Published Research

Found 110 results for Evans.

• Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2 AuthorsEvans L.D., Strano A., Tuck E., Campbell A., Smith J., Hung C., Behr T.S., Ghetti B., Ryskeldi-Falcon B., Karakoc E., Iorio F., Reith A., Bassett A.R., Livesey F.J. Journal The EMBO Journal (2025)
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  DOI10.1038/s44318-025-00514‑0 PMID40790356 PMCID  DivisionNeurobiology
• Engineered receptor capture combined with mass spectrometry enables high-throughput detection and quantitation of SARS-CoV-2 spike protein AuthorsBate N., Lane D., Evans S.E., Salim F., Allcock N.S., Haigh R., Sale J.E., Jones D.J.L., Brindle N.P.J. Journal JACS Au 5(2):747-755 (2025)
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  DOI10.1021/jacsau.4c00980 PMID40017752 PMCIDPMC11862925 DivisionProtein & Nucleic Acid Chemistry
• Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP(1,2) in a position elevated from the virion membrane AuthorsHastie K. M., Salie Z. L., Ke Z., Halfmann P. J., Evans DeWald L., McArdle S., Grinyó A., Davidson E., Schendel S. L., Hariharan C., Norris M. J., Yu X., Chennareddy C., Xiong X., Heinrich M., Holbrook M. R., Doranz B., Crozier I., Karaoka Y., Branco L. M., Kuhn J. H., Briggs J. A. G., Worwa G., Davis C. W., Ahmed R., Ollmann Saphire E. Journal Nature Communications 16(1):1293 (2025)
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  DOIdoi.org/10.1038/s41467-025-56452-2 PMID39900911 PMCIDPMC11791206 DivisionStructural Studies
• How do gepotidacin and zoliflodacin stabilize DNA cleavage complexes with bacterial type IIA topoisomerases? 1. experimental definition of metal binding sites AuthorsMorgan H., Nicholls R. A., Warren A. J., Ward S. E., Evans G., Long F., Murshudov G. N., Duman R., Bax B. D. Journal International Journal of Molecular Sciences 25(21):11688 (2024)
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  DOIdoi.org/10.3390/ijms252111688 PMID39519241 PMCIDPMC11546367 DivisionStructural Studies
• A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus AuthorsBolton R, Machelett MM, Stubbs J, Axford D, Caramello N, Catapano L, Malý M, Rodrigues MJ, Cordery C, Tizzard GJ, MacMillan F, Engilberge S, von Stetten D, Tosha T, Sugimoto H, Worrall JAR, Webb JS, Zubkov M, Coles S, Mathieu E, Steiner RA, Murshudov G, Schrader TE, Orville AM, Royant A, Evans G, Hough MA, Owen RL, Tews I. Journal Proceedings of the National Academy of Sciences of the United States of America 121(12):e2308478121 (2024)
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  DOI10.1073/pnas.2308478121 PMID38489389 PMCIDPMC10962944 DivisionStructural Studies
• The CCP4 suite: integrative software for macromolecular crystallography AuthorsAgirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K. Journal Acta crystallographica. Section D, Structural Biology 79(Pt 6):449-461 (2023)
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  DOI10.1107/s2059798323003595 PMID37259835 PMCIDPMC10233625 DivisionStructural Studies
• The CCP4 suite: integrative software for macromolecular crystallography AuthorsAgirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K. Journal Acta crystallographica. Section D, Structural Biology 79(Pt 6):449-461 (2023)
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  DOI10.1107/s2059798323003595 PMID37259835 PMCIDPMC10233625 DivisionStructural Studies
• Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs AuthorsRathinaswamy M. K., Jenkins M. L., Duewell B. R., Zhang X., Harris N. J., Evans J. T., Stariha J. T. B., Dalwadi U., Fleming K. D., Ranga-Prasad H., Yip C. K., Williams R. L., Hansen S. D., Burke J. E. Journal Cell Reports 42(3):112172 (2023)
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  DOIPMC10068899 PMID36842083 PMCIDPMC10068899 DivisionProtein & Nucleic Acid Chemistry
• In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding AuthorsBate N., Savva C.G., Moody P.C.E., Brown E.A., Evans S.E., Ball J.K., Schwabe J.W.R., Sale J.E., Brindle N.P.J. Journal Plos Pathogens 18(7):e1010733 (2022)
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  DOI10.1371/journal.ppat.1010733 PMID35849637 PMCIDPMC9333441 DivisionProtein & Nucleic Acid Chemistry
• FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch AuthorsZaccai N. R., Kadlecova Z., Dickson V. K., Korobchevskaya K., Kamenicky J., Kovtun O., Umasankar P. K., Wrobel A. G., Kaufman J. G. G., Gray S. R., Qu K., Evans P. R., Fritzsche M., Sroubek F., Höning S., Briggs J. A. G., Kelly B. T., Owen D. J., Traub L. M. Journal Science Advances 8(17):eabn2018 (2022)
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  DOI10.1126/sciadv. Abn2018 PMID35486718 PMCIDPMC9054013 DivisionStructural Studies
• The predictive power of data-processing statistics AuthorsVollmar M., Parkhurst J. M., Jaques D., Baslé A., Murshudov G. N., Waterman D. G., Evans G. Journal Iucrj 7(Pt 2):342-354. March 2020 (2020)
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  DOI10.1107/s2052252520000895 PMID32148861 PMCIDPMC7055369 DivisionStructural Studies
• Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation AuthorsWrobel A. G., Kadlecova Z., Kamenicky J., Yang J. C., Herrmann T., Kelly B. T., McCoy A. J., Evans P. R., Martin S., Müller S., Sroubek F., Neuhaus D., Höning S., Owen D. J. Journal Developmental Cell 50(4):494-508.e11. 19 August 2019 (2019)
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  DOI10.1016/j. devcel.2019.07.017 PMID31430451 PMCIDPMC6706699 DivisionStructural Studies
• A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice AuthorsVale R., Evans D., Branco T. Journal Journal of Visualized Experiments : Jove (137):56988 (2018)
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  DOI10.3791/56988 PMID30080198 PMCIDPMC6126525 DivisionNeurobiology
• A synaptic threshold mechanism for computing escape decisions AuthorsEvans D. 1., Stempel A. V., Vale R., Ruehle S., Lefler Y., Branco T. Journal Nature 558(7711):590-594. 28 June 2018 (2018)
