Published Research

Found 119 results for Bienz.

• VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing AuthorsSchulten A., Jang G.J., Payne-Dwyer A., Fielder M., Nielsen M.L., Mateo-Bonmatí E., Bienz M., Leake M.C., Dean C. Journal Molecular Cell 85(17):3321-3332.e5 (2025)
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  DOI10.1016/j.molcel.2025.08.002 PMID40858112 PMCID  DivisionStructural Studies
• Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor AuthorsGammons M.V., Franco-Echevarría E., Li T.M., Rutherford T.J., Renko M., Batters C., Bienz M. Journal Nature Communications 16(1):4718 (2025)
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  DOI10.1038/s41467-025-59984-9 PMID40399324 PMCIDPMC12095580 DivisionStructural Studies, Facilties (NMR and Biophysics), PNAC (Emeritus)
• Distinct accessory roles of Arabidopsis VEL proteins in Polycomb silencing AuthorsFranco-Echevarría E, Nielsen M, Schulten A, Cheema J, Morgan TE, Bienz M, Dean C. Journal Genes & Development 10.1101/gad.350814.123 (2023)
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  DOI10.1101/gad.350814.123 PMID37734835 PMCIDPMC7615239 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome AuthorsWang H., Bienz M., Yan X. X., Xu W. Journal Nature Communications 14(1):3702 (2023)
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  DOI10.1038/s41467-023-39439‑9 PMID37349336 PMCIDPMC10287724 DivisionProtein & Nucleic Acid Chemistry
• Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control AuthorsMarc Fiedler, Elsa Franco-Echevarrıa, Anna Schulten, Bilal Ahsan, Caroline Dean, Mariann Bienz Journal Cell reports 41(6): 111607 (2023)
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  DOI10.1016/j. Celrep.2022.111607 PMID36351412 PMCIDPMC7614096 DivisionProtein & Nucleic Acid Chemistry
• Plant vernalization proteins contain unusual PHD superdomains without histone H3 binding activity AuthorsFranco-Echevarría E., Rutherford T.J., Fiedler M., Dean C., Bienz M. Journal Journal of Biological Chemistry 298(11):102540 (2022)
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  DOI10.1016/j.jbc.2022.102540 PMID36174674 PMCIDPMC9640981 DivisionProtein & Nucleic Acid Chemistry
• Selective function of the PDZ domain of Dishevelled in noncanonical Wnt signalling AuthorsMieszczanek J., Strutt H., Rutherford T.J., Strutt D., Bienz M., Gammons M.V. Journal Journal of Cell Science 135(11):jcs259547 (2022)
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  DOI10.1242/jcs.259547 PMID35542970 PMCIDPMC9234668 DivisionProtein & Nucleic Acid Chemistry
• Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites AuthorsBeitia G. J., Rutherford T. J., Freund S. M. V., Pelham H. R., Bienz M., Gammons M. V. Journal Proceedings of the National Academy of Sciences of the United States of America 118(26). 29 June 2021 (2021)
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  DOI10.1073/pnas.2103258118 PMID34155117 PMCIDPMC8256032 DivisionStructural Studies, Cell Biology, Protein & Nucleic Acid Chemistry
• The deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1 AuthorsHarris L. D., Le Pen J., Scholz N., Mieszczanek J., Vaughan N., Davis S., Berridge G., Kessler B., Bienz M., Licchesi J. D. F. Journal Journal of Biological Chemistry 296:100246. January 2021 (2021)
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  DOI10.1074/jbc.ra120.015162 PMID33853758 PMCIDPMC7948964 DivisionProtein & Nucleic Acid Chemistry
• Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin AuthorsGammons M. V., Renko M., Flack J. E., Mieszczanek J., Bienz M. Journal Elife 9: e59879. 7 October 2020 (2020)
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  DOI10.7554/elife.59879 PMID33025907 PMCIDPMC7581431 DivisionProtein & Nucleic Acid Chemistry
• Head-to-Tail Polymerization in the Assembly of Biomolecular Condensates AuthorsBienz M. Journal Cell 182(4):799-811. 20 August 2020 (2020)
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  DOI10.1016/j. Cell.2020.07.037 PMID32822572 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas AuthorsKrishnan A., Berthelet J., Renaud E., Rosigkeit S., Distler U., Stawiski E., Wang J., Modrusan Z., Fiedler M., Bienz M., Tenzer S., Schad A., Roth W., Thiede B., Seshagiri S., Musholt T. J., Rajalingam K. Journal Nature Communications 11(1):2056. 28 April 2020 (2020)
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  DOI10.1038/s41467-020-15955‑w PMID32345963 PMCIDPMC7188865 DivisionProtein & Nucleic Acid Chemistry
• Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction AuthorsKan W., Enos M. D., Korkmazhan E., Muennich S., Chen D. H., Gammons M. V., Vasishtha M., Bienz M., Dunn A. R., Skiniotis G., Weis W. I. Journal Elife 9: e55015. 16 April 2020 (2020)
