.1073/pnas.1211550109 PMID22869713 PMCIDPMC3427094 DivisionProtein & Nucleic Acid Chemistry
• Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 AuthorsWilcken R., Liu X., Zimmermann M. O., Rutherford T. J, Fersht A. R., Joerger A. C., Boeckler F. M. Journal Journal of the American Chemical Society 134(15):6810-6818. 18 April 2012 (2012)
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  DOI10.1021/ja301056a PMID22439615 PMCIDPMC3789257 DivisionProtein & Nucleic Acid Chemistry
• Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53 AuthorsLum J. K., Neuweiler H., Fersht A. R. Journal Journal of the American Chemical Society 134(3):1617-1622. 25 January 2012 (2012)
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  DOI10.1021/ja2078619 PMID22176582 PMCIDPMC3265989 DivisionProtein & Nucleic Acid Chemistry
• Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer AuthorsNatan E., Baloglu C., Pagel K., Freund S. M., Morgner N., Robinson C. V., Fersht A. R., Joerger A. C. Journal Journal of Molecular Biology 409(3):358-368. 10 June 2011 (2011)
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  DOI10.1016/j.jmb.2011.03.047 PMID21457718 PMCIDPMC3176915 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration AuthorsArbely E., Natan E., Brandt T., Allen M. D., Veprintsev D. B., Robinson C. V., Chin J. W., Joerger A. C., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 108(20):8251-8256. 17 May 2011 (2011)
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  DOI10.1073/pnas.1105028108 PMID21525412 PMCIDPMC3100949 DivisionProtein & Nucleic Acid Chemistry; Structural Studies
• Malleability of folding intermediates in the homeodomain superfamily AuthorsBanachewicz W., Religa T. L., Schaeffer R. D., Daggett V., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 108(14):5596-5601. 5 April 2011 (2011)
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  DOI10.1073/pnas.1101752108 PMID21422286 PMCIDPMC3078393 DivisionProtein & Nucleic Acid Chemistry
• Folding of the Pit1 homeodomain near the speed limit AuthorsBanachewicz W , Johnson C M , Fersht A R Journal Proceedings of the National Academy of Sciences, USA 108(2):569-573. 11 January 2011 (2011)
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  DOI10.1073/pnas.1017832108 PMID21187427 PMCIDPMC3021018 DivisionProtein & Nucleic Acid Chemistry
• Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA AuthorsMelero R., Rajagopalan S., Lázaro M., Joerger A. C., Brandt T., Veprintsev D. B., Lasso G., Gil D., Scheres S. H., Carazo J. M., Fersht A. R., Valle M. Journal Proceedings of the National Academy of Sciences, USA 108(2):557-562. 11 January 2011 (2011)
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  DOI10.1073/pnas.1015520107 PMID21178074 PMCIDPMC3021029 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• A single-molecule characterization of p53 search on DNA AuthorsTafvizi A., Huang F., Fersht A. R., Mirny L. A., van Oijen A. M. Journal Proceedings of the National Academy of Sciences, USA 108(2):563-568. 11 January 2011 (2011)
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  DOI10.1073/pnas.1016020107 PMID21178072 PMCIDPMC3021058 DivisionProtein & Nucleic Acid Chemistry
• Kinetics of chain motions within a protein-folding intermediate AuthorsNeuweiler H., Banachewicz W., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 107(51):22106-22110. 21 December 2010 (2010)
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  DOI10.1073/pnas.1011666107 PMID21135210 PMCIDPMC3009767 DivisionProtein & Nucleic Acid Chemistry
• Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding AuthorsKaar J. L., Basse N., Joerger A. C., Stephens E., Rutherford T. J., Fersht A. R. Journal Protein Science 19(12): 2267-2278. December 2010 (2010)
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  DOI10.1002/pro.507 PMID20878668 PMCIDPMC3009395 DivisionProtein & Nucleic Acid Chemistry
• Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2 AuthorsRajagopalan S., Andreeva A., Rutherford T. J., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 107(19):8587-8592. 11 May 2010 (2010)
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  DOI10.1073/pnas.1003689107 PMID20421506 PMCIDPMC2889359 DivisionStructural Studies
• Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53 Authorsvan Dieck J., Teufel D. P., Jaulent A. M., Fernandez-Fernandez M. R., Rutherford T. J., Wyslouch-Cieszynska A., Fersht A. R. Journal Journal of Molecular Biology 394(5):922-930. 18 December 2009 (2009)
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  DOI10.1016/j.jmb.2009.10.002 PMID19819244 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation AuthorsBurge S., Teufel D. P., Townsley F. M., Freund S. M., Bycroft M., Fersht A. R. Journal Proceedings of the National Academy of Sciences, USA 106 (9): 3142-7. 3 March 2009 (2009)