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  DOI10.1038/s41586-018-0244‑6 PMID29925954 PMCIDPMC6235113 DivisionNeurobiology
• CCP4i2: the new graphical user interface to the CCP4 program suite AuthorsPotterton L., Agirre J., Ballard C., Cowtan K., Dodson E., Evans P. R.,Jenkins H. T., Keegan R., Krissinel E., Stevenson K., Lebedev A., McNicholas S. J., Nicholls R. A., Noble M., Pannu N. S., Roth C., Sheldrick G., Skubak P., Turkenburg J., Uski V., von Delft F., Waterman D., Wilson K., Winn M., Wojdyr M. Journal Acta crystallographica. Section D, Structural Biology 74(Pt 2):68-84. 1 February 2018 (2018)
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  DOI10.1107/s2059798317016035 PMID29533233 PMCIDPMC5947771 DivisionStructural Studies
• UV-light-driven prebiotic synthesis of iron-sulfur clusters AuthorsBonfio C., Valer L., Scintilla S., Shah S., Evans D. J., Jin L., Szostak J. W., Sasselov D. D., Sutherland J. D., Mansy S. S. Journal Nature Chemistry 9(12):1229-1234. December 2017 (2017)
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  DOI10.1038/nchem.2817 PMID29168482 PMCIDPMC5808832 DivisionProtein & Nucleic Acid Chemistry
• Molecular basis of USP7 inhibition by selective small-molecule inhibitors AuthorsTurnbull A. P., Ioannidis S., Krajewski W. W., Pinto-Fernandez A., Heride C., Martin A. C. L., Tonkin L. M., Townsend E. C., Buker S. M., Lancia D. R., Caravella J. A., Toms A. V., Charlton T. M., Lahdenranta J., Wilker E., Follows B. C., Evans N. J., Stead L., Alli C., Zarayskiy V. V., Talbot A. C., Buckmelter A. J., Wang M., McKinnon C. L., Saab F., McGouran J. F., Century H., Gersch M., Pittman M. S., Marshall C. G., Raynham T. M., Simcox M., Stewart L. M. D., McLoughlin S. B., Escobedo J. A., Bair K. W., Dinsmore C. J., Hammonds T. R., Kim S., Urbé S., Clague M. J., Kessler B. M., Komander D. Journal Nature 550(7677):481-486. 26 October 2017 (2017)
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  DOI10.1038/nature24451 PMID29045389 PMCIDPMC6029662 DivisionProtein & Nucleic Acid Chemistry
• AUSPEX: a graphical tool for X-ray diffraction data analysis AuthorsThorn A., Parkhurst J., Emsley P., Nicholls R. A., Vollmar M., Evans G., Murshudov G. N. Journal Acta Crystallographica. Section D, Structural Biology 73(Pt 9):729-737. September 2017 (2017)
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  DOI10.1107/S205979831700969X PMID28876236 PMCIDPMC5586246 DivisionStructural Studies
• Background modelling of diffraction data in the presence of ice rings AuthorsParkhurst J. M., Thorn A., Vollmar M., Winter G., Waterman D. G., Fuentes-Montero L., Gildea R. J., Murshudov G. N., Evans G. Journal Iucrj 4(Pt 5):626-638 (2017)
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  DOI10.1107/s2052252517010259 PMID28989718 PMCIDPMC5619854 DivisionStructural Studies
• Rapid Spatial Learning Controls Instinctive Defensive Behavior in Mice AuthorsVale R., Evans D. A., Branco T. Journal Current Biology 27(9):1342-1349. 8 May 2017 (2017)
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  DOI10.1016/j. Cub.2017.03.031 PMID28416117 PMCIDPMC5434248 DivisionNeurobiology
• Robust background modelling in DIALS AuthorsParkhurst J. M., Winter G., Waterman D. G., Fuentes-Montero L., Gildea R. J., Murshudov G. N., Evans G. Journal Journal of Applied Crystallography 49(Pt 6):1912-1921. 1 December 2016 (2016)
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  DOI10.1107/S1600576716013595 PMID27980508 PMCIDPMC5139990 DivisionStructural Studies
• Structural basis for the binding of tryptophan-based motifs by δ-COP AuthorsSuckling R. J., Poon P. P., Travis S. M., Majoul I. V., Hughson F. M., Evans P. R., Duden R., Owen D. J. Journal Proceedings of the National Academy of Sciences of the United States of America 112(46):14242-14247. 17 November (2015)
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  DOI10.1073/pnas.1506186112 PMID26578768 PMCIDPMC4655537 DivisionStructural Studies
• Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back AuthorsBrancaccio M., Enoki R., Mazuski C. N., Jones J., Evans J. A., Azzi A. Journal Journal of Neuroscience 34(46):15192-15199. 12 November 2014 (2014)
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  DOI10.1523/JNEUROSCI.3233-14.2014 PMID25392488 PMCIDPMC4228128 DivisionNeurobiology
• VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface AuthorsHesketh G. G., Pérez-Dorado I., Jackson L. P., Wartosch L., Schäfer I. B., Gray S. R., McCoy A. J., Zeldin O. B., Garman E. F., Harbour M. E., Evans P. R., Seaman M. N., Luzio J. P., Owen D. J. Journal Developmental Cell 29(5):591-606. 9 June 2014 (2014)
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  DOI10.1016/j. devcel.2014.04.010 PMID24856514 PMCIDPMC4059916 DivisionStructural Studies
• How good are my data and what is the resolution? AuthorsEvans P. R., Murshudov G. N. Journal Acta Crystallographica. Section D, Biological Crystallography 69(Pt 7):1204-1214. 1 July 2013 (2013)
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  DOI10.1107/S0907444913000061 PMID23793146 PMCIDPMC3689523 DivisionStructural Studies
• Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis AuthorsSánchez-Barrena M. J., Vallis Y., Clatworthy M. R., Doherty G. J., Veprintsev D. B., Evans P. R., McMahon H. T. Journal PloS one 7(12):e52401. 20 December 2012 (2012)
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  DOI10.1371/journal.pone.0052401 PMID23285027 PMCIDPMC3527510 DivisionNeurobiology, Structural Studies, Protein & Nucleic Acid Chemistry
• Molecular basis for recognition of dilysine trafficking motifs by COPI AuthorsJackson L. P., Lewis M., Kent H. M., Edeling M. A., Evans P. R., Duden R., Owen D. J. Journal Developmental Cell 23(6):1255-1262. 11 December 2012 (2012)
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  DOI10.1016/j. devcel.2012.10.017 PMID23177648 PMCIDPMC3521961 DivisionStructural Studies; Cell Biology