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  DOI10.7554/elife.55015 PMID32297861 PMCIDPMC7200158 DivisionProtein & Nucleic Acid Chemistry
• DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes Authorsvan Dop M., Fiedler M., Mutte S., de Keijzer J., Olijslager L., Albrecht C., Liao C. Y., Janson M. E., Bienz M., Weijers D. Journal Cell 180(3):427-439.e12. 6 February 2020 (2020)
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  DOI10.1016/j. Cell.2020.01.011 PMID32004461 PMCIDPMC7042713 DivisionProtein & Nucleic Acid Chemistry
• A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to β-catenin AuthorsYamanishi K., Fiedler M., Terawaki S. I., Higuchi Y., Bienz M., Shibata N. Journal Science Signaling 12(611). 10 December 2019 (2019)
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  DOI10.1126/scisignal. Aaw5505 PMID31822591 PMCIDPMC6923138 DivisionProtein & Nucleic Acid Chemistry
• Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome AuthorsRenko M., Fiedler M., Rutherford T. J., Schaefer J. V., Plückthun A., Bienz M. Journal Proceedings of the National Academy of Sciences of the United States of America 116(42):20977-20983. 15 October 2019 (2019)
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  DOI10.1073/pnas.1912705116 PMID31570581 PMCIDPMC6800368 DivisionProtein & Nucleic Acid Chemistry
• Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models AuthorsMieszczanek J., van Tienen L. M., Ibrahim A. E. K., Winton D. J., Bienz M. Journal Nature Communications 10(1):724. 13 February 2019 (2019)
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  DOI10.1038/s41467-018-08164‑z PMID30760710 PMCIDPMC6374407 DivisionProtein & Nucleic Acid Chemistry
• Multiprotein complexes governing Wnt signal transduction AuthorsGammons M., Bienz M. Journal Current Opinion in Cell Biology 51:42-49. April 2018 (2018)
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  DOI10.1016/j. Ceb.2017.10.008 PMID29153704 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5 AuthorsFlack J. E., Mieszczanek J., Novcic N., Bienz M. Journal Molecular Cell 67(2):181-193.e5. 20 July 2017 (2017)
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  DOI10.1016/j.molcel.2017.06.009 PMID28689657 PMCIDPMC5592244 DivisionProtein & Nucleic Acid Chemistry
• Histone modifications for chromatin dynamics and cellular plasticity AuthorsKutateladze T. G., Gozani O., Bienz M., Ostankovitch M. Journal Journal of Molecular Biology 429(13):1921-1923. 30 June 2017 (2017)
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  DOI10.1016/j.jmb.2017.06.001 PMID28623961 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Correction: Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9 Authorsvan Tienen L. M., Mieszczanek J., Fiedler M., Rutherford T. J., Bienz M. Journal ELife 6: e27150. 30 March 2017 (2017)
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  DOI10.7554/eLife.27150 PMID28358670 PMCIDPMC5373820 DivisionProtein & Nucleic Acid Chemistry
• Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9 Authorsvan Tienen L. M., Mieszczanek J., Fiedler M., Rutherford T. J., Bienz M. Journal ELife 6: e20882. 15 March 2017 (2017)
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  DOI10.7554/eLife.20882 PMID28296634 PMCIDPMC5352222 DivisionProtein & Nucleic Acid Chemistry
• Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay AuthorsGammons M. V., Rutherford T. J., Steinhart Z., Angers S., Bienz M. Journal Journal of Cell Science 129(20):3892-3902. 15 October 2016 (2016)
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  DOI10.1242/jcs.195685 PMID27744318 PMCIDPMC5087658 DivisionProtein & Nucleic Acid Chemistry
• Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled AuthorsGammons M. V., Renko M., Johnson C. M., Rutherford T. J., Bienz M. Journal Molecular Cell 64(1):92-104. 6 October 2016 (2016)
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  DOI10.1016/j.molcel.2016.08.026 PMID27692984 PMCIDPMC5065529 DivisionProtein & Nucleic Acid Chemistry
• Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled AuthorsMund T., Graeb M., Mieszczanek J., Gammons M., Pelham H. R., Bienz M. Journal Open Biology 5(12). 23 December 2015 (2015)
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  DOI10.1098/rsob.150185 PMID26701932 PMCIDPMC4703060 DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations AuthorsTeo A. E., Garg S., Shaikh L. H., Zhou J., Karet Frankl F. E., Gurnell M., Happerfield L., Marker A., Bienz M., Azizan E. A., Brown M. J. Journal The New England Journal of Medicine 373(15):1429-1436. 8 October 2015 (2015)
