Published Research
Found 37 results for Bullock S.
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Structural basis for recognition of diverse localizing mRNAs by Egl‑BicD
AuthorsSingh K., Chilaeva S., McClintock M. A., Carter A. P., Bullock S. L.
Journal
Nature Structural & Molecular Biology
33(5):882-893 (2026)
Details
DOI10.1038/s41594-026-01794-8 PMID42086746 PMCIDPMC13186709 DivisionCell Biology/Structural Studies -
A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression
AuthorsSalvador-Garcia D, Jin L, Hensley A, Gölcük M, Gallaud E, Chaaban S, Port F, Vagnoni A, Planelles-Herrero VJ, McClintock MA, Derivery E, Carter AP, Giet R, Gür M, Yildiz A, Bullock SL.
Journal
Journal of Cell Biology
(10):e202310022 (2024)
Details
DOI10.1083/jcb.202310022 PMID38949648 PMCIDPMC11215527 DivisionStructural Studies, Cell Biology - Genome-scale requirements for dynein-based transport revealed by a high-content arrayed CRISPR screen AuthorsWong CH, Wingett SW, Qian C, Hunter MR, Taliaferro JM, Ross-Thriepland D, Bullock SL. Journal Journal of Cell Biology 223(5):e202306048 (2024)
- Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport AuthorsHeber S., McClintock M. A., Simon B., Mehtab E, Lapouge K., Hennig J., Bullock S. L., Ephrussi A. Journal Nature Structural & Molecular Biology 31(3):476-488 (2024)
- HEATR5B associates with dynein-dynactin and promotes motility of AP1-bound endosomal membranes AuthorsMadan V., Albacete-Albacete L., Jin L., Scaturro P., Watson J. L., Muschalik N., Begum F., Boulanger J., Bauer K., Kiebler M. A., Derivery E., Bullock S. L Journal The EMBO Journal 42(23):e114473 (2023)
- An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport AuthorsGáspár I., Phea L. J, McClintock M. A., Heber S., Bullock S. L, Ephrussi A. Journal The Journal of Cell Biology 222(7):e202301113 (2023)
- C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility AuthorsFumagalli L., et al (including Young F. L., Madan V., Bullock S. L.) Journal Science Advances 7(15):eabg3013. 9 April 2021 (2021)
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A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport
AuthorsVincent J., Preston M., Mouchet E., Laugier N., Corrigan A., Boulanger J., Brown D. G., Clark R., Wigglesworth M., Carter A. P., Bullock S. L.
Journal
SLAS Discovery : Advancing Life Sciences R & D
25(9):985-999 (2020)
Details
DOI10.1177/2472555220920581 PMID32436764 PMCIDPMC7116108 DivisionCell Biology, Structural Studies - Lis1 activates dynein motility by modulating its pairing with dynactin AuthorsElshenawy M. M., Kusakci E., Volz S., Baumbach J., Bullock S. L., Yildiz A. Journal Nature Cell Biology 22(5):570-578. May 2020 (2020)
- Meeting report - Nuclear and cytoplasmic molecular machines at work AuthorsBullock S. L., Visa N., Pederson T. Journal Journal of Cell Science 133(7). 6 April 2020 (2020)
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RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs
AuthorsMcClintock M. A., Dix C. I., Johnson C. M., McLaughlin S. H., Maizels R. J., Hoang H. T., Bullock S. L.
Journal
ELife
7:e36312. 26 June 2018 (2018)
Details
DOI10.7554/eLife.36312 PMID29944118 PMCIDPMC6056234 DivisionCell Biology, Protein & Nucleic Acid Chemistry - A cAMP/PKA/Kinesin-1 axis promotes the axonal transport of mitochondria in aging drosophila neurons AuthorsVagnoni A., Bullock S. L. Journal Current Biology 28(8):1265-1272.e4. 23 April 2018 (2018)
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Lissencephaly-1 is a context-dependent regulator of the human dynein complex
AuthorsBaumbach J., Murthy A., McClintock M. A., Dix C. I, Zalyte R., Hoang H. T., Bullock S. L.
Journal
ELife
6: e21768. 13 April 2017 (2017)
Details
DOI10.7554/eLife.21768 PMID28406398 PMCIDPMC5413349 DivisionCell Biology, Structural Studies - SnapShot: Subcellular mRNA Localization AuthorsMofatteh M., Bullock S. L. Journal Cell 169(1):178-178.e1. 23 March 2017 (2017)
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DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes
AuthorsHoang H. T., Schlager M. A., Carter A. P., Bullock S. L.