• The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation AuthorsSchäfer I. B., Hesketh G. G., Bright N. A., Gray S. R., Pryor P. R., Evans P. R., Luzio J. P., Owen D. J. Journal Nature Structural & Molecular Biology 19(12):1300-1309. December 2012 (2012)
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  DOI10.1038/nsmb.2414 PMID23104059 PMCIDPMC3605791 DivisionStructural Studies
• Outrunning free radicals in room-temperature macromolecular crystallography AuthorsOwen R. L., Axford D., Nettleship J. E, Owens R. J., Robinson J. I, Morgan A. W., Doré A. S., Lebon G., Tate C. G., Fry E. E., Ren J., Stuart D. I., Evans G. Journal Acta Crystallographica. Section D, Biological Crystallography 68(Pt 7):810-818. July 2012 (2012)
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  DOI10.1107/S0907444912012553 PMID22751666 PMCIDPMC4791751 DivisionStructural Studies
• Biochemistry. Resolving some old problems in protein crystallography AuthorsEvans P. Journal Science 336(6084):986-987. 25 May 2012 (2012)
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  DOI10.1126/science.1222162 PMID22628641 PMCID  DivisionStructural Studies
• Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex AuthorsKent H. M., Evans P. R., Schäfer I. B., Gray S. R., Sanderson C. M., Luzio J. P., Peden A. A., Owen D. J. Journal Developmental Cell 22(5):979-988. 15 May 2012 (2012)
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  DOI10.1016/j. devcel.2012.01.018 PMID22521722 PMCIDPMC3549491 DivisionStructural Studies
• An introduction to data reduction: space-group determination, scaling and intensity statistics AuthorsEvans P. R. Journal Acta Crystallographica. Section D D67(4):282-292. 1 April 2011 (2011)
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  DOI10.1107/S090744491003982X PMID21460446 PMCIDPMC3069743 DivisionStructural Studies
• Overview of the CCP4 suite and current developments AuthorsWinn M. D., Ballard C. C., Cowtan K. D., Dodson E. J., Emsley P., Evans P. R., Keegan R. M., Krissinel E. B., Leslie A. G., McCoy A., McNicholas S. J., Murshudov G. N., Pannu N. S., Potterton E. A., Powell H. R., Read R. J., Vagin A., Wilson K. S. Journal Acta Crystallographica. Section D 67(4):235-242. April 2011 (2011)
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  DOI10.1107/S0907444910045749 PMID21460441 PMCIDPMC3069738) DivisionStructural Studies
• A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex AuthorsJackson L. P., Kelly B. T., McCoy A. J., Gaffry T., James L. C., Collins B. M., Höning S., Evans P. R., Owen D. J. Journal Cell 141(7):1220-1229. 25 June 2010 (2010)
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  DOI10.1016/j. Cell.2010.05.006 PMID20603002 PMCIDPMC3655264 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling AuthorsMerav Cohen, Vincenzina Reale, Birgitta Olofsson, Andrew Knights, Peter Evans, Mario de Bono Journal Cell Metabolism 9(4):375-385. 8 April 2009 (2009)
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  DOI10.1016/j. Cmet.2009.02.003 PMID19356718 PMCID  DivisionCell Biology
• The Multidimensional Integrated Intelligent Imaging project(MI‑3) AuthorsN. Allinson, T. Anaxagoras, J. Aveyard, C. Arvanitis, R. Bates, A. Blue, S. Bohndiek, J. Cabello, L. Chen, S. Chen, A. Clark, C. Clayton, E. Cook, A. Cossins, J. Crooks, M. El-Gomati, P. M. Evans, W. Faruqi, M. French, J. Gow, T. Greenshaw, T. Greig, N. Guerrini, E. J. Harris, R. Henderson, A. Holland, G. Jeyasundra, D. Karadaglic, A. Konstantinidis, H. X. Liang, K. M. S. Maini, G. McMullen, A. Olivo, V. O’Shea, J. Osmond, R. J. Ott, M. Prydderch, L. Qiang, G. Riley, G. Royle, G. Segneri, R Speller, J. R. N. Symonds-Tayler, S. Triger, R. Turchetta, C. Venanzi, K. Wells, X. Zha, H. Zin Journal Nuclear Instruments and Methods in Physics Research A 604: 196–198 (2009) (2009)
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  DOI10.1016/j.nima.2009.01.112 PMID  PMCID  DivisionStructural Studies
• Molecular Basis for the Sorting of the SNARE VAMP7 into Endocytic Clathrin-Coated Vesicles by the ArfGAP Hrb AuthorsPaul R. Pryor, Lauren Jackson, Sally R. Gray, Melissa A. Edeling, Amanda Thompson, Christopher M. Sanderson, Philip R. Evans, David J. Owen, Paul Luzio Journal Cell 134 (5): 817-827. 5 September 2008 (2008)
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  DOI10.1016/j. Cell.2008.07.023 PMID18775314 PMCIDPMC2648964 Division 
• An introduction to molecular replacement AuthorsPhilip Evans, Airlie McCoy Journal Acta Crystallogr Section D Biological Crystallography 64 (Pt 1): 1-10 (2008)
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  DOI  PMID  PMCID  Division 
• Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex AuthorsMarc Fiedler, María José Sánchez-Barrena, Maxim Nekrasov, Juliusz Mieszczanek, Vladimir Rybin, Jürg Müller, Phil Evans, Mariann Bienz Journal Molecular Cell 30 (4): 507-18. (2008)
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  DOI  PMID18498752 PMCIDPMC2726290 Division 
• Common variants near MC4R are associated with fat mass, weight and risk of obesity AuthorsRuth J. F. Loos, Cecilia M. Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, Inga Prokopenko, Michael Inouye, Rachel M. Freathy, Antony P. Attwood, Jacques S Beckmann, Sonja I Berndt, The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Sven Bergmann, Amanda J. Bennett, Sheila A. Bingham, Murielle Bochud, Morris Brown, Stéphane Cauchi, John M Connell, Cyrus Cooper, George Davey Smith, Ian Day, Christian Dina, Subhajyoti De, Emmanouil T Dermitzakis, Alex S. F. Doney, Katherine S. Elliott, Paul Elliott, David M Evans, I. Sadaf Farooqi, Philippe Froguel, Jilur Ghori, Christopher J. Groves, Rhian Gwilliam, David Hadley, Alistair S. Hall, Andrew T. Hattersley, Johannes Hebebrand, Iris M. Heid, KORA, Blanca Herrera, Anke Hinney, Sarah E. Hunt, Marjo-Riitta Jarvelin, Toby Johnson, Jennifer D. M. Jolley, Fredrik Karpe, Andrew Keniry, Kay-Tee Khaw, Robert N. Luben, Massimo Mangino, Jonathan Marchini, Wendy L. McArdle, Ralph McGinnis, David Meyre, Patricia B. Munroe, Andrew