Published Research

Found 60 results for Crowther R.

• Tau and neurodegeneration AuthorsGoedert M., Crowther R. A., Scheres S. H. W., Spillantini M. G. Journal Cytoskeleton 81(1):95-102 (2024)
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  DOI10.1002/cm.21812 PMID38073060 PMCIDPMC7615684 DivisionNeurobiology
• Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau AuthorsSchweighauser M., Murzin A. G., Macdonald J., Lavenir I., Crowther R. A., Scheres S. H. W., Goedert M. Journal Acta Neuropathologica Communications 11(1):160 (2023)
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  DOI10.1186/s40478-023-01658‑y PMID37798679 PMCIDPMC10552433 DivisionStructural Studies
• MRC2020: improvements to Ximdisp and the MRC image-processing programs AuthorsShort J. M., Palmer C. M., Burnley T., Winn M. D., Zhang Q., Venkataram Prasad B. V., Chen S., Crowther R. A., Unwin P. N. T., Henderson R. Journal Iucrj 10(Pt 5):579-583 (2023)
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  DOI10(Pt 5):579‑583 PMID37493524 PMCIDPMC10478516 DivisionStructural Studies
• Insights into neurodegeneration from electron microscopy studies AuthorsCrowther R. A. Journal Biochemical Society Transactions 49(6):2777-2786 (2021)
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  DOI10.1042/bst20210719 PMID34812894 PMCIDPMC8786292 DivisionStructural Studies
• Sir Aaron Klug OM. 11 August 1926—20 November 2018 AuthorsCrowther R. A. Journal Biographical Memoirs of Fellows of the Royal Society 68:273–296. June 2020 (2020)
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  DOI10.1098/rsbm.2019.0034 PMID  PMCID  DivisionStructural Studies
• Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules AuthorsFalcon B., Zivanov J., Zhang W., Murzin A. G., Garringer H. J., Vidal R., Crowther R. A., Newell K. L., Ghetti B., Goedert M., Scheres S. H. W. Journal Nature 568(7752):420-423. April 2019 (2019)
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  DOI10.1038/s41586-019-1026-5 PMID30894745 PMCIDPMC6472968 DivisionNeurobiology, Structural Studies
• Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases AuthorsZhang W., Falcon B., Murzin A. G., Fan J., Crowther R. A., Goedert M., Scheres S. H. Journal ELife 8: e43584. 5 February 2019 (2019)
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  DOI10.7554/eLife.43584 PMID30720432 PMCIDPMC6375701 DivisionNeurobiology, Structural Studies
• Structures of filaments from Pick's disease reveal a novel tau protein fold AuthorsFalcon B., Zhang W., Murzin A. G., Murshudov G., Garringer H. J., Vidal R., Crowther R. A., Ghetti B., Scheres S. H. W., Goedert M. Journal Nature 561(7721):137-140. 6 September 2018 (2018)
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  DOI10.1038/s41586-018-0454-y PMID30158706 PMCIDPMC6204212 DivisionStructural Studies, Neurobiology
• Cryo-EM structures of tau filaments from Alzheimer's disease AuthorsFitzpatrick A. W. P., Falcon B., He S., Murzin A. G., Murshudov G., Garringer H. J., Crowther R. A., Ghetti B., Goedert M., Scheres S. H. W. Journal Nature 547(7662):185-190 (2017)
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  DOI10.1038/nature23002 PMID28678775 PMCIDPMC5552202 DivisionNeurobiology, Structural Studies
• Propagation of Tau Aggregates and Neurodegeneration AuthorsGoedert M., Eisenberg D. S., Crowther R. A. Journal Annual Review of Neuroscience 40:189-210 (2017)
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  DOI10.1146/annurev-neuro-072116‑031153 PMID28772101 PMCID  DivisionNeurobiology, Structural Studies
• The Resolution Revolution: Recent Advances In cryoEM AuthorsCrowther R. A. (Ed) Journal Methods in Enzymology 597: 2-445 (2016)
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  DOI  PMID  PMCID  DivisionStructural Studies
