Published Research
Found 38 results for Bertolotti.
- Quality control of glycogen through direct ubiquitylation by RNF213 AuthorsYip M. C. J., Naydenova K., Otten E. G., Heatley A., Moe A., Anton L., de Los Reyes-Ramírez L., Jolin H. E., Langevin F., Wiacek M., Franco C., Bertolotti A., Kukulski W., McKenzie A. N. J., Randow F. Journal Nature (2026)
- Termination of the integrated stress response AuthorsDe Miguel C., Thorkelsson S. R., Fatalska A., Hodgson G., Dalglish M., Wang C., Bertolotti A. Journal Science 391(6787):eadw5137 (2026)
- Termination of the integrated stress response AuthorsClaudia De Miguel, Sigurdur R. Thorkelsson, Agnieszka Fatalska, George Hodgson, Chao Wang, Anne Bertolotti Journal Science :eadw5137 (2025)
- Integrated stress response activator halofuginone protects mice from diabetes-like phenotypes AuthorsRai S, Szaruga M, Pitera AP, Bertolotti A. Journal Journal of Cell Biology Oct 7;223(10):e202405175. (2024)
- Keeping goblet cells unstressed: new insights into a general principle AuthorsBertolotti A. Journal The EMBO Journal 43(5):663-665 (2024)
- Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B AuthorsFatalska A., Hodgson G., Freund S. M. V., Maslen S. L., Morgan T., Thorkelsson S. R., van Slegtenhorst M., Lorenz S., Andreeva A., Kaat L. D., Bertolotti A. Journal Molecular Cell 84(3):506-521.e11 (2024)
- Activation of the integrated stress response by inhibitors of its kinases AuthorsSzaruga M., Janssen D. A., de Miguel C., Hodgson G, Fatalska A., Pitera A. P., Andreeva A., Bertolotti A. Journal https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10491595&blobtype=pdf, Bertolotti A. 14(1):5535 (2023)
- Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response AuthorsPitera A. P., Szaruga M., Peak-Chew S. Y., Wingett S. W., Bertolotti A. Journal EMBO Journal 41(11):e109985 (2022)
- An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress Response AuthorsKrzyzosiak A., Pitera A. P., Bertolotti A. Journal Methods in Molecular Biology 2428:3-18 (2022)
- Substrate recognition determinants of human eIF2α phosphatases AuthorsHodgson G., Andreeva A., Bertolotti A. Journal Open Biology 11(12):210205 (2021)
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Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation
AuthorsSchneider K., Nelson G. M., Watson J. L., Morf J., Dalglish M., Luh L. M., Weber A., Bertolotti A.
Journal
Cell Reports
32(11):108154. 15 September 2020 (2020)
Details
DOI10.1016/j. Celrep.2020.108154 PMID32937139 PMCIDPMC7495045 DivisionNeurobiology, Cell Biology - Potential benefit of manipulating protein quality control systems in neurodegenerative diseases AuthorsLuh L. M., Bertolotti A. Journal Current Opinion in Neurobiology 61:125-132. April 2020 (2020)
- The split protein phosphatase system AuthorsBertolotti A. Journal The Biochemical Journal 475(23):3707-3723. 12 December 2018 (2018)
- Regulation of proteasome assembly and activity in health and disease AuthorsRousseau A., Bertolotti A. Journal Nature Reviews. Molecular Cell Biology 19(11):697-712. November 2018 (2018)
- Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B AuthorsKrzyzosiak A., Sigurdardottir A., Luh L., Carrara M., Das I., Schneider K., Bertolotti A. Journal Cell 174(5):1216-1228.e19. 23 August 2018 (2018)
- Importance of the subcellular location of protein deposits in neurodegenerative diseases AuthorsBertolotti A. Journal Current Opinion in Neurobiology 51:127-133. August 2018 (2018)
- Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells AuthorsZhong Z., Grasso L., Sibilla C., Stevens T. J., Barry N., Bertolotti A. Journal EMBO Journal 37(6). 1 March 2018 (2018)
- Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy AuthorsSibilla C., Bertolotti A. Journal Cold Spring Harbor Perspectives in Biology 9(10). October 2017 (2017)
