Published Research
Found 29 results for Aricescu.
- Determining the molecular and physiological actions of subtype-selective nanobodies of GABAA receptors AuthorsGonzalez-Prada J. E., Liu S., Shang C., Chernoff C. S., Bright D. P., Mortensen M., Jones C. F., Nestorow S., Kasaragod V. B., Chen W. N., Hannan S., Zhou J., Dunn A. W. E., Soltani A., Turner R. J., Duggan N. M., Yuan Y., Wahid A. A., Hardwick S. W., Scott S., Chirgadze D. Y., Pardon E., Steyaert J., Aricescu A. R., Paulsen O., Belin D., Smart T. G., Miller P. S. Journal Science Advances 12(31):eaeg3548 (2026)
- Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum AuthorsAlexander M. Scrutton, Nayanika Sengupta, Josip Ivica, Imogen Stockwell, Sew Peak-Chew, Bishal Singh, Kunimichi Suzuki, Veronica T. Chang, Stephen H. McLaughlin, James M. Krieger, A. Radu Aricescu, Ingo H. Greger Journal Science :eaeb3577 (2025)
- Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum AuthorsScrutton A. M., Sengupta N., Ivica J., Stockwell I., Peak-Chew S., Singh B., Suzuki K., Chang V. T., McLaughlin S. H., Krieger J. M., Aricescu A. R., Greger I. H. Journal Science 391(6792):1361-1367 (2026)
- Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV AuthorsKaria D., Koh A.F., Yang W., Cushing V.I., Basanta B., Mihaylov D.B., Khavnekar S., Vyroubal O., Malínský M., Shánel O., Doležal V., Plitzko J, Yu L, Lander GC, Aricescu AR, Greber BK, Kotecha A. Journal Structure (London, England : 1993) :S0969-2126(25)00255-2 (2025)
- One-step nanoscale expansion microscopy reveals individual protein shapes AuthorsShaib A. H., Chouaib A. A., Chowdhury R., Altendorf J., Mihaylov D., Zhang C., Krah D., Imani V., Spencer R. K. W., Georgiev S. V., Mougios N., Monga M., Reshetniak S., Mimoso T., Chen H., Fatehbasharzad P., Crzan D., Saal K. A., Alawieh M. M., Alawar N., Eilts J., Kang J., Soleimani A., Müller M., Pape C., Alvarez L., Trenkwalder C., Mollenhauer B., Outeiro T. F., Köster S., Preobraschenski J., Becherer U., Moser T., Boyden E. S., Aricescu A. R., Sauer M., Opazo F., Rizzoli S. O. Journal Nature Biotechnology (2024)
- The molecular basis of drug selectivity for α5 subunit-containing GABA(A) receptors AuthorsKasaragod V. B., Malinauskas T., Wahid A. A., Lengyel J., Knoflach F., Hardwick S. W., Jones C. F., Chen W. N., Lucas X., El Omari K., Chirgadze D. Y., Aricescu A. R., Cecere G., Hernandez M. C., Miller P. S. Journal Nature Structural & Molecular Biology 30(12): 1936–1946. (2023)
- Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes AuthorsNonaka H., Mino T., Sakamoto S., Oh J.H., Watanabe Y., Ishikawa M., Tsushima A., Amaike K., Kiyonaka S., Tamura T., Aricescu A.R., Kakegawa W., Miura E., Yuzaki M., Hamachi I. Journal Chem 9(2):523-540 (2023)
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Differential assembly diversifies GABAA receptor structures and signalling
AuthorsSente A., Desai R., Naydenova K., Malinauskas T., Jounaidi Y., Miehling J., Zhou X., Masiulis S., Hardwick S. W., Chirgadze D. Y., Miller K. W., Aricescu A. R.
Journal
Nature
604(7904):190-194 (2022)
Details
DOI10.1038/s41586-022-04517‑3 PMID35355020 PMCIDPMC7612593 DivisionNeurobiology, Structural Studies -
Differential assembly diversifies GABAA receptor structures and signalling
AuthorsSente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR.