• A Brief History of Tau AuthorsGoedert M., Spillantini M. G., Crowther R. A. Journal Clinical Chemistry 61(11):1417-1418. November 2015 (2015)
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  DOI10.1373/clinchem.2015.245142 PMID26330509 PMCID  DivisionNeurobiology
• Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies AuthorsMellone M., Kestoras D., Andrews M. R., Dassie E., Crowther R. A., Stokin G. B., Tinsley J., Horne G., Goedert M., Tolkovsky A. M., Spillantini M. G. Journal Journal of Neuroscience 33(46):18175-18189. 13 November 2013 (2013)
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  DOI10.1523/JNEUROSCI.4933-12.2013 PMID24227726 PMCIDPMC3828468 DivisionNeurobiology, Structural Studies
• Brain homogenates from human tauopathies induce tau inclusions in mouse brain AuthorsClavaguera F., Akatsu H., Fraser G., Crowther R. A., Frank S., Hench J., Probst A., Winkler D. T., Reichwald J., Staufenbiel M., Ghetti B., Goedert M., Tolnay M. Journal Proceedings of the National Academy of Sciences, USA. 110(23):9535-9540. 4 June 2013 (2013)
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  DOI10.1073/pnas.1301175110 PMID23690619 PMCIDPMC3677441 DivisionNeurobiology, Structural Studies
• Structures of hepatitis B virus cores presenting a model epitope and their complexes with antibodies AuthorsRoseman A. M., Borschukova O., Berriman J. A., Wynne S. A., Pumpens P., Crowther R. A. Journal Journal of Molecular Biology 423(1):63-78. 12 October 2012 (2012)
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  DOI10.1016/j.jmb.2012.06.032 PMID22750730 PMCIDPMC3465560 DivisionStructural Studies
• Regulation of Virus Neutralization and the Persistent Fraction by TRIM21 AuthorsMcEwan W. A., Hauler F., Williams C. R., Bidgood S. R., Mallery D. L., Crowther R. A., James L. C. Journal Journal of Virology 86(16):8482-8491. August 2012 (2012)
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  DOI10.1128/JVI.00728‑12 PMID22647693 PMCIDPMC3421726 DivisionProtein & Nucleic Acid Chemistry; Structural Studies
• Phenotypic variation of autosomal-dominant corticobasal degeneration AuthorsJung H. H., Bremer J., Streffer J., Virdee K., Spillantini M. G., Crowther R. A., Brugger P., Van Broeckhoven C., Aguzzi A., Tolnay M. Journal European Neurology 67(3):142-150. March 2012 (2012)
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  DOI10.1159/000334731 PMID22261560 PMCIDPMC3638994 DivisionStructural Studies
• Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy AuthorsHenderson R., Chen S., Chen J. Z., Grigorieff N., Passmore L. A., Ciccarelli L., Rubinstein J. L., Crowther R. A., Stewart P. L., Rosenthal P. B. Journal Journal of Molecular Biology 413(5):1028-1046. 11 November 2011 (2011)
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  DOI10.1016/j.jmb.2011.09.008 PMID21939668 PMCIDPMC3220764 DivisionStructural Studies
• Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability AuthorsGasparini L., Crowther R. A., Martin K. R., Berg N., Coleman M., Goedert M., Spillantini M. G. Journal Neurobiology of Aging 32(3):419-433. March 2011 (2011)
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  DOIdoi:10.1016/j.neurobiolaging PMID19356824 PMCID  DivisionNeurobiology, Structural Studies
• Human beta-synuclein rendered fibrillogenic by designed mutations AuthorsZibaee S., Fraser G., Jakes R., Owen D., Serpell L. C., Crowther R. A., Goedert M. Journal Journal of Biological Chemistry 285(49):38555-38567 3 December 2010 (2010)
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  DOI10.1074/jbc. M110.160721 PMID20833719 PMCIDPMC2992288 DivisionNeurobiology, Protein and Nucleic Acid Chemistry, Structural Studies
• From envelopes to atoms: The remarkable progress of biological electron microscopy AuthorsCrowther R. A. Journal Advances in Protein Chemistry and Structural Biology 81:1-32. 27 November 2010 (online) (2010)