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  DOI10.1073/pnas.0900383106 PMID19218448 PMCIDPMC2651247 DivisionProtein & Nucleic Acid Chemistry
• Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns AuthorsTidow H. , Andreeva A., Rutherford T. J., Fersht A. R. Journal Structure 17 (2): 294-302. 13 February 2009 (2009)
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  DOI10.1016/j.str.2008.11.013 PMID19217400 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53 AuthorsTuck Seng Wong, Sridharan Rajagopalan, Fiona M. Townsley, Stefan M. Freund, Miriana Petrovich, David Loakes, Alan R. Fersht Journal Nucleic Acids Research 37(2): 568-581 (2009) (2009)
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  DOI10.1093/nar/gkn974 PMIDPMID:19066201 PMCIDPMC2632919 DivisionProtein & Nucleic Acid Chemistry
• Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents AuthorsLuis Briseno-Roa, Jim Hill, Stuart Notman, David Sellers, Andy P. Smith, Christopher M. Timperley, Janet Wetherell, Nichola H. Williams, Gareth R. Williams, Alan R. Fersht, Andrew D. Griffiths Journal J. Med. Chem. 49: 246-255 (2006) (2006 )
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• Rapid amyloid fiber formation from the fast-folding WW domain FBP28 AuthorsNeil Ferguson, John Berriman, Miriana Petrovich, Timothy D. Sharpe, John T. Finch, Alan R. Fersht Journal Proceedings of the National Academy of Sciences, USA 100: 9814-9819 (2003) (2003)
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• Max Ferdinand Perutz OM FRS AuthorsFersht A. F. Journal Nature Structural Biology 9(4):245-246. April 2002 (2002)
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  DOI10.1038/nsb0402‑245 PMID11914731 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Ligand-independent assembly of recombinant human CD1 by using oxidative refolding chromatography AuthorsAltamirano M. M., Woolfson A., Donda A., Shamshiev A., Briseno-Roa L., Foster N. W., Veprinstev D. B., De Libero G., Fersht A. R., Milstein C. Journal Proceedings of the National Academy of Sciences 98(6):3288-3293. 13 March 2001 (2001)
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  DOI10.1073/pnas.041596598 PMID11248071 PMCIDPMC30646 DivisionProtein & Nucleic Acid Chemistry
• Biophysical characterization of elongin C from Saccharomyces cerevisiae AuthorsBuchberger A., Howard M. J., Freund S. M. V., Proctor M., Butler P. J. G.,Fersht A. R., Bycroft M. Journal Biochemistry 39(36):11137-11146. 12 August 2000 (2000)
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  DOI10.1021/bi0008231 PMID10998253 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Equilibrium folding properties of the yeast prion protein determinant Ure2 AuthorsPerrett S., Freeman S. J., Jonathan P. Butler G., Fersht A. R. Journal Journal of Molecular Biology 290(1):331-345. 2 July 1999 (1999)
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  DOI10.1006/jmbi.1999.2872 PMID10388576 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Interdomain interactions within the gene 3 protein of filamentous phage AuthorsJean Chatellier, Oliver Hartley, Andrew D. Griffiths, Alan R. Fersht, Greg Winter, Lutz Riechmann Journal FEBS Letters 463: 371-374 (1999) (1999)
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• Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase AuthorsJacqueline M. Matthews, Alan R. Fersht Journal Biochemistry 34: 6805-6814 (1995) (1995)
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• Protein engineering AuthorsAlan Fersht, Greg Winter Journal Trends in Biochemical Sciences 17: 293-294 (1992) (1992)
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• Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: a mobile loop envelopes the transition state in an induced-fit mechanism AuthorsAlan R. Fersht, Jack W. Knill-Jones, Hugues Bedouelle, Greg Winter Journal Biochemistry 27: 1581-1587 (1988) (1988)
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• Structure-activity relationships in engineered proteins: characterization of disruptive deletions in the alpha-ammonium group binding site of tyrosyl-tRNA synthetase AuthorsLowe D. M., Winter G., Fersht A. R. Journal Biochemistry 26(19):6038-6043. 22 September 1987 (1987)
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  DOI10.1021/bi00393a014 PMID3480006 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase AuthorsFrankie Tat-Kwong Lau, Alan R. Fersht, Homme W. Hellinga, Philip R. Evans Journal Biochemistry 26: 4142-4148 (1987) (1987)
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• Hydrogen bonding and biological specificity analysed by protein engineering AuthorsAlan R. Fersht, Jian-Ping Shi, Jack Knill-Jones, Denise M. Lowe, Anthony J. Wilkinson, David M. Blow, Peter Brick, Paul Carter, Mary M. Y. Waye, Greg Winter Journal Nature 314: 235-238 (1985) (1985)