D. Morris, Andrew R. Ness, Matthew J. Neville, Alexandra C. Nica, Ken K. Ong, Stephen O'Rahilly, Katharine R. Owen, Colin N. A. Palmer, Konstantinos Papadakis, Simon Potter, Anneli Pouta, Lu Qi, Nurses' Health Study, Joshua C Randall, Nigel W. Rayner, Susan M. Ring, Manjinder S. Sandhu, André Scherag, Matthew A. Sims, Kijoung Song, Nicole Soranzo, Elizabeth K. Speliotes, Diabetes Genetics Initiative, Holly E. Syddall, Sarah A. Teichmann, Nicholas J. Timpson, Jonathan H. Tobias, Manuela Uda, The SardiNIA Study, Carla I. Ganz Vogel, Chris Wallace, Dawn M. Waterworth, Michael N. Weedon, The Wellcome Trust Case Control Consortium, Cristen J. Willer, FUSION, Vicki L. Wraight, Xin Yuan, Eleftheria Zeggini, Joel N. Hirschhorn, David P. Strachan, Willem H. Ouwehand, Mark J. Caulfield, Nilesh J. Samani, Timothy M. Frayling, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Panos Deloukas, Mark I. McCarthy, Nicholas J. Wareham, Inês Barroso, Kevin B. Jacobs, Stephen J. Chanock, Richard B. Hayes, Claudia Lamina, Christian Gieger, Thomas Illig, Thomas Meitinger, H-Erich Wichmann, Peter Kraft, Susan E. Hankinson, David J. Hunter, Frank B. Hu, Helen N. Lyon, Benjamin F. Voight, Martin Ridderstrale, Leif Groop, Paul Scheet, Serena Sanna, Goncalo R. Abecasis, Giuseppe Albai, Ramaiah Nagaraja, David Schlessinger, Anne U. Jackson, Jaakko Tuomilehto, Francis S. Collins, Michael Boehnke, Karen L. Mohlke Journal Nature Genetics 40 (6): 768-775 (2008)
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  DOI  PMID18454148 PMCIDPMC2669167 Division 
• A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex AuthorsBernard T. Kelly, Airlie J. McCoy, Kira Späte, Sharon E. Miller, Philip R. Evans, Stefan Höning, David J. Owen Journal Nature 456(7224): 976 (2008) (2008)
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  DOI10.1038/nature07422 PMID18978775 PMCID  DivisionStructural Studies
• Structure and analysis of FCHo2 F-BAR domain : a dimerizing and membrane recrutiment module that effects membrane curvature AuthorsWilliam Mike Henne, Helen M. Kent, Marijn G. J. Ford, Balachandra G. Hegde, Oliver Daumke, P. Jonathan G. Butler, Rohit Mittal, Ralf Langen, Philip R. Evans, Harvey T. McMahon Journal Structure 15(7): 839-852 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• An introduction to stereochemical restraints AuthorsEvans P. R. Journal Acta Crystallogr. Sect. D-Biol. Crystallogr 63(1): 58-61 (2007) (2007)
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  DOI10.1107/S090744490604604X PMID17164527 PMCIDPMC2483478 DivisionStructural Studies
• Structural analysis of the interaction between the SNARE Tlg1 and Vps51 AuthorsFridmann-Sirkis Y., Kent H. M., Lewis M. J., Evans P. R., Pelham H. R. B. Journal Traffic 7(2):182-190. February 2006 (2006 )
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  DOI10.1111/j.1600-0854.2005.00374.x PMID16420526 PMCID  DivisionStructural Studies, Cell Biology
• Scaling and assessment of data quality AuthorsEvans P. Journal Acta Crystallographica Section D: Biological Crystallography D62: 72-82. January 2006 (2006)
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  DOI10.1107/s0907444905036693 PMID16369096 PMCID  DivisionStructural Studies
• NMR analysis of Caenorhabditis elegans FLP-18 neuropeptides: implications for NPR-1 activation AuthorsAaron T. Dossey, Vincenzina Reale, Heather Chatwin, Cherian Zachariah, Mario de Bono, Peter D. Evans, Arthur S. Edison Journal Biochemistry 45: 7586-7597 (2006) (2006)
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  DOI  PMID  PMCID  Division 
• Mechanism of endophilin N-BAR domain-mediated membrane curvature AuthorsJennifer L. Gallop, Christine C. Jao, Helen M. Kent, P. Jonathan G. Butler, Philip R. Evans, Ralf Langen, Harvey T. McMahon Journal EMBO Journal 25: 2898-2910 (2006) (2006)
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  DOI  PMID  PMCID  Division 
• CMOS monolithic active pixel sensors (MAPS): new 'eyes' for science AuthorsR. Turchetta, P. P. Allport, G. Casse, A. Clark, J. Crooks, A. Evans, A. Fant, A. R. Faruqi, M. J. French, R. Henderson, Q. Morrissey, D. Prior, M. Prydderch, J. J. Velthuis, G. Villani, N. Waltham, B. Willmore, P. Willmore Journal Nuclear Instruments & Methods in Physics Research A 560: 139-142 (2006) (2006)
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  DOI  PMID  PMCID  Division 
• Non-canonical YXXGphi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors AuthorsRoyle S. J., Qureshi O. S., Bobanovic L. K., Evans P. R., Owen D. J.,Murrell-Lagnado R. D. Journal Journal of Cell Science 118(Pt 14):3073-3080. July 2005 (2005)
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  DOI10.1242/jcs.02451 PMID15985462 PMCID  DivisionStructural Studies
• CMOS active pixel sensors for ionising radiation AuthorsEvans D. A., Allport P. P., Casse G., Faruqi A. R., Gallop B., Henderson R., Prydderch M., Turchetta R., Tyndel M., Velthuis J., Villani G., Waltham N. Journal Nuclear Instruments and Methods in Physics Research A 546: 281-285. 1 July 2005 (2005)
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• Direct single electron detection with a CMOS detector for electron microscopy AuthorsA. R. Faruqi, R. Henderson, M. Pryddetch, P. Allport, A. Evans Journal Nuclear Instruments and Methods in Physics Research A 546 : 170-175 (2005) (2005)
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• Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta‑propeller AuthorsAdriana E. Miele, Peter J. Watson, Philip R. Evans, Linton M. Traub, David J. Owen Journal Nature Structural & Molecular Biology 11(3):242-248. March 2004 (2004)
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  DOI10.1038/nsmb736 PMID14981508 PMCID  Division 
• BAR domains as sensors of membrane curvature: the amphiphysin BAR structure AuthorsBrian J. Peter, Helen M. Kent, Ian G. Mills, Yvonne Vallis, P. Jonathan G. Butler, Philip R. Evans, Harvey T. McMahon Journal Science 303(5657):495-499 (2004) (2004)
  Details

