LMB / Science / Research Leaders / Molecular Immunity Unit / Tetsuo Hasegawa
Molecular Immunity Unit

Tetsuo Hasegawa

The role of neuroimmune interactions in the joint

Tetsuo Hasegawa
Molecular Immunity Unit
Group Members
  • Yvswenne Liew
  • Tammie Sow

Joint pain and inflammation are common manifestations of various systemic diseases. We are generating a 3D molecular atlas of the membrane in the joint, called the synovium, to investigate why joints are responsive to diverse systemic pathologies, how communication between synovial cells and nociceptors influences disease progression and what mechanisms underlie immune-driven pain in the joints.

Immune challenges extravasating from fenestrated capillaries in the joint
Immune challenges extravasating from fenestrated capillaries in the joint.

Selected Publications

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge.Hasegawa T, Lee CYC, Hotchen AJ, Fleming A, Singh R, Suzuki K, Yuzaki M, Watanabe M, Birch MA, McCaskie AW, Lénárt N, Tóth K, Dénes Á, Liu Z, Ginhoux F, Richoz N, Clatworthy MRNat Immunol 25(12): 2270-2283 (2024)
Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1.Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii MNat Immunol 20(12): 1631-1643 (2020)
Periportal macrophages protect against commensal-driven liver inflammation.Miyamoto Y, Kikuta J, Matsui T, Hasegawa T, Fujii K, Okuzaki D, Liu YC, Yoshioka T, Seno S, Motooka D, Uchida Y, Yamashita E, Kobayashi S, Eguchi H, Morii E, Tryggvason K, Shichita T, Kayama H, Atarashi K, Kunisawa J, Honda K, Takeda K, Ishii MNature 629(8013): 901-909 (2024)
Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo.Hasegawa T, Kikuta J, Sudo T, Yamashita E, Seno S, Takeuchi T, Ishii MSci Rep 10(1): 13480 (2020) Epub