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  DOI10.1056/NEJMoa1504869ws PMID26397949 PMCIDPMC4612399 DivisionProtein & Nucleic Acid Chemistry
• An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB‑SSDP AuthorsFiedler M., Graeb M., Mieszczanek J., Rutherford T. J., Johnson C. M., Bienz M. Journal ELife 4.: e09073. 27 August 2015 (2015)
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  DOI10.7554/eLife.09073 PMID26312500 PMCIDPMC4571689 DivisionProtein & Nucleic Acid Chemistry
• Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization AuthorsMadrzak J., Fiedler M,. Johnson C. M., Ewan R., Knebel A., Bienz M., Chin J. W. Journal Nature Communications 6:6718. 24 April 2015 (2015)
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  DOI10.1038/ncomms7718 PMID25907794 PMCIDPMC4423210 DivisionProtein & Nucleic Acid Chemistry
• Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger AuthorsMiller T. C., Rutherford T. J., Birchall K., Chugh J., Fiedler M., Bienz M. Journal ACS Chemical Biology 9(12):2864-2874. 19 December 2014 (2014)
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  DOI10.1021/cb500585s PMID25323450 PMCIDPMC4330097 DivisionProtein & Nucleic Acid Chemistry
• Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists AuthorsSilva A. L., Dawson S. N., Arends M. J., Guttula K., Hall N., Cameron E. A., Huang T. H., Brenton J. D., Tavaré S., Bienz M., Ibrahim A. E. Journal BMC Cancer 14:891. 29 November 2014 (2014)
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  DOI10.1186/1471-2407-14‑891 PMID25432628 PMCIDPMC4265460 DivisionProtein & Nucleic Acid Chemistry
• Signalosome assembly by domains undergoing dynamic head-to-tail polymerization AuthorsBienz M. Journal Trends in Biochemical Sciences 39(10):487-495. October 2014 (2014)
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  DOI10.1016/j.tibs.2014.08.006 PMID25239056 PMCID  DivisionProtein & Nucleic Acid Chemistry
• LEF1 and B9L Shield β-Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors. Authorsde la Roche M., Ibrahim A. E,. Mieszczanek J., Bienz M. Journal Cancer Research 74(5):1495-1505. 1 March 2014 (2014)
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  DOI10.1158/0008-5472. CAN-13‑2682 PMID24419084 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2 AuthorsMiller T. C., Mieszczanek J., Sánchez-Barrena M. J., Rutherford T. J., Fiedler M., Bienz M. Journal Structure 21(12):2208-2220. 3 December 2013 (2013)
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  DOI10.1016/j.str.2013.09.013 PMID24183574 PMCIDPMC3851687 DivisionProtein & Nucleic Acid Chemistry
• Biochemistry. A lipid linchpin for Wnt-Fz docking AuthorsBienz M., He X. Journal Science 337(6090):44-45. 6 July 2012 (2012)
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  DOI10.1126/science.1224468 PMID22653728 PMCID  DivisionProtein & Nucleic Acid Chemistry
• An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid Authorsde la Roche M., Rutherford T. J., Gupta D., Veprintsev D. B., Saxty B., Freund S. M., Bienz M. Journal Nature Communications 3:680. 21 February 2012 (2012)
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  DOI10.1038/ncomms1680 PMID22353711 PMCIDPMC3293410 DivisionProtein & Nucleic Acid Chemistry
• An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains AuthorsLicchesi J. D., Mieszczanek J., Mevissen T. E., Rutherford T. J., Akutsu M., Virdee S., El Oualid F., Chin J. W., Ovaa H., Bienz M., Komander D. Journal Nature Structural & Molecular Biology 19(1):62-71. January 2012 (2012)
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  DOI10.1038/nsmb.2169 PMID22157957 PMCIDPMC5260945 DivisionProtein & Nucleic Acid Chemistry, Structural Studies
• Inhibition of GSK3 by Wnt signalling--two contrasting models AuthorsMetcalfe C., Bienz M. Journal Journal of Cell Science 124(Pt 21):3537-3544. 1 November 2011 (2011)
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  DOI10.1242/jcs.091991 PMID22083140 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled AuthorsMendoza-Topaz C., Mieszczanek J., Bienz M. Journal Open Biology 1(3):110013. November 2011 (2011)
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  DOI10.1098/rsob.110013 PMID22645652 PMCIDPMC3352083 DivisionProtein & Nucleic Acid Chemistry
• Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin AuthorsFiedler M., Mendoza-Topaz C., Rutherford T. J., Mieszczanek J., Bienz M. Journal Proceedings of the National Academy of Sciences, USA 108(5):1937-1942. 1 February 2011 (2011)
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  DOI10.1073/pnas.1017063108 PMID21245303 PMCIDPMC3033301 DivisionProtein & Nucleic Acid Chemistry
• Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co‑factor AuthorsMiller T. C., Rutherford T. J., Johnson C. M., Fiedler M., Bienz M. Journal Journal of Molecular Biology 401(5):969-984. 3 September 2010 (2010)
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  DOI10.1016/j.jmb.2010.07.007 PMID20637214 PMCIDPMC2927781 DivisionProtein & Nucleic Acid Chemistry
• Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer AuthorsMetcalfe C., Ibrahim A. E., Graeb M., de la Roche M., Schwarz-Romond T., Fiedler M., Winton D. J., Corfield A., Bienz M. Journal Cancer Research 70(16):6629-6638. 15 August 2010 (2010)
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  DOI10.1158/0008-5472. CAN-10‑1616 PMID20663899 PMCIDPMC2923074 DivisionProtein & Nucleic Acid Chemistry
• Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization AuthorsMetcalfe C., Mendoza-Topaz C., Mieszczanek J., Bienz M. Journal Journal of Cell Science 123(9):1588-1599. 1 May 2010 (2010)
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  DOI10.1242/jcs.067546 PMID20388731 PMCIDPMC2858023 DivisionProtein & Nucleic Acid Chemistry
• Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains AuthorsTran, H., Hamada, F., Schwarz-Romond, T., Bienz, M. Journal Genes & Development 22(4):528-542 (2008)
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  DOIdoi.org/10.1101/gad.463208 PMID18281465 PMCIDPMC2238673 Division 
• The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells AuthorsMarc de la Roche, Jesper Worm, Mariann Bienz Journal BMC Cancer 8: 199 (2008)
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  DOI  PMID18627596 PMCIDPMC2478683 Division 
• Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex AuthorsMarc Fiedler, María José Sánchez-Barrena, Maxim Nekrasov, Juliusz Mieszczanek, Vladimir Rybin, Jürg Müller, Phil Evans, Mariann Bienz Journal Molecular Cell 30 (4): 507-18. (2008)
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  DOI  PMID18498752 PMCIDPMC2726290 Division 
• A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription AuthorsJuliusz Mieszczanek, Marc de la Roche, Mariann Bienz Journal Proceedings of the National Academy of Sciences, USA 105(49): 19324-9 (2008) (2008)
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  DOI  PMID19036929 PMCIDPMC2614760 Division 
• Dynamic recruitment of axin by Dishevelled protein assemblies AuthorsSchwarz-Romond, T., Metcalfe, C., Bienz, M. Journal Journal of Cell Science 120(Pt 14):2402-2412 (2007)
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  DOIdoi.org/10.1242/jcs.002956 PMID17606995 PMCID  Division 
• Wnt induces LRP6 signalosomes and promotes Dishevelled-dependent LRP6 phosphorylation AuthorsBilic, J., Huang, Y.L., Davidson, G., Zimmerman, T., Cruciat, C.M., Bienz, M., Niehrs, C. Journal Science 316(5831):1619-1622 (2007)
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  DOIdoi.org/10.1126/science.1137065 PMID17569865 PMCID  Division 
• Wingless-independent association of Pygopus with dTCF target genes Authorsde la Roche, M., Bienz, M. Journal Current Biology : CB 17(6):556-561 (2007)
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  DOIdoi.org/10.1016/j.cub.2007.01.063 PMID17320388 PMCID  Division 
• The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization AuthorsThomas Schwarz-Romond, Marc Fiedler, Naoki Shibata, P. Jonathan G Butler, Akira Kikuchi, Yoshiki Higuchi, Mariann Bienz Journal Nature Structural Biology 14(6): 484-492 (2007) (2007)
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  DOI  PMID  PMCID  Division 
• The PHD finger, a nuclear protein-interaction domain AuthorsBienz M. Journal Trends in Biochemical Sciences 31(1):35-40. January 2006 (2006 )
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  DOI10.1016/j.tibs.2005.11.001 PMID16297627 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The Wnt signalling effector dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles AuthorsSchwarz-Romond, T., Merrifield, C., Nichols, B.J., Bienz, M. Journal Journal of Cell Science 118(Pt 22):5269-5277 (2005)
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  DOIdoi.org/10.1242/jcs.02646 PMID16263762 PMCID  Division 
• Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development AuthorsHanson, K.K., Kelley, A.C., Bienz, M. Journal Development (Cambridge, England) 132(21):4777-4787 (2005)
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  DOIdoi.org/10.1242/dev.02057 PMID16224046 PMCID  Division 
• Bre1 is required for notch signaling and histone modification AuthorsBray, S., Musisi, H., Bienz, M. Journal Developmental Cell 8(2):279-286 (2005)
