Published Research
Found 50 results for Bharat.
- Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes AuthorsIsbilir B., Bharat T. A., Alva V. Journal Current Opinion in Microbiology 94:102839 (2026)
- Eukaryotic-like microtubules and dynamic instability of Asgard archaeal tubulins AuthorsLöwe J., von Kügelgen A., Planelles-Herrero V. J., McAndrew M. B. L., Oliva M. A., Vosseberg J., Köstlbacher S., Dharamshi J. E., Appler K. E., MacLeod F. I., Nobs S. J., Jørgensen S. L., Burns B. P., Baker B. J., Bharat T. A. M., Derivery E., Tamarit D., Ettema T. J. G. Journal Science Advances 12(30):eaeh1082 (2026)
- Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms AuthorsTarafder A. K., Graham M., Davis L. K., Pratt S., Böhning J., Manivannan P., Wang Z., Clemente C. M., Weimann A., Floto R. A., Owens R. J., O'Toole G. A., Pearce P., Bharat T. A. M. Journal Plos Biology 24(6):e3003834 (2026)
- Subcellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging AuthorsOchner H., Isbilir B., Blasche S., Scheidweiler D., Zhang Y., Wang Z., Smith T., Franco C., Bradley R., Patil K. R., Bharat T. A. M. Journal Nature Methods 23(6):1174-1183 (2026)
- Applications and prospects of cryo-electron tomography in drug discovery and understanding disease AuthorsClemente C. M., Mobarec J. C., Bharat T. A. M. Journal Current Opinion in Structural Biology 98:103283 (2026)
- Interaction of Pf4 tactoids with bacteria and synthetic colloidal rods AuthorsSilva M. O., Grobas I., Tarafder A. K., Bharat T. A. M., Aarts D. G. A. L. Journal European Biophysics Journal : EBJ (2026)
- Assembly, architecture and functional roles of microbial surface layers AuthorsBuse Isbilir, Andriko von Kügelgen, Vikram Alva, Tanmay A. M. Bharat Journal Nature reviews. Microbiology (2025)
- Assembly, architecture and functional roles of microbial surface layers AuthorsIsbilir B., von Kügelgen A., Alva V., Bharat T. A. M. Journal Nature reviews. Microbiology 24(5):344-358 (2026)
- Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance AuthorsFountain A.J., Böhning J., McLaughlin S.H., Morgan T.E., Edelstein P.H., Troll M., Lamers M.H., Bharat T.A.M., Luisi B.F., Ramakrishnan L. Journal Proceedings of the National Academy of Sciences of the United States of America 122(39):e2516660122 (2025)
- Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAΦ AuthorsBöhning J., Graham M., Coureuil M., Tarafder A.K., Meyer J., Nassif X., Bille E., Bharat T.A.M. Journal Proceedings of the National Academy of Sciences of the United States of America 122(25):e2420157122 (2025)
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A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon
AuthorsFoo S., Caspy I., Cezanne A., Bharat T.A.M., Baum B.
Journal
Proceedings of the National Academy of Sciences of the United States of America
122(25):e2501044122 (2025)
Details
DOI10.1073/pnas.2501044122 PMID40531877 PMCIDPMC12207459 DivisionCell Biology, Structural Studies -
Mapping the ultrastructural topology of the corynebacterial cell surface
AuthorsIsbilir B., Yeates A., Alva V., Bharat T.A.M.
Journal
PloS Biology
23(4):e3003130 (2025)
Details
DOIdoi.org/10.1371/journal.pbio.3003130 PMID40233127 PMCIDPMC12021427 DivisionStructural Studies, Facilities (Electron Microscopy) - Tissue-like multicellular development triggered by mechanical compression in archaea AuthorsRados T., Leland O.S., Escudeiro P., Mallon J., Andre K., Caspy I., von Kügelgen A., Stolovicki E., Nguyen S., Lucía Patop I., Thiberio Rangel L., Kadener S., Renner L.D., Thiel V., Soen Y., Bharat T.A.M., Alva V., Bisson A. Journal Science 388(6742):109-115 (2025)
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Structural biology inside multicellular specimens using electron cryotomography
AuthorsCaspy I., Wang Z., Bharat T. A. M.