  DOI10.1126/science.1092586 PMID14645856 PMCID  DivisionNeurobiology
• Adaptors for clathrin coats: structure and function AuthorsDavid J. Owen, Brett M. Collins, Philip R. Evans Journal Annu. Rev. Cell Dev. Biol. 20: 153-191 (2004) (2004)
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• Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1 AuthorsRogers C., Reale V., Kim K., Chatwin H., Li C., Evans P., de Bono M. Journal Nature Neuroscience 6(11):1178-1185. November 2003 (2003)
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  DOI10.1038/nn1140 PMID14555955 PMCID  DivisionCell Biology
• EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking AuthorsMills I. G., Praefcke G. J. K., Vallis Y., Peter B. J., Olesen L. E., Gallop J. L., Butler P. J. G., Evans P. R.,McMahon H. T. Journal Journal of Cell Biology 160(2):213-222. 21 January 2003 (2003)
  Details

  DOI10.1083/jcb.200208023 PMID12538641 PMCIDPMC2172650 DivisionNeurobiology, Structural Studies
• Phasing the AP2 core complex with Xe, Hg and Se AuthorsPhilip Evans Journal Acta Crystallographica Section D: Biological Crystallography D59: 2039-2043 (2003) (2003)
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• A conformational switch between transcriptional repression and replication initiation in the RepA dimerization domain AuthorsRafael Giraldo, Carlos Fernandez-Tornero, Philip R. Evans, Ramon Diaz-Orejas, Antonio Romero Journal Nature Structural Biology 10: 565-571 (2003) (2003)
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• Endocytosis and vesicle trafficking AuthorsEvans P. R., Owen D. J. Journal Current Opinion in Structural Biology 12(6):814-821. 1 December 2002 (2002)
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  DOI10.1016/s0959-440x(02)00395-0 PMID12504687 PMCID  DivisionStructural Studies
• Curvature of clathrin-coated pits driven by epsin AuthorsFord M. G. J., Mills I. G., Peter B. J., Vallis Y., Praefcke G. J. K., Evans P. R., McMahon H. T. Journal Nature 419(6905):361-366. 26 September 2002 (2002)
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  DOI10.1038/nature01020 PMID12353027 PMCID  DivisionStructural Studies, Neurobiology
• Gamma-Adaptin appendage domain: structure and binding site for Eps15 and gamma‑synergin AuthorsKent H. M., McMahon H. T., Evans P. R., Benmerah A., Owen D. J. Journal Structure 10(8):1139-1148. August 2002 (2002)
  Details