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• Engineering of tyrosyl tRNA synthetase AuthorsHugues Bedouelle, Paul Carter, Mary M. Y. Waye, Greg Winter, Denise M. Lowe, Anthony J. Wilkinson, Alan R. Fersht Journal Biochimie 67: 737-743 (1985) (1985)
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• Probing histidine-substrate interactions in tyrosyl-tRNA synthetase using asparagine and glutamine replacements AuthorsDenise M. Lowe, Alan R. Fersht, Anthony J. Wilkinson, Paul Carter, Greg Winter Journal Biochemistry 24: 5106-5109 (1985) (1985)
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• Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering AuthorsRobin J. Leatherbarrow, Alan R. Fersht, Greg Winter Journal Proceedings of the National Academy of Sciences, USA 82: 7840-7844 (1985) (1985)
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• Reversible dissociation of dimeric tyrosyl-tRNA synthetase by mutagenesis at the subunit interface AuthorsD. Hugh Jones, Andrew J. McMillan, Alan R. Fersht, Greg Winter Journal Biochemistry 24: 5852-5857 (1985) (1985)
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• Fine structure-activity analysis of mutations at position 51 of tyrosyl-tRNA synthetase AuthorsAlan R. Fersht, Anthony J. Wilkinson, Paul Carter, Greg Winter Journal Biochemistry 24: 5858-5861 (1985) (1985)
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• Redesigning enzymes by site-directed mutagenesis AuthorsA. R. Fersht, G. P. Winter Journal Ciba Foundation Symposium (Enzymes in organic synthesis) 111: 204-218 (1985) (1985)
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• Genetic dissection of tyrosyl-tRNA synthetase AuthorsGreg Winter, Paul Carter, Mary M. Y. Waye, D. M. Blow, Anthony J. Wilkinson, J.-P. Shi, Alan R. Fersht Journal Biochemical Society Transactions 12: 224-225 (1984) (1984)
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• A large increase in enzyme-substrate affinity by protein engineering AuthorsAnthony J. Wilkinson, Alan R. Fersht, D. M. Blow, Paul Carter, Greg Winter Journal Nature 307: 187-188 (1984) (1984)
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• Studying enzyme-substrate interactions by site-directed mutagenesis AuthorsAlan R. Fersht, Greg Winter Journal Pontificiae Academiae Scientiarum Scripta Varia (Abstracts of the Proceedings of the Working Group on: Specificity in Biological Interactions) 55: 123-132 (1984) (1984)
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• Analysis of enzyme structure and activity by protein engineering AuthorsAlan R. Fersht, Jian-Ping Shi, Anthony J. Wilkinson, David M. Blow, Paul Carter, Mary M. Y. Waye, Greg P. Winter Journal Angewandte Chemie International Edition 23: 467-473 (1984) (1984)
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• The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus) AuthorsPaul J. Carter, Greg Winter, Anthony J. Wilkinson, Alan R. Fersht Journal Cell 38: 835-840 (1984) (1984)
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• Engineering enzymes AuthorsGreg Winter, Alan R. Fersht Journal Trends in Biotechnology 2: 115-119 (1984) (1984)
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• Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation AuthorsAnthony J. Wilkinson, Alan R. Fersht, David M. Blow, Greg Winter Journal Biochemistry 22: 3581-3586 (1983) (1983)
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• Deletion mutagenesis using an 'M13 splint': the N-terminal structural domain of tyrosyl-tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate AuthorsMary M. Y. Waye, Greg Winter, Anthony J. Wilkinson, Alan R. Fersht Journal EMBO Journal 2: 1827-1929 (1983) (1983)
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• Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding AuthorsGreg Winter, Alan R. Fersht, Anthony J. Wilkinson, Mark Zoller, Michael Smith Journal Nature 299: 756-758 (1982) (1982)
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• Mechanism and specificity of aminoacyl-tRNA synthetases: "double-sieve" sorting AuthorsFersht A. R., Dingwall C. Journal FEBS 12th Meeting, Dresden, 1978. (Protein: Structure, Function and Industrial Applications. Edited by E. Hofmann et al) 52: 69-80 (1979) (1979)
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  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Establishing the misacylation/deacylation of the tRNA pathway for the editing mechanism of prokaryotic and eukaryotic valyl-tRNA synthetases AuthorsFersht A. R., Dingwall C. Journal Biochemistry 18: 1238-1245 (1979) (1979)