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  DOI10.1016/B978-0-12-381357-2.00001-3 PMID21115171 PMCID  DivisionStructural Studies
• Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection AuthorsEl Chaar M., Candotti D., Crowther R. A., Allain J. P. Journal Hepatology 52(5):1600-1610. 1 November 2010 (2010)
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  DOI10.1002/hep.23886 PMID20815025 PMCID  DivisionStructural Studies
• Tau protein, the paired helical filament and Alzheimer's disease AuthorsGoedert M., Klug A., Crowther R. A. Journal Journal of Alzheimer's Disease 9(3 suppl):195-207. August 2006 (2006)
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  DOI  PMID16914859 PMCID  DivisionNeurobiology, Structural Studies
• A structural model for maturation of the hepatitis B virus core AuthorsRoseman A. M., Berriman J. A., Wynne S. A., Butler P. J. G., Crowther R. A. Journal Proceedings of the National Academy of Sciences, USA 102(44):15821-15826. 1 November 2005 (2005)
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  DOI10.1073/pnas.0504874102 PMID16247012 PMCIDPMC1276056 DivisionStructural Studies
• Mutation E46K increases phospholipid binding and assembly into filaments of human alpha‑synuclein AuthorsChoi W., Zibaee S., Jakes R., Serpell L. C., Davletov B., Crowther R. A., Goedert M. Journal FEBS Letters 576(3):363-368. 22 October 2004 (2004)
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  DOI10.1016/j.febslet.2004.09.038 PMID15498564 PMCID  DivisionNeurobiology, Structural Studies
• Macromolecular assemblages - putting the pieces together AuthorsCrowther R. A., Prasad B. V. Journal Current Opinion in Structural Biology 14(2):117-120. April 2004 (2004)
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  DOI10.1016/j.sbi.2004.03.015 PMID15093824 PMCID  DivisionStructural Studies
• Viruses and the development of quantitative biological electron microscopy AuthorsCrowther R. A. Journal Notes Rec. R. Soc. Lond. 58(1):65-81. 22 January 2004 (2004)
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  DOI10.1098/rsnr.2003.0225 PMID14979296 PMCID  DivisionStructural Studies
• Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein AuthorsAllen B., Ingram E., Takao M., Smith M. j., Jakes R., Virdee K., Yoshida H., Holzer M., Craxton M., Emson P. C., Atzori C., Migheli A., Crowther R. A., Ghetti B., Spillantini M. G., Goedert M. Journal Journal of Neuroscience 22(21):9340-9351 (2002) (2002)
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  DOI10.1523/jneurosci.22-21-09340.2002 PMID12417659 PMCIDPMC6758022 DivisionNeurobiology
• Functional effects of tau gene mutations N296 and N296H AuthorsYoshida H., Crowther R. A., Goedert M. Journal Journal of Neurochemistry 80(3):548-551. February 2002 (2002)
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  DOI10.1046/j.0022-3042.2001.00729.x PMID11906000 PMCID  DivisionStructural Studies, Neurobiology
• Pick's disease associated with the novel Tau gene mutation K369I AuthorsNeumann M., Schulz-Schaeffer W., Crowther R. A., Smith M. J., Spillantini M G., Goedert M., Kretzschmar H. Journal Annals of Neurology 50(4):503-513 (2001) (2001)
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  DOI10.1002/ana.1223 PMID11601501 PMCID  DivisionStructural Studies, Neurobiology
• Macromolecular assemblages. Editorial overview AuthorsCrowther R. A., Harrison S. C. Journal Current Opinion in Structural Biology 11: 141-143 (2001) (2001)
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  DOI  PMID  PMCID  Division 
• Abnormal tau-containing filaments in neurodegenerative diseases AuthorsCrowther R. A., Goedert M. Journal Journal of Structural Biology 130(2-3):271-279 (2000) (2000)
  Details