  DOI10.1016/s0969-2126(02)00801-8 PMID12176391 PMCID  DivisionNeurobiology, Structural Studies
• Molecular architecture and functional model of the endocytic AP2 complex AuthorsCollins B. M., McCoy A. J., Kent H. M., Evans P. R., Owen D. J. Journal Cell 109(4):523-535. 17 May 2002 (2002)
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  DOI10.1016/s0092-8674(02)00735‑3 PMID12086608 PMCID  DivisionStructural Studies
• The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12 AuthorsLove J. D., Gooch J. T., Benko S., Li C., Nagy L., Chatterjee V. K, Evans R. M., Schwabe J. W. R. Journal Journal of Biological Chemistry 277(13):11385-11391. 29 March 2002 (2002)
  Details

  DOI10.1074/jbc.m110869200 PMID11782480 PMCID  Division 
• The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation AuthorsClayton G. M., Peak-Chew S. Y., Evans R. M., Schwabe J. W. R. Journal Proceedings of the National Academy of Sciences 98(4):1549-1554. 13 February 2001 (2001)
  Details

  DOI10.1073/pnas.98.4.1549 PMID11171988 PMCIDPMC29294 DivisionStructural Studies
• Simultaneous binding of Ptdlns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes AuthorsFord M. G. J., Pearse B. M. F., Higgins M. K., Vallis Y., Owen D. J., Gibson A., Hopkins C. R., Evans P. R., McMahon H. T. Journal Science 291(5506):1051-1055. 9 February 2001 (2001)
  Details

  DOI10.1126/science.291.5506.1051 PMID11161218 PMCID  DivisionStructural Studies, Neurobiology
• The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p AuthorsOwen D. J., Ornaghi P., Yang J-C., Lowe N., Evans P. R., Ballario P., Neuhaus D., Filetici P., Travers A. A. Journal EMBO Journal 19(22):6141-6149. 15 November 2000 (2000)
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  DOI10.1093/emboj/19.22.6141 PMID11080160 PMCIDPMC305837 DivisionCell Biology
• The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p AuthorsOwen D. J., Ornaghi P., Yang J-C., Lowe N., Evans P. R., Ballario P., Neuhaus D., Filetici P., Travers A. A. Journal EMBO Journal 19(22):6141-6149 (2000) (2000)
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  DOI10.1093/emboj/19.22.6141 PMID11080160 PMCIDPMC305837 Division 
• The structure and function of the beta2-adaptin appendage domain AuthorsOwen D. J., Vallis Y., Pearse B. M. F., McMahon H. T., Evans P. R. Journal EMBO Journal 19(16):4216-4227. 15 August 2000 (2000)
  Details

  DOI10.1093/emboj/19.16.4216 PMID10944104 PMCIDPMC302036 DivisionNeurobiology
• The structure and function of the beta2-adaptin appendage domain AuthorsOwen D. J., Vallis Y., Pearse B. M. F., McMahon H. T., Evans P. R. Journal EMBO Journal 19(16):4216-4227 (2000) (2000)
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  DOI10.1093/emboj/19.16.4216 PMID10944104 PMCIDPMC302036 DivisionNeurobiology
• Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody AuthorsFassio A., Evans G., Grisshammer R., Bolam J. P., Mimmack M., Emson P. C. Journal Neuropharmacology 39(8):1430-1442 (2000) (2000)
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  DOI10.1016/s0028-3908(00)00060‑5 PMID10818259 PMCID  Division 
• Mechanism of corepressor binding and release from nuclear hormone receptors AuthorsNagy L., Kao H-Y., Love J. D., Li C., Banayo E., Gooch J. T., Krishna V., Chatterjee K., Evans R. M., Schwabe J. W. R. Journal Genes & Development 13(24):3209-3216. 15 December 1999 (1999)
  Details