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  DOIdoi.org/10.1016/j.devcel.2004.11.020 PMID15691768 PMCID  Division 
• Beta-catenin : a pivot between cell adhesion and Wnt signalling AuthorsMariann Bienz Journal Current Biology 15 : R64-R67 (2005 )
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• Beta-catenin: a pivot between cell adhesion and Wnt signalling AuthorsMariann Bienz Journal Current Biology 15: R64-R67 (2005) (2005)
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• The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF AuthorsFumihiko Hamada, Mariann Bienz Journal Developmental Cell 7(5):677-685 (2004) (2004)
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  DOI10.1016/j. devcel.2004.08.022 PMID15525529 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Adenomatous polyposis coli proteins and cell adhesion AuthorsMariann Bienz, Fumihiko Hamada Journal Current Opinion in Cell Biology 16(5):528-535 (2004) (2004)
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  DOI10.1016/j. Ceb.2004.08.001 PMID15363803 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Intracellular shuttling of a Drosophila APC tumour suppressor homolog AuthorsAdam Cliffe, Julius Mieszczanek, Mariann Bienz Journal BMC Cell Biology 5: 37 (pp.1-12) (2004) (2004)
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  DOI10.1186/1471-2121-5‑37 PMID15458577 PMCIDPMC522808 DivisionProtein & Nucleic Acid Chemistry
• Pygopus and legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function AuthorsTownsley, F.M., Cliffe, A., Bienz, M. Journal Nature Cell Biology 6(7):626-633 (2004)
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  DOIdoi.org/10.1038/ncb1141 PMID15208637 PMCID  Division 
• Pygopus residues required for its binding to legless are critical for transcription and development AuthorsTownsley, F.M., Thompson, B., Bienz, M. Journal The Journal of Biological Chemistry 279(7):5177-5183 (2004)
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  DOIdoi.org/10.1074/jbc.m309722200 PMID14612447 PMCID  Division 
• Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription AuthorsRosin-Arbesfeld, R., Cliffe, A., Brabletz, T., Bienz, M. Journal EMBO Journal 22(5):1101-1113. 1 March 2003 (2003)
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  DOI10.1093/emboj/cdg105 PMID12606575 PMCIDPMC150338 DivisionCell Biology
• The transcriptional repressor Brinker antagonizes Wingless signaling AuthorsSaller E., Kelley A., Bienz M. Journal Genes & Development 16(14):1828-1838 (2002) (2002)
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  DOI10.1101/gad.230002 PMID12130542 PMCIDPMC186385 DivisionProtein & Nucleic Acid Chemistry
• The subcellular destinations of APC proteins AuthorsBienz M. Journal Nature Reviews Molecular Cell Biology 3(5):328-338. May 2002 (2002)
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  DOI10.1038/nrm806 PMID11988767 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A new nuclear component of the Wnt signalling pathway AuthorsThompson B., Townsley F., Rosin-Arbesfeld R., Musisi H., Bienz M. Journal Nature Cell Biology 4(5):367-373. May 2002 (2002)
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  DOI10.1038/ncb786 PMID11988739 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A Drosophila APC tumour suppressor homologue functions in cellular adhesion AuthorsHamada F., Bienz M. Journal Nature Cell Biology 4(3):208-213. March 2002 (2002)
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  DOI10.1038/ncb755 PMID11862214 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells AuthorsRosin-Arbesfeld R., Ihrke G., Bienz M. Journal EMBO Journal 20(21):5929-39 (2001) (2001)
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  DOI10.1093/emboj/20.21.5929 PMID11689433 PMCIDPMC125686 DivisionProtein & Nucleic Acid Chemistry
• The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation AuthorsBarker N., Hurlstone A., Musisi H., Miles A., Bienz M., Clevers H. Journal EMBO Journal 20(17):4935-4943 (2001) (2001)
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  DOI10.1093/emboj/20.17.4935 PMID11532957 PMCIDPMC125268 DivisionProtein & Nucleic Acid Chemistry
• Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription AuthorsSaller E., Bienz M. Journal EMBO Reports 2(4):298-305 (2001) (2001)
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  DOI10.1093/embo-reports/kve068 PMID11306550 PMCIDPMC1083865 DivisionProtein & Nucleic Acid Chemistry
• EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye AuthorsFreeman, M., Bienz, M. Journal EMBO Reports 2(2):157-162. 15 February 2001 (2001)