  DOI10.1006/jsbi.2000.4270 PMID10940231 PMCID  DivisionStructural Studies, Neurobiology
• Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation AuthorsSerpell L. C., Berriman J., Jakes R., Goedert M., Crowther R. A. Journal Proceedings of the National Academy of Sciences, USA 97(9):4897-4902 (2000) (2000)
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  DOI10.1073/pnas.97.9.4897 PMID10781096 PMCIDPMC18329 DivisionNeurobiology, Structural Studies
• A novel mutation at position+12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD‑Kumamoto) AuthorsYasuda M., Takamatsu J., D'Souza I., Crowther R. A., Kawamata T.,Hasegawa M., Hasegawa H., Spillantini M. G., Tanimukai S., Poorkaj P.,Varani L., Varani G., Iwatsubo T., Goedert M., Schellenberg G. D.,Tanaka C. Journal Annals of Neurology 47(4):422-429 (2000) (2000)
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  DOI10.1002/1531-8249(200004)47:4<422::aid-ana4>3.0. Co;2‑g PMID10762152 PMCID  DivisionStructural Studies, Neurobiology
• Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein AuthorsProbst A., Gotz J., Wiederhold K. H., Tolnay M., Mistl C., Jaton A. L., Hong M., Ishihara T., Lee V. M-Y., Trojanowski J. Q., Jakes R., Crowther R. A., Spillantini M. G., Burki K., Goedert M. Journal Acta Neuropathol. 99(5):469-481 (2000) (2000)
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  DOI10.1007/s004010051148 PMID10805089 PMCID  DivisionNeurobiology, Structural Studies
• Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke family 1684 AuthorsHulette C. M., Pericak-Vance M. A., Roses A. D., Schmechel D. E.,Yamaoka L. H., Gaskell P. C., Welsh-Bohmer K. A., Crowther R. A., Spillantini M. G. Journal Journal of Neuropathology and Experimental Neurology 58(8):859-866 (1999 ) (1999)
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  DOI10.1097/00005072-199908000‑00008 PMID10446810 PMCID  DivisionStructural Studies
• The crystal structure of the human hepatitis B virus capsid AuthorsWynne S. A., Crowther R. A., Leslie A. G. W. Journal Molecular Cell 3(6):771-780 (1999) (1999)
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  DOI10.1016/s1097-2765(01)80009-5 PMID10394365 PMCID  Division 
• Crystallization of hepatitis B virus core protein shells: determination of cryoprotectant conditions and preliminary X-ray characterization AuthorsWynne S. A., Leslie A. G. W., Butler P. J. G., Crowther R. A. Journal Acta Crystallographica Section D D55: 557-560 (1999) (1999)
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  DOI10.1107/s0907444998012621 PMID10089378 PMCID  Division 
• Peptides that block hepatitis B virus assembly: analysis by cryomicroscopy, mutagenesis and transfection AuthorsBottcher B., Tsuji N., Takahashi H., Dyson M. R., Zhao S., Crowther R. A., Murray K. Journal EMBO Journal 17(23):6839-6845 (1998) (1998)
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  DOI10.1093/emboj/17.23.6839 PMID9843489 PMCIDPMC1171031 DivisionStructural Studies
• Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau AuthorsSpillantini M. G., Crowther R. A., Kamphorst W., Heutink P., van Swieten J. C. Journal American Journal of Pathology 153(5):1359-1363. November 1998 (1998)
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  DOI10.1016/s0002-9440(10)65721-5 PMID9811325 PMCIDPMC1853390 DivisionStructural Studies
• Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies AuthorsSpillantini M. G., Crowther R. A., Jakes R., Cairns N., Lantos P. L., Goedert M. Journal Neuroscience Letters 251(3):205-208 (1998) (1998)
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  DOI10.1016/S0304-3940(98)00504‑7 PMID9726379 PMCID  DivisionNeurobiology
• Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans AuthorsGoedert M., Jakes R., Spillantini M. G., Hasegawa M., Smith M. J., Crowther R. A. Journal Nature 383(6600):550-553. 10 October 1996 (1996)
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  DOI10.1038/383550a0 PMID8849730 PMCID  DivisionNeurobiology, Structural Studies
• MRC image processing programs AuthorsCrowther R. A., Henderson R., Smith J. M. Journal Journal of Structural Biology 116(1):9-16. January 1996 (1996)
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  DOI10.1006/jsbi.1996.0003 PMID8742717 PMCID  DivisionStructural Studies
• Molecular dissection of the paired helical filament AuthorsGoedert M., Spillantini M. G., Jakes R., Crowther R. A., Vanmechelen E., Probst A., Gotz J., Burki K., Cohen P. Journal Neurobiology of Aging 16(3):325-334. May-June 1995 (1995)
  Details