  DOI10.1101/gad.13.24.3209 PMID10617570 PMCIDPMC317208 DivisionStructural Studies
• Crystal structure of substrate complexes of methylmalonyl-CoA Mutase AuthorsMancia F., Smith G. A., Evans P. R. Journal Biochemistry 38(25):7999-8005 (1999) (1999)
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  DOI10.1021/bi9903852 PMID10387043 PMCID  Division 
• A structural explanation for the binding of multiple ligands by the alpha - adaptin appendage domain AuthorsOwen D. J., Vallis Y., Noble M. E. M., Hunter J. B., Dafforn T. R., Evans P. R., McMahon H. T. Journal Cell 97(6):805-815 (1999) (1999)
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  DOI10.1016/S0092-8674(00)80791‑6 PMID10380931 PMCID  Division 
• Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis AuthorsVallis Y., Wigge P., Marks B., Evans P. R., McMahon H. T. Journal Current Biology 9(5):257-260 (1999) (1999)
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  DOI10.1016/s0960-9822(99)80114-6 PMID10074456 PMCID  DivisionNeurobiology, Structural Studies
• Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis AuthorsVallis Y., Wigge P., Marks B., Evans P. R., McMahon H. T. Journal Current Biology 9(5):257-260 (1999) (1999)
  Details

  DOI10.1016/s0960-9822(99)80114‑6 PMID10074456 PMCID  DivisionNeurobiology
• A structural explanation for the recognition of tyrosine-based endocytotic signals AuthorsDavid J. Owen, Philip R. Evans Journal Science 282(5392):1327-1332. 13 November 1998 (1998)
  Details

  DOI10.1126/science.282.5392.1327 PMID9812899 PMCID  Division 
• Crystal structure of the spliceosomal U2B''-U2A' protein complex bound to a fragment of U2 small nuclear RNA AuthorsPrice S. R., Evans P. R., Nagai K. Journal Nature 394(6694):645-650. 13 August 1998 (1998)
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  DOI10.1038/29234 PMID9716128 PMCID  DivisionStructural Studies
• Conformational changes on substrate binding to methylmalonyl coA mutase and new insights into the free radical mechanism AuthorsMancia F., Evans P. R. Journal Structure 6(6):711-720. 15 June 1998 (1998)
  Details

  DOI10.1016/s0969-2126(98)00073-2 PMID9655823 PMCID  DivisionStructural Studies
• Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation AuthorsD. J. Owen, P. Wigge, Y. Vallis, J. D. A. Moore, P. R. Evans, H. T. McMahon Journal EMBO Journal 17: 5273-5285 (1998) (1998)
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• Following cell fate in the living mouse embryo AuthorsZernicka-Goetz M., Pines J., McLean Hunter S., Dixon J. P., Siemering K. R., Haseloff J., Evans M. J. Journal Development 124(6):1133-1137. March 1997 (1997)
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  DOI  PMID9102300 PMCID  DivisionCell Biology
• An indelible lineage marker for Xenopus using a mutated green fluorescent protein AuthorsZernicka-Goetz M., Pines J., Ryan K., Siemering K. R., Haseloff J., Evans M. J., Gurdon J. B. Journal Development 122(12):3719-3724. December 1996 (1996)
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  DOI  PMID9012493 PMCID  DivisionCell Biology
• How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 angstrom resolution AuthorsFilippo Mancia, Nicholas H. Keep, Atsushi Nakagawa, Peter F. Leadlay, Sean McSweeney, Bjarne Rasmussen, Peter Bosecke, Olivier Diat, Philip R. Evans Journal Structure 4(3):339-350. March 1996 (1996)
  Details

  DOI10.1016/S0969-2126(96)00037‑8 PMID8805541 PMCID  Division 
• The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA AuthorsNagai K., Oubridge C., Ito N., Avis J., Evans P. Journal Trends in Biochemical Sciences 20(6):235-240. June 1995 (1995)
  Details

  DOI10.1016/s0968-0004(00)89024-6 PMID7543225 PMCID  DivisionStructural Studies
• The Hox11 gene is essential for cell survival during spleen development AuthorsT. N. Dear, W. H. Colledge, M. B. L. Carlton, I. Lavenir, T. Larson, A. J. H. Smith, A. J. Warren, M. J. Evans, M. V. Sofroniew, T. H. Rabbitts Journal Development 121: 2909-2915 (1995) (1995)
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• Crystal structure at 1.92 angstrom resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin AuthorsOubridge C., Ito N., Evans P. R., Teo C. H., Nagai K. Journal Nature 372(6505):432-438. 1 December 1994 (1994)
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  DOI10.1038/372432a0 PMID7984237 PMCID  DivisionStructural Studies
• The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development AuthorsAlan J. Warren, William H. Colledge, Mark B. L. Carlton, Martin J. Evans, Andrew J. H. Smith, Terence H. Rabbitts Journal Cell 78: 45-57 (1994) (1994)
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• Structural studies of proteins in solution using proton nuclear magnetic resonance AuthorsNeuhaus D., Evans P. A. Journal Methods in Molecular Biology, Vol. 17: Spectroscopic Methods and Analyses: NMR, Mass Spectrometry, and Metalloprotein Techniques. Edited by C. Jones, B. Mulloy and A. H. Thomas 17:15-67 (1993) (1993)
  Details

