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• Pioneering lab at Bourn Hall Clinic uncovers secrets about the biology of human eggs
  Authors Brackley, Paul Source Cambridge Independent 21 November 2017 Year 2017
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  Subject Dr Melina Schuh’s new laboratory at Bourn Hall Clinic is carrying out ground-breaking research into human eggs. It is seeking to uncover the secrets of why older women find it harder to fall pregnant Keywords Melina Schuh; Bourn Hall Clinic; Chromosomal abnormalities; human egg; Bianka Seres; meiosis; aneuploidy; spindle fibres; Max Planck Institute; older women; miscarriage
• Potassium is critical to circadian rhythms in human red blood cells
  Authors Meredith, Natasha Source University of Surrey 12 December 2017 Year 2017
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  Subject An innovative new study from the University of Surrey and John O’Neill’s group from the LMB’s Cell Biology Division has uncovered the secrets of the circadian rhythms in red blood cells and identified potassium as the key to unravelling the mystery. Keywords John O’Neill; University of Surrey; red blood cells; Fatima Labeed; potassium; circadian rhythms; dielectrophoresis; ‘clock genes’
• Prof. Alison Woollard appointed as Academic Champion for Public Engagement with Research
  Authors Garman, Elspeth Source University of Oxford 10 February 2017 Year 2017
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  Subject Former LMB Postdoctoral Fellow Professor Alison Woollard, Department of Biochemistry and Fellow of Hertford College, has been appointed as the University of Oxford’s next Academic Champion for Public Engagement with Research. Keywords Alison Woollard; University of Oxford; Public Engagement; Research; Academic Champion; alumni
• Researchers “drug the undruggable” through unique collaboration
  Authors Cancer Research UK Source Cancer Research UK 18 October 2017 Year 2017
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  Subject A new approach to targeting key cancer-linked proteins, thought to be ‘undruggable’, has been discovered through an alliance between industry and academia created by Cancer Research UK. David Komander’s group is one of the groups involved in this unique collaboration. Keywords David Komander; p53; ubiquitin-proteasome system; USP7; ‘undruggable’; cancer;
• Researchers create first 3D structures of active DNA
  Authors Medical Research Council Source Medical Research Council 13 March 2017 Year 2017
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  Subject Scientists, have determined the first 3D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately folds to fit together inside the cell nuclei. Keywords Mammalian genomes; 3D structures; ‘master cells’; chromosomes; Tim Stevens; Ernest Laue; nuclear lamina; nuclei
• Scientists established a comprehensive protein interactions map of the replication machinery of a chronic virus
  Authors Medical Press Source Medical Press 20 December 2017 Year 2017
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  Subject Chronic viral infections are amongst the biggest threats to human health worldwide. Leo James’ group from the LMB’s PNAC Division, in collaboration with scientists at the Austrian Academy of Sciences and University of Basel, have established the first comprehensive overview of cellular proteins interacting with the LCMV polymerase. Keywords Chronic viral infections; HIV; hepatitis; LCMV polymerase; human proteome; antiviral therapeutics; viral proteins; Kseniya Khamina; TRIM21; DDX3X; infection; Andreas Bergthaler; Leo James
• Sharp focus on Alzheimer’s may help target drugs
  Authors Gallagher, James Source BBC News 5 July 2017 Year 2017
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  Subject Abnormal deposits that build up in the brain during Alzheimer’s have been pictured in unprecedented detail in research led by Sjors Scheres and Michel Goedert Keywords Alzheimer’s; Sjors Scheres; Michel Goedert; beta amyloid; Parkinson’s; alpha synuclein; tau; neurodegenerative disease;”resolution revolution”; tangles; Nature journal
• Soul of a Molecular Machine – A Conversation with Venki Ramakrishnan
  Authors Edge Source Edge 4 May 2017 Year 2017
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  Subject Conversation with Venki Ramakrishnan taking about his research, and looking at the past and future of structural biology. Keywords Venki Ramakrishnan; ribosome; atomic; mitochondrial; viruses; hepatitis C; Max Perutz; Royal Society; machine learning; Francis Crick; RNA; Bayesian algorithms; structural biologist; Tony Crowther; Aaron Klug; Joachim Frank; Marin van Heel; amino acids
• Student shares data on research to parliament
  Authors Welch, George Source Oxfordshire Guardian 20 March 2017 Year 2017
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  Subject Cara Ellison a PhD student at the LMB takes part in the STEM (Science Technology, Engineering and Maths) for Britain event at Westminster Keywords Cara Ellison; STEM; Oxfordshire; Stephen Metcalfe MP; PhD Student; Westminster; bacteria; viruses; Parliament; Scientific Committee
• Tau Filaments from the Alzheimer’s Brain Revealed at Atomic Resolution
  Authors Alzforum Source Alzforum 7 July 2017 Year 2017
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  Subject Tau filaments isolated from an Alzheimer’s brain are the latest, high-profile exploit of cryo-electron microscopy. Using his technique his, Sjors Scheres, teamed up with Michel Goedert,to solve 3.4-Angstrom resolution structures of both straight and paired helical filaments of tau Keywords Alzheimer’s; Sjors Scheres; Michel Goedert; tau; Cryo-EM microscopy; fibrils; β-helix; C-shaped protofilament monomer; AD; paired helical filaments (PHFs); straight filaments (SFs); N-terminus; “fuzzy coat”; Nature