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  DOI10.1093/embo-reports/kve019 PMID11258709 PMCIDPMC1083815 DivisionCell Biology
• Spindles cotton on to junctions, APC and EB1 AuthorsMariann Bienz Journal Nature Cell Biology 3: E67-E69 (2001) (2001)
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• Teashirt is required for transcriptional repression mediated by high wingless levels AuthorsLucas Waltzer, Laurence Vandel, Mariann Bienz Journal EMBO Journal 20: 137-145 (2001) (2001)
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• An autoregulatory function of Dfos during Drosophila endoderm induction AuthorsSzüts, D., Bienz, M. Journal Mechanisms of Development 98(1-2):71-76 (2000)
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  DOIdoi.org/10.1016/s0925-4773(00)00455-x PMID11044608 PMCID  Division 
• Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo AuthorsTownsley, F.M., Bienz, M. Journal Current Biology 10(21):1339-1348 (2000)
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  DOIdoi.org/10.1016/s0960-9822(00)00770-3 PMID11084333 PMCID  Division 
• Linking colorectal cancer to Wnt signaling AuthorsBienz, M., Clevers, H. Journal Cell 103(2):311-320 (2000)
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  DOIdoi.org/10.1016/s0092-8674(00)00122‑7 PMID11057903 PMCID  Division 
• The APC tumour suppressor has a nuclear export function AuthorsRosin-Arbesfeld, R., Townsley, F., Bienz, M. Journal Nature 406(6799):1009-1012 (2000)
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  DOIdoi.org/10.1038/35023016 PMID10984057 PMCID  Division 
• LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator AuthorsSzuts D., Bienz M. Journal Proceedings of the National Academy of Sciences, USA 97(10):5351-5356 (2000) (2000)
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  DOI10.1073/pnas.97.10.5351 PMID10805795 PMCIDPMC25832 DivisionProtein & Nucleic Acid Chemistry
• APC: the plot thickens AuthorsBienz M. Journal Current Opinion in Genetics & Development 9(5):595-603 (1999 ) (1999)
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  DOI10.1016/s0959-437x(99)00016-7 PMID10508699 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A new Drosophila APC homologue associated with adhesive zones of epithelial cells AuthorsYu X., Waltzer L., Bienz M. Journal Nature Cell Biology 1(3):144-151 (1999) (1999)
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  DOI10.1038/11064 PMID10559900 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps AuthorsYu X., Bienz M. Journal Mechanisms of Development 84(1-2):69-73 (1999 ) (1999)
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  DOI10.1016/s0925-4773(99)00072‑6 PMID10473121 PMCID  DivisionProtein & Nucleic Acid Chemistry
• The control of beta-catenin and TCF during embryonic development and cancer AuthorsWaltzer L., Bienz M. Journal Cancer and Metastasis Reviews 18(2):231-246 (1999) (1999)
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  DOI10.1023/a:1006321324190 PMID10728986 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A function of CBP as a transcriptional co-activator during Dpp signalling AuthorsWaltzer L., Bienz M. Journal EMBO Journal 18(6):1630-1641 (1999) (1999)
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  DOI10.1093/emboj/18.6.1630 PMID10075933 PMCIDPMC1171250 DivisionProtein & Nucleic Acid Chemistry
• dMi-2, a Hunchback-interacting protein that functions in Polycomb repression AuthorsKehle J., Beuchle D., Treuheit S., Christen B., Kennison J. A., Bienz M., Muller J. Journal Science 282(5395):1897-1900. 4 December 1998 (1998)
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  DOI10.1126/science.282.5395.1897 PMID9836641 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Transcriptional repression due to high levels of wingless signalling AuthorsYu X., Riese J., Eresh S., Bienz M. Journal EMBO Journal 17(23):7021-7032. December 1998 (1998)
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  DOI10.1093/emboj/17.23.7021 PMID9835654 PMCIDPMC1171050 DivisionProtein & Nucleic Acid Chemistry
• Drosophila CBP represses the transcription factor TCF to antagonize wingless signalling AuthorsWaltzer L., Bienz M. Journal Nature 395(6701):521-525 (1998)
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  DOI10.1038/26785 PMID9774110 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction AuthorsDavid Szuts, Salih Eresh, Mariann Bienz Journal Genes & Development 12(13):2022-2035. 1 July 1998 (1998)
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  DOI10.1101/gad.12.13.2022 PMID9649506 PMCIDPMC316971 Division 
• TCF: transcriptional activator or repressor? AuthorsBienz M. Journal Current Opinion in Cell Biology 10(3):366-372 (1998) (1998)