  DOI10.1385/0-89603-215-9:15 PMID21400133 PMCID  Division 
• Site-directed mutagenesis identifies catalytic residues in the active site of Escherichia coli phosphofructokinase AuthorsStuart A. Berger, Philip R. Evans Journal Biochemistry 31: 9237-9242 (1992) (1992)
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• The mechanism of Z alpha1-antitrypsin accumulation in the liver AuthorsDavid A. Lomas, Dyfed LI. Evans, John T. Finch, Robin W. Carrell Journal Nature 357: 605-607 (1992) (1992)
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• Activity and allosteric regulation in bacterial phosphofructokinase AuthorsEvans P. R. Journal Proceedings of The Robert A. Welch Foundation Conference on Chemical Research. XXXVI. Regulation of proteins by Ligands pp.39-54 (1992) (1992)
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• Structural aspects of allostery AuthorsEvans P. R. Journal Current Opinion in Structural Biology 1(5): 773-779 (1991) (1991)
  Details

  DOI10.1016/0959-440X(91)90178-V PMID  PMCID  Division 
• Steady-state fluorescence of Escherichia coli phosphofructokinase reveals a regulatory role for ATP AuthorsStuart A. Berger, Philip R. Evans Journal Biochemistry 30(34): 8477-8480 (1991 ) (1991)
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  DOI10.1021/bi00098a027 PMID1832014 PMCID  Division 
• Designing an allosterically locked phosphofructokinase AuthorsCraig E. Kundrot, Philip R. Evans Journal Biochemistry 30: 1478-1484 (1991) (1991)
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• Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A AuthorsNagai K., Oubridge C., Jessen T. H., Li J., Evans P R. Journal Nature 348(6301):515-520 (1990) (1990)
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  DOI10.1038/348515a0 PMID2147232 PMCID  DivisionStructural Studies
• Active-site mutants altering the cooperativity of E. coli phosphofructokinase AuthorsBerger S. A., Evans P. R. Journal Nature 343(6258):575-576. 8 February 1990 (1990)
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  DOI10.1038/343575a0 PMID2137204 PMCID  DivisionStructural Studies
• Structural basis of the allosteric behaviour of phosphofructokinase AuthorsSchirmer T., Evans P. R. Journal Nature 343(6254):140-145. 11 January 1990 (1990)
  Details

  DOI10.1038/343140a0 PMID2136935 PMCID  DivisionStructural Studies
• Biotinyl and phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides AuthorsKonrad Misiura, Ian Durrant, Michael R. Evans, Michael J. Gait Journal Nucleic Acids Research 18: 4345-4354 (1990) (1990)
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• Crystal structure of unliganded phosphofructokinase from Escherichia coli AuthorsWojciech R. Rypniewski, Philip R. Evans Journal Journal of Molecular Biology 207: 805-821 (1989) (1989)
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• Crystallization and preliminary diffraction data for adenosylcobalamin-dependent methlmalonyl-CoA mutase from Propionibacterium shermanii AuthorsNeil Marsh, Peter F. Leadlay, Philip R. Evans Journal Journal of Molecular Biology 200: 421-422 (1988) (1988)
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• Crystal structure of the complex of phosphofructokinase from Escherichia coli with its reaction products AuthorsYasuo Shirakihara, Philip R. Evans Journal Journal of Molecular Biology 204: 973-994 (1988) (1988)
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• Mutations in the active site of Escherichia coli phosphofructokinase AuthorsHomme W. Hellinga, Philip R. Evans Journal Nature 327: 437-439 (1987) (1987)
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• Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase AuthorsFrankie Tat-Kwong Lau, Alan R. Fersht, Homme W. Hellinga, Philip R. Evans Journal Biochemistry 26: 4142-4148 (1987) (1987)
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• The mechanism of action of interferon-alpha (IFN-alpha) in hairy-cell leukaemia; Hu-IFN-alpha2 receptor expression by hairy cells and other normal and leukaemic cell types AuthorsRoya Dadmarz, Tom Evans, David Secher, Nicholas Marshall, John Cawley Journal Leukemia Research 10: 1279-1285 (1986) (1986)
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• Crystallographic structure of aIIosterically inhibited phosphofructokinase at 7Angstrom resolution AuthorsP. R. Evans, G. W. Farrants, M. C. Lawrence Journal Journal of Molecular Biology 191: 713-720 (1986) (1986)
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• Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase AuthorsHomme W. Hellinga, Philip R. Evans Journal European Journal of Biochemistry 149: 363-373 (1985) (1985)
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• Relative absorption correction for rotation film data AuthorsC. E. Schutt, P. R. Evans Journal Acta Cryst. A41: 568-570 (1985) (1985)
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• Clinical testing of gliadin fractions in coeliac patients AuthorsCiclitira P. J., Evans D. J., Fagg N. L. K., Lennox E. S., Dowling R. H. Journal Clinical Science 66(3):357-364. 1 March 1984 (1984)
  Details

  DOI10.1042/cs0660357 PMID6692666 PMCID  Division 
• Kinetics of internalisation and degradation of surface-bound interferon in human lymphoblastoid cells AuthorsTom Evans, David Secher Journal EMBO Journal 3: 2975-2978 (1984) (1984)
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• Phosphofructokinase: structure and control AuthorsEvans P. R., Farrants G. W., Hudson P. J. Journal Phil. Trans. R. Soc. Lond. B 293(1063):53-62 (1981) (1981)
  Details

  DOI10.1098/rstb.1981.0059 PMID6115424 PMCID  Division 
• Structure and control of phosphofructokinase from Bacillus stearothermophilus AuthorsP. R. Evans, P. J. Hudson Journal Nature 279: 500-504 (1979) (1979)
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