Journal
Quarterly Reviews of Biophysics
58:e6 (2025)
Details
DOIdoi.org/10.1017/s0033583525000010 PMID39801355 PMCIDPMC7617309 DivisionStructural Studies - Cryoelectron microscopy with elemental sensitivity AuthorsOchner H., Bharat T. A. M. Journal Structure (London, England : 1993) 33(1):13-14 (2025)
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Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
AuthorsOchner H., Böhning J., Wang Z., Tarafder A. K., Caspy I., Bharat T. A. M.
Journal
Plos Pathogens
20(12):e1012773 (2024)
Details
DOIdoi.org/10.1371/journal.ppat.1012773 PMID39666767 PMCIDPMC11670995 DivisionStructural Studies - Architectural dissection of adhesive bacterial cell surface appendages from a "molecular machines" viewpoint AuthorsSmith O. E. R., Bharat T. A. M. Journal Journal of Bacteriology 206(12):e0029024 (2024)
- Serial lift-out for in situ structural biology of multicellular specimens AuthorsWang Z., Bharat T. A. M. Journal Nature Methods 21(9):1587-1588 (2024)
- An image processing pipeline for electron cryo-tomography in RELION-5 AuthorsBurt A, Toader B, Warshamanage R, von Kügelgen A, Pyle E, Zivanov J, Kimanius D, Bharat TAM, Scheres SHW. Journal FEBS Open bio 14(11):1788-1804 (2024)
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The parasitic lifestyle of an archaeal symbiont
AuthorsHamm JN, Liao Y, von Kügelgen A, Dombrowski N, Landers E, Brownlee C, Johansson EMV, Whan RM, Baker MAB, Baum B, Bharat TAM, Duggin IG, Spang A, Cavicchioli R.
Journal
Nature Communications
15(1):6449 (2024)
Details
DOI10.1038/s41467-024-49962‑y PMID39085207 PMCIDPMC11291902 DivisionStructural Studies, Cell Biology -
Membraneless channels sieve cations in ammonia-oxidizing marine archaea
Authorsvon Kügelgen A, Cassidy CK, van Dorst S, Pagani LL, Batters C, Ford Z, Löwe J, Alva V, Stansfeld PJ, Bharat TAM.
Journal
Nature
630(8015):230-236 (2024)
Details
DOI10.1038/s41586-024-07462‑5 PMID38811725 PMCIDPMC11153153 DivisionProtein & Nucleic Acid Chemistry - Cell cycle dependent coordination of surface layer biogenesis in Caulobacter crescentus AuthorsHerdman M, Isbilir B, von Kügelgen A, Schulze U, Wainman A, Bharat TAM. Journal Nature Communications 15(1):3355 (2024)
- Cryo-EM of soft-landed β-galactosidase: Gas-phase and native structures are remarkably similar AuthorsEsser T. K., Böhning J., Önür A., Chinthapalli D. K., Eriksson L., Grabarics M., Fremdling P., Konijnenberg A., Makarov A., Botman A. Peter C., Benesch J. L. P., Robinson C. V., Gault J., Baker L., Bharat T. A. M., Rauschenbach S. Journal Science Advances 10(7):eadl4628 (2024)
- The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms AuthorsBöhning J., Tarafder A. K., Bharat T. A. M. Journal The Biochemical Journal 481(4):245-263 (2024)
- Charting the molecular landscape of the cell AuthorsOchner H., Bharat T. A. M. Journal Structure 31(11):1297-1305 (2023)
- Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa AuthorsBöhning J., Dobbelstein A. W., Sulkowski N., Eilers K., von Kügelgen A., Tarafder A. K., Peak-Chew S. Y, Skehel M., Alva V., Filloux A., Bharat T. A. M. Journal Plos Pathogens, 19(4):e1011177 (2023)
- Interdigitated immunoglobulin arrays form the hyperstable surface layer of the extremophilic bacterium Deinococcus radiodurans Authorsvon Kügelgen A., van Dorst S., Yamashita K., Sexton D. L, Tocheva E. I., Murshudov G., Alva V., Bharat T. A. M. Journal Proceedings of the National Academy of Sciences of the United States of America 120(16):e2215808120 (2023)