Journal
Nature
10.1038/s41586-022-04517-3 (2022)
Details
DOI10.1038/s41586-022-04517‑3 PMID35355020 PMCIDPMC7612593 DivisionStructural Studies , Neurobiology -
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
AuthorsRalf Salzer, Jordan J. Clark, Marina Vaysburd, Veronica T. Chang, Anna Albecka, Leo Kiss, Parul Sharma, Andres Gonzalez Llamazares, Anja Kipar, Julian A. Hiscox, Andrew Owen, A. Radu Aricescu, James P. Stewart, Leo C. James, Jan Löwe
Journal
FEBS Letters
595(18):2323-2340 (2021)
Details
DOI10.1002/1873-3468.14171 PMID34331769 PMCIDPMC8426897 DivisionNeurobiology, Protein & Nucleic Acid Chemistry, Structural Studies - Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling AuthorsRobinson R. A., Griffiths S. C., van de Haar L. L., Malinauskas T., van Battum E. Y., Zelina P., Schwab R. A., Karia D., Malinauskaite L., Brignani S., van den Munkhof M. H., Düdükcü Ö., De Ruiter A. A., Van den Heuvel D. M. A., Bishop B., Elegheert J., Aricescu A. R., Pasterkamp R. J., Siebold C. Journal Cell 184(8):2103-2120.e31. 15 April 2021 (2021)
- Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent AuthorsThimaradka V., Hoon Oh J., Heroven C., Radu Aricescu A., Yuzaki M., Tamura T., Hamachi I. Journal Bioorganic & Medicinal Chemistry 30:115947 (2021)
- Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo‑EM AuthorsUchański T., Masiulis S., Fischer B., Kalichuk V., López-Sánchez U., Zarkadas E., Weckener M., Sente A., Ward P., Wohlkönig A., Zögg T., Remaut H., Naismith J. H., Nury H., Vranken W., Aricescu A. R., Pardon E., Steyaert J. Journal Nature Methods 18(1):60-68. January 2021 (2021)
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Single-particle cryo-EM at atomic resolution
AuthorsNakane T., Kotecha A., Sente A., McMullan G., Masiulis S., Brown P. M. G. E., Grigoras I. T., Malinauskaite L., Malinauskas T., Miehling J., Uchański T., Yu L., Karia D., Pechnikova E. V., de Jong E., Keizer J., Bischoff M., McCormack J., Tiemeijer P., Hardwick S. W., Chirgadze D. Y., Murshudov G., Aricescu A. R., Scheres S. H. W.
Journal
Nature
587(7832):152-156. 5 November 2020 (2020)
Details
DOI10.1038/s41586-020-2829‑0 PMID33087931 PMCIDPMC7611073 DivisionNeurobiology, Structural Studies - A synthetic synaptic organizer protein restores glutamatergic neuronal circuits AuthorsSuzuki K., Elegheert J., Song I., Sasakura H., Senkov O., Matsuda K., Kakegawa W., Clayton A. J., Chang V. T., Ferrer-Ferrer M., Miura E., Kaushik R., Ikeno M., Morioka Y., Takeuchi Y., Shimada T., Otsuka S., Stoyanov S., Watanabe M., Takeuchi K., Dityatev A., Aricescu A. R., Yuzaki M. Journal Science 369(6507). 28 August 2020 (2020)
- A structural perspective on GABAA receptor pharmacology AuthorsScott S., Aricescu A. R. Journal Current Opinion in Structural Biology 54:189-197. 1 February 2019 (2019)
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Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer
AuthorsLaverty D., Desai R., Uchański T., Masiulis S., Stec W. J., Malinauskas T., Zivanov J., Pardon E., Steyaert J., Miller K. W., Aricescu A. R.
Journal
Nature
565(7740):516-520. 24 January 2019 (2019)
Details
DOI10.1038/s41586-018-0833‑4 PMID30602789 PMCIDPMC6364807 DivisionNeurobiology, Structural Studies -
GABAA receptor signalling mechanisms revealed by structural pharmacology
AuthorsMasiulis S., Desai R., Uchański T., Serna Martin I., Laverty D., Karia D., Malinauskas T., Zivanov J., Pardon E., Kotecha A., Steyaert J., Miller K. W., Aricescu A. R.