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  DOI  PMID  PMCID  DivisionProtein & Nucleic Acid Chemistry
• Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions AuthorsFersht A. R., Dingwall C. Journal Biochemistry 18: 1245-1249 (1979) (1979)
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• An editing mechanism for the methionyl-tRNA synthetase in the selection of amino acids in protein synthesis AuthorsFersht A. R., Dingwall C. Journal Biochemistry 18: 1250-1256 (1979) (1979)
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• Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases AuthorsFersht A. R., Dingwall C. Journal Biochemistry 18: 2627-2631 (1979) (1979)
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• Mechanism of aminoacylation of transfer RNA. A pre-steady-state analysis of the reaction pathway catalyzed by the methionyl-tRNA synthetase of Bacillus stearothermophilus AuthorsMulvey R. S., Fersht A. R. Journal Biochemistry 17(26):5591-5597. 1 December 1978 (1978)
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  DOI10.1021/bi00619a002 PMID728419 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Rapid intramolecular coupling of active sites in the pyruvate dehydrogenase complex of Escherichia coli: mechanism for rate enhancement in a multimeric structure AuthorsDanson M. J., Fersht A. R., Perham R. N. Journal Proceedings of the National Academy of Sciences, USA 75(11):5386-5390. 1 November 1978 (1978)
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  DOI10.1073/pnas.75.11.5386 PMID214786 PMCIDPMC392968 DivisionProtein & Nucleic Acid Chemistry
• The aminoacyladenylate mechanism in the aminoacylation reaction of yeast phenylalanyl-tRNA synthetase AuthorsFranco Fasiolo, Alan R. Fersht Journal Eur. J. Biochem. 85: 85-88 (1978) (1978)
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• Reaction pathway and rate-determining step in the aminoacylation of tRNA(Arg) catalyzed by the arginyl-tRNA synthetase from yeast AuthorsAlan R. Fersht, Jean Gangloff, Guy Dirheimer Journal Biochemistry 17: 3740-3746 (1978) (1978)
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• Energy expenditure in the editing mechanism of protein synthesis AuthorsRoderick S. Mulvey, Alan R. Fersht Journal Biochemical Society Transactions 5: 672-675 (1977) (1977)
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• Editing mechanisms in protein synthesis. Rejection of valine by the isoleucyl-tRNA synthetase AuthorsAlan R. Fersht Journal Biochemistry 16: 1025-1030 (1977) (1977)
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• Editing mechanisms in aminoacylation of tRNA: ATP consumption and the binding of aminoacyl-tRNA by elongation factor Tu AuthorsRoderick S. Mulvey, Alan R. Fersht Journal Biochemistry 16: 4731-4737 (1977) (1977)
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• Ligand binding stoichiometries, subunit structure, and slow transitions in aminoacyl-tRNA synthetases AuthorsRoderick S. Mulvey, Alan R. Fersht Journal Biochemistry 16: 4005-4013 (1977) (1977)
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• Subunit interactions in the methionyl-tRNA synthetase of Bacillus stearothermophilus AuthorsRoderick S. Mulvey, Alan R. Fersht Journal Biochemistry 15: 243-249 (1976) (1976)
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• Mechanism of aminoacylation of tRNA. Proof of the aminoacyl adenylate pathway for the isoleucyl- and tyrosyl-tRNA synthetases from Escherichia coli KI2 AuthorsAlan R. Fersht, Meredith M. Kaethner Journal Biochemistry 15: 818-823 (1976) (1976)
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• Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing AuthorsAlan R. Fersht, Meredith M. Kaethner Journal Biochemistry 15: 3342-3346 (1976) (1976)
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• Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases AuthorsAlan R. Fersht, Jeremy S. Ashford, Christopher J. Bruton, Ross Jakes, Gordon L. E. Koch, Brian S. Hartley Journal Biochemistry 14: 1-4 (1975) (1975)
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• Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes AuthorsAlan R. Fersht Journal Biochemistry 14: 5-12 (1975) (1975)
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• Ligand binding and enzymic catalysis coupled through subunits in tyrosyl-tRNA synthetase AuthorsAlan R. Fersht, Roderick S. Mulvey, Gordon L. E. Koch Journal Biochemistry 14: 13-18 (1975) (1975)
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• Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation AuthorsRoss Jakes, Alan R. Fersht Journal Biochemistry 14: 3344-3349 (1975) (1975)
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• Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique AuthorsAlan R. Fersht, Ross Jakes Journal Biochemistry 14: 3350-3356 (1975) (1975)