- Seeing the wood for the trees AuthorsSmith O.E.R., Bharat T.A.M. Journal Nature Methods 20(2):183-184 (2023)
- A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0 AuthorsZivanov J, Otón J, Ke Z, von Kügelgen A, Pyle E, Qu K, Morado D, Castaño-Díez D, Zanetti G, Bharat TAM, Briggs JAG, Scheres SHW. Journal Elife Dec 5;11:e83724 (2022)
- Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms AuthorsBöhning J, Ghrayeb M, Pedebos C, Abbas DK, Khalid S, Chai L, Bharat TAM. Journal Nature Communications Nov 18;13(1):7082 (2022)
- Cryo-EM samples of gas-phase purified protein assemblies using native electrospray ion-beam deposition AuthorsEsser T.K., Böhning J., Fremdling P., Bharat T., Gault J., Rauschenbach S. Journal Faraday Discussions 240(0):67-80 (2022)
- A multidomain connector links the outer membrane and cell wall in phylogenetically deep-branching bacteria Authorsvon Kügelgen A, van Dorst S, Alva V, Bharat TAM. Journal Proceedings of the National Academy of Sciences of the United States of America Aug 16;119(33):e2203156119 (2022)
- The importance of biofilm formation for cultivation of a Micrarchaeon and its interactions with its Thermoplasmatales host AuthorsKrause S., Gfrerer S., von Kügelgen A., Reuse C., Dombrowski N., Villanueva L., Bunk B., Spröer C., Neu T. R., Kuhlicke U., Schmidt-Hohagen K., Hiller K., Bharat T. A. M., Rachel R., Spang A., Gescher J. Journal Nature Communications 13(1):1735 (2022)
- High-resolution mapping of metal ions reveals principles of surface layer assembly in Caulobacter crescentus cells AuthorsHerdman M., von Kügelgen A., Kureisaite-Ciziene D., Duman R., El Omari K., Garman E. F., Kjaer A., Kolokouris D., Löwe J., Wagner A., Stansfeld P. J., Bharat T. A. M. Journal Structure 30(2):215-228.e5 (2022)
- Architecture of cell-cell junctions in situ reveals a mechanism for bacterial biofilm inhibition AuthorsMelia C. E., Bolla J. R., Katharios-Lanwermeyer S., Mihaylov D. B., Hoffmann P. C., Huo J., Wozny M. R., Elfari L. M., Böhning J., Morgan A. N., Hitchman C. J., Owens R. J., Robinson C. V., O'Toole G. A., Bharat T. A. M. Journal Proceedings of the National Academy of Sciences of the United States of America 118(31):e2109940118 (2021)
- Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction AuthorsDjeghloul D., Patel B., Kramer H., Dimond A., Whilding C., Brown K., Kohler A. C., Feytout A., Veland N., Elliott J., Bharat T. A. M., Tarafder A. K., Löwe J., Ng B. L., Guo Y., Guy J., Huseyin M. K., Klose R. J., Merkenschlager M., Fisher A. G. Journal Nature Communications 11(1):4118. 17 August 2020 (2020)
- InSitu Structure of an Intact Lipopolysaccharide-Bound Bacterial Surface Layer Authorsvon Kügelgen A., Tang H., , Hardy G. G., Kureisaite-Ciziene D., Brun Y. V., Stansfeld P. J., Robinson C. V., Bharat T. A. M. Journal Cell 180(2):348-358.e15. 23 January 2020 (2020)
- Tricalbins Contribute to Cellular Lipid Flux and Form Curved ER-PM Contacts that Are Bridged by Rod-Shaped Structures AuthorsHoffmann P. C., Bharat T. A. M., Wozny M. R., Boulanger J., Miller E. A., Kukulski W. Journal Developmental Cell 51(4):488-502.e8 (2019)
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Cryo-correlative light and electron microscopy: towards in situ structural biology
AuthorsBharat T. A., Kukulski W.