Journal
Proceedings of the National Academy of Sciences of the United States of America
114(9):E1597-E1606. 28 February 2017 (2017)
Details
DOI10.1073/pnas.1620141114 PMID28196890 PMCIDPMC5338514 DivisionStructural Studies, Cell Biology - Augmenting CRISPR applications in Drosophila with tRNA-flanked sgRNAs AuthorsPort F., Bullock S. L. Journal Nature Methods 13(10):852-854. October 2016 (2016)
- A simple method for imaging axonal transport in aging neurons using the adult Drosophila wing AuthorsVagnoni A., Bullock S. L. Journal Nature Protocols 11(9):1711-1723. September 2016 (2016)
- Reducing Lissencephaly-1 levels augments mitochondrial transport and has a protective effect in adult Drosophila neurons AuthorsVagnoni A., Hoffmann P. C., Bullock S. L. Journal Journal of Cell Science 129(1):178-90. 1 January 2016 (2016)
- Creating Heritable Mutations in Drosophila with CRISPR‑Cas9 AuthorsPort F., Bullock S. L. Journal Methods in Molecular Biology 1478:145-160 (2016)
- Safeguarding gene drive experiments in the laboratory AuthorsAkbari B. O., Bellen H. J., Bier E., Bullock S. L., Burt A., Church G. M., Cook K. R., Duchek P., Edwards O. R., Esvelt K. M., Gantz V. M., Golic K. G., Gratz S. J,. Harrison M. M., Hayes K. R., James A. A., Kaufman T. C., Knoblich J., Malik H. S., Matthews K. A., O'Connor-Giles K. M., Parks A. L., Perrimon N., Port F., Russell S., Ueda R., Wildonger J. Journal Science 349(6251):927-929. 28 August 2015 (2015)
- Systematic Evaluation of Drosophila CRISPR Tools Reveals Safe and Robust Alternatives to Autonomous Gene Drives in Basic Research AuthorsPort F., Muschalik N., Bullock S. L. Journal G3 5(7):1493-1502. July 2015 (2015)
- Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2. AuthorsRossor A. M., Oates E. C., Salter H. K., Liu Y., Murphy S. M., Schule R., Gonzalez M. A., Scoto M., Phadke R., Sewry C. A., Houlden H., Jordanova A., Tournev I., Chamova T., Litvinenko I., Zuchner S., Herrmann D. N. Blake J., Sowden J. E., Acsadi G., Rodriguez M. L., Menezes M. P., Clarke N. F., Auer Grumbach M., Bullock S. L., Muntoni F., Reilly M. M., North K. N. Journal Brain : a Journal of Neurology 38(Pt 2):293-310. February 2015 (2015)
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In vitro reconstitution of a highly processive recombinant human dynein complex
AuthorsSchlager M. A., Hoang H. T., Urnavicius L., Bullock S. L., Carter A. P.
Journal
EMBO Journal
33(17):1855-1868. 1 September 2014 (2014)
Details
DOI10.15252/embj.201488792 PMID24986880 PMCIDPMC4158905 DivisionCell Biology, Structural Studies - Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila AuthorsPort F., Chen H. M., Lee T., Bullock S. L. Journal Proceedings of the National Academy of Sciences, USA 111(29):E2967-76. 22 July 2014 (2014)
- The Drosophila MAST kinase Drop out is required to initiate membrane compartmentalisation during cellularisation and regulates dynein-based transport AuthorsHain D., Langlands A., Sonnenberg H. C., Bailey C., Bullock S. L., Müller H. A. Journal Development 141(10):2119-2130. May 2014 (2014)
- The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA AuthorsSoundararajan H. C., Bullock S. L. Journal ELife 3:e01596. 15 April 2014 (2014)
- A stem-loop structure directs oskar mRNA to microtubule minus ends AuthorsJambor H. Mueller S., Bullock S. L., Ephrussi A. Journal RNA 20(4):429-439. April 2014 (2014)
- Dynein associates with oskar mRNPs and is required for their efficient net plus-end localization in Drosophila oocytes AuthorsSanghavi P., Laxani S., Li X., Bullock S. L., Gonsalvez G. B. Journal PloS one 8(11):e80605. 11 November 2013 (2013)
- Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs AuthorsDix C. I., Soundararajan H. C., Dzhindzhev N. S., Begum F., Suter B., Ohkura H., Stephens E., Bullock S. L. Journal Journal of Cell Biology 202(3):479-494. 5 August 2013 (2013)
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Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein
AuthorsLiu Y., Salter H. K., Holding A. N., Johnson C. M., Stephens E., Lukavsky P. J., Walshaw J., Bullock S. L.
Journal
Genes & Development
27(11):1233-1246. 1 June 2013 (2013)
Details
DOI10.1101/gad.212381.112 PMID23723415 PMCID DivisionCell Biology, Protein & Nucleic Acid Chemistry - Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes AuthorsAmrute-Nayak M., Bullock S. L. Journal Nature Cell Biology 14(4):416-423. April 2012 (2012)
- Messengers, motors and mysteries: sorting of eukaryotic mRNAs by cytoskeletal transport AuthorsBullock S. L. Journal Biochemical Society Transactions 39(5):1161-1165. October 2011 (2011)
- Bicaudal-D regulates fragile X mental retardation protein levels, motility, and function during neuronal morphogenesis AuthorsBianco A., Dienstbier M., Salter H. K., Gatto G., Bullock S. L. Journal Current Biology 20(16):1487-1492. 24 August 2010 (2010)
- Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling AuthorsLi X., Kuromi, H., Briggs L., Green D. B., Rocha J. J., Sweeney S. T., Bullock S. L. Journal EMBO Journal 29(5):992-1006. 2 June 2010 (2010)
- A'-form RNA helices are required for cytoplasmic mRNA transport in Drosophila AuthorsBullock S. L., Ringel I., Ish-Horowicz D., Lukavsky P. J. Journal Nature Structural & Molecular Biology 17(6):703-709. June 2010 (2010)
- Subcellular mRNA localization in animal cells and why it matters AuthorsHolt C. E., Bullock S. L. Journal Science 326(5957):1212-1216. 27 November 2009 (2009)
- Translocation of mRNAs by molecular motors: think complex? AuthorsBullock S. L. Journal Seminars in Cell & Developmental Biology 18(2): 194-201. April 2007 (2007)