- Coping with Protein Quality Control Failure AuthorsPilla E., Schneider K., Bertolotti A. Journal Annual Review of Cell and Developmental Biology 33:439-465. October 2017 (2017)
- Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors AuthorsCarrara M., Sigurdardottir A., Bertolotti A. Journal Nature Structural & Molecular Biology 24(9):708-716. September 2017 (2017)
- qMotor, a set of rules for sensitive, robust and quantitative measurement of motor performance in mice AuthorsLuh L. M., Das I., Bertolotti A. Journal Nature Protocols 12(7):1451-1457. July 2017 (2017)
- Decoding the Protein Destruction Code: A Panoramic View AuthorsPilla E., Bertolotti A. Journal Molecular Cell 63(6):915-917.15 September 2016 (2016)
- An evolutionarily conserved pathway controls proteasome homeostasis AuthorsRousseau A., Bertolotti A. Journal Nature 536(7615):184-9. 11 August 2016 (2016)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) AuthorsKlionsky D. J., et al (including Bertolotti A.) Journal Autophagy 12(1):1-222. 2 January 2016 (2016)
- Surviving protein quality control catastrophes - from cells to organisms AuthorsSchneider K., Bertolotti A. Journal Journal of Cell Science 128(21):3861-3869. 1 November 2015 (2015)
- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit AuthorsDas I., Krzyzosiak A., Schneider K., Wrabetz L., D'Antonio M., Barry N., Sigurdardottir A., Bertolotti A. Journal Science 348(6231):239-242. 10 April 2015 (2015)
- An inducible chaperone adapts proteasome assembly to stress AuthorsHanssum A., Zhong Z., Rousseau A., Krzyzosiak A., Sigurdardottir A., Bertolotti A. Journal Molecular Cell 55(4):566-577. 21 August 2014 (2014)
- Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention AuthorsTsaytler P., Bertolotti A. Journal FEBS Journal 280(2):766-770. January 2013 (2013)
- Failure of amino acid homeostasis causes cell death following proteasome inhibition AuthorsSuraweera A., Münch C., Hanssum A., Bertolotti A. Journal Molecular Cell 48(2):242-253. 26 October 2012 (2012)
- Propagation of the prion phenomenon: beyond the seeding principle AuthorsMünch C., Bertolotti A. Journal Journal of Molecular Biology 421(4-5):491-498. 24 August 2012 (2012)
- Sustained translational repression by eIF2α-P mediates prion neurodegeneration AuthorsMoreno J. A., Radford H., Peretti D., Steinert J. R., Verity N., Martin M. G, Halliday M., Morgan J., Dinsdale D., Ortori C. A., Barrett D. A., Tsaytler P., Bertolotti A., Willis A. E., Bushell M., Mallucci G. R. Journal Nature 485(7399):507-511. 6 May 2012 (2012)
- Self-propagation and transmission of misfolded mutant SOD1: prion or prion-like phenomenon? AuthorsMünch C., Bertolotti A. Journal Cell Cycle 10(11):1711. 1 June 2011 (2011)
- Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis AuthorsTsaytler P., Harding H. P., Ron D., Bertolotti A. Journal Science 332(6025):91-94. 1 April 2011 (2011)
- Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells AuthorsMünch C., O'Brien J., Bertolotti A. Journal Proceedings of the National Academy of Sciences, USA 108(9):3548-3553. 1 March 2011 (2011)
- Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants AuthorsMünch C., Bertolotti A. Journal Journal of Molecular Biology 399(3):512-525. 11 June 2010 (2010)
- Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones AuthorsRousseau E, Kojima R, Hoffner G, Djian P, Bertolotti A Journal Journal of Biological Chemistry 284 (3): 1917-29 (2009)
- Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones AuthorsErwann Rousseau, Rieko Kojima, Guylaine Hoffner, Philippe Djian, Anne Bertolotti Journal Journal of Biological Chemistry 284 (3): 1917-29 (2008)
- Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity AuthorsDehay B., Weber C., Trottier Y., Bertolotti A. Journal Biotechnol. J. 2(5): 559-564. May 2007 (2007)