Journal
Correlative Imaging Focusing on the Future
pp 137-147 (2019)
Details
DOI PMID PMCID DivisionCell Biology -
Correlative microscopy of vitreous sections provides insights into BAR-domain organization In situ
AuthorsBharat T. A. M., Hoffmann P. C., Kukulski W.
Journal
Structure
26(6):879-886.e3. 5 June 2018 (2018)
Details
DOI10.1016/j.str.2018.03.015 PMID29681471 PMCIDPMC5992340 DivisionCell Biology, Structural Studies - Cryo-tomography tilt-series alignment with consideration of the beam-induced sample motion AuthorsFernandez J. J., Li S., Bharat T. A. M., Agard D. A. Journal Journal of Structural Biology 202(3):200-209. June 2018 (2018)
- Four-stranded mini microtubules formed by Prosthecobacter BtubAB show dynamic instability AuthorsDeng X., Fink G., Bharat T. A. M., He S., Kureisaite-Ciziene D., Löwe J. Journal Proceedings of the National Academy of Sciences of the United States of America 114(29):E5950-E5958. 18 July 2017 (2017)
- Structure of the hexagonal surface layer on Caulobacter crescentus cells AuthorsBharat T. A. M,, Kureisaite-Ciziene D., Hardy G. G., Yu E. W., Devant J. M., Hagen W. J. H., Brun Y. V., Briggs J. A. G., Löwe J. Journal Nature Microbiology 2:17059. 18 April 2017 (2017)
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Design of a molecular support for cryo-EM structure determination
AuthorsMartin T. G., Bharat T. A., Joerger A. C., Bai X. C., Praetorius F., Fersht A. R., Dietz H., Scheres S. H.
Journal
Proceedings of the National Academy of Sciences of the United States of America
113(47):E7456-E7463. 22 November 2016 (2016)
Details
DOI10.1073/pnas.1612720113 PMID27821763 PMCIDPMC5127339 DivisionProtein & Nucleic Acid Chemistry, Structural Studies - Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION AuthorsBharat T. A., Scheres S. H. Journal Nature Protocols 11(11):2054-2065. November 2016 (2016)
- Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging AuthorsBharat T. A., Russo C. J., Löwe J., Passmore L. A., Scheres S. H. Journal Structure 23(9):1743-1753. 1 September 2015 (2015)
- Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles AuthorsBharat T. A., Murshudov G. N., Sachse C., Löwe J. Journal Nature 523(7558):106-110. 2 July 2015 (2015)
- Seeing tobacco mosaic virus through direct electron detectors. AuthorsFromm S. A., Bharat T. A., Jakobi A. J., Hagen W. J., Sachse C. Journal Journal of Structural Biology 189(2):87-97. 1 February 2015 (2015)
- Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly AuthorsBharat T. A., Castillo Menendez L. R., Hagen W. J., Lux V., Igonet S., Schorb M., Schur F. K., Kräusslich H. G., Briggs J. A. Journal Proceedings of the National Academy of Sciences, USA 111(22):8233-8238. 3 June 2014 (2014)
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Bacterial actin MreB forms antiparallel double filaments
Authorsvan den Ent F., Izoré T., Bharat T. A., Johnson C. M., Löwe J.
Journal
ELife
3:e02634. 2 May 2014 (2014)
Details
DOI10.7554/eLife.02634 PMID24843005 PMCIDPMC4051119 DivisionProtein & Nucleic Acid Chemistry, Structural Studies