  DOI10.1016/0197-4580(95)00017‑9 PMID7566342 PMCID  DivisionNeurobiology, Structural Studies
• Assembly of Alzheimer-like filaments from full-length tau protein AuthorsCrowther R. A., Olesen O. F., Smith M. J., Jakes R., Goedert M. Journal FEBS Letters 337(2):135-138. 10 January 1994 (1994)
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  DOI10.1016/0014-5793(94)80260-2 PMID8287967 PMCID  DivisionStructural Studies, Neurobiology
• Assembly of Alzheimer-like filaments from full-length tau protein AuthorsCrowther R. A., Olesen O. F., Smith M. J., Jakes R., Goedert M. Journal FEBS Letters 337(2):135-138. 10 January 1994 (1994)
  Details

  DOI10.1016/0014-5793(94)80260‑2 PMID8287967 PMCID  DivisionStructural Studies, Neurobiology
• Tau protein and Alzheimer's disease AuthorsGoedert M., Jakes R., Spillantini M. G., Crowther R. A. Journal Microtubules pp.183-200 (1994) (1994)
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  DOI  PMID  PMCID  DivisionNeurobiology, Structural Studies
• The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development AuthorsGoedert M., Jakes R., Crowther R. A., Six J., Lubke U., Vandermeeren M.,Cras P., Trojanowski J. Q., Lee V. M. Y. Journal Proceedings of the National Academy of Sciences USA 90: 5066-5070. 1 June 1993 (1993)
  Details

  DOI10.1073/pnas.90.11.5066 PMID8506352 PMCIDPMC46655 DivisionNeurobiology
• Tau protein and paired helical filaments of Alzheimer's disease AuthorsCrowther R. A. Journal Current Opinion in Structural Biology 3(2): 202-206 (1993) (1993)
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• A protocol for 3D image reconstruction from a single image of an oblique section AuthorsTaylor K. A., Crowther R. A. Journal Ultramicroscopy 38(1):85-103. October 1991 (1991)
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  DOI10.1016/0304-3991(91)90110‑r PMID1805475 PMCID  DivisionStructural Studies
• Tau proteins and neurofibrillary degeneration AuthorsGoedert M., Spillantini M. G., Crowther R. A. Journal Brain Pathology 1(4):279-286. July 1991 (1991)
  Details

  DOI10.1111/j.1750-3639.1991.tb00671.x PMID1669718 PMCID  DivisionNeurobiology, Structural Studies
• Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain AuthorsGoedert M., Spillantini M. G., Potier M. C., Ulrich J., Crowther R. A. Journal EMBO Journal 8(2):393-399. 1 February 1989 (1989)
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  DOI10.1002/j.1460-2075.1989.tb03390.x PMID2498079 PMCIDPMC400819 DivisionNeurobiology, Structural Studies
• Three-dimensional reconstruction of a periodic specimen from a single view of an oblique section AuthorsCrowther R. A. Journal Ultramicroscopy 13: 295-304 (1984) (1984)
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  DOI10.1016/0304-3991(84)90207-9 PMID  PMCID  DivisionStructural Studies
• Packing of clathrin into coats AuthorsPearse B. M. F., Crowther R. A. Journal Cold Spring Harbor Symposia on Quantitative Biology XLVI: 703-706 (1982) (1982)
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  DOI10.1101/SQB.1982.046.01.066 PMID6955105 PMCID  Division 
• An analysis of the fine structure of the surface layers from two strains of Clostridia, including correction for distorted images AuthorsCrowther R. A., Sleytr U. B. Journal Journal of Ultrastructure Research 58(1):41-49. January 1977 (1977)
  Details

  DOI10.1016/s0022-5320(77)80006‑3 PMID833917 PMCID  DivisionStructural Studies
• The use of non-crystallographic symmetry for phase determination AuthorsCrowther R. A. Journal Acta Crystallographica, B 25: 2571-2580 (1969)
  Details

  DOI10.1107/s0567740869006091 PMID5395580 PMCID  Division 
• Identification of residues responsible for the alkaline Bohr effect in haemoglobin AuthorsPerutz M. F., Muirhead H., Mazzarella L., Crowther R. A., Greer J.,Kilmartin J. V. Journal Nature 222(5200):1240-1243 (1969)
  Details

  DOI10.1038/2221240a0 PMID5789657 PMCID  Division 
• A computer linked cathode-ray tube microdensitometer for X-ray crystallography AuthorsArndt U. W., Crowther R. A., Mallett J. F. W. Journal Journal of Scientific Instruments (Journal of Physics E). Series 2 1(5):510-516 (1968)
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  DOI10.1088/0022-3735/1/5/303 PMID5317723 PMCID  DivisionStructural Studies
• A method of positioning a known molecule in an unknown crystal structure AuthorsCrowther R. A., Blow D. M. Journal Acta Crystallographica 23: 544-548 (1967)
  Details

  DOI10.1107/S0365110X67003172 PMID  PMCID  Division 
• A linear analysis of the non-crystallographic symmetry problem AuthorsCrowther R. A. Journal Acta Crystallographica 22: 758-764 (1967)
  Details

  DOI10.1107/S0365110X67001513 PMID  PMCID  DivisionStructural Studies