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  DOI10.1016/s0955-0674(98)80013‑6 PMID9640538 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Endoderm induction in Drosophila: the nuclear targets of the inducing signals AuthorsBienz, M. Journal Current Opinion in Genetics & Development 7(5):683-688 (1997)
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  DOIdoi.org/10.1016/s0959-437x(97)80017‑2 PMID9388786 PMCID  Division 
• D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction AuthorsJens Riese, Gabi Tremml, Mariann Bienz Journal Development 124(17):3353-3361. 1 September 1997 (1997)
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• Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila AuthorsSzuts D., Freeman M., Bienz M. Journal Development (Cambridge, England) 124(16):3209-3219 (1997)
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  DOI  PMID9272961 PMCID  DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction AuthorsSalih Eresh, Jens Riese, David B. Jackson, Dirk Bohmann, Mariann Bienz Journal EMBO Journal 16(8):2014-2022. 15 April 1997 (1997)
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  DOI10.1093/emboj/16.8.2014 PMID9155027 PMCIDPMC1169804 Division 
• LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic AuthorsJens Riese, Xiang Yu, Audrey Munnerlyn, Salih Eresh, Shu-Chi Hsu, Rudolf Grosschedl, Mariann Bienz Journal Cell 88(6):777-787 (1997) (1997)
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  DOI10.1016/S0092-8674(00)81924‑8 PMID9118221 PMCID  DivisionProtein & Nucleic Acid Chemistry
• A test for cell autonomy, based on di-cistronic messenger translation AuthorsHart, K., Bienz, M. Journal Development (Cambridge, England) 122(3):747-751 (1996)
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  DOIdoi.org/10.1242/dev.122.3.747 PMID8631252 PMCID  Division 
• decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut AuthorsYu, X., Hoppler, S., Eresh, S., Bienz, M. Journal Development (Cambridge, England) 122(3):849-858 (1996)
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  DOIdoi.org/10.1242/dev.122.3.849 PMID8631263 PMCID  Division 
• Induction of the endoderm in Drosophila AuthorsBienz, M. Journal Seminars in Cell & Developmental Biology 7: 113-119 (1996) (1996)
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• Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut AuthorsHoppler, S., Bienz, M. Journal The EMBO Journal 14(20):5016-5026 (1995)
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  DOIdoi.org/10.1002/j.1460-2075.1995.tb00184.x PMID7588630 PMCIDPMC394605 Division 
• Transcriptional silencing of homeotic genes in Drosophila AuthorsBienz, M., Müller, J. Journal Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 17(9):775-784 (1995)
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  DOIdoi.org/10.1002/bies.950170907 PMID8763830 PMCID  Division 
• Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx AuthorsPöpperl, H., Bienz, M., Studer, M., Chan, S.K., Aparicio, S., Brenner, S., Mann, R.S., Krumlauf, R. Journal Cell 81(7):1031-1042 (1995)
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  DOIdoi.org/10.1016/s0092-8674(05)80008-x PMID7600572 PMCID  Division 
• Specification of a single cell type by a Drosophila homeotic gene AuthorsHoppler S., Bienz M. Journal Cell 76(4):689-702. 25 February 1994 (1994)
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  DOI10.1016/0092-8674(94)90508-8 PMID7907275 PMCID  DivisionProtein & Nucleic Acid Chemistry
• Homeotic genes and positional signalling in the Drosophila viscera AuthorsBienz, M. Journal Trends in Genetics : TIG 10(1):22-26 (1994)
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  DOIdoi.org/10.1016/0168-9525(94)90015-9 PMID7908470 PMCID  Division 
• Dissection of an indirect autoregulatory response of a homeotic Drosophila gene AuthorsThüringer, F., Cohen, S.M., Bienz, M. Journal The EMBO Journal 12(6):2419-2430 (1993)
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  DOIdoi.org/10.1002/j.1460-2075.1993.tb05896.x PMID8099546 PMCIDPMC413477 Division 
• Indirect autoregulation of a homeotic Drosophila gene mediated by extracellular signaling AuthorsThüringer, F., Bienz, M. Journal Proceedings of the National Academy of Sciences of the United States of America 90(9):3899-3903 (1993)
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  DOIdoi.org/10.1073/pnas.90.9.3899 PMID8097881 PMCIDPMC46413 Division 
• Silencers in abdominal-B, a homeotic Drosophila gene AuthorsBusturia, A., Bienz, M. Journal The EMBO Journal 12(4):1415-1425 (1993)