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• Influence of globin structure on the state of the heme. II. Allosteric transitions in methaemoglobin AuthorsPerutz M. F., Fersht A. R., Simon S. R., Roberts G. C. K. Journal Biochemistry 13(10):2174-2186. May 1974 (1974)
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  DOI10.1021/bi00707a027 PMID4857061 PMCID  Division 
• Catalysis, binding and enzyme-substrate complementarity AuthorsA. R. Fersht Journal Proc. R. Soc. Lond. B. 187: 397-407 (1974) (1974)
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• pH dependence of chymotrypsin catalysis. Appendix: Substrate binding to dimeric alpha-chymotrypsin studied by X-ray diffraction and the equilibrium method AuthorsAlan R. Fersht, M. Renard Journal Biochemistry 13: 1416-1426 (1974) (1974)
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• Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin AuthorsJacques Fastrez, Alan R. Fersht Journal Biochemistry 12: 2025-2034 (1973)
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  DOI10.1021/bi00735a001 PMID4705984 PMCID  Division 
• Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. A stereochemical interpretation AuthorsAlan R. Fersht, D. M. Blow, Jacques Fastrez Journal Biochemistry 12: 2035-2041 (1973)
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  DOI10.1021/bi00735a002 PMID4735878 PMCID  Division 
• Mechanism of chymotrypsin . Structure, reactivity and nonproductive binding relationships AuthorsJacques Fastrez, Alan R. Fersht Journal Biochemistry 12(6):1067-1074 (1973)
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  DOI10.1021/bi00730a008 PMID4688860 PMCID  Division 
• The charge relay system in chymotrypsin and chymotrypsinogen AuthorsAlan R. Fersht, Joseph Sperling Journal Journal of Molecular Biology 74: 137-149 (1973)
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  DOI10.1016/0022-2836(73)90103-4 PMID4689953 PMCID  Division 
• The catalytic activity of the inactive conformation of delta- chymotrypsin AuthorsAlan R. Fersht Journal FEBS Letters 29 (3 ):283-285 (1973)
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  DOI10.1016/0014-5793(73)80039‑0 PMID11946933 PMCID  Division 
• Anomalous pH dependence of kcat /Km in enzyme reactions. Rate constants for the association of chymotrypsin with substrates AuthorsM. Renard, Alan R. Fersht Journal Biochemistry 12: 4713-4718 (1973) (1973)
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• Conformational equilibria in alpha- and delta-chymotrypsin. The energetics and importance of the salt bridge AuthorsAlan R. Fersht Journal Journal of Molecular Biology 64: 497-509 (1972)
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  DOI10.1016/0022-2836(72)90513-X PMID5023185 PMCID  Division 
• Mechanism of the alpha- chymotrypsin-catalyzed hydrolysis of specific amide substrates AuthorsA. R. Fersht Journal Journal of the American Chemical Society 94: 293-295 (1972)
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  DOI10.1021/ja00756a061 PMID5007247 PMCID  Division 
• Mechanism of the alpha- chymotrypsin-catalysed hydrolysis of amides. ph dependence of kc and Km. Kinetic detection of an intermediate AuthorsAlan R. Fersht, Yolanda Requena Journal Journal of the American Chemical Society 93: 7079-7087 (1971)
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  DOI10.1021/ja00754a066 PMID5133099 PMCID  Division 
• Equilibrium and rate constants for the interconversion of two conformations of alpha‑chymotrypsin AuthorsAlan R. Fersht, Yolanda Requena Journal Journal of Molecular Biology 60: 279-290 (1971)
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  DOI10.1016/0022-2836(71)90294-4 PMID5099294 PMCID  Division 
• Acyl-transfer reactions of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases. Concerning the N protonation of amides and amide-imidate equilibria AuthorsAlan R. Fersht Journal Journal of the American Chemical Society 93: 3504-3515 (1971)
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  DOI10.1021/ja00743a035 PMID5560470 PMCID  Division 
• Free energies of hydrolysis of amides and peptides in aqueous solution at 25 degrees AuthorsAlan R. Fersht, Yolanda Requena Journal Journal of the American Chemical Society 93: 3499-3504 (1971)
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• Conformational equilibria and the salt bridge in chymotrypsin AuthorsAlan R. Fersht Journal Cold Spring Harbor Symposia on Quantitative Biology XXXVI: 71-73 (1971)
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• Intramolecular catalysis AuthorsA. Kirby, A. R. Fersht Journal Progress in Bioorganic Chemistry 1:1-82 (1971)
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