Journal
Nature
565(7740):454-459. 24 January 2019 (2019)
Details
DOI10.1038/s41586-018-0832-5 PMID30602790 PMCIDPMC6370056 DivisionNeurobiology, Structural Studies - Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins AuthorsElegheert J., Behiels E., Bishop B., Scott S., Woolley R. E., Griffiths S. C., Byrne E. F. X., Chang V. T., Stuart D. I., Jones E. Y., Siebold C., Aricescu A. R. Journal Nature Protocols 13(12):2991-3017. 19 November 2018 (2018)
- Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships AuthorsZhang P., Lu H., Peixoto R. T., Pines M. K., Ge Y., Oku S., Siddiqui T. J., Xie Y., Wu W., Archer-Hartmann S., Yoshida K., Tanaka K. F., Aricescu A. R., Azadi P., Gordon M. D., Sabatini B. L., Wong R. O. L., Craig A. M. Journal Cell 174(6):1450-1464.e23. 6 September 2018 (2018)
- Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome AuthorsBerridge G., Menassa D. A., Moloney T., Waters P. J., Welding I., Thomsen S., Zuberi S., Fischer R., Aricescu A. R., Pike M., Dale R. C., Kessler B., Vincent A., Lim M., Irani S. R., Lang B. Journal Neurology 91(8):e714-e723. 21 August 2018 (2018)
- Heteromeric GABAA receptor structures in positively-modulated active states AuthorsMiller P. S., Masiulis S., Malinauskas T., Kotecha A., Rao S., Chavali S., De Colibus L., Pardon E., Hannan S., Scott S., Sun Z., Frenz B., Klesse G., Li S., Diprose J. M., Siebert C. A., Esnouf R. M., DiMaio F.,Tucker S. J., Smart T. G., Steyaert J., Babu M. M., Sansom M. S. P., Huiskonen J. T., Aricescu A. R. Journal bioRxiv (2018)
- Structural basis for GABAA receptor potentiation by neurosteroids AuthorsMiller P. S., Scott S., Masiulis S., De Colibus L., Pardon E., Steyaert J., Aricescu A. R. Journal Nature Structural & Molecular Biology 24(11):986-992. November 2017 (2017)
- A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability AuthorsDavies B., Brown L. A., Cais O., Watson J., Clayton A. J., Chang V. T., Biggs D., Preece C., Hernandez-Pliego P., Krohn J., Bhomra A., Twigg S. R. F, Rimmer A., Kanapin A.; W. G. S. 500 Consortium, Sen A., Zaiwalla Z., McVean G., Foster R., Donnelly P., Taylor J. C., Blair E., Nutt D., Aricescu A. R., Greger I. H., Peirson S. N., Flint J., Martin H. C. Journal Human Molecular Genetics 26(20):3869-3882. 15 October 2017 (2017)
- Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation AuthorsFarhy-Tselnicker I., van Casteren A. C. M., Lee A., Chang V. T., Aricescu A. R., Allen N. J. Journal Neuron 96(2):428-445.e13. 11 October 2017 (2017)
- Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins AuthorsElegheert J., Cvetkovska V., Clayton A. J., Heroven C., Vennekens K. M., Smukowski S. N., Regan M. C., Jia W., Smith A. C., Furukawa H., Savas J. N., de Wit J., Begbie J., Craig A. M., Aricescu A. R. Journal Neuron 96(1):242-244. 27 September 2017 (2017)
- Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins AuthorsElegheert J., Cvetkovska V., Clayton A. J., Heroven C., Vennekens K. M., Smukowski S. N, Regan M. C., Jia W., Smith A. C., Furukawa H., Savas J. N., de Wit J., Begbie J., Craig A. M., Aricescu A. R. Journal Neuron 95(4):896-913.e10. 16 August 2017 (2017)
- Structural basis for integration of GluD receptors within synaptic organizer complexes. AuthorsElegheert J., Kakegawa W., Clay J. E., Shanks N. F., Behiels E., Matsuda K., Kohda K., Miura E., Rossmann M., Mitakidis N., Motohashi J., Chang V. T., Siebold C., Greger I. H., Nakagawa T., Yuzaki M., Aricescu A. R. Journal Science 353(6296):295-299. 15 July 2016 (2016)
- Factors influencing success of clinical genome sequencing across a broad spectrum of disorders AuthorsTaylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G Journal Nature Genetics 47(7):717-726. July 2015 (2015)