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  DOIdoi.org/10.1002/j.1460-2075.1993.tb05785.x PMID8096812 PMCIDPMC413353 Division 
• Molecular mechanisms of determination in Drosophila AuthorsBienz, M. Journal Current Opinion in Cell Biology 4(6):955-961 (1992)
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  DOIdoi.org/10.1016/0955-0674(92)90124-u PMID1485964 PMCID  Division 
• Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein AuthorsMüller, J., Bienz, M. Journal EMBO Journal 11(10):3653-3661 (1992)
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  DOIdoi.org/10.1002/j.1460-2075.1992.tb05450.x PMID1356761 PMCIDPMC556825 Division 
• Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation AuthorsTremml, G., Bienz, M. Journal Development (Cambridge, England) 116(2):447-456 (1992)
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  DOIdoi.org/10.1242/dev.116.2.447 PMID1363088 PMCID  Division 
• Induction across germ layers in Drosophila mediated by a genetic cascade AuthorsImmerglück, K., Lawrence, P.A., Bienz, M. Journal Cell 62(2):261-268 (1990)
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  DOIdoi.org/10.1016/0092-8674(90)90364-k PMID1973634 PMCID  Division 
• Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein AuthorsMauro DeLorenzi, Nazeem Ali, Gena Saari, Charles Henry, Michael Wilcox, Mariann Bienz Journal EMBO Journal 7(10):3223-3231 (1988)
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  DOIdoi.org/10.1002/j.1460-2075.1988.tb03189.x PMID2903049 PMCIDPMC454722 Division 
• Differential regulation of Ultrabithorax in two germ layers of Drosophila AuthorsBienz, M., Saari, G., Tremml, G., Müller, J., Züst, B., Lawrence, P.A. Journal Cell 53(4):567-576 (1988)
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  DOIdoi.org/10.1016/0092-8674(88)90573-9 PMID2897241 PMCID  Division 
• A CCAAT box confers cell-type-specific regulation on the Xenopus hsp70 gene in oocytes AuthorsBienz, M. Journal Cell 46(7):1037-1042 (1986)
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  DOIdoi.org/10.1016/0092-8674(86)90703-8 PMID3757032 PMCID  Division 
• Heat shock regulatory elements function as an inducible enhancer in the Xenopus hsp70 gene and when linked to a heterologous promoter AuthorsBienz M., Pelham H. R. B. Journal Cell 45(5):753-760. 6 June 1986 (1986)
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  DOI10.1016/0092-8674(86)90789‑0 PMID3085957 PMCID  DivisionProtein & Nucleic Acid Chemistry, Cell Biology
• Transient and developmental activation of heat-shock genes AuthorsBienz, M. Journal Trends in Biochemical Sciences 10: 157-161 (1985) (1985)
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• Developmental control of the heat shock response in Xenopus AuthorsBienz M. Journal Proceedings of the National Academy of Sciences, USA 81(10):3138-3142 (1984) (1984)
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  DOI10.1073/pnas.81.10.3138 PMID6203112 PMCIDPMC345236 DivisionProtein & Nucleic Acid Chemistry
• Xenopus hsp 70 genes are constitutively expressed in injected oocytes AuthorsMariann Bienz Journal EMBO Journal 3: 2477-2483 (1984) (1984)
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• A human tRNAGlu gene of high transcriptional activity AuthorsGoddard, J.P., Squire, M., Bienz, M., Smith, J.D. Journal Nucleic Acids Research 11(9):2551-2562 (1983)
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  DOIdoi.org/10.1093/nar/11.9.2551 PMID6134271 PMCIDPMC325907 Division 
• The heat-shock response in Xenopus oocytes is controlled at the translational level AuthorsBienz, M., Gurdon, J.B. Journal Cell 29(3):811-9 (1982)
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  DOI10.1016/0092-8674(82)90443-3 PMID6891290 PMCID  Division 
• Expression of a Drosophila heat-shock protein in Xenopus oocytes: conserved and divergent regulatory signals AuthorsBienz, M., Pelham, H.R. Journal The EMBO Journal 1(12):1583-1588 (1982)
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  DOIdoi.org/10.1002/j.1460-2075.1982.tb01359.x PMID6821336 PMCIDPMC553255 Division 
• A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene AuthorsPelham, H.R., Bienz, M. Journal The EMBO Journal 1(11):1473-1477 (1982)
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  DOIdoi.org/10.1002/j.1460-2075.1982.tb01340.x PMID6327271 PMCIDPMC553234 Division 
• DNA sequences required for transcriptional regulation of the Drosophila hsp70 heat-shock gene in monkey cells and Xenopus oocytes AuthorsHugh Pelham, Mariann Bienz Journal Heat Shock from Bacteria to Man. Edited by M. J. Schlesinger, M. Ashburner, A. Tissieres pp.43-48 (